Propofol, midazolam, vancomycin and cyclosporine therapeutic drug monitoring in extracorporeal membrane oxygenation circuits primed with whole human blood View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12-01

AUTHORS

Florian Lemaitre, Nesrine Hasni, Pascal Leprince, Emmanuel Corvol, Ghassen Belhabib, Pierre Fillâtre, Charles-Edouard Luyt, Cyril Leven, Robert Farinotti, Christine Fernandez, Alain Combes

ABSTRACT

INTRODUCTION: As a result of drug sequestration and increased volume of distribution, the extracorporeal membrane oxygenation (ECMO) procedure might lead to a decrease in drug concentrations during a patient's treatment. The aim of this study was to evaluate sedative, antibiotic and immunosuppressive drug loss in ECMO circuit using ex-vivo and in-vitro experiments. METHODS: Blood concentrations of propofol, midazolam, cyclosporine and vancomycin were measured in an ex-vivo ECMO circuit primed with whole human blood, and compared to controls stored in polypropylene tubes. In vitro experiments were also conducted to further explore the role of temperature, oxygen exposure and polyvinylchloride surfaces on propofol loss in the ECMO circuit. RESULTS: Propofol concentration decreased rapidly; 70% of its baseline concentration was lost after only 30 minutes, and only 11% remained after five hours (P <0.001 for the comparison with control polypropylene tube propofol concentration). Further experiments demonstrated that oxygen exposure and contact with polyvinylchloride tubing were respectively responsible for 70% and 85% of propofol loss after 45 minutes. Midazolam concentration also rapidly decreased in the ECMO circuit, with only 54% and 11% of baseline concentration being detected at 30 minutes and 24 hours respectively (P = 0.01 versus control). Alternatively, cyclosporine concentration remained stable for the five first hours, then decreased to 78% and 73% of the baseline value after 24 hours and 48 hours, (P = 0.35 versus control). Lastly, vancomycin concentration remained stable in the ECMO circuit for the 48-hour experimental protocol. CONCLUSIONS: We observed important losses of propofol and midazolam, while cyclosporine concentration decreased slowly and moderately, and vancomycin concentration remained unchanged in the ex-vivo ECMO circuit primed with whole human blood. These data might help intensive care unit physicians planning clinical trials with a final objective to better adapt doses of these drugs while treating critically ill ECMO patients. More... »

PAGES

40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13054-015-0772-5

DOI

http://dx.doi.org/10.1186/s13054-015-0772-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030765358

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25886890


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Infective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Critical Illness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclosporine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Monitoring", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracorporeal Membrane Oxygenation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypnotics and Sedatives", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Midazolam", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polyvinyl Chloride", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Propofol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vancomycin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Inserm, CIC-P 1414 Clinical Investigation Center, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "Faculty of Pharmacy, EA4123 Barri\u00e8res physiologiques et r\u00e9ponses th\u00e9rapeutiques, Paris Sud University, Ch\u00e2tenay-Malabry, France", 
            "Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, Rennes University Hospital, Rennes, France", 
            "Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, Rennes 1 University, Rennes, France", 
            "Inserm, CIC-P 1414 Clinical Investigation Center, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lemaitre", 
        "givenName": "Florian", 
        "id": "sg:person.01110354341.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110354341.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Pharmacy, EA4123 Barri\u00e8res physiologiques et r\u00e9ponses th\u00e9rapeutiques, Paris Sud University, Ch\u00e2tenay-Malabry, France", 
          "id": "http://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "Faculty of Pharmacy, EA4123 Barri\u00e8res physiologiques et r\u00e9ponses th\u00e9rapeutiques, Paris Sud University, Ch\u00e2tenay-Malabry, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasni", 
        "givenName": "Nesrine", 
        "id": "sg:person.01312065302.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312065302.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Surgery department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique H\u00f4pitaux de Paris, AP-HP, 47-83 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Paris 6 University Pierre et Marie Curie, 91-105 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France", 
            "Cardiovascular Surgery department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique H\u00f4pitaux de Paris, AP-HP, 47-83 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leprince", 
        "givenName": "Pascal", 
        "id": "sg:person.01246012577.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246012577.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Surgery department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique H\u00f4pitaux de Paris, AP-HP, 47-83 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Cardiovascular Surgery department, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance Publique H\u00f4pitaux de Paris, AP-HP, 47-83 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corvol", 
        "givenName": "Emmanuel", 
        "id": "sg:person.0754216253.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754216253.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Pharmacy, EA4123 Barri\u00e8res physiologiques et r\u00e9ponses th\u00e9rapeutiques, Paris Sud University, Ch\u00e2tenay-Malabry, France", 
          "id": "http://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "Faculty of Pharmacy, EA4123 Barri\u00e8res physiologiques et r\u00e9ponses th\u00e9rapeutiques, Paris Sud University, Ch\u00e2tenay-Malabry, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belhabib", 
        "givenName": "Ghassen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inserm, CIC-P 1414 Clinical Investigation Center, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, Rennes University Hospital, Rennes, France", 
            "Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, Rennes 1 University, Rennes, France", 
            "Inserm, CIC-P 1414 Clinical Investigation Center, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fill\u00e2tre", 
        "givenName": "Pierre", 
        "id": "sg:person.01273730565.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273730565.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris 6 University Pierre et Marie Curie, 91-105 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, iCAN, Institute of Cardiometabolism and Nutrition, 47, Boulevard de l\u2019H\u00f4pital, 75651 Paris, Cedex 13 France", 
            "Paris 6 University Pierre et Marie Curie, 91-105 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luyt", 
        "givenName": "Charles-Edouard", 
        "id": "sg:person.01310337776.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310337776.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inserm, CIC-P 1414 Clinical Investigation Center, Rennes, France", 
          "id": "http://www.grid.ac/institutes/grid.7429.8", 
          "name": [
            "Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, Rennes University Hospital, Rennes, France", 
            "Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, Rennes 1 University, Rennes, France", 
            "Inserm, CIC-P 1414 Clinical Investigation Center, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leven", 
        "givenName": "Cyril", 
        "id": "sg:person.01247140265.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247140265.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Pharmacy, EA4123 Barri\u00e8res physiologiques et r\u00e9ponses th\u00e9rapeutiques, Paris Sud University, Ch\u00e2tenay-Malabry, France", 
          "id": "http://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "Faculty of Pharmacy, EA4123 Barri\u00e8res physiologiques et r\u00e9ponses th\u00e9rapeutiques, Paris Sud University, Ch\u00e2tenay-Malabry, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farinotti", 
        "givenName": "Robert", 
        "id": "sg:person.01221026417.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221026417.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pharmacy Department, Saint-Antoine Hospital, Assistance Publique H\u00f4pitaux de Paris, AP-HP, 184 rue du faubourg Saint-Antoine, 75012 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.412370.3", 
          "name": [
            "Faculty of Pharmacy, EA4123 Barri\u00e8res physiologiques et r\u00e9ponses th\u00e9rapeutiques, Paris Sud University, Ch\u00e2tenay-Malabry, France", 
            "Pharmacy Department, Saint-Antoine Hospital, Assistance Publique H\u00f4pitaux de Paris, AP-HP, 184 rue du faubourg Saint-Antoine, 75012 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fernandez", 
        "givenName": "Christine", 
        "id": "sg:person.01307767706.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307767706.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris 6 University Pierre et Marie Curie, 91-105 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.462844.8", 
          "name": [
            "Service de R\u00e9animation M\u00e9dicale, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, iCAN, Institute of Cardiometabolism and Nutrition, 47, Boulevard de l\u2019H\u00f4pital, 75651 Paris, Cedex 13 France", 
            "Paris 6 University Pierre et Marie Curie, 91-105 Boulevard de l\u2019H\u00f4pital, 75013 Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Combes", 
        "givenName": "Alain", 
        "id": "sg:person.0710520012.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710520012.16"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00134-007-0606-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019529811", 
          "https://doi.org/10.1007/s00134-007-0606-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bmt.1702196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023586512", 
          "https://doi.org/10.1038/sj.bmt.1702196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03009997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051974101", 
          "https://doi.org/10.1007/bf03009997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-2041-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022458689", 
          "https://doi.org/10.1007/s00134-010-2041-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-010-1882-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050143005", 
          "https://doi.org/10.1007/s00134-010-1882-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc11679", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006765673", 
          "https://doi.org/10.1186/cc11679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200342050-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006056958", 
          "https://doi.org/10.2165/00003088-200342050-00001"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12-01", 
    "datePublishedReg": "2015-12-01", 
    "description": "INTRODUCTION: As a result of drug sequestration and increased volume of distribution, the extracorporeal membrane oxygenation (ECMO) procedure might lead to a decrease in drug concentrations during a patient's treatment. The aim of this study was to evaluate sedative, antibiotic and immunosuppressive drug loss in ECMO circuit using ex-vivo and in-vitro experiments.\nMETHODS: Blood concentrations of propofol, midazolam, cyclosporine and vancomycin were measured in an ex-vivo ECMO circuit primed with whole human blood, and compared to controls stored in polypropylene tubes. In vitro experiments were also conducted to further explore the role of temperature, oxygen exposure and polyvinylchloride surfaces on propofol loss in the ECMO circuit.\nRESULTS: Propofol concentration decreased rapidly; 70% of its baseline concentration was lost after only 30\u00a0minutes, and only 11% remained after five hours (P <0.001 for the comparison with control polypropylene tube propofol concentration). Further experiments demonstrated that oxygen exposure and contact with polyvinylchloride tubing were respectively responsible for 70% and 85% of propofol loss after 45\u00a0minutes. Midazolam concentration also rapidly decreased in the ECMO circuit, with only 54% and 11% of baseline concentration being detected at 30\u00a0minutes and 24\u00a0hours respectively (P\u2009=\u20090.01 versus control). Alternatively, cyclosporine concentration remained stable for the five first hours, then decreased to 78% and 73% of the baseline value after 24\u00a0hours and 48\u00a0hours, (P\u2009=\u20090.35 versus control). Lastly, vancomycin concentration remained stable in the ECMO circuit for the 48-hour experimental protocol.\nCONCLUSIONS: We observed important losses of propofol and midazolam, while cyclosporine concentration decreased slowly and moderately, and vancomycin concentration remained unchanged in the ex-vivo ECMO circuit primed with whole human blood. These data might help intensive care unit physicians planning clinical trials with a final objective to better adapt doses of these drugs while treating critically ill ECMO patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13054-015-0772-5", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1117766", 
        "issn": [
          "1364-8535", 
          "1466-609X"
        ], 
        "name": "Critical Care", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "keywords": [
      "ECMO circuit", 
      "cyclosporine concentrations", 
      "vancomycin concentrations", 
      "whole human blood", 
      "extracorporeal membrane oxygenation procedures", 
      "vivo ECMO circuits", 
      "baseline concentrations", 
      "extracorporeal membrane oxygenation circuit", 
      "human blood", 
      "volume of distribution", 
      "membrane oxygenation circuit", 
      "therapeutic drug monitoring", 
      "unit physicians", 
      "ECMO patients", 
      "clinical trials", 
      "blood concentrations", 
      "midazolam concentrations", 
      "propofol concentration", 
      "baseline values", 
      "drug monitoring", 
      "patient treatment", 
      "midazolam", 
      "propofol", 
      "drug concentrations", 
      "blood", 
      "first hour", 
      "drug sequestration", 
      "oxygenation procedure", 
      "polyvinylchloride tubing", 
      "vancomycin", 
      "oxygen exposure", 
      "hours", 
      "minutes", 
      "treatment", 
      "exposure", 
      "drug loss", 
      "cyclosporine", 
      "patients", 
      "experimental protocol", 
      "doses", 
      "physicians", 
      "trials", 
      "drugs", 
      "loss", 
      "Further experiments", 
      "concentration", 
      "polypropylene tubes", 
      "aim", 
      "decrease", 
      "control", 
      "study", 
      "role", 
      "protocol", 
      "volume", 
      "procedure", 
      "objective", 
      "monitoring", 
      "tubing", 
      "important loss", 
      "data", 
      "contact", 
      "tube", 
      "results", 
      "sequestration", 
      "values", 
      "experiments", 
      "circuit", 
      "distribution", 
      "final objective", 
      "surface", 
      "role of temperature", 
      "temperature", 
      "membrane oxygenation (ECMO) procedure", 
      "immunosuppressive drug loss", 
      "ex-vivo ECMO circuit", 
      "propofol loss", 
      "care unit physicians", 
      "ill ECMO patients", 
      "oxygenation circuits"
    ], 
    "name": "Propofol, midazolam, vancomycin and cyclosporine therapeutic drug monitoring in extracorporeal membrane oxygenation circuits primed with whole human blood", 
    "pagination": "40", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030765358"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13054-015-0772-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25886890"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13054-015-0772-5", 
      "https://app.dimensions.ai/details/publication/pub.1030765358"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_672.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13054-015-0772-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0772-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0772-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0772-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0772-5'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      22 PREDICATES      125 URIs      110 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13054-015-0772-5 schema:about N0ac4b512daef4f3e9d478af9f0757035
2 N12e1f3bae15c4264b451f6589d515361
3 N15c8ceaa7eff4d5fb5b793c827409b7a
4 N29df8d016c68442f9fdbc604b4ec6f98
5 N8ae74cc93a7b4b1e9cc302e4ce05cea9
6 N911f1cc66ab843f4a715dcb6faa67c45
7 N9dbaebe5e5654824b254e5b889ea4558
8 Nab25ecacaa144c158f091ca78675429b
9 Nc45f50033da04e94809f8cbf9562bd72
10 Nd5be9154b49e416c95fa7c9bc428af26
11 Nddc0fa1750a84bad94f12e8789f5fbb2
12 Nf77832d793a943f0a3d685c639cee068
13 Nffe78caf5569445d8ad32167a691154a
14 anzsrc-for:11
15 anzsrc-for:1103
16 schema:author N95ff550cadca4f6ea59a6845aef54bd7
17 schema:citation sg:pub.10.1007/bf03009997
18 sg:pub.10.1007/s00134-007-0606-2
19 sg:pub.10.1007/s00134-010-1882-9
20 sg:pub.10.1007/s00134-010-2041-z
21 sg:pub.10.1038/sj.bmt.1702196
22 sg:pub.10.1186/cc11679
23 sg:pub.10.2165/00003088-200342050-00001
24 schema:datePublished 2015-12-01
25 schema:datePublishedReg 2015-12-01
26 schema:description INTRODUCTION: As a result of drug sequestration and increased volume of distribution, the extracorporeal membrane oxygenation (ECMO) procedure might lead to a decrease in drug concentrations during a patient's treatment. The aim of this study was to evaluate sedative, antibiotic and immunosuppressive drug loss in ECMO circuit using ex-vivo and in-vitro experiments. METHODS: Blood concentrations of propofol, midazolam, cyclosporine and vancomycin were measured in an ex-vivo ECMO circuit primed with whole human blood, and compared to controls stored in polypropylene tubes. In vitro experiments were also conducted to further explore the role of temperature, oxygen exposure and polyvinylchloride surfaces on propofol loss in the ECMO circuit. RESULTS: Propofol concentration decreased rapidly; 70% of its baseline concentration was lost after only 30 minutes, and only 11% remained after five hours (P <0.001 for the comparison with control polypropylene tube propofol concentration). Further experiments demonstrated that oxygen exposure and contact with polyvinylchloride tubing were respectively responsible for 70% and 85% of propofol loss after 45 minutes. Midazolam concentration also rapidly decreased in the ECMO circuit, with only 54% and 11% of baseline concentration being detected at 30 minutes and 24 hours respectively (P = 0.01 versus control). Alternatively, cyclosporine concentration remained stable for the five first hours, then decreased to 78% and 73% of the baseline value after 24 hours and 48 hours, (P = 0.35 versus control). Lastly, vancomycin concentration remained stable in the ECMO circuit for the 48-hour experimental protocol. CONCLUSIONS: We observed important losses of propofol and midazolam, while cyclosporine concentration decreased slowly and moderately, and vancomycin concentration remained unchanged in the ex-vivo ECMO circuit primed with whole human blood. These data might help intensive care unit physicians planning clinical trials with a final objective to better adapt doses of these drugs while treating critically ill ECMO patients.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree true
30 schema:isPartOf N6c66f110bb294bf6bb39973f3db172ff
31 Ncd4cac260e9f409dafc72f966a5b9e1b
32 sg:journal.1117766
33 schema:keywords ECMO circuit
34 ECMO patients
35 Further experiments
36 aim
37 baseline concentrations
38 baseline values
39 blood
40 blood concentrations
41 care unit physicians
42 circuit
43 clinical trials
44 concentration
45 contact
46 control
47 cyclosporine
48 cyclosporine concentrations
49 data
50 decrease
51 distribution
52 doses
53 drug concentrations
54 drug loss
55 drug monitoring
56 drug sequestration
57 drugs
58 ex-vivo ECMO circuit
59 experimental protocol
60 experiments
61 exposure
62 extracorporeal membrane oxygenation circuit
63 extracorporeal membrane oxygenation procedures
64 final objective
65 first hour
66 hours
67 human blood
68 ill ECMO patients
69 immunosuppressive drug loss
70 important loss
71 loss
72 membrane oxygenation (ECMO) procedure
73 membrane oxygenation circuit
74 midazolam
75 midazolam concentrations
76 minutes
77 monitoring
78 objective
79 oxygen exposure
80 oxygenation circuits
81 oxygenation procedure
82 patient treatment
83 patients
84 physicians
85 polypropylene tubes
86 polyvinylchloride tubing
87 procedure
88 propofol
89 propofol concentration
90 propofol loss
91 protocol
92 results
93 role
94 role of temperature
95 sequestration
96 study
97 surface
98 temperature
99 therapeutic drug monitoring
100 treatment
101 trials
102 tube
103 tubing
104 unit physicians
105 values
106 vancomycin
107 vancomycin concentrations
108 vivo ECMO circuits
109 volume
110 volume of distribution
111 whole human blood
112 schema:name Propofol, midazolam, vancomycin and cyclosporine therapeutic drug monitoring in extracorporeal membrane oxygenation circuits primed with whole human blood
113 schema:pagination 40
114 schema:productId N348c263254da4706990a2f52fb436f20
115 N7b362d3ef7924c89808a46abeaa23374
116 Nfa985ff303cc4c33a92ecfce3add221a
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030765358
118 https://doi.org/10.1186/s13054-015-0772-5
119 schema:sdDatePublished 2022-01-01T18:37
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher N015919ff96fb47e3a5400dc4181706f6
122 schema:url https://doi.org/10.1186/s13054-015-0772-5
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N00111c87571d4ae98a7a650fd08ed91d rdf:first sg:person.01312065302.61
127 rdf:rest N9c077bc105884950b9462e3a98b17837
128 N015919ff96fb47e3a5400dc4181706f6 schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N04b1235cc329433ea2b42ba6c5b24192 rdf:first sg:person.01307767706.21
131 rdf:rest N0cb930a7010047e0af6e6881457737ab
132 N0ac4b512daef4f3e9d478af9f0757035 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Hypnotics and Sedatives
134 rdf:type schema:DefinedTerm
135 N0cb930a7010047e0af6e6881457737ab rdf:first sg:person.0710520012.16
136 rdf:rest rdf:nil
137 N12e1f3bae15c4264b451f6589d515361 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Drug Monitoring
139 rdf:type schema:DefinedTerm
140 N15c8ceaa7eff4d5fb5b793c827409b7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Critical Illness
142 rdf:type schema:DefinedTerm
143 N1e5f610a051f4fdc94587e48a15f8fcf rdf:first sg:person.0754216253.06
144 rdf:rest N4c33df1881ad4c8290b74537aba1591c
145 N29df8d016c68442f9fdbc604b4ec6f98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Midazolam
147 rdf:type schema:DefinedTerm
148 N348c263254da4706990a2f52fb436f20 schema:name pubmed_id
149 schema:value 25886890
150 rdf:type schema:PropertyValue
151 N4c33df1881ad4c8290b74537aba1591c rdf:first Nc1b5cf0c9d3c454ba9bfe0b718933467
152 rdf:rest N8c667a6e3a154d5db76bfd0d58c49bf8
153 N6c66f110bb294bf6bb39973f3db172ff schema:issueNumber 1
154 rdf:type schema:PublicationIssue
155 N7b362d3ef7924c89808a46abeaa23374 schema:name dimensions_id
156 schema:value pub.1030765358
157 rdf:type schema:PropertyValue
158 N8ae74cc93a7b4b1e9cc302e4ce05cea9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Vancomycin
160 rdf:type schema:DefinedTerm
161 N8c667a6e3a154d5db76bfd0d58c49bf8 rdf:first sg:person.01273730565.40
162 rdf:rest Ne1e05fd80bfc4bdd82107c2d6ad506a5
163 N911f1cc66ab843f4a715dcb6faa67c45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Cyclosporine
165 rdf:type schema:DefinedTerm
166 N95ff550cadca4f6ea59a6845aef54bd7 rdf:first sg:person.01110354341.05
167 rdf:rest N00111c87571d4ae98a7a650fd08ed91d
168 N9c077bc105884950b9462e3a98b17837 rdf:first sg:person.01246012577.20
169 rdf:rest N1e5f610a051f4fdc94587e48a15f8fcf
170 N9dbaebe5e5654824b254e5b889ea4558 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Blood
172 rdf:type schema:DefinedTerm
173 Nab25ecacaa144c158f091ca78675429b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Propofol
175 rdf:type schema:DefinedTerm
176 Nb492923e4642496085d066d1e19cbf77 rdf:first sg:person.01247140265.87
177 rdf:rest Nd1b910c55bef4413845bd1f915ce0c3e
178 Nc1b5cf0c9d3c454ba9bfe0b718933467 schema:affiliation grid-institutes:grid.5842.b
179 schema:familyName Belhabib
180 schema:givenName Ghassen
181 rdf:type schema:Person
182 Nc45f50033da04e94809f8cbf9562bd72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Polyvinyl Chloride
184 rdf:type schema:DefinedTerm
185 Ncd4cac260e9f409dafc72f966a5b9e1b schema:volumeNumber 19
186 rdf:type schema:PublicationVolume
187 Nd1b910c55bef4413845bd1f915ce0c3e rdf:first sg:person.01221026417.13
188 rdf:rest N04b1235cc329433ea2b42ba6c5b24192
189 Nd5be9154b49e416c95fa7c9bc428af26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Humans
191 rdf:type schema:DefinedTerm
192 Nddc0fa1750a84bad94f12e8789f5fbb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Extracorporeal Membrane Oxygenation
194 rdf:type schema:DefinedTerm
195 Ne1e05fd80bfc4bdd82107c2d6ad506a5 rdf:first sg:person.01310337776.72
196 rdf:rest Nb492923e4642496085d066d1e19cbf77
197 Nf77832d793a943f0a3d685c639cee068 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Anti-Infective Agents
199 rdf:type schema:DefinedTerm
200 Nfa985ff303cc4c33a92ecfce3add221a schema:name doi
201 schema:value 10.1186/s13054-015-0772-5
202 rdf:type schema:PropertyValue
203 Nffe78caf5569445d8ad32167a691154a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Models, Biological
205 rdf:type schema:DefinedTerm
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
210 schema:name Clinical Sciences
211 rdf:type schema:DefinedTerm
212 sg:journal.1117766 schema:issn 1364-8535
213 1466-609X
214 schema:name Critical Care
215 schema:publisher Springer Nature
216 rdf:type schema:Periodical
217 sg:person.01110354341.05 schema:affiliation grid-institutes:grid.7429.8
218 schema:familyName Lemaitre
219 schema:givenName Florian
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110354341.05
221 rdf:type schema:Person
222 sg:person.01221026417.13 schema:affiliation grid-institutes:grid.5842.b
223 schema:familyName Farinotti
224 schema:givenName Robert
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221026417.13
226 rdf:type schema:Person
227 sg:person.01246012577.20 schema:affiliation grid-institutes:grid.411439.a
228 schema:familyName Leprince
229 schema:givenName Pascal
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246012577.20
231 rdf:type schema:Person
232 sg:person.01247140265.87 schema:affiliation grid-institutes:grid.7429.8
233 schema:familyName Leven
234 schema:givenName Cyril
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247140265.87
236 rdf:type schema:Person
237 sg:person.01273730565.40 schema:affiliation grid-institutes:grid.7429.8
238 schema:familyName Fillâtre
239 schema:givenName Pierre
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273730565.40
241 rdf:type schema:Person
242 sg:person.01307767706.21 schema:affiliation grid-institutes:grid.412370.3
243 schema:familyName Fernandez
244 schema:givenName Christine
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307767706.21
246 rdf:type schema:Person
247 sg:person.01310337776.72 schema:affiliation grid-institutes:grid.462844.8
248 schema:familyName Luyt
249 schema:givenName Charles-Edouard
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310337776.72
251 rdf:type schema:Person
252 sg:person.01312065302.61 schema:affiliation grid-institutes:grid.5842.b
253 schema:familyName Hasni
254 schema:givenName Nesrine
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312065302.61
256 rdf:type schema:Person
257 sg:person.0710520012.16 schema:affiliation grid-institutes:grid.462844.8
258 schema:familyName Combes
259 schema:givenName Alain
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0710520012.16
261 rdf:type schema:Person
262 sg:person.0754216253.06 schema:affiliation grid-institutes:grid.411439.a
263 schema:familyName Corvol
264 schema:givenName Emmanuel
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754216253.06
266 rdf:type schema:Person
267 sg:pub.10.1007/bf03009997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051974101
268 https://doi.org/10.1007/bf03009997
269 rdf:type schema:CreativeWork
270 sg:pub.10.1007/s00134-007-0606-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019529811
271 https://doi.org/10.1007/s00134-007-0606-2
272 rdf:type schema:CreativeWork
273 sg:pub.10.1007/s00134-010-1882-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050143005
274 https://doi.org/10.1007/s00134-010-1882-9
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/s00134-010-2041-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1022458689
277 https://doi.org/10.1007/s00134-010-2041-z
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/sj.bmt.1702196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023586512
280 https://doi.org/10.1038/sj.bmt.1702196
281 rdf:type schema:CreativeWork
282 sg:pub.10.1186/cc11679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006765673
283 https://doi.org/10.1186/cc11679
284 rdf:type schema:CreativeWork
285 sg:pub.10.2165/00003088-200342050-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006056958
286 https://doi.org/10.2165/00003088-200342050-00001
287 rdf:type schema:CreativeWork
288 grid-institutes:grid.411439.a schema:alternateName Cardiovascular Surgery department, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, AP-HP, 47-83 Boulevard de l’Hôpital, 75013 Paris, France
289 schema:name Cardiovascular Surgery department, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, AP-HP, 47-83 Boulevard de l’Hôpital, 75013 Paris, France
290 Paris 6 University Pierre et Marie Curie, 91-105 Boulevard de l’Hôpital, 75013 Paris, France
291 rdf:type schema:Organization
292 grid-institutes:grid.412370.3 schema:alternateName Pharmacy Department, Saint-Antoine Hospital, Assistance Publique Hôpitaux de Paris, AP-HP, 184 rue du faubourg Saint-Antoine, 75012 Paris, France
293 schema:name Faculty of Pharmacy, EA4123 Barrières physiologiques et réponses thérapeutiques, Paris Sud University, Châtenay-Malabry, France
294 Pharmacy Department, Saint-Antoine Hospital, Assistance Publique Hôpitaux de Paris, AP-HP, 184 rue du faubourg Saint-Antoine, 75012 Paris, France
295 rdf:type schema:Organization
296 grid-institutes:grid.462844.8 schema:alternateName Paris 6 University Pierre et Marie Curie, 91-105 Boulevard de l’Hôpital, 75013 Paris, France
297 schema:name Paris 6 University Pierre et Marie Curie, 91-105 Boulevard de l’Hôpital, 75013 Paris, France
298 Service de Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, iCAN, Institute of Cardiometabolism and Nutrition, 47, Boulevard de l’Hôpital, 75651 Paris, Cedex 13 France
299 rdf:type schema:Organization
300 grid-institutes:grid.5842.b schema:alternateName Faculty of Pharmacy, EA4123 Barrières physiologiques et réponses thérapeutiques, Paris Sud University, Châtenay-Malabry, France
301 schema:name Faculty of Pharmacy, EA4123 Barrières physiologiques et réponses thérapeutiques, Paris Sud University, Châtenay-Malabry, France
302 rdf:type schema:Organization
303 grid-institutes:grid.7429.8 schema:alternateName Inserm, CIC-P 1414 Clinical Investigation Center, Rennes, France
304 schema:name Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Center, Rennes University Hospital, Rennes, France
305 Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, Rennes 1 University, Rennes, France
306 Faculty of Pharmacy, EA4123 Barrières physiologiques et réponses thérapeutiques, Paris Sud University, Châtenay-Malabry, France
307 Inserm, CIC-P 1414 Clinical Investigation Center, Rennes, France
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...