Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator interaction View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12-01

AUTHORS

Matthieu Schmidt, Felix Kindler, Jérôme Cecchini, Tymothée Poitou, Elise Morawiec, Romain Persichini, Thomas Similowski, Alexandre Demoule

ABSTRACT

IntroductionThe objective was to compare the impact of three assistance levels of different modes of mechanical ventilation; neurally adjusted ventilatory assist (NAVA), proportional assist ventilation (PAV), and pressure support ventilation (PSV) on major features of patient-ventilator interaction.MethodsPSV, NAVA, and PAV were set to obtain a tidal volume (VT) of 6 to 8 ml/kg (PSV100, NAVA100, and PAV100) in 16 intubated patients. Assistance was further decreased by 50% (PSV50, NAVA50, and PAV50) and then increased by 50% (PSV150, NAVA150, and PAV150) with all modes. The three modes were randomly applied. Airway flow and pressure, electrical activity of the diaphragm (EAdi), and blood gases were measured. VT, peak EAdi, coefficient of variation of VT and EAdi, and the prevalence of the main patient-ventilator asynchronies were calculated.ResultsPAV and NAVA prevented the increase of VT with high levels of assistance (median 7.4 (interquartile range (IQR) 5.7 to 10.1) ml/kg and 7.4 (IQR, 5.9 to 10.5) ml/kg with PAV150 and NAVA150 versus 10.9 (IQR, 8.9 to 12.0) ml/kg with PSV150, P <0.05). EAdi was higher with PAV than with PSV at level100 and level150. The coefficient of variation of VT was higher with NAVA and PAV (19 (IQR, 14 to 31)% and 21 (IQR 16 to 29)% with NAVA100 and PAV100 versus 13 (IQR 11 to 18)% with PSV100, P <0.05). The prevalence of ineffective triggering was lower with PAV and NAVA than with PSV (P <0.05), but the prevalence of double triggering was higher with NAVA than with PAV and PSV (P <0.05).ConclusionsPAV and NAVA both prevent overdistention, improve neuromechanical coupling, restore the variability of the breathing pattern, and decrease patient-ventilator asynchrony in fairly similar ways compared with PSV. Further studies are needed to evaluate the possible clinical benefits of NAVA and PAV on clinical outcomes.Trial registrationClinicaltrials.gov NCT02056093. Registered 18 December 2013. More... »

PAGES

56

References to SciGraph publications

  • 2003-06-12. Noninvasive pressure support versus proportional assist ventilation in acute respiratory failure in INTENSIVE CARE MEDICINE
  • 2006-08-01. Patient-ventilator asynchrony during assisted mechanical ventilation in INTENSIVE CARE MEDICINE
  • 1995-11. Respiratory response and inspiratory effort during pressure support ventilation in COPD patients in INTENSIVE CARE MEDICINE
  • 2008-07-16. Physiologic response to varying levels of pressure support and neurally adjusted ventilatory assist in patients with acute respiratory failure in INTENSIVE CARE MEDICINE
  • 2013-10-17. Unrecognized suffering in the ICU: addressing dyspnea in mechanically ventilated patients in INTENSIVE CARE MEDICINE
  • 2008-09-11. Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm in CRITICAL CARE
  • 2013-06-07. Decreased respiratory rate variability during mechanical ventilation is associated with increased mortality in INTENSIVE CARE MEDICINE
  • 2010-09-25. Neurally adjusted ventilatory assist improves patient–ventilator interaction in INTENSIVE CARE MEDICINE
  • 2009-09-16. Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury in INTENSIVE CARE MEDICINE
  • 2008-07-08. Proportional assist ventilation with load-adjustable gain factors in critically ill patients: comparison with pressure support in INTENSIVE CARE MEDICINE
  • 2011-11-30. Respiratory pattern during neurally adjusted ventilatory assist in acute respiratory failure patients in INTENSIVE CARE MEDICINE
  • 2010-01-29. Primary hydatid cyst of the gallbladder: a case report in JOURNAL OF MEDICAL CASE REPORTS
  • 1999-08. Proportional assist versus pressure support ventilation: effects on breathing pattern and respiratory work of patients with chronic obstructive pulmonary disease in INTENSIVE CARE MEDICINE
  • 1998-05. Life-support system benefits from noise in NATURE
  • 2009-09-25. A novel adaptive control system for noisy pressure-controlled ventilation: a numerical simulation and bench test study in INTENSIVE CARE MEDICINE
  • 2006-03-08. Respiratory load compensation during mechanical ventilation—proportional assist ventilation with load-adjustable gain factors versus pressure support in INTENSIVE CARE MEDICINE
  • 1999-12. Neural control of mechanical ventilation in respiratory failure in NATURE MEDICINE
  • 2009-08-04. Evaluation of the catheter positioning for neurally adjusted ventilatory assist in INTENSIVE CARE MEDICINE
  • 2008-04-24. Reduction of patient-ventilator asynchrony by reducing tidal volume during pressure-support ventilation in INTENSIVE CARE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13054-015-0763-6

    DOI

    http://dx.doi.org/10.1186/s13054-015-0763-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1002250523

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25879592


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Physiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Gas Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Critical Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diaphragm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nervous System Physiological Phenomena", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Random Allocation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiration, Artificial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiratory Insufficiency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiratory Mechanics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiratory Muscles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tidal Volume", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Service de Pneumologie et R\u00e9animation M\u00e9dicale, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 boulevard de l\u2019H\u00f4pital, 75651, Paris, Cedex 13, France", 
              "id": "http://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
                "INSERM, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
                "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France", 
                "Service de Pneumologie et R\u00e9animation M\u00e9dicale, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, 47-83 boulevard de l\u2019H\u00f4pital, 75651, Paris, Cedex 13, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schmidt", 
            "givenName": "Matthieu", 
            "id": "sg:person.01234316166.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234316166.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.50550.35", 
              "name": [
                "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kindler", 
            "givenName": "Felix", 
            "id": "sg:person.01100101155.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100101155.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "INSERM, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.7429.8", 
              "name": [
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
                "INSERM, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cecchini", 
            "givenName": "J\u00e9r\u00f4me", 
            "id": "sg:person.0672405325.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672405325.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Pierre et Marie Curie-CNRS-INSERM, ICM, Equipe Neurologie et Th\u00e9rapeutique Exp\u00e9rimentale, H\u00f4pital de la Salp\u00eatri\u00e8re, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.411439.a", 
              "name": [
                "Universit\u00e9 Pierre et Marie Curie-CNRS-INSERM, ICM, Equipe Neurologie et Th\u00e9rapeutique Exp\u00e9rimentale, H\u00f4pital de la Salp\u00eatri\u00e8re, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Poitou", 
            "givenName": "Tymoth\u00e9e", 
            "id": "sg:person.0705537245.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705537245.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.50550.35", 
              "name": [
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
                "INSERM, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
                "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morawiec", 
            "givenName": "Elise", 
            "id": "sg:person.01232376071.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232376071.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.50550.35", 
              "name": [
                "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Persichini", 
            "givenName": "Romain", 
            "id": "sg:person.01224470142.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224470142.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.50550.35", 
              "name": [
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
                "INSERM, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
                "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Similowski", 
            "givenName": "Thomas", 
            "id": "sg:person.01235111105.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235111105.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "U974, Institut National de la Sant\u00e9 et de la Recherche m\u00e9dicale, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.457369.a", 
              "name": [
                "Sorbonne Universit\u00e9s, UPMC Univ Paris 06, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
                "INSERM, UMR_S 1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, F-75005, Paris, France", 
                "AP-HP, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re Charles Foix, Service de Pneumologie et R\u00e9animation M\u00e9dicale (D\u00e9partement R3S), F-75013, Paris, France", 
                "U974, Institut National de la Sant\u00e9 et de la Recherche m\u00e9dicale, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Demoule", 
            "givenName": "Alexandre", 
            "id": "sg:person.0673253666.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673253666.83"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00134-010-2052-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015084725", 
              "https://doi.org/10.1007/s00134-010-2052-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0301-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014901079", 
              "https://doi.org/10.1007/s00134-006-0301-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/30130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004108480", 
              "https://doi.org/10.1038/30130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1665-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002147120", 
              "https://doi.org/10.1007/s00134-009-1665-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01712327", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029308347", 
              "https://doi.org/10.1007/bf01712327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1752-1947-4-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043816253", 
              "https://doi.org/10.1186/1752-1947-4-29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1587-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029354365", 
              "https://doi.org/10.1007/s00134-009-1587-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/71012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006785474", 
              "https://doi.org/10.1038/71012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-013-2937-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051849180", 
              "https://doi.org/10.1007/s00134-013-2937-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0110-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007764291", 
              "https://doi.org/10.1007/s00134-006-0110-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1121-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050480887", 
              "https://doi.org/10.1007/s00134-008-1121-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc7010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001523045", 
              "https://doi.org/10.1186/cc7010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-011-2433-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051413231", 
              "https://doi.org/10.1007/s00134-011-2433-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-003-1768-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007218879", 
              "https://doi.org/10.1007/s00134-003-1768-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001340050954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007466500", 
              "https://doi.org/10.1007/s001340050954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1208-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052333233", 
              "https://doi.org/10.1007/s00134-008-1208-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-013-3117-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030106051", 
              "https://doi.org/10.1007/s00134-013-3117-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-008-1209-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029491849", 
              "https://doi.org/10.1007/s00134-008-1209-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1626-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046833328", 
              "https://doi.org/10.1007/s00134-009-1626-x"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-12-01", 
        "datePublishedReg": "2015-12-01", 
        "description": "IntroductionThe objective was to compare the impact of three assistance levels of different modes of mechanical ventilation; neurally adjusted ventilatory assist (NAVA), proportional assist ventilation (PAV), and pressure support ventilation (PSV) on major features of patient-ventilator interaction.MethodsPSV, NAVA, and PAV were set to obtain a tidal volume (VT) of 6 to 8\u00a0ml/kg (PSV100, NAVA100, and PAV100) in 16 intubated patients. Assistance was further decreased by 50% (PSV50, NAVA50, and PAV50) and then increased by 50% (PSV150, NAVA150, and PAV150) with all modes. The three modes were randomly applied. Airway flow and pressure, electrical activity of the diaphragm (EAdi), and blood gases were measured. VT, peak EAdi, coefficient of variation of VT and EAdi, and the prevalence of the main patient-ventilator asynchronies were calculated.ResultsPAV and NAVA prevented the increase of VT with high levels of assistance (median 7.4 (interquartile range (IQR) 5.7 to 10.1) ml/kg and 7.4 (IQR, 5.9 to 10.5) ml/kg with PAV150 and NAVA150 versus 10.9 (IQR, 8.9 to 12.0) ml/kg with PSV150, P <0.05). EAdi was higher with PAV than with PSV at level100 and level150. The coefficient of variation of VT was higher with NAVA and PAV (19 (IQR, 14 to 31)% and 21 (IQR 16 to 29)% with NAVA100 and PAV100 versus 13 (IQR 11 to 18)% with PSV100, P <0.05). The prevalence of ineffective triggering was lower with PAV and NAVA than with PSV (P <0.05), but the prevalence of double triggering was higher with NAVA than with PAV and PSV (P <0.05).ConclusionsPAV and NAVA both prevent overdistention, improve neuromechanical coupling, restore the variability of the breathing pattern, and decrease patient-ventilator asynchrony in fairly similar ways compared with PSV. Further studies are needed to evaluate the possible clinical benefits of NAVA and PAV on clinical outcomes.Trial registrationClinicaltrials.gov NCT02056093. Registered 18 December 2013.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s13054-015-0763-6", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1117766", 
            "issn": [
              "1364-8535", 
              "1466-609X"
            ], 
            "name": "Critical Care", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "keywords": [
          "pressure support ventilation", 
          "proportional assist ventilation", 
          "patient-ventilator interaction", 
          "patient-ventilator asynchrony", 
          "ventilatory assist", 
          "assist ventilation", 
          "possible clinical benefit", 
          "IntroductionThe objective", 
          "support ventilation", 
          "intubated patients", 
          "clinical outcomes", 
          "mechanical ventilation", 
          "ineffective triggering", 
          "clinical benefit", 
          "blood gases", 
          "neuromechanical coupling", 
          "airway flow", 
          "peak Eadi", 
          "increase of VT", 
          "tidal volume", 
          "double triggering", 
          "breathing pattern", 
          "electrical activity", 
          "prevalence", 
          "ventilation", 
          "EAdi", 
          "Further studies", 
          "coefficient of variation", 
          "NAVA", 
          "VT", 
          "high levels", 
          "overdistention", 
          "patients", 
          "assistance level", 
          "outcomes", 
          "levels", 
          "diaphragm", 
          "asynchrony", 
          "triggering", 
          "assistance", 
          "activity", 
          "assists", 
          "major features", 
          "study", 
          "benefits", 
          "increase", 
          "volume", 
          "objective", 
          "pressure", 
          "similar way", 
          "patterns", 
          "impact", 
          "variability", 
          "different modes", 
          "features", 
          "interaction", 
          "variation", 
          "flow", 
          "mode", 
          "coefficient", 
          "way", 
          "gases", 
          "coupling"
        ], 
        "name": "Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator interaction", 
        "pagination": "56", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1002250523"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13054-015-0763-6"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25879592"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13054-015-0763-6", 
          "https://app.dimensions.ai/details/publication/pub.1002250523"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-10-01T06:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_657.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s13054-015-0763-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0763-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0763-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0763-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13054-015-0763-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    333 TRIPLES      21 PREDICATES      123 URIs      96 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13054-015-0763-6 schema:about N007184d43aa046e5b420c261fcf23164
    2 N03f8a45376e5492aa3e6a8ddf85c5e51
    3 N0765bcc82d554c9ca4a4bdd2e9af3c4c
    4 N10822fbd2f624f35bf95694a9bd4318c
    5 N451e2bc80ed94a7486a510d7bfebb204
    6 N5ff097335200422e89e4e79e489340ac
    7 N7ccc277c36c245f3a839440262853264
    8 N7fdac20b8a95400fa4baf80aa51f363d
    9 N825d218e3f834179b60b8b2d58feebaf
    10 N98f1cd7d088d4978a87c7b45b5b1f009
    11 Na700d6fbbe274c19a2bdbdaa51fb8f78
    12 Nb5de9ed10cd44227a44837c4d71ee360
    13 Nc6036b103dc648e3bcacf66e3c74b4f1
    14 Ne1eaf2f6d1e040928055add5af7f7556
    15 Necaa1b3f44c94caa8864c73525a691b7
    16 Necfe18342efe43ff879ae54c8db546ed
    17 anzsrc-for:11
    18 anzsrc-for:1116
    19 schema:author N084c96c35cb244feb56334a7f1c75e4c
    20 schema:citation sg:pub.10.1007/bf01712327
    21 sg:pub.10.1007/s00134-003-1768-1
    22 sg:pub.10.1007/s00134-006-0110-0
    23 sg:pub.10.1007/s00134-006-0301-8
    24 sg:pub.10.1007/s00134-008-1121-9
    25 sg:pub.10.1007/s00134-008-1208-3
    26 sg:pub.10.1007/s00134-008-1209-2
    27 sg:pub.10.1007/s00134-009-1587-0
    28 sg:pub.10.1007/s00134-009-1626-x
    29 sg:pub.10.1007/s00134-009-1665-3
    30 sg:pub.10.1007/s00134-010-2052-9
    31 sg:pub.10.1007/s00134-011-2433-8
    32 sg:pub.10.1007/s00134-013-2937-5
    33 sg:pub.10.1007/s00134-013-3117-3
    34 sg:pub.10.1007/s001340050954
    35 sg:pub.10.1038/30130
    36 sg:pub.10.1038/71012
    37 sg:pub.10.1186/1752-1947-4-29
    38 sg:pub.10.1186/cc7010
    39 schema:datePublished 2015-12-01
    40 schema:datePublishedReg 2015-12-01
    41 schema:description IntroductionThe objective was to compare the impact of three assistance levels of different modes of mechanical ventilation; neurally adjusted ventilatory assist (NAVA), proportional assist ventilation (PAV), and pressure support ventilation (PSV) on major features of patient-ventilator interaction.MethodsPSV, NAVA, and PAV were set to obtain a tidal volume (VT) of 6 to 8 ml/kg (PSV100, NAVA100, and PAV100) in 16 intubated patients. Assistance was further decreased by 50% (PSV50, NAVA50, and PAV50) and then increased by 50% (PSV150, NAVA150, and PAV150) with all modes. The three modes were randomly applied. Airway flow and pressure, electrical activity of the diaphragm (EAdi), and blood gases were measured. VT, peak EAdi, coefficient of variation of VT and EAdi, and the prevalence of the main patient-ventilator asynchronies were calculated.ResultsPAV and NAVA prevented the increase of VT with high levels of assistance (median 7.4 (interquartile range (IQR) 5.7 to 10.1) ml/kg and 7.4 (IQR, 5.9 to 10.5) ml/kg with PAV150 and NAVA150 versus 10.9 (IQR, 8.9 to 12.0) ml/kg with PSV150, P <0.05). EAdi was higher with PAV than with PSV at level100 and level150. The coefficient of variation of VT was higher with NAVA and PAV (19 (IQR, 14 to 31)% and 21 (IQR 16 to 29)% with NAVA100 and PAV100 versus 13 (IQR 11 to 18)% with PSV100, P <0.05). The prevalence of ineffective triggering was lower with PAV and NAVA than with PSV (P <0.05), but the prevalence of double triggering was higher with NAVA than with PAV and PSV (P <0.05).ConclusionsPAV and NAVA both prevent overdistention, improve neuromechanical coupling, restore the variability of the breathing pattern, and decrease patient-ventilator asynchrony in fairly similar ways compared with PSV. Further studies are needed to evaluate the possible clinical benefits of NAVA and PAV on clinical outcomes.Trial registrationClinicaltrials.gov NCT02056093. Registered 18 December 2013.
    42 schema:genre article
    43 schema:isAccessibleForFree true
    44 schema:isPartOf Na769f1b62ff54496b63b1b923d0d422a
    45 Nca2b337c6102432b979e4d0916f3c980
    46 sg:journal.1117766
    47 schema:keywords EAdi
    48 Further studies
    49 IntroductionThe objective
    50 NAVA
    51 VT
    52 activity
    53 airway flow
    54 assist ventilation
    55 assistance
    56 assistance level
    57 assists
    58 asynchrony
    59 benefits
    60 blood gases
    61 breathing pattern
    62 clinical benefit
    63 clinical outcomes
    64 coefficient
    65 coefficient of variation
    66 coupling
    67 diaphragm
    68 different modes
    69 double triggering
    70 electrical activity
    71 features
    72 flow
    73 gases
    74 high levels
    75 impact
    76 increase
    77 increase of VT
    78 ineffective triggering
    79 interaction
    80 intubated patients
    81 levels
    82 major features
    83 mechanical ventilation
    84 mode
    85 neuromechanical coupling
    86 objective
    87 outcomes
    88 overdistention
    89 patient-ventilator asynchrony
    90 patient-ventilator interaction
    91 patients
    92 patterns
    93 peak Eadi
    94 possible clinical benefit
    95 pressure
    96 pressure support ventilation
    97 prevalence
    98 proportional assist ventilation
    99 similar way
    100 study
    101 support ventilation
    102 tidal volume
    103 triggering
    104 variability
    105 variation
    106 ventilation
    107 ventilatory assist
    108 volume
    109 way
    110 schema:name Neurally adjusted ventilatory assist and proportional assist ventilation both improve patient-ventilator interaction
    111 schema:pagination 56
    112 schema:productId N07ac437612364f818078709df4bbd54b
    113 N921d89714fc94e32a9d7b1a368e22d8b
    114 Nd99e3b3fa2684674ab8d83d328c4b5d6
    115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002250523
    116 https://doi.org/10.1186/s13054-015-0763-6
    117 schema:sdDatePublished 2022-10-01T06:40
    118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    119 schema:sdPublisher N9e58bcd0cd314152823acf0e74bde390
    120 schema:url https://doi.org/10.1186/s13054-015-0763-6
    121 sgo:license sg:explorer/license/
    122 sgo:sdDataset articles
    123 rdf:type schema:ScholarlyArticle
    124 N007184d43aa046e5b420c261fcf23164 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Respiratory Muscles
    126 rdf:type schema:DefinedTerm
    127 N0184c5efd3854f2db4e51e86a8e01abb rdf:first sg:person.0672405325.65
    128 rdf:rest Nc04e371d6bee4b2f8a4bcb0d87500910
    129 N03f8a45376e5492aa3e6a8ddf85c5e51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Aged, 80 and over
    131 rdf:type schema:DefinedTerm
    132 N0765bcc82d554c9ca4a4bdd2e9af3c4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Random Allocation
    134 rdf:type schema:DefinedTerm
    135 N07ac437612364f818078709df4bbd54b schema:name pubmed_id
    136 schema:value 25879592
    137 rdf:type schema:PropertyValue
    138 N084c96c35cb244feb56334a7f1c75e4c rdf:first sg:person.01234316166.01
    139 rdf:rest N41b0a709c0534136abc0ee20f88cc5c9
    140 N10822fbd2f624f35bf95694a9bd4318c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Respiration, Artificial
    142 rdf:type schema:DefinedTerm
    143 N152aa16c090e4e26a21e60176fc8dad4 rdf:first sg:person.01232376071.84
    144 rdf:rest N23b38d1f7e35420db856cb322fb7f776
    145 N23b38d1f7e35420db856cb322fb7f776 rdf:first sg:person.01224470142.43
    146 rdf:rest N7bd748346c364b8db7697b8f51f5ec08
    147 N41b0a709c0534136abc0ee20f88cc5c9 rdf:first sg:person.01100101155.53
    148 rdf:rest N0184c5efd3854f2db4e51e86a8e01abb
    149 N451e2bc80ed94a7486a510d7bfebb204 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Blood Gas Analysis
    151 rdf:type schema:DefinedTerm
    152 N5ff097335200422e89e4e79e489340ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Respiratory Mechanics
    154 rdf:type schema:DefinedTerm
    155 N7bd748346c364b8db7697b8f51f5ec08 rdf:first sg:person.01235111105.45
    156 rdf:rest N963ad53f1429479783b9fd7dceb8d13a
    157 N7ccc277c36c245f3a839440262853264 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Aged
    159 rdf:type schema:DefinedTerm
    160 N7fdac20b8a95400fa4baf80aa51f363d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Female
    162 rdf:type schema:DefinedTerm
    163 N825d218e3f834179b60b8b2d58feebaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Nervous System Physiological Phenomena
    165 rdf:type schema:DefinedTerm
    166 N921d89714fc94e32a9d7b1a368e22d8b schema:name dimensions_id
    167 schema:value pub.1002250523
    168 rdf:type schema:PropertyValue
    169 N963ad53f1429479783b9fd7dceb8d13a rdf:first sg:person.0673253666.83
    170 rdf:rest rdf:nil
    171 N98f1cd7d088d4978a87c7b45b5b1f009 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Critical Care
    173 rdf:type schema:DefinedTerm
    174 N9e58bcd0cd314152823acf0e74bde390 schema:name Springer Nature - SN SciGraph project
    175 rdf:type schema:Organization
    176 Na700d6fbbe274c19a2bdbdaa51fb8f78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Diaphragm
    178 rdf:type schema:DefinedTerm
    179 Na769f1b62ff54496b63b1b923d0d422a schema:volumeNumber 19
    180 rdf:type schema:PublicationVolume
    181 Nb5de9ed10cd44227a44837c4d71ee360 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Male
    183 rdf:type schema:DefinedTerm
    184 Nc04e371d6bee4b2f8a4bcb0d87500910 rdf:first sg:person.0705537245.80
    185 rdf:rest N152aa16c090e4e26a21e60176fc8dad4
    186 Nc6036b103dc648e3bcacf66e3c74b4f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Humans
    188 rdf:type schema:DefinedTerm
    189 Nca2b337c6102432b979e4d0916f3c980 schema:issueNumber 1
    190 rdf:type schema:PublicationIssue
    191 Nd99e3b3fa2684674ab8d83d328c4b5d6 schema:name doi
    192 schema:value 10.1186/s13054-015-0763-6
    193 rdf:type schema:PropertyValue
    194 Ne1eaf2f6d1e040928055add5af7f7556 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Tidal Volume
    196 rdf:type schema:DefinedTerm
    197 Necaa1b3f44c94caa8864c73525a691b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Respiratory Insufficiency
    199 rdf:type schema:DefinedTerm
    200 Necfe18342efe43ff879ae54c8db546ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Middle Aged
    202 rdf:type schema:DefinedTerm
    203 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    204 schema:name Medical and Health Sciences
    205 rdf:type schema:DefinedTerm
    206 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
    207 schema:name Medical Physiology
    208 rdf:type schema:DefinedTerm
    209 sg:journal.1117766 schema:issn 1364-8535
    210 1466-609X
    211 schema:name Critical Care
    212 schema:publisher Springer Nature
    213 rdf:type schema:Periodical
    214 sg:person.01100101155.53 schema:affiliation grid-institutes:grid.50550.35
    215 schema:familyName Kindler
    216 schema:givenName Felix
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100101155.53
    218 rdf:type schema:Person
    219 sg:person.01224470142.43 schema:affiliation grid-institutes:grid.50550.35
    220 schema:familyName Persichini
    221 schema:givenName Romain
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224470142.43
    223 rdf:type schema:Person
    224 sg:person.01232376071.84 schema:affiliation grid-institutes:grid.50550.35
    225 schema:familyName Morawiec
    226 schema:givenName Elise
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232376071.84
    228 rdf:type schema:Person
    229 sg:person.01234316166.01 schema:affiliation grid-institutes:grid.411439.a
    230 schema:familyName Schmidt
    231 schema:givenName Matthieu
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234316166.01
    233 rdf:type schema:Person
    234 sg:person.01235111105.45 schema:affiliation grid-institutes:grid.50550.35
    235 schema:familyName Similowski
    236 schema:givenName Thomas
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235111105.45
    238 rdf:type schema:Person
    239 sg:person.0672405325.65 schema:affiliation grid-institutes:grid.7429.8
    240 schema:familyName Cecchini
    241 schema:givenName Jérôme
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672405325.65
    243 rdf:type schema:Person
    244 sg:person.0673253666.83 schema:affiliation grid-institutes:grid.457369.a
    245 schema:familyName Demoule
    246 schema:givenName Alexandre
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673253666.83
    248 rdf:type schema:Person
    249 sg:person.0705537245.80 schema:affiliation grid-institutes:grid.411439.a
    250 schema:familyName Poitou
    251 schema:givenName Tymothée
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705537245.80
    253 rdf:type schema:Person
    254 sg:pub.10.1007/bf01712327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029308347
    255 https://doi.org/10.1007/bf01712327
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1007/s00134-003-1768-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007218879
    258 https://doi.org/10.1007/s00134-003-1768-1
    259 rdf:type schema:CreativeWork
    260 sg:pub.10.1007/s00134-006-0110-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007764291
    261 https://doi.org/10.1007/s00134-006-0110-0
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s00134-006-0301-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014901079
    264 https://doi.org/10.1007/s00134-006-0301-8
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s00134-008-1121-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050480887
    267 https://doi.org/10.1007/s00134-008-1121-9
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s00134-008-1208-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052333233
    270 https://doi.org/10.1007/s00134-008-1208-3
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s00134-008-1209-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029491849
    273 https://doi.org/10.1007/s00134-008-1209-2
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1007/s00134-009-1587-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029354365
    276 https://doi.org/10.1007/s00134-009-1587-0
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1007/s00134-009-1626-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046833328
    279 https://doi.org/10.1007/s00134-009-1626-x
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/s00134-009-1665-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002147120
    282 https://doi.org/10.1007/s00134-009-1665-3
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1007/s00134-010-2052-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015084725
    285 https://doi.org/10.1007/s00134-010-2052-9
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1007/s00134-011-2433-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051413231
    288 https://doi.org/10.1007/s00134-011-2433-8
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1007/s00134-013-2937-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051849180
    291 https://doi.org/10.1007/s00134-013-2937-5
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1007/s00134-013-3117-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030106051
    294 https://doi.org/10.1007/s00134-013-3117-3
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1007/s001340050954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007466500
    297 https://doi.org/10.1007/s001340050954
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/30130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004108480
    300 https://doi.org/10.1038/30130
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/71012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006785474
    303 https://doi.org/10.1038/71012
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1186/1752-1947-4-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043816253
    306 https://doi.org/10.1186/1752-1947-4-29
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1186/cc7010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001523045
    309 https://doi.org/10.1186/cc7010
    310 rdf:type schema:CreativeWork
    311 grid-institutes:grid.411439.a schema:alternateName Service de Pneumologie et Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, 47-83 boulevard de l’Hôpital, 75651, Paris, Cedex 13, France
    312 Université Pierre et Marie Curie-CNRS-INSERM, ICM, Equipe Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, Paris, France
    313 schema:name AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pneumologie et Réanimation Médicale (Département R3S), F-75013, Paris, France
    314 INSERM, UMR_S 1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France
    315 Service de Pneumologie et Réanimation Médicale, Groupe Hospitalier Pitié-Salpêtrière, 47-83 boulevard de l’Hôpital, 75651, Paris, Cedex 13, France
    316 Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France
    317 Université Pierre et Marie Curie-CNRS-INSERM, ICM, Equipe Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, Paris, France
    318 rdf:type schema:Organization
    319 grid-institutes:grid.457369.a schema:alternateName U974, Institut National de la Santé et de la Recherche médicale, Paris, France
    320 schema:name AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pneumologie et Réanimation Médicale (Département R3S), F-75013, Paris, France
    321 INSERM, UMR_S 1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France
    322 Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France
    323 U974, Institut National de la Santé et de la Recherche médicale, Paris, France
    324 rdf:type schema:Organization
    325 grid-institutes:grid.50550.35 schema:alternateName AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pneumologie et Réanimation Médicale (Département R3S), F-75013, Paris, France
    326 schema:name AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pneumologie et Réanimation Médicale (Département R3S), F-75013, Paris, France
    327 INSERM, UMR_S 1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France
    328 Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France
    329 rdf:type schema:Organization
    330 grid-institutes:grid.7429.8 schema:alternateName INSERM, UMR_S 1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France
    331 schema:name INSERM, UMR_S 1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France
    332 Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1158 Neurophysiologie Respiratoire Expérimentale et Clinique, F-75005, Paris, France
    333 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...