Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Toni T. Seppälä, Aysel Ahadova, Mev Dominguez-Valentin, Finlay Macrae, D. Gareth Evans, Christina Therkildsen, Julian Sampson, Rodney Scott, John Burn, Gabriela Möslein, Inge Bernstein, Elke Holinski-Feder, Kirsi Pylvänäinen, Laura Renkonen-Sinisalo, Anna Lepistö, Charlotte Kvist Lautrup, Annika Lindblom, John-Paul Plazzer, Ingrid Winship, Douglas Tjandra, Lior H. Katz, Stefan Aretz, Robert Hüneburg, Stefanie Holzapfel, Karl Heinimann, Adriana Della Valle, Florencia Neffa, Nathan Gluck, Wouter H. de Vos tot Nederveen Cappel, Hans Vasen, Monika Morak, Verena Steinke-Lange, Christoph Engel, Nils Rahner, Wolff Schmiegel, Deepak Vangala, Huw Thomas, Kate Green, Fiona Lalloo, Emma J. Crosbie, James Hill, Gabriel Capella, Marta Pineda, Matilde Navarro, Ignacio Blanco, Sanne ten Broeke, Maartje Nielsen, Ken Ljungmann, Sigve Nakken, Noralane Lindor, Ian Frayling, Eivind Hovig, Lone Sunde, Matthias Kloor, Jukka-Pekka Mecklin, Mette Kalager, Pål Møller

ABSTRACT

Background: Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in expert centres. This observation conflicts with the paradigm that removal of all visible polyps should prevent the vast majority of CRC in path_MMR carriers, provided the screening interval is sufficiently short and colonoscopic practice is optimal. Methods: To inform the debate, we examined, in the Prospective Lynch Syndrome Database (PLSD), whether the time since last colonoscopy was associated with the pathological stage at which CRC was diagnosed during prospective surveillance. Path_MMR carriers were recruited for prospective surveillance by colonoscopy. Only variants scored by the InSiGHT Variant Interpretation Committee as class 4 and 5 (clinically actionable) were included. CRCs detected at the first planned colonoscopy, or within one year of this, were excluded as prevalent cancers. Results: Stage at diagnosis and interval between last prospective surveillance colonoscopy and diagnosis were available for 209 patients with 218 CRCs, including 162 path_MLH1, 45 path_MSH2, 10 path_MSH6 and 1 path_PMS2 carriers. The numbers of cancers detected within < 1.5, 1.5-2.5, 2.5-3.5 and at > 3.5 years since last colonoscopy were 36, 93, 56 and 33, respectively. Among these, 16.7, 19.4, 9.9 and 15.1% were stage III-IV, respectively (p = 0.34). The cancers detected more than 2.5 years after the last colonoscopy were not more advanced than those diagnosed earlier (p = 0.14). Conclusions: The CRC stage and interval since last colonoscopy were not correlated, which is in conflict with the accelerated adenoma-carcinoma paradigm. We have previously reported that more frequent colonoscopy is not associated with lower incidence of CRC in path_MMR carriers as was expected. In contrast, point estimates showed a higher incidence with shorter intervals between examinations, a situation that may parallel to over-diagnosis in breast cancer screening. Our findings raise the possibility that some CRCs in path_MMR carriers may spontaneously disappear: the host immune response may not only remove CRC precursor lesions in path_MMR carriers, but may remove infiltrating cancers as well. If confirmed, our suggested interpretation will have a bearing on surveillance policy for path_MMR carriers. More... »

PAGES

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13053-019-0106-8

DOI

http://dx.doi.org/10.1186/s13053-019-0106-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112465820

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30858900


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland", 
            "University of Helsinki, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sepp\u00e4l\u00e4", 
        "givenName": "Toni T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Heidelberg University Hospital and DKFZ, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahadova", 
        "givenName": "Aysel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway", 
            "Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dominguez-Valentin", 
        "givenName": "Mev", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Royal Melbourne Hospital, Melbourne, Australia", 
            "University of Melbourne, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Macrae", 
        "givenName": "Finlay", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Manchester", 
          "id": "https://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "University of Manchester & Manchester University Hospitals Foundation Trust, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Evans", 
        "givenName": "D. Gareth", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "The Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Therkildsen", 
        "givenName": "Christina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Medical Genetics, Cardiff University, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sampson", 
        "givenName": "Julian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "University of Newcastle and the Hunter Medical Research Institute, Callaghan, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scott", 
        "givenName": "Rodney", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Newcastle University", 
          "id": "https://www.grid.ac/institutes/grid.1006.7", 
          "name": [
            "University of Newcastle, Newcastle upon Tyne, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burn", 
        "givenName": "John", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Witten/Herdecke University", 
          "id": "https://www.grid.ac/institutes/grid.412581.b", 
          "name": [
            "University Witten-Herdecke, Wuppertal, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00f6slein", 
        "givenName": "Gabriela", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aalborg Hospital", 
          "id": "https://www.grid.ac/institutes/grid.27530.33", 
          "name": [
            "Dept. of Surgical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bernstein", 
        "givenName": "Inge", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Genetics Center", 
          "id": "https://www.grid.ac/institutes/grid.491982.f", 
          "name": [
            "Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universit\u00e4t M\u00fcnchen, Munich, Germany", 
            "MGZ- Medical Genetics Center, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holinski-Feder", 
        "givenName": "Elke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Central Finland Health Care District", 
          "id": "https://www.grid.ac/institutes/grid.460356.2", 
          "name": [
            "Central Finland Central Hospital, Education and Research, Jyv\u00e4skyl\u00e4, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pylv\u00e4n\u00e4inen", 
        "givenName": "Kirsi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Renkonen-Sinisalo", 
        "givenName": "Laura", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lepist\u00f6", 
        "givenName": "Anna", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aalborg Hospital", 
          "id": "https://www.grid.ac/institutes/grid.27530.33", 
          "name": [
            "Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lautrup", 
        "givenName": "Charlotte Kvist", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Karolinska Institutet, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindblom", 
        "givenName": "Annika", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Melbourne Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416153.4", 
          "name": [
            "The Royal Melbourne Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Plazzer", 
        "givenName": "John-Paul", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Melbourne", 
          "id": "https://www.grid.ac/institutes/grid.1008.9", 
          "name": [
            "The Royal Melbourne Hospital, Melbourne, Australia", 
            "University of Melbourne, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winship", 
        "givenName": "Ingrid", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Melbourne Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416153.4", 
          "name": [
            "The Royal Melbourne Hospital, Melbourne, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tjandra", 
        "givenName": "Douglas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hadassah Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.17788.31", 
          "name": [
            "Hadassah Medical Center, Jerusalem, and Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katz", 
        "givenName": "Lior H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Bonn", 
          "id": "https://www.grid.ac/institutes/grid.10388.32", 
          "name": [
            "Institute of Human Genetics, University of Bonn, Bonn, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aretz", 
        "givenName": "Stefan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany", 
            "Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "H\u00fcneburg", 
        "givenName": "Robert", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany", 
            "Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holzapfel", 
        "givenName": "Stefanie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Basel", 
          "id": "https://www.grid.ac/institutes/grid.410567.1", 
          "name": [
            "Institute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heinimann", 
        "givenName": "Karl", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigaci\u00f3n de Afecciones Oncol\u00f3gicas Hereditarias (GCU), Montevideo, Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valle", 
        "givenName": "Adriana Della", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigaci\u00f3n de Afecciones Oncol\u00f3gicas Hereditarias (GCU), Montevideo, Uruguay"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neffa", 
        "givenName": "Florencia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Tel-Aviv Soursky Medical Center, Tel-Aviv, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gluck", 
        "givenName": "Nathan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Isala", 
          "id": "https://www.grid.ac/institutes/grid.452600.5", 
          "name": [
            "Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Vos tot Nederveen Cappel", 
        "givenName": "Wouter H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vasen", 
        "givenName": "Hans", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Genetics Center", 
          "id": "https://www.grid.ac/institutes/grid.491982.f", 
          "name": [
            "Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universit\u00e4t M\u00fcnchen, Munich, Germany", 
            "MGZ- Medical Genetics Center, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morak", 
        "givenName": "Monika", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Genetics Center", 
          "id": "https://www.grid.ac/institutes/grid.491982.f", 
          "name": [
            "Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universit\u00e4t M\u00fcnchen, Munich, Germany", 
            "MGZ- Medical Genetics Center, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steinke-Lange", 
        "givenName": "Verena", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leipzig University", 
          "id": "https://www.grid.ac/institutes/grid.9647.c", 
          "name": [
            "Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Engel", 
        "givenName": "Christoph", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
          "id": "https://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Medical School, Institute of Human Genetics, Heinrich-Heine-University, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rahner", 
        "givenName": "Nils", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmiegel", 
        "givenName": "Wolff", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vangala", 
        "givenName": "Deepak", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial College London", 
          "id": "https://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "St Mark\u2019s Hospital, Department of Surgery and Cancer, Imperial College London, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "Huw", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Manchester", 
          "id": "https://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "University of Manchester & Manchester University Hospitals Foundation Trust, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Green", 
        "givenName": "Kate", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Manchester", 
          "id": "https://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "University of Manchester & Manchester University Hospitals Foundation Trust, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lalloo", 
        "givenName": "Fiona", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Manchester", 
          "id": "https://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "University of Manchester and St Mary\u2019s Hospital, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crosbie", 
        "givenName": "Emma J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Manchester", 
          "id": "https://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "University of Manchester & Manchester University Hospitals Foundation Trust, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hill", 
        "givenName": "James", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Catal\u00e0 d'Oncologia", 
          "id": "https://www.grid.ac/institutes/grid.418701.b", 
          "name": [
            "Hereditary Cancer Program, Catalan Institute of Oncology, Insititut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), ONCOBELL Program, L\u2019Hospitalet de Llobregat, Barcelona, Spain", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Capella", 
        "givenName": "Gabriel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Catal\u00e0 d'Oncologia", 
          "id": "https://www.grid.ac/institutes/grid.418701.b", 
          "name": [
            "Hereditary Cancer Program, Catalan Institute of Oncology, Insititut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), ONCOBELL Program, L\u2019Hospitalet de Llobregat, Barcelona, Spain", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pineda", 
        "givenName": "Marta", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Catal\u00e0 d'Oncologia", 
          "id": "https://www.grid.ac/institutes/grid.418701.b", 
          "name": [
            "Hereditary Cancer Program, Catalan Institute of Oncology, Insititut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), ONCOBELL Program, L\u2019Hospitalet de Llobregat, Barcelona, Spain", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Navarro", 
        "givenName": "Matilde", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Catal\u00e0 d'Oncologia", 
          "id": "https://www.grid.ac/institutes/grid.418701.b", 
          "name": [
            "Hereditary Cancer Program, Catalan Institute of Oncology, Insititut d\u2019Investigaci\u00f3 Biom\u00e8dica de Bellvitge (IDIBELL), ONCOBELL Program, L\u2019Hospitalet de Llobregat, Barcelona, Spain", 
            "Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blanco", 
        "givenName": "Ignacio", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Groningen", 
          "id": "https://www.grid.ac/institutes/grid.4494.d", 
          "name": [
            "University Medical Center Groningen, Groningen, the Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "ten Broeke", 
        "givenName": "Sanne", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Leiden University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.10419.3d", 
          "name": [
            "Leids Universitair Medisch Centrum, Leiden, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nielsen", 
        "givenName": "Maartje", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.154185.c", 
          "name": [
            "Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ljungmann", 
        "givenName": "Ken", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakken", 
        "givenName": "Sigve", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.417468.8", 
          "name": [
            "Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lindor", 
        "givenName": "Noralane", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiff University", 
          "id": "https://www.grid.ac/institutes/grid.5600.3", 
          "name": [
            "Medical Genetics, Cardiff University, Cardiff, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frayling", 
        "givenName": "Ian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway", 
            "Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hovig", 
        "givenName": "Eivind", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aarhus University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.154185.c", 
          "name": [
            "Department of Medical Genetics, Aarhus University Hospital, Aarhus, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sunde", 
        "givenName": "Lone", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Heidelberg University Hospital and DKFZ, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kloor", 
        "givenName": "Matthias", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Jyv\u00e4skyl\u00e4", 
          "id": "https://www.grid.ac/institutes/grid.9681.6", 
          "name": [
            "Department of Surgery, Central Finland Central Hospital, Jyv\u00e4skyl\u00e4, Finland", 
            "Faculty of Sport and Health Sciences, University of Jyv\u00e4skyl\u00e4, Jyv\u00e4skyl\u00e4, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mecklin", 
        "givenName": "Jukka-Pekka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway", 
            "University of Oslo, Oslo, Norway", 
            "Harvard School of Public Health, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kalager", 
        "givenName": "Mette", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oslo University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.55325.34", 
          "name": [
            "Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway", 
            "University Witten-Herdecke, Wuppertal, Germany", 
            "Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00f8ller", 
        "givenName": "P\u00e5l", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1136/gutjnl-2015-309675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005324911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(87)90565-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010438436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10689-005-5442-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010892086", 
          "https://doi.org/10.1007/s10689-005-5442-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10552-014-0438-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012480799", 
          "https://doi.org/10.1007/s10552-014-0438-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2016-312044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020757835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.62.2035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022112347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90546-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023000446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd001877.pub5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024290422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371075a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024767107", 
          "https://doi.org/10.1038/371075a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2008.01.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026686970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2012-304356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026703287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)90487-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027418568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(78)90487-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027418568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trecan.2016.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028267554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/codi.12778", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029505081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2007.08.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031382674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0266462307051616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032549769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2010.02.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036690615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd004720.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037160767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70109-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038847888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.30284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039370693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1193-279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039824484", 
          "https://doi.org/10.1038/ng1193-279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(00)70168-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040475844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1197-271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042080593", 
          "https://doi.org/10.1038/ng1197-271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.50.2.228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043467728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.33.6.783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043774800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365520601010230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045597107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)91016-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046740712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)91016-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046740712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/00365521.2014.966317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047078250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.g366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050650252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(95)90688-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051860566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-013-1745-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051870595", 
          "https://doi.org/10.1007/s00384-013-1745-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8484120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062655778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8484121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062655779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2016-311403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062813712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-100-5-700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073689147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/m16-0270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079399231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/m16-0270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079399231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gutjnl-2017-314057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090927084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13053-017-0078-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092156195", 
          "https://doi.org/10.1186/s13053-017-0078-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.31300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100922442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2018.07.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105897558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12957-018-1552-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111441099", 
          "https://doi.org/10.1186/s12957-018-1552-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12957-018-1552-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111441099", 
          "https://doi.org/10.1186/s12957-018-1552-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Background: Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in expert centres. This observation conflicts with the paradigm that removal of all visible polyps should prevent the vast majority of CRC in path_MMR carriers, provided the screening interval is sufficiently short and colonoscopic practice is optimal.\nMethods: To inform the debate, we examined, in the Prospective Lynch Syndrome Database (PLSD), whether the time since last colonoscopy was associated with the pathological stage at which CRC was diagnosed during prospective surveillance. Path_MMR carriers were recruited for prospective surveillance by colonoscopy. Only variants scored by the InSiGHT Variant Interpretation Committee as class 4 and 5 (clinically actionable) were included. CRCs detected at the first planned colonoscopy, or within one year of this, were excluded as prevalent cancers.\nResults: Stage at diagnosis and interval between last prospective surveillance colonoscopy and diagnosis were available for 209 patients with 218 CRCs, including 162 path_MLH1, 45 path_MSH2, 10 path_MSH6 and 1 path_PMS2 carriers. The numbers of cancers detected within <\u20091.5, 1.5-2.5, 2.5-3.5 and at >\u20093.5\u2009years since last colonoscopy were 36, 93, 56 and 33, respectively. Among these, 16.7, 19.4, 9.9 and 15.1% were stage III-IV, respectively (p\u00a0=\u20090.34). The cancers detected more than 2.5\u2009years after the last colonoscopy were not more advanced than those diagnosed earlier (p\u00a0=\u20090.14).\nConclusions: The CRC stage and interval since last colonoscopy were not correlated, which is in conflict with the accelerated adenoma-carcinoma paradigm. We have previously reported that more frequent colonoscopy is not associated with lower incidence of CRC in path_MMR carriers as was expected. In contrast, point estimates showed a higher incidence with shorter intervals between examinations, a situation that may parallel to over-diagnosis in breast cancer screening. Our findings raise the possibility that some CRCs in path_MMR carriers may spontaneously disappear: the host immune response may not only remove CRC precursor lesions in path_MMR carriers, but may remove infiltrating cancers as well. If confirmed, our suggested interpretation will have a bearing on surveillance policy for path_MMR carriers.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13053-019-0106-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1034424", 
        "issn": [
          "1731-2302", 
          "1897-4287"
        ], 
        "name": "Hereditary Cancer in Clinical Practice", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report", 
    "pagination": "8", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fd40368398d9f64260052c85a8b43c3ad7de8196806af6d59d5eae520cd94182"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30858900"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101231179"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13053-019-0106-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112465820"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13053-019-0106-8", 
      "https://app.dimensions.ai/details/publication/pub.1112465820"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78968_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13053-019-0106-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13053-019-0106-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13053-019-0106-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13053-019-0106-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13053-019-0106-8'


 

This table displays all metadata directly associated to this object as RDF triples.

649 TRIPLES      21 PREDICATES      70 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13053-019-0106-8 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N181574f8b92c4320ac4a71200cbc0c49
4 schema:citation sg:pub.10.1007/s00384-013-1745-2
5 sg:pub.10.1007/s10552-014-0438-7
6 sg:pub.10.1007/s10689-005-5442-3
7 sg:pub.10.1038/371075a0
8 sg:pub.10.1038/ng1193-279
9 sg:pub.10.1038/ng1197-271
10 sg:pub.10.1186/s12957-018-1552-x
11 sg:pub.10.1186/s13053-017-0078-5
12 https://doi.org/10.1002/14651858.cd001877.pub5
13 https://doi.org/10.1002/14651858.cd004720.pub3
14 https://doi.org/10.1002/ijc.30284
15 https://doi.org/10.1002/ijc.31300
16 https://doi.org/10.1016/0016-5085(87)90565-8
17 https://doi.org/10.1016/0016-5085(95)90688-6
18 https://doi.org/10.1016/0092-8674(93)90546-3
19 https://doi.org/10.1016/j.trecan.2016.02.004
20 https://doi.org/10.1016/s0016-5085(00)70168-5
21 https://doi.org/10.1016/s0140-6736(78)90487-7
22 https://doi.org/10.1016/s0140-6736(95)91016-6
23 https://doi.org/10.1016/s1470-2045(12)70109-2
24 https://doi.org/10.1017/s0266462307051616
25 https://doi.org/10.1053/j.gastro.2007.08.019
26 https://doi.org/10.1053/j.gastro.2008.01.015
27 https://doi.org/10.1053/j.gastro.2010.02.053
28 https://doi.org/10.1053/j.gastro.2018.07.030
29 https://doi.org/10.1080/00365520601010230
30 https://doi.org/10.1111/codi.12778
31 https://doi.org/10.1126/science.8484120
32 https://doi.org/10.1126/science.8484121
33 https://doi.org/10.1136/bmj.g366
34 https://doi.org/10.1136/gut.33.6.783
35 https://doi.org/10.1136/gut.50.2.228
36 https://doi.org/10.1136/gutjnl-2012-304356
37 https://doi.org/10.1136/gutjnl-2015-309675
38 https://doi.org/10.1136/gutjnl-2016-311403
39 https://doi.org/10.1136/gutjnl-2016-312044
40 https://doi.org/10.1136/gutjnl-2017-314057
41 https://doi.org/10.1200/jco.2015.62.2035
42 https://doi.org/10.3109/00365521.2014.966317
43 https://doi.org/10.7326/0003-4819-100-5-700
44 https://doi.org/10.7326/m16-0270
45 schema:datePublished 2019-12
46 schema:datePublishedReg 2019-12-01
47 schema:description Background: Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in expert centres. This observation conflicts with the paradigm that removal of all visible polyps should prevent the vast majority of CRC in path_MMR carriers, provided the screening interval is sufficiently short and colonoscopic practice is optimal. Methods: To inform the debate, we examined, in the Prospective Lynch Syndrome Database (PLSD), whether the time since last colonoscopy was associated with the pathological stage at which CRC was diagnosed during prospective surveillance. Path_MMR carriers were recruited for prospective surveillance by colonoscopy. Only variants scored by the InSiGHT Variant Interpretation Committee as class 4 and 5 (clinically actionable) were included. CRCs detected at the first planned colonoscopy, or within one year of this, were excluded as prevalent cancers. Results: Stage at diagnosis and interval between last prospective surveillance colonoscopy and diagnosis were available for 209 patients with 218 CRCs, including 162 path_MLH1, 45 path_MSH2, 10 path_MSH6 and 1 path_PMS2 carriers. The numbers of cancers detected within < 1.5, 1.5-2.5, 2.5-3.5 and at > 3.5 years since last colonoscopy were 36, 93, 56 and 33, respectively. Among these, 16.7, 19.4, 9.9 and 15.1% were stage III-IV, respectively (p = 0.34). The cancers detected more than 2.5 years after the last colonoscopy were not more advanced than those diagnosed earlier (p = 0.14). Conclusions: The CRC stage and interval since last colonoscopy were not correlated, which is in conflict with the accelerated adenoma-carcinoma paradigm. We have previously reported that more frequent colonoscopy is not associated with lower incidence of CRC in path_MMR carriers as was expected. In contrast, point estimates showed a higher incidence with shorter intervals between examinations, a situation that may parallel to over-diagnosis in breast cancer screening. Our findings raise the possibility that some CRCs in path_MMR carriers may spontaneously disappear: the host immune response may not only remove CRC precursor lesions in path_MMR carriers, but may remove infiltrating cancers as well. If confirmed, our suggested interpretation will have a bearing on surveillance policy for path_MMR carriers.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N3aa567473f824b0f82ba7a7a336f65cc
52 Naa8cbf0504f349d2ac1fd0d08e8acf90
53 sg:journal.1034424
54 schema:name Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report
55 schema:pagination 8
56 schema:productId N23d347286eaa4949afc42912f965c8a1
57 N99c963be385a496a9af4160f307dfa98
58 Na6ff7db6080e4303b3459ae777073e97
59 Nb87bdbf25c7f4dfabc8a4dafd8bf5025
60 Nf2c9b316a3a4428a9cd8549e1e8c04d9
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112465820
62 https://doi.org/10.1186/s13053-019-0106-8
63 schema:sdDatePublished 2019-04-11T13:20
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher N0593c78b76be48eb81004b53246e78be
66 schema:url https://link.springer.com/10.1186%2Fs13053-019-0106-8
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N0208652b4e4e430ebef36b76771b240d schema:affiliation https://www.grid.ac/institutes/grid.55325.34
71 schema:familyName Nakken
72 schema:givenName Sigve
73 rdf:type schema:Person
74 N0593c78b76be48eb81004b53246e78be schema:name Springer Nature - SN SciGraph project
75 rdf:type schema:Organization
76 N05a056bec7e74b1b97d7b68d7d75ebb9 schema:affiliation https://www.grid.ac/institutes/grid.418701.b
77 schema:familyName Navarro
78 schema:givenName Matilde
79 rdf:type schema:Person
80 N09719666d7334455b15c43b4e856be48 rdf:first Nb3e2cdcaf0614f2dae6ff5c2243f957d
81 rdf:rest Nf1dee36e9ac8468c893eb8528955c3b9
82 N0ef72e69e67443658019fcb4c22fe496 rdf:first Ne0e7761fb03444ab80a5d357a2d03f7a
83 rdf:rest N2a3693075d884af1a54f463d6bc42208
84 N12b719f305224b1cb8a4b175684aca46 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
85 schema:familyName Lepistö
86 schema:givenName Anna
87 rdf:type schema:Person
88 N13be57c083cf4a4daf95af0cd44d2aa8 rdf:first N4a2c4c887f5543409fb9860bb71a9e62
89 rdf:rest N8daa9bccb31a4c558ca6369c6c335d1d
90 N14345c409c29420296d109119bad30ae rdf:first N2666640e5d3349108f1e2e60c1319701
91 rdf:rest Na1bcf4971a0740d6a1575bc24e4cc972
92 N169474a04113491390a3f364d254bbec rdf:first Nf321f15e4ca84e439d0d5ffde5f9f8a0
93 rdf:rest N8353d81a056740efa04d1fe5b2573705
94 N16ba269eca1e4385b079a65f80853f42 schema:name Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany
95 Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
96 rdf:type schema:Organization
97 N181574f8b92c4320ac4a71200cbc0c49 rdf:first N94d0c43cc1624cfd822854b12e895d02
98 rdf:rest N1dc5f11861bc45648de1052701daf8ee
99 N182360e936234701b8d4847c3b6f68a9 schema:name The Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark
100 rdf:type schema:Organization
101 N19140cec689e47d3a69801e38dd04130 rdf:first Nec959818002c48d2a1831d1f97e4e2a3
102 rdf:rest Na36589d5077b4ffdb60e98ef8acbdf88
103 N1a74fdf0304943809c58434d29a38708 rdf:first Ne65e83da3846445a8e0907c331e3afc1
104 rdf:rest Ndec3acb9fbcb42b581503b979b5e0d77
105 N1ac16b4b5609443e80432fd3ecfcec30 rdf:first N3cee33e1ea4040219f2951f64cf8c03f
106 rdf:rest Na7078518fa1a4990a4e87fb81eefc15a
107 N1c3c897ec1d545f1be41f07fb08b2991 rdf:first N4b7732ef77424625a7fca11294b735c4
108 rdf:rest Nd2ea1dc9014848bcb6824217e260cf33
109 N1c6249e1d79d42a2b81cc957fb382025 rdf:first Na87f536899754cf4afbd00d4b13e4276
110 rdf:rest N1ac16b4b5609443e80432fd3ecfcec30
111 N1dc5f11861bc45648de1052701daf8ee rdf:first Nf197964663144e19bbbd4cd76a28018b
112 rdf:rest N37b1de88341d4697acc79d3ff9abc846
113 N23d347286eaa4949afc42912f965c8a1 schema:name pubmed_id
114 schema:value 30858900
115 rdf:type schema:PropertyValue
116 N2666640e5d3349108f1e2e60c1319701 schema:affiliation https://www.grid.ac/institutes/grid.412581.b
117 schema:familyName Möslein
118 schema:givenName Gabriela
119 rdf:type schema:Person
120 N2a3693075d884af1a54f463d6bc42208 rdf:first N70215eaa753c4c53bc9827fc7cfaa2bc
121 rdf:rest N3e07591ae414468d9bee50d3a156b067
122 N2af1b80767d3453097d4928e5bb08359 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
123 schema:familyName Vasen
124 schema:givenName Hans
125 rdf:type schema:Person
126 N3014348a790147049f6e8172efd96f5c schema:affiliation https://www.grid.ac/institutes/grid.411327.2
127 schema:familyName Rahner
128 schema:givenName Nils
129 rdf:type schema:Person
130 N327c850c2f30407fb0e02f881177a9f3 schema:affiliation https://www.grid.ac/institutes/grid.410567.1
131 schema:familyName Heinimann
132 schema:givenName Karl
133 rdf:type schema:Person
134 N32ff92668eda454dbb5a04960780b0b1 rdf:first Nd00c51e28c40476abc9a71514abad831
135 rdf:rest N19140cec689e47d3a69801e38dd04130
136 N35235d0c1974421bb1b5a238321fd7f7 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
137 schema:familyName Frayling
138 schema:givenName Ian
139 rdf:type schema:Person
140 N360a1088a8784616b9535ab3df180c3e schema:affiliation https://www.grid.ac/institutes/grid.7445.2
141 schema:familyName Thomas
142 schema:givenName Huw
143 rdf:type schema:Person
144 N37b1de88341d4697acc79d3ff9abc846 rdf:first N5233253e27654d479f0b74c15f14100d
145 rdf:rest N71468cdb3d4c483e9d2efbaee1e6cbd8
146 N3886ff48fedf4d378188ddbbc9c063d9 schema:affiliation https://www.grid.ac/institutes/grid.417468.8
147 schema:familyName Lindor
148 schema:givenName Noralane
149 rdf:type schema:Person
150 N3a0d1a5a4cc947dabb6528eac8c812d4 schema:affiliation Ndf07224bcae945fd868237343c0356ce
151 schema:familyName Scott
152 schema:givenName Rodney
153 rdf:type schema:Person
154 N3aa567473f824b0f82ba7a7a336f65cc schema:issueNumber 1
155 rdf:type schema:PublicationIssue
156 N3cee33e1ea4040219f2951f64cf8c03f schema:affiliation https://www.grid.ac/institutes/grid.154185.c
157 schema:familyName Sunde
158 schema:givenName Lone
159 rdf:type schema:Person
160 N3d5438e73f234173b1f58812542ada35 rdf:first Na2dcd21d822c4fbca30d0135c872a62b
161 rdf:rest N9e598eddde414ebc8d1c18c12a5f008c
162 N3e07591ae414468d9bee50d3a156b067 rdf:first N581f8d730a8f4318a00d5404791dd97f
163 rdf:rest Ne910eb04c7964f07af9628551ee9f14b
164 N40f2167b37a747d5b37b855ea878e34a rdf:first Nec51bee632d74d71ac4e1688038bd8ee
165 rdf:rest N169474a04113491390a3f364d254bbec
166 N41c821c9050b4b57abf2e0e651f20e28 rdf:first N3a0d1a5a4cc947dabb6528eac8c812d4
167 rdf:rest N525ffb328a3e4fdabfe14b0733ad9d41
168 N489e876ad30d4ff7b19daaf6f3fd7651 schema:affiliation https://www.grid.ac/institutes/grid.418701.b
169 schema:familyName Blanco
170 schema:givenName Ignacio
171 rdf:type schema:Person
172 N4a2c4c887f5543409fb9860bb71a9e62 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
173 schema:familyName Vangala
174 schema:givenName Deepak
175 rdf:type schema:Person
176 N4a7ba6b20ef147e9ad5241938053bf4e rdf:first N5f6c2de6f1a649c5a7341d50413220b3
177 rdf:rest Na65045e97ccd4e7a893cc888db38a63a
178 N4ab6af653cc54a7783e5d51fb6b0bb5c schema:affiliation https://www.grid.ac/institutes/grid.9647.c
179 schema:familyName Engel
180 schema:givenName Christoph
181 rdf:type schema:Person
182 N4b7732ef77424625a7fca11294b735c4 schema:affiliation Nb7da76cbf3224a79b466c195bc8c00cd
183 schema:familyName Gluck
184 schema:givenName Nathan
185 rdf:type schema:Person
186 N4ea4a2dff8374ed88b3205bb4bc72b39 rdf:first Nb28a9b4bd11e4f7eb40546257bb77fac
187 rdf:rest N1a74fdf0304943809c58434d29a38708
188 N5233253e27654d479f0b74c15f14100d schema:affiliation https://www.grid.ac/institutes/grid.55325.34
189 schema:familyName Dominguez-Valentin
190 schema:givenName Mev
191 rdf:type schema:Person
192 N525ffb328a3e4fdabfe14b0733ad9d41 rdf:first Ndf622757f54741c4872ae3fd50f677f3
193 rdf:rest N14345c409c29420296d109119bad30ae
194 N530e9ff7a1004aacbdf62179ab87ba1d rdf:first N3014348a790147049f6e8172efd96f5c
195 rdf:rest N6b82ac3536434bfeb76bb1f7fde9fc9a
196 N55c05b2edcde4f7ea3c13e9416c0df5c schema:affiliation https://www.grid.ac/institutes/grid.491982.f
197 schema:familyName Steinke-Lange
198 schema:givenName Verena
199 rdf:type schema:Person
200 N57e8ee1a69a04c46b7d75ce893531c26 rdf:first Na542e5af85b14700ab204207005aa0b9
201 rdf:rest N0ef72e69e67443658019fcb4c22fe496
202 N581f8d730a8f4318a00d5404791dd97f schema:affiliation https://www.grid.ac/institutes/grid.1008.9
203 schema:familyName Winship
204 schema:givenName Ingrid
205 rdf:type schema:Person
206 N5b22aa62a5c9411c930009dc221250ec schema:affiliation https://www.grid.ac/institutes/grid.17788.31
207 schema:familyName Katz
208 schema:givenName Lior H.
209 rdf:type schema:Person
210 N5e77677f30df44bbb92ceabf282842a3 rdf:first Ncc8c94e816ff4dd1983a4ef8f5ec5843
211 rdf:rest N828f1355540240569069bdf5d6bdfbe0
212 N5f6c2de6f1a649c5a7341d50413220b3 schema:affiliation https://www.grid.ac/institutes/grid.491982.f
213 schema:familyName Holinski-Feder
214 schema:givenName Elke
215 rdf:type schema:Person
216 N6553f8addfcb445cb1498448f94db8c0 schema:affiliation https://www.grid.ac/institutes/grid.452600.5
217 schema:familyName de Vos tot Nederveen Cappel
218 schema:givenName Wouter H.
219 rdf:type schema:Person
220 N6acadf8650f04d868c6c33c6e0403062 schema:affiliation Ndc7946070abe45068142a705e4133b09
221 schema:familyName Valle
222 schema:givenName Adriana Della
223 rdf:type schema:Person
224 N6b82ac3536434bfeb76bb1f7fde9fc9a rdf:first N9f97d0070a4f49d2992955762c41580f
225 rdf:rest N13be57c083cf4a4daf95af0cd44d2aa8
226 N6bed8fc810634b578a5662691bbc893f rdf:first Nab1ce7a184f34b48999ee1819c5cca7f
227 rdf:rest Ne1bca310f28446c3ad9a0b376e8ed578
228 N70215eaa753c4c53bc9827fc7cfaa2bc schema:affiliation https://www.grid.ac/institutes/grid.416153.4
229 schema:familyName Plazzer
230 schema:givenName John-Paul
231 rdf:type schema:Person
232 N71468cdb3d4c483e9d2efbaee1e6cbd8 rdf:first N82410dc4eaab44bfbc9987b04cdb7081
233 rdf:rest N714a2614c70b4d339531fd6d6f2b4a5c
234 N714a2614c70b4d339531fd6d6f2b4a5c rdf:first Na9ea03d34a3c4981a44b60a348013d68
235 rdf:rest N6bed8fc810634b578a5662691bbc893f
236 N74b7720276a049c3aaef9bd901b5d58f schema:affiliation https://www.grid.ac/institutes/grid.418701.b
237 schema:familyName Pineda
238 schema:givenName Marta
239 rdf:type schema:Person
240 N774a33d8e254431481f717cf20f92903 rdf:first N489e876ad30d4ff7b19daaf6f3fd7651
241 rdf:rest Nff5fdccf29f7448fb8afcae783957d64
242 N7824ac238844438287382d83b6ea9054 schema:affiliation https://www.grid.ac/institutes/grid.4494.d
243 schema:familyName ten Broeke
244 schema:givenName Sanne
245 rdf:type schema:Person
246 N82410dc4eaab44bfbc9987b04cdb7081 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
247 schema:familyName Macrae
248 schema:givenName Finlay
249 rdf:type schema:Person
250 N828f1355540240569069bdf5d6bdfbe0 rdf:first N55c05b2edcde4f7ea3c13e9416c0df5c
251 rdf:rest N9defae9f1bd04117ab658b09c73c05cd
252 N8353d81a056740efa04d1fe5b2573705 rdf:first N0208652b4e4e430ebef36b76771b240d
253 rdf:rest N975429c6b6284f7ca654d9558853d6e5
254 N84d9b1ac1d9f4458913415f11e367086 schema:affiliation Na18c47e644484a9b885aeeb76cef63ec
255 schema:familyName Neffa
256 schema:givenName Florencia
257 rdf:type schema:Person
258 N88c9b35da6b449c6ab8901fdb42f5b06 rdf:first N2af1b80767d3453097d4928e5bb08359
259 rdf:rest N5e77677f30df44bbb92ceabf282842a3
260 N8b6feb1c976f46cd8952c3bfd4298e16 schema:affiliation https://www.grid.ac/institutes/grid.5600.3
261 schema:familyName Sampson
262 schema:givenName Julian
263 rdf:type schema:Person
264 N8daa9bccb31a4c558ca6369c6c335d1d rdf:first N360a1088a8784616b9535ab3df180c3e
265 rdf:rest N9d65dacb93844e1b8be7b64f2d4eb02f
266 N8f89a7b947664d01a004e5189105aa5f rdf:first Nab817d54835648019f6499ddb3e6309a
267 rdf:rest Ndab2e0bea7ec4c27ab316aa6bea212ee
268 N934740ec7edc433c9ed479bfed4b6eb3 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
269 schema:familyName Crosbie
270 schema:givenName Emma J.
271 rdf:type schema:Person
272 N94d0c43cc1624cfd822854b12e895d02 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
273 schema:familyName Seppälä
274 schema:givenName Toni T.
275 rdf:type schema:Person
276 N96ec0d4631224f4cbdeb815273b2e22f schema:affiliation https://www.grid.ac/institutes/grid.416153.4
277 schema:familyName Tjandra
278 schema:givenName Douglas
279 rdf:type schema:Person
280 N975429c6b6284f7ca654d9558853d6e5 rdf:first N3886ff48fedf4d378188ddbbc9c063d9
281 rdf:rest Nd66e5802c13a4a19ace3c326512729c6
282 N99c963be385a496a9af4160f307dfa98 schema:name readcube_id
283 schema:value fd40368398d9f64260052c85a8b43c3ad7de8196806af6d59d5eae520cd94182
284 rdf:type schema:PropertyValue
285 N9d65dacb93844e1b8be7b64f2d4eb02f rdf:first Ndf2211e0a59746fb896cb3306ae0b966
286 rdf:rest N09719666d7334455b15c43b4e856be48
287 N9d7813ff4239418d9d74f7dcd56ae3c1 schema:affiliation https://www.grid.ac/institutes/grid.460356.2
288 schema:familyName Pylvänäinen
289 schema:givenName Kirsi
290 rdf:type schema:Person
291 N9defae9f1bd04117ab658b09c73c05cd rdf:first N4ab6af653cc54a7783e5d51fb6b0bb5c
292 rdf:rest N530e9ff7a1004aacbdf62179ab87ba1d
293 N9e598eddde414ebc8d1c18c12a5f008c rdf:first N12b719f305224b1cb8a4b175684aca46
294 rdf:rest N57e8ee1a69a04c46b7d75ce893531c26
295 N9f97d0070a4f49d2992955762c41580f schema:affiliation https://www.grid.ac/institutes/grid.5570.7
296 schema:familyName Schmiegel
297 schema:givenName Wolff
298 rdf:type schema:Person
299 Na18c47e644484a9b885aeeb76cef63ec schema:name Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay
300 rdf:type schema:Organization
301 Na1bcf4971a0740d6a1575bc24e4cc972 rdf:first Nc6767e61288f487b8797e4d1e511d714
302 rdf:rest N4a7ba6b20ef147e9ad5241938053bf4e
303 Na2dcd21d822c4fbca30d0135c872a62b schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
304 schema:familyName Renkonen-Sinisalo
305 schema:givenName Laura
306 rdf:type schema:Person
307 Na36589d5077b4ffdb60e98ef8acbdf88 rdf:first N74b7720276a049c3aaef9bd901b5d58f
308 rdf:rest Nc8ed88d8a4214326a9bdb00271326a66
309 Na42808fe2eae492e9d159afbdc67bb15 rdf:first N6acadf8650f04d868c6c33c6e0403062
310 rdf:rest Nbd54593894c44fe1a8af7b2bfef6b56c
311 Na542e5af85b14700ab204207005aa0b9 schema:affiliation https://www.grid.ac/institutes/grid.27530.33
312 schema:familyName Lautrup
313 schema:givenName Charlotte Kvist
314 rdf:type schema:Person
315 Na65045e97ccd4e7a893cc888db38a63a rdf:first N9d7813ff4239418d9d74f7dcd56ae3c1
316 rdf:rest N3d5438e73f234173b1f58812542ada35
317 Na6ff7db6080e4303b3459ae777073e97 schema:name nlm_unique_id
318 schema:value 101231179
319 rdf:type schema:PropertyValue
320 Na7078518fa1a4990a4e87fb81eefc15a rdf:first Nddb71d6c2395452c8df6c06f35cc2881
321 rdf:rest N8f89a7b947664d01a004e5189105aa5f
322 Na87f536899754cf4afbd00d4b13e4276 schema:affiliation https://www.grid.ac/institutes/grid.55325.34
323 schema:familyName Hovig
324 schema:givenName Eivind
325 rdf:type schema:Person
326 Na9ea03d34a3c4981a44b60a348013d68 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
327 schema:familyName Evans
328 schema:givenName D. Gareth
329 rdf:type schema:Person
330 Naa8cbf0504f349d2ac1fd0d08e8acf90 schema:volumeNumber 17
331 rdf:type schema:PublicationVolume
332 Nab1ce7a184f34b48999ee1819c5cca7f schema:affiliation N182360e936234701b8d4847c3b6f68a9
333 schema:familyName Therkildsen
334 schema:givenName Christina
335 rdf:type schema:Person
336 Nab817d54835648019f6499ddb3e6309a schema:affiliation https://www.grid.ac/institutes/grid.9681.6
337 schema:familyName Mecklin
338 schema:givenName Jukka-Pekka
339 rdf:type schema:Person
340 Nb28a9b4bd11e4f7eb40546257bb77fac schema:affiliation https://www.grid.ac/institutes/grid.10388.32
341 schema:familyName Aretz
342 schema:givenName Stefan
343 rdf:type schema:Person
344 Nb3e2cdcaf0614f2dae6ff5c2243f957d schema:affiliation https://www.grid.ac/institutes/grid.5379.8
345 schema:familyName Lalloo
346 schema:givenName Fiona
347 rdf:type schema:Person
348 Nb648080646cb4cd787a31dcfdae8c298 rdf:first N327c850c2f30407fb0e02f881177a9f3
349 rdf:rest Na42808fe2eae492e9d159afbdc67bb15
350 Nb7da76cbf3224a79b466c195bc8c00cd schema:name Tel-Aviv Soursky Medical Center, Tel-Aviv, Israel
351 rdf:type schema:Organization
352 Nb87bdbf25c7f4dfabc8a4dafd8bf5025 schema:name dimensions_id
353 schema:value pub.1112465820
354 rdf:type schema:PropertyValue
355 Nbd54593894c44fe1a8af7b2bfef6b56c rdf:first N84d9b1ac1d9f4458913415f11e367086
356 rdf:rest N1c3c897ec1d545f1be41f07fb08b2991
357 Nc18d3c9bfb14411885ea789be140abfd schema:affiliation Necfd4a5768fc4907a051fd70897579a4
358 schema:familyName Holzapfel
359 schema:givenName Stefanie
360 rdf:type schema:Person
361 Nc6767e61288f487b8797e4d1e511d714 schema:affiliation https://www.grid.ac/institutes/grid.27530.33
362 schema:familyName Bernstein
363 schema:givenName Inge
364 rdf:type schema:Person
365 Nc8ed88d8a4214326a9bdb00271326a66 rdf:first N05a056bec7e74b1b97d7b68d7d75ebb9
366 rdf:rest N774a33d8e254431481f717cf20f92903
367 Ncc8c94e816ff4dd1983a4ef8f5ec5843 schema:affiliation https://www.grid.ac/institutes/grid.491982.f
368 schema:familyName Morak
369 schema:givenName Monika
370 rdf:type schema:Person
371 Nd00c51e28c40476abc9a71514abad831 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
372 schema:familyName Hill
373 schema:givenName James
374 rdf:type schema:Person
375 Nd2358928b3b641c7b614bbd752183746 rdf:first Ndc73f643dd3649f389bfdb07e629575f
376 rdf:rest rdf:nil
377 Nd2ea1dc9014848bcb6824217e260cf33 rdf:first N6553f8addfcb445cb1498448f94db8c0
378 rdf:rest N88c9b35da6b449c6ab8901fdb42f5b06
379 Nd66e5802c13a4a19ace3c326512729c6 rdf:first N35235d0c1974421bb1b5a238321fd7f7
380 rdf:rest N1c6249e1d79d42a2b81cc957fb382025
381 Ndab0314bda8e49039b5523c2f052bdb7 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
382 schema:familyName Kalager
383 schema:givenName Mette
384 rdf:type schema:Person
385 Ndab2e0bea7ec4c27ab316aa6bea212ee rdf:first Ndab0314bda8e49039b5523c2f052bdb7
386 rdf:rest Nd2358928b3b641c7b614bbd752183746
387 Ndc73f643dd3649f389bfdb07e629575f schema:affiliation https://www.grid.ac/institutes/grid.55325.34
388 schema:familyName Møller
389 schema:givenName Pål
390 rdf:type schema:Person
391 Ndc7946070abe45068142a705e4133b09 schema:name Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay
392 rdf:type schema:Organization
393 Nddb71d6c2395452c8df6c06f35cc2881 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
394 schema:familyName Kloor
395 schema:givenName Matthias
396 rdf:type schema:Person
397 Ndec3acb9fbcb42b581503b979b5e0d77 rdf:first Nc18d3c9bfb14411885ea789be140abfd
398 rdf:rest Nb648080646cb4cd787a31dcfdae8c298
399 Ndf07224bcae945fd868237343c0356ce schema:name University of Newcastle and the Hunter Medical Research Institute, Callaghan, Australia
400 rdf:type schema:Organization
401 Ndf2211e0a59746fb896cb3306ae0b966 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
402 schema:familyName Green
403 schema:givenName Kate
404 rdf:type schema:Person
405 Ndf622757f54741c4872ae3fd50f677f3 schema:affiliation https://www.grid.ac/institutes/grid.1006.7
406 schema:familyName Burn
407 schema:givenName John
408 rdf:type schema:Person
409 Ne0e7761fb03444ab80a5d357a2d03f7a schema:affiliation https://www.grid.ac/institutes/grid.4714.6
410 schema:familyName Lindblom
411 schema:givenName Annika
412 rdf:type schema:Person
413 Ne1bca310f28446c3ad9a0b376e8ed578 rdf:first N8b6feb1c976f46cd8952c3bfd4298e16
414 rdf:rest N41c821c9050b4b57abf2e0e651f20e28
415 Ne65e83da3846445a8e0907c331e3afc1 schema:affiliation N16ba269eca1e4385b079a65f80853f42
416 schema:familyName Hüneburg
417 schema:givenName Robert
418 rdf:type schema:Person
419 Ne6a1c0283ded4c009647169fa894c6ad rdf:first N5b22aa62a5c9411c930009dc221250ec
420 rdf:rest N4ea4a2dff8374ed88b3205bb4bc72b39
421 Ne910eb04c7964f07af9628551ee9f14b rdf:first N96ec0d4631224f4cbdeb815273b2e22f
422 rdf:rest Ne6a1c0283ded4c009647169fa894c6ad
423 Nec51bee632d74d71ac4e1688038bd8ee schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
424 schema:familyName Nielsen
425 schema:givenName Maartje
426 rdf:type schema:Person
427 Nec959818002c48d2a1831d1f97e4e2a3 schema:affiliation https://www.grid.ac/institutes/grid.418701.b
428 schema:familyName Capella
429 schema:givenName Gabriel
430 rdf:type schema:Person
431 Necfd4a5768fc4907a051fd70897579a4 schema:name Center for Hereditary Tumor Syndromes, University Hospital Bonn, Bonn, Germany
432 Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany
433 rdf:type schema:Organization
434 Nf197964663144e19bbbd4cd76a28018b schema:affiliation https://www.grid.ac/institutes/grid.5253.1
435 schema:familyName Ahadova
436 schema:givenName Aysel
437 rdf:type schema:Person
438 Nf1dee36e9ac8468c893eb8528955c3b9 rdf:first N934740ec7edc433c9ed479bfed4b6eb3
439 rdf:rest N32ff92668eda454dbb5a04960780b0b1
440 Nf2c9b316a3a4428a9cd8549e1e8c04d9 schema:name doi
441 schema:value 10.1186/s13053-019-0106-8
442 rdf:type schema:PropertyValue
443 Nf321f15e4ca84e439d0d5ffde5f9f8a0 schema:affiliation https://www.grid.ac/institutes/grid.154185.c
444 schema:familyName Ljungmann
445 schema:givenName Ken
446 rdf:type schema:Person
447 Nff5fdccf29f7448fb8afcae783957d64 rdf:first N7824ac238844438287382d83b6ea9054
448 rdf:rest N40f2167b37a747d5b37b855ea878e34a
449 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
450 schema:name Medical and Health Sciences
451 rdf:type schema:DefinedTerm
452 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
453 schema:name Oncology and Carcinogenesis
454 rdf:type schema:DefinedTerm
455 sg:journal.1034424 schema:issn 1731-2302
456 1897-4287
457 schema:name Hereditary Cancer in Clinical Practice
458 rdf:type schema:Periodical
459 sg:pub.10.1007/s00384-013-1745-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051870595
460 https://doi.org/10.1007/s00384-013-1745-2
461 rdf:type schema:CreativeWork
462 sg:pub.10.1007/s10552-014-0438-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012480799
463 https://doi.org/10.1007/s10552-014-0438-7
464 rdf:type schema:CreativeWork
465 sg:pub.10.1007/s10689-005-5442-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010892086
466 https://doi.org/10.1007/s10689-005-5442-3
467 rdf:type schema:CreativeWork
468 sg:pub.10.1038/371075a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024767107
469 https://doi.org/10.1038/371075a0
470 rdf:type schema:CreativeWork
471 sg:pub.10.1038/ng1193-279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039824484
472 https://doi.org/10.1038/ng1193-279
473 rdf:type schema:CreativeWork
474 sg:pub.10.1038/ng1197-271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042080593
475 https://doi.org/10.1038/ng1197-271
476 rdf:type schema:CreativeWork
477 sg:pub.10.1186/s12957-018-1552-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1111441099
478 https://doi.org/10.1186/s12957-018-1552-x
479 rdf:type schema:CreativeWork
480 sg:pub.10.1186/s13053-017-0078-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092156195
481 https://doi.org/10.1186/s13053-017-0078-5
482 rdf:type schema:CreativeWork
483 https://doi.org/10.1002/14651858.cd001877.pub5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024290422
484 rdf:type schema:CreativeWork
485 https://doi.org/10.1002/14651858.cd004720.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037160767
486 rdf:type schema:CreativeWork
487 https://doi.org/10.1002/ijc.30284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039370693
488 rdf:type schema:CreativeWork
489 https://doi.org/10.1002/ijc.31300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100922442
490 rdf:type schema:CreativeWork
491 https://doi.org/10.1016/0016-5085(87)90565-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010438436
492 rdf:type schema:CreativeWork
493 https://doi.org/10.1016/0016-5085(95)90688-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051860566
494 rdf:type schema:CreativeWork
495 https://doi.org/10.1016/0092-8674(93)90546-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023000446
496 rdf:type schema:CreativeWork
497 https://doi.org/10.1016/j.trecan.2016.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028267554
498 rdf:type schema:CreativeWork
499 https://doi.org/10.1016/s0016-5085(00)70168-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040475844
500 rdf:type schema:CreativeWork
501 https://doi.org/10.1016/s0140-6736(78)90487-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027418568
502 rdf:type schema:CreativeWork
503 https://doi.org/10.1016/s0140-6736(95)91016-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046740712
504 rdf:type schema:CreativeWork
505 https://doi.org/10.1016/s1470-2045(12)70109-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038847888
506 rdf:type schema:CreativeWork
507 https://doi.org/10.1017/s0266462307051616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032549769
508 rdf:type schema:CreativeWork
509 https://doi.org/10.1053/j.gastro.2007.08.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031382674
510 rdf:type schema:CreativeWork
511 https://doi.org/10.1053/j.gastro.2008.01.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026686970
512 rdf:type schema:CreativeWork
513 https://doi.org/10.1053/j.gastro.2010.02.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036690615
514 rdf:type schema:CreativeWork
515 https://doi.org/10.1053/j.gastro.2018.07.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105897558
516 rdf:type schema:CreativeWork
517 https://doi.org/10.1080/00365520601010230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045597107
518 rdf:type schema:CreativeWork
519 https://doi.org/10.1111/codi.12778 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029505081
520 rdf:type schema:CreativeWork
521 https://doi.org/10.1126/science.8484120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062655778
522 rdf:type schema:CreativeWork
523 https://doi.org/10.1126/science.8484121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062655779
524 rdf:type schema:CreativeWork
525 https://doi.org/10.1136/bmj.g366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050650252
526 rdf:type schema:CreativeWork
527 https://doi.org/10.1136/gut.33.6.783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043774800
528 rdf:type schema:CreativeWork
529 https://doi.org/10.1136/gut.50.2.228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043467728
530 rdf:type schema:CreativeWork
531 https://doi.org/10.1136/gutjnl-2012-304356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026703287
532 rdf:type schema:CreativeWork
533 https://doi.org/10.1136/gutjnl-2015-309675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005324911
534 rdf:type schema:CreativeWork
535 https://doi.org/10.1136/gutjnl-2016-311403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062813712
536 rdf:type schema:CreativeWork
537 https://doi.org/10.1136/gutjnl-2016-312044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020757835
538 rdf:type schema:CreativeWork
539 https://doi.org/10.1136/gutjnl-2017-314057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090927084
540 rdf:type schema:CreativeWork
541 https://doi.org/10.1200/jco.2015.62.2035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022112347
542 rdf:type schema:CreativeWork
543 https://doi.org/10.3109/00365521.2014.966317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047078250
544 rdf:type schema:CreativeWork
545 https://doi.org/10.7326/0003-4819-100-5-700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073689147
546 rdf:type schema:CreativeWork
547 https://doi.org/10.7326/m16-0270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079399231
548 rdf:type schema:CreativeWork
549 https://www.grid.ac/institutes/grid.1006.7 schema:alternateName Newcastle University
550 schema:name University of Newcastle, Newcastle upon Tyne, UK
551 rdf:type schema:Organization
552 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
553 schema:name The Royal Melbourne Hospital, Melbourne, Australia
554 University of Melbourne, Melbourne, Australia
555 rdf:type schema:Organization
556 https://www.grid.ac/institutes/grid.10388.32 schema:alternateName University of Bonn
557 schema:name Institute of Human Genetics, University of Bonn, Bonn, Germany
558 rdf:type schema:Organization
559 https://www.grid.ac/institutes/grid.10419.3d schema:alternateName Leiden University Medical Center
560 schema:name Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands
561 Leids Universitair Medisch Centrum, Leiden, Netherlands
562 rdf:type schema:Organization
563 https://www.grid.ac/institutes/grid.154185.c schema:alternateName Aarhus University Hospital
564 schema:name Department of Medical Genetics, Aarhus University Hospital, Aarhus, Denmark
565 Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark
566 rdf:type schema:Organization
567 https://www.grid.ac/institutes/grid.15485.3d schema:alternateName Helsinki University Central Hospital
568 schema:name Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland
569 rdf:type schema:Organization
570 https://www.grid.ac/institutes/grid.17788.31 schema:alternateName Hadassah Medical Center
571 schema:name Hadassah Medical Center, Jerusalem, and Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel
572 rdf:type schema:Organization
573 https://www.grid.ac/institutes/grid.27530.33 schema:alternateName Aalborg Hospital
574 schema:name Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark
575 Dept. of Surgical Gastroenterology, Aalborg University Hospital, Aalborg, Denmark
576 rdf:type schema:Organization
577 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
578 schema:name Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway
579 Harvard School of Public Health, Boston, MA, USA
580 University of Oslo, Oslo, Norway
581 rdf:type schema:Organization
582 https://www.grid.ac/institutes/grid.410567.1 schema:alternateName University Hospital of Basel
583 schema:name Institute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland
584 rdf:type schema:Organization
585 https://www.grid.ac/institutes/grid.411327.2 schema:alternateName Heinrich Heine University Düsseldorf
586 schema:name Medical School, Institute of Human Genetics, Heinrich-Heine-University, Düsseldorf, Germany
587 rdf:type schema:Organization
588 https://www.grid.ac/institutes/grid.412581.b schema:alternateName Witten/Herdecke University
589 schema:name University Witten-Herdecke, Wuppertal, Germany
590 rdf:type schema:Organization
591 https://www.grid.ac/institutes/grid.416153.4 schema:alternateName Royal Melbourne Hospital
592 schema:name The Royal Melbourne Hospital, Melbourne, Australia
593 rdf:type schema:Organization
594 https://www.grid.ac/institutes/grid.417468.8 schema:alternateName Mayo Clinic
595 schema:name Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA
596 rdf:type schema:Organization
597 https://www.grid.ac/institutes/grid.418701.b schema:alternateName Institut Català d'Oncologia
598 schema:name Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Barcelona, Spain
599 Hereditary Cancer Program, Catalan Institute of Oncology, Insititut d’Investigació Biomèdica de Bellvitge (IDIBELL), ONCOBELL Program, L’Hospitalet de Llobregat, Barcelona, Spain
600 rdf:type schema:Organization
601 https://www.grid.ac/institutes/grid.4494.d schema:alternateName University Medical Center Groningen
602 schema:name University Medical Center Groningen, Groningen, the Netherlands
603 rdf:type schema:Organization
604 https://www.grid.ac/institutes/grid.452600.5 schema:alternateName Isala
605 schema:name Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands
606 rdf:type schema:Organization
607 https://www.grid.ac/institutes/grid.460356.2 schema:alternateName Central Finland Health Care District
608 schema:name Central Finland Central Hospital, Education and Research, Jyväskylä, Finland
609 rdf:type schema:Organization
610 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
611 schema:name Karolinska Institutet, Stockholm, Sweden
612 rdf:type schema:Organization
613 https://www.grid.ac/institutes/grid.491982.f schema:alternateName Medical Genetics Center
614 schema:name MGZ- Medical Genetics Center, Munich, Germany
615 Medizinische Klinik und Poliklinik IV, Campus Innenstadt, Klinikum der Universität München, Munich, Germany
616 rdf:type schema:Organization
617 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
618 schema:name Heidelberg University Hospital and DKFZ, Heidelberg, Germany
619 rdf:type schema:Organization
620 https://www.grid.ac/institutes/grid.5379.8 schema:alternateName University of Manchester
621 schema:name University of Manchester & Manchester University Hospitals Foundation Trust, Manchester, UK
622 University of Manchester and St Mary’s Hospital, Manchester, UK
623 rdf:type schema:Organization
624 https://www.grid.ac/institutes/grid.55325.34 schema:alternateName Oslo University Hospital
625 schema:name Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway
626 Department of Medical Genetics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
627 Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, part of Oslo University Hospital, Olso, Norway
628 University Witten-Herdecke, Wuppertal, Germany
629 rdf:type schema:Organization
630 https://www.grid.ac/institutes/grid.5570.7 schema:alternateName Ruhr University Bochum
631 schema:name Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany
632 rdf:type schema:Organization
633 https://www.grid.ac/institutes/grid.5600.3 schema:alternateName Cardiff University
634 schema:name Medical Genetics, Cardiff University, Cardiff, UK
635 rdf:type schema:Organization
636 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
637 schema:name St Mark’s Hospital, Department of Surgery and Cancer, Imperial College London, London, UK
638 rdf:type schema:Organization
639 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
640 schema:name Department of Surgery, Helsinki University Central Hospital, P.O. Box 340, 00029 HUS, Helsinki, Finland
641 University of Helsinki, Helsinki, Finland
642 rdf:type schema:Organization
643 https://www.grid.ac/institutes/grid.9647.c schema:alternateName Leipzig University
644 schema:name Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
645 rdf:type schema:Organization
646 https://www.grid.ac/institutes/grid.9681.6 schema:alternateName University of Jyväskylä
647 schema:name Department of Surgery, Central Finland Central Hospital, Jyväskylä, Finland
648 Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland
649 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...