Emotional impact on the results of BRCA1 and BRCA2 genetic test: an observational retrospective study View Full Text


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Article Info

DATE

2017-12

AUTHORS

Sara Mella, Barbara Muzzatti, Riccardo Dolcetti, Maria Antonietta Annunziata

ABSTRACT

BACKGROUND: BRCA1 and BRCA2 mutations are associated with a higher risk of breast and ovarian tumors. This study evaluated the emotional states of women 1 month after having received the results of the genetic test and assessed eventual associations with the type of outcome, personal/familiar disease history and major socio-demographic variables. METHODS: The study, an observational retrospective one, involved 91 women, evaluated 1 month after receiving their results. Patients were administered the Hospital Anxiety and Depression Scale, the Profile of Mood States and emotional Thermometers. RESULTS: Anxiety was significantly higher than depression (p < 0.001), and 21.3% and 21.3% of the sample were, respectively, possible and probable cases for anxiety, whereas 13.5% and 10.1% were possible and probable cases for depression. Within the six mood states, Confusion-Bewilderment (M = 48.5) was the lowest, whereas Fatigue-Inertia (M = 52.3) was the highest. Differences were recorded within the ten assessed emotions too. Being a proband/nonproband and being or not a cancer patient were associated with many tested variables. CONCLUSION: The psycho-emotional screening of women undertaking genetic counseling is relevant and should cover a large range of dimensions. More... »

PAGES

16

References to SciGraph publications

  • 2010-04. Women’s Perceptions of the Personal and Family Impact of Genetic Cancer Risk Assessment: Focus Group Findings in JOURNAL OF GENETIC COUNSELING
  • 2013. Psychological Implications of Testing Positive for the BRCA Gene in MANAGEMENT OF THE PATIENT AT HIGH RISK FOR BREAST CANCER
  • 2011-06. Distress and Psychosocial Needs of a Heterogeneous High Risk Familial Cancer Population in JOURNAL OF GENETIC COUNSELING
  • 2009-01. Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation in BRITISH JOURNAL OF CANCER
  • 2011-06. Genetic testing for familial/hereditary breast cancer—comparison of guidelines and recommendations from the UK, France, the Netherlands and Germany in JOURNAL OF COMMUNITY GENETICS
  • 2008-01. A systematic review of perceived risks, psychological and behavioral impacts of genetic testing in GENETICS IN MEDICINE
  • 2008-06. Psychological Factors Associated with Emotional Responses to Receiving Genetic Risk Information in JOURNAL OF GENETIC COUNSELING
  • 2008-08. Health Behaviors and Psychological Distress in Women Initiating BRCA1/2 Genetic Testing: Comparison with Control Population in JOURNAL OF GENETIC COUNSELING
  • 2000-03. Looking forward and back: Distress among women at familial risk for breast cancer in ANNALS OF BEHAVIORAL MEDICINE
  • 2010-09. Can self-esteem, mastery and perceived stigma predict long-term adjustment in women carrying a BRCA1/2-mutation? Evidence from a multi-center study in FAMILIAL CANCER
  • 2011-09. A counselee-oriented perspective on risk communication in genetic counseling: Explaining the inaccuracy of the counselees' risk perception shortly after BRCA1/2 test result disclosure in GENETICS IN MEDICINE
  • 2013-03. Short-term psychological impact of the BRCA1/2 test result in women with breast cancer according to their perceived probability of genetic predisposition to cancer in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13053-017-0077-6

    DOI

    http://dx.doi.org/10.1186/s13053-017-0077-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1092051490

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29026449


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