Faecal calprotectin and ultrasonography as non-invasive screening tools for detecting colorectal polyps in children with sporadic rectal bleeding: a prospective ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-05-20

AUTHORS

Giovanni Di Nardo, Francesco Esposito, Chiara Ziparo, Caterina Strisciuglio, Francesca Vassallo, Marco Di Serafino, Maria Pia Villa, Pasquale Parisi, Melania Evangelisti, Claudia Pacchiarotti, Vito Domenico Corleto

ABSTRACT

BackgroundColorectal polyps are reported in 6,1% of paediatric colonoscopies and in 12% of those performed for lower gastrointestinal bleeding. Although colonoscopy is widely used in paediatric patients, it requires bowel preparation and general anaesthesia or deep sedation, and in rare cases, it can cause complications. Non-invasive screening techniques able to predict polyps in children with isolated and sporadic rectal bleeding may play a key role in the selection of patients needing colonoscopy.MethodsWe enrolled all children undergoing colonoscopy for isolated and sporadic rectal bleeding to determine the diagnostic accuracy of faecal calprotectin, ultrasonography (US) and digital rectal examination as diagnostic methods for screening colorectal polyps.ResultsA total of 26 of 59 enrolled patients (44.1%) had colonic polyps, one patient had multiple polyps, and 23% of children had polyps proximal to the splenic flexure. The diagnostic accuracy of faecal calprotectin for detecting colorectal polyps was 96.6%, with a sensitivity of 100%. False-positive faecal calprotectin was shown in 2 patients with non-steroidal anti-inflammatory drug-related lesions. The diagnostic accuracy of ultrasound was 77.9%. Polyps not seen with ultrasound tended to be relatively smaller (1.5 vs 2.3, p = 0.001) and located in the rectum. The combined use of FC, US and digital rectal examination obtained a specificity and PPV of 100%.ConclusionsFC combined with US and digital rectal examination is a good and promising non-invasive screening test for detecting colorectal polyps in children with isolated and sporadic rectal bleeding. More... »

PAGES

66

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13052-020-00828-1

DOI

http://dx.doi.org/10.1186/s13052-020-00828-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1127756583

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32434534


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child, Preschool", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Polyps", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonoscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Digital Rectal Examination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feces", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocyte L1 Antigen Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rectum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultrasonography", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Nardo", 
        "givenName": "Giovanni", 
        "id": "sg:person.01365174736.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365174736.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pediatric Radiology Unit, Santobono-Pausilipon Children Hospital, Naples, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Pediatric Radiology Unit, Santobono-Pausilipon Children Hospital, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Esposito", 
        "givenName": "Francesco", 
        "id": "sg:person.0663126607.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663126607.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ziparo", 
        "givenName": "Chiara", 
        "id": "sg:person.01370265210.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370265210.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy", 
          "id": "http://www.grid.ac/institutes/grid.9841.4", 
          "name": [
            "Department of Woman, Child and General and Specialistic Surgery, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Strisciuglio", 
        "givenName": "Caterina", 
        "id": "sg:person.01164506726.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164506726.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vassallo", 
        "givenName": "Francesca", 
        "id": "sg:person.01240625725.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240625725.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "General and Emergency Radiology Unit, Antonio Cardarelli Hospital, Naples, Italy", 
          "id": "http://www.grid.ac/institutes/grid.413172.2", 
          "name": [
            "General and Emergency Radiology Unit, Antonio Cardarelli Hospital, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Serafino", 
        "givenName": "Marco", 
        "id": "sg:person.01253552507.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253552507.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Villa", 
        "givenName": "Maria Pia", 
        "id": "sg:person.01014514434.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014514434.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Parisi", 
        "givenName": "Pasquale", 
        "id": "sg:person.0747261540.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747261540.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Evangelisti", 
        "givenName": "Melania", 
        "id": "sg:person.0625431413.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625431413.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pacchiarotti", 
        "givenName": "Claudia", 
        "id": "sg:person.01037446635.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037446635.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gastroenterology and Gastrointestinal Endoscopy Unit, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Rome, Italy", 
          "id": "http://www.grid.ac/institutes/grid.7841.a", 
          "name": [
            "Gastroenterology and Gastrointestinal Endoscopy Unit, Sapienza University of Rome, Sant\u2019Andrea University Hospital, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corleto", 
        "givenName": "Vito Domenico", 
        "id": "sg:person.0635161675.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635161675.99"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s00247-019-04467-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1117994952", 
          "https://doi.org/10.1007/s00247-019-04467-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40477-014-0091-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038372690", 
          "https://doi.org/10.1007/s40477-014-0091-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2013.131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031187212", 
          "https://doi.org/10.1038/ajg.2013.131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01316581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004786720", 
          "https://doi.org/10.1007/bf01316581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.1998.176_b.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006858838", 
          "https://doi.org/10.1111/j.1572-0241.1998.176_b.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12664-015-0612-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046761904", 
          "https://doi.org/10.1007/s12664-015-0612-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-011-1972-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009470868", 
          "https://doi.org/10.1007/s10620-011-1972-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40477-018-00355-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1112096486", 
          "https://doi.org/10.1007/s40477-018-00355-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00383-004-1194-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024752593", 
          "https://doi.org/10.1007/s00383-004-1194-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-05-20", 
    "datePublishedReg": "2020-05-20", 
    "description": "BackgroundColorectal polyps are reported in 6,1% of paediatric colonoscopies and in 12% of those performed for lower gastrointestinal bleeding. Although colonoscopy is widely used in paediatric patients, it requires bowel preparation and general anaesthesia or deep sedation, and in rare cases, it can cause complications. Non-invasive screening techniques able to predict polyps in children with isolated and sporadic rectal bleeding may play a key role in the selection of patients needing colonoscopy.MethodsWe enrolled all children undergoing colonoscopy for isolated and sporadic rectal bleeding to determine the diagnostic accuracy of faecal calprotectin, ultrasonography (US) and digital rectal examination as diagnostic methods for screening colorectal polyps.ResultsA total of 26 of 59 enrolled patients (44.1%) had colonic polyps, one patient had multiple polyps, and 23% of children had polyps proximal to the splenic flexure. The diagnostic accuracy of faecal calprotectin for detecting colorectal polyps was 96.6%, with a sensitivity of 100%. False-positive faecal calprotectin was shown in 2 patients with non-steroidal anti-inflammatory drug-related lesions. The diagnostic accuracy of ultrasound was 77.9%. Polyps not seen with ultrasound tended to be relatively smaller (1.5 vs 2.3, p\u2009=\u20090.001) and located in the rectum. The combined use of FC, US and digital rectal examination obtained a specificity and PPV of 100%.ConclusionsFC combined with US and digital rectal examination is a good and promising non-invasive screening test for detecting colorectal polyps in children with isolated and sporadic rectal bleeding.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13052-020-00828-1", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1320494", 
        "issn": [
          "1720-8424", 
          "1824-7288"
        ], 
        "name": "Italian Journal of Pediatrics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "46"
      }
    ], 
    "keywords": [
      "digital rectal examination", 
      "rectal bleeding", 
      "fecal calprotectin", 
      "rectal examination", 
      "colorectal polyps", 
      "diagnostic accuracy", 
      "non-invasive screening test", 
      "non-invasive screening technique", 
      "drug-related lesions", 
      "lower gastrointestinal bleeding", 
      "selection of patients", 
      "non-invasive screening tool", 
      "pediatric colonoscopy", 
      "gastrointestinal bleeding", 
      "pediatric patients", 
      "splenic flexure", 
      "bowel preparation", 
      "general anesthesia", 
      "prospective study", 
      "deep sedation", 
      "ResultsA total", 
      "multiple polyps", 
      "rare case", 
      "bleeding", 
      "patients", 
      "ultrasonography", 
      "calprotectin", 
      "colonoscopy", 
      "colonic polyps", 
      "screening test", 
      "polyps", 
      "screening tool", 
      "children", 
      "diagnostic methods", 
      "examination", 
      "ultrasound", 
      "combined use", 
      "screening technique", 
      "sedation", 
      "complications", 
      "anesthesia", 
      "rectum", 
      "lesions", 
      "MethodsWe", 
      "key role", 
      "total", 
      "PPV", 
      "specificity", 
      "FC", 
      "cases", 
      "study", 
      "role", 
      "sensitivity", 
      "test", 
      "use", 
      "preparation", 
      "flexure", 
      "tool", 
      "accuracy", 
      "technique", 
      "selection", 
      "method"
    ], 
    "name": "Faecal calprotectin and ultrasonography as non-invasive screening tools for detecting colorectal polyps in children with sporadic rectal bleeding: a prospective study", 
    "pagination": "66", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1127756583"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13052-020-00828-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32434534"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13052-020-00828-1", 
      "https://app.dimensions.ai/details/publication/pub.1127756583"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:36", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_839.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13052-020-00828-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13052-020-00828-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13052-020-00828-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13052-020-00828-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13052-020-00828-1'


 

This table displays all metadata directly associated to this object as RDF triples.

305 TRIPLES      22 PREDICATES      113 URIs      96 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13052-020-00828-1 schema:about N01d5038daeec4475bb2e20eb11b79f46
2 N03a21bbf9e4040fdbc919b15952f69af
3 N296ba0d9cf684d45a5c4d1d2f773a0a6
4 N4a83b82c63424023ba91f53435a8a1cb
5 N5eaee9282b2f4d23bb9c7322045e601f
6 N8190d56091db4df4985589d915d688de
7 N9fd4978423884341a92df63812527d2d
8 Na206aee2516d4f3d91b9b606ca0f1133
9 Naf63dbc3a73b4ab08f6df7097a615d5f
10 Nbc4d8929395f4b22a1f2dcc2028ad6f8
11 Nca43756c895c4adb9dcc87df8856dd2e
12 Ncd91d723653843178ef0857d23a31160
13 Nd069106b1f6b4d28b0de4eeb52ad002f
14 Nd180b43930c14e80a88ce62a19163761
15 Nd8af366fdca34df38f8e0108078a549b
16 Ne9770af2d0904b45a93d6fda9a0ef1e1
17 anzsrc-for:11
18 anzsrc-for:1114
19 schema:author Nfdaa67b23cfb4c96a0bf35551ecf559b
20 schema:citation sg:pub.10.1007/bf01316581
21 sg:pub.10.1007/s00247-019-04467-5
22 sg:pub.10.1007/s00383-004-1194-7
23 sg:pub.10.1007/s10620-011-1972-8
24 sg:pub.10.1007/s12664-015-0612-1
25 sg:pub.10.1007/s40477-014-0091-8
26 sg:pub.10.1007/s40477-018-00355-0
27 sg:pub.10.1038/ajg.2013.131
28 sg:pub.10.1111/j.1572-0241.1998.176_b.x
29 schema:datePublished 2020-05-20
30 schema:datePublishedReg 2020-05-20
31 schema:description BackgroundColorectal polyps are reported in 6,1% of paediatric colonoscopies and in 12% of those performed for lower gastrointestinal bleeding. Although colonoscopy is widely used in paediatric patients, it requires bowel preparation and general anaesthesia or deep sedation, and in rare cases, it can cause complications. Non-invasive screening techniques able to predict polyps in children with isolated and sporadic rectal bleeding may play a key role in the selection of patients needing colonoscopy.MethodsWe enrolled all children undergoing colonoscopy for isolated and sporadic rectal bleeding to determine the diagnostic accuracy of faecal calprotectin, ultrasonography (US) and digital rectal examination as diagnostic methods for screening colorectal polyps.ResultsA total of 26 of 59 enrolled patients (44.1%) had colonic polyps, one patient had multiple polyps, and 23% of children had polyps proximal to the splenic flexure. The diagnostic accuracy of faecal calprotectin for detecting colorectal polyps was 96.6%, with a sensitivity of 100%. False-positive faecal calprotectin was shown in 2 patients with non-steroidal anti-inflammatory drug-related lesions. The diagnostic accuracy of ultrasound was 77.9%. Polyps not seen with ultrasound tended to be relatively smaller (1.5 vs 2.3, p = 0.001) and located in the rectum. The combined use of FC, US and digital rectal examination obtained a specificity and PPV of 100%.ConclusionsFC combined with US and digital rectal examination is a good and promising non-invasive screening test for detecting colorectal polyps in children with isolated and sporadic rectal bleeding.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N289756e3d5994f40a465d29c7ffc4db7
36 N297f282546b84291a17197cb59183949
37 sg:journal.1320494
38 schema:keywords FC
39 MethodsWe
40 PPV
41 ResultsA total
42 accuracy
43 anesthesia
44 bleeding
45 bowel preparation
46 calprotectin
47 cases
48 children
49 colonic polyps
50 colonoscopy
51 colorectal polyps
52 combined use
53 complications
54 deep sedation
55 diagnostic accuracy
56 diagnostic methods
57 digital rectal examination
58 drug-related lesions
59 examination
60 fecal calprotectin
61 flexure
62 gastrointestinal bleeding
63 general anesthesia
64 key role
65 lesions
66 lower gastrointestinal bleeding
67 method
68 multiple polyps
69 non-invasive screening technique
70 non-invasive screening test
71 non-invasive screening tool
72 patients
73 pediatric colonoscopy
74 pediatric patients
75 polyps
76 preparation
77 prospective study
78 rare case
79 rectal bleeding
80 rectal examination
81 rectum
82 role
83 screening technique
84 screening test
85 screening tool
86 sedation
87 selection
88 selection of patients
89 sensitivity
90 specificity
91 splenic flexure
92 study
93 technique
94 test
95 tool
96 total
97 ultrasonography
98 ultrasound
99 use
100 schema:name Faecal calprotectin and ultrasonography as non-invasive screening tools for detecting colorectal polyps in children with sporadic rectal bleeding: a prospective study
101 schema:pagination 66
102 schema:productId N167b1b3bfe7d4a2e94fe8b9b9ac0a2f1
103 N210ebd67f1554b56bbffadf9a3338ee8
104 Ne2df1539d4914c8288037bbea343fe57
105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1127756583
106 https://doi.org/10.1186/s13052-020-00828-1
107 schema:sdDatePublished 2022-05-20T07:36
108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
109 schema:sdPublisher Nf6a78450428546fe934581a17e18f9da
110 schema:url https://doi.org/10.1186/s13052-020-00828-1
111 sgo:license sg:explorer/license/
112 sgo:sdDataset articles
113 rdf:type schema:ScholarlyArticle
114 N01d5038daeec4475bb2e20eb11b79f46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Child, Preschool
116 rdf:type schema:DefinedTerm
117 N03a21bbf9e4040fdbc919b15952f69af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Prospective Studies
119 rdf:type schema:DefinedTerm
120 N167b1b3bfe7d4a2e94fe8b9b9ac0a2f1 schema:name dimensions_id
121 schema:value pub.1127756583
122 rdf:type schema:PropertyValue
123 N210ebd67f1554b56bbffadf9a3338ee8 schema:name pubmed_id
124 schema:value 32434534
125 rdf:type schema:PropertyValue
126 N289756e3d5994f40a465d29c7ffc4db7 schema:issueNumber 1
127 rdf:type schema:PublicationIssue
128 N296ba0d9cf684d45a5c4d1d2f773a0a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Humans
130 rdf:type schema:DefinedTerm
131 N297f282546b84291a17197cb59183949 schema:volumeNumber 46
132 rdf:type schema:PublicationVolume
133 N2f8d8643853446ec9543dedfd57f2e2f rdf:first sg:person.01240625725.56
134 rdf:rest N933fbf610f05405f9d2a933e6b73e887
135 N4a83b82c63424023ba91f53435a8a1cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Male
137 rdf:type schema:DefinedTerm
138 N5eaee9282b2f4d23bb9c7322045e601f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Leukocyte L1 Antigen Complex
140 rdf:type schema:DefinedTerm
141 N75f0a7237f8d456a9dd3a5537e9ad08c rdf:first sg:person.01164506726.01
142 rdf:rest N2f8d8643853446ec9543dedfd57f2e2f
143 N8163bc223e4845e79ca004a155d96267 rdf:first sg:person.01014514434.47
144 rdf:rest N9f48fd6c5dfb4831aaaf075ca05d119a
145 N8190d56091db4df4985589d915d688de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Colonic Polyps
147 rdf:type schema:DefinedTerm
148 N933fbf610f05405f9d2a933e6b73e887 rdf:first sg:person.01253552507.24
149 rdf:rest N8163bc223e4845e79ca004a155d96267
150 N9e348b74fab5439c9adb8f785a2463ec rdf:first sg:person.0635161675.99
151 rdf:rest rdf:nil
152 N9f48fd6c5dfb4831aaaf075ca05d119a rdf:first sg:person.0747261540.14
153 rdf:rest Nb421a63fd3a444b7b7fcf52d8e2d09ce
154 N9fd4978423884341a92df63812527d2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Rectum
156 rdf:type schema:DefinedTerm
157 Na206aee2516d4f3d91b9b606ca0f1133 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Ultrasonography
159 rdf:type schema:DefinedTerm
160 Na57e5af7c7614c55ad33001c85189d12 rdf:first sg:person.01370265210.76
161 rdf:rest N75f0a7237f8d456a9dd3a5537e9ad08c
162 Naf63dbc3a73b4ab08f6df7097a615d5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Colonoscopy
164 rdf:type schema:DefinedTerm
165 Nb421a63fd3a444b7b7fcf52d8e2d09ce rdf:first sg:person.0625431413.07
166 rdf:rest Nea9a7877f5bf48f299e35368dea23d8f
167 Nb9f5cbe789a140078ccbfea1b9f376eb rdf:first sg:person.0663126607.55
168 rdf:rest Na57e5af7c7614c55ad33001c85189d12
169 Nbc4d8929395f4b22a1f2dcc2028ad6f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Child
171 rdf:type schema:DefinedTerm
172 Nca43756c895c4adb9dcc87df8856dd2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Digital Rectal Examination
174 rdf:type schema:DefinedTerm
175 Ncd91d723653843178ef0857d23a31160 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Sensitivity and Specificity
177 rdf:type schema:DefinedTerm
178 Nd069106b1f6b4d28b0de4eeb52ad002f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Female
180 rdf:type schema:DefinedTerm
181 Nd180b43930c14e80a88ce62a19163761 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Adolescent
183 rdf:type schema:DefinedTerm
184 Nd8af366fdca34df38f8e0108078a549b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Gastrointestinal Hemorrhage
186 rdf:type schema:DefinedTerm
187 Ne2df1539d4914c8288037bbea343fe57 schema:name doi
188 schema:value 10.1186/s13052-020-00828-1
189 rdf:type schema:PropertyValue
190 Ne9770af2d0904b45a93d6fda9a0ef1e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Feces
192 rdf:type schema:DefinedTerm
193 Nea9a7877f5bf48f299e35368dea23d8f rdf:first sg:person.01037446635.14
194 rdf:rest N9e348b74fab5439c9adb8f785a2463ec
195 Nf6a78450428546fe934581a17e18f9da schema:name Springer Nature - SN SciGraph project
196 rdf:type schema:Organization
197 Nfdaa67b23cfb4c96a0bf35551ecf559b rdf:first sg:person.01365174736.47
198 rdf:rest Nb9f5cbe789a140078ccbfea1b9f376eb
199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
200 schema:name Medical and Health Sciences
201 rdf:type schema:DefinedTerm
202 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
203 schema:name Paediatrics and Reproductive Medicine
204 rdf:type schema:DefinedTerm
205 sg:journal.1320494 schema:issn 1720-8424
206 1824-7288
207 schema:name Italian Journal of Pediatrics
208 schema:publisher Springer Nature
209 rdf:type schema:Periodical
210 sg:person.01014514434.47 schema:affiliation grid-institutes:grid.7841.a
211 schema:familyName Villa
212 schema:givenName Maria Pia
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014514434.47
214 rdf:type schema:Person
215 sg:person.01037446635.14 schema:affiliation grid-institutes:grid.7841.a
216 schema:familyName Pacchiarotti
217 schema:givenName Claudia
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037446635.14
219 rdf:type schema:Person
220 sg:person.01164506726.01 schema:affiliation grid-institutes:grid.9841.4
221 schema:familyName Strisciuglio
222 schema:givenName Caterina
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164506726.01
224 rdf:type schema:Person
225 sg:person.01240625725.56 schema:affiliation grid-institutes:grid.7841.a
226 schema:familyName Vassallo
227 schema:givenName Francesca
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240625725.56
229 rdf:type schema:Person
230 sg:person.01253552507.24 schema:affiliation grid-institutes:grid.413172.2
231 schema:familyName Di Serafino
232 schema:givenName Marco
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253552507.24
234 rdf:type schema:Person
235 sg:person.01365174736.47 schema:affiliation grid-institutes:grid.7841.a
236 schema:familyName Di Nardo
237 schema:givenName Giovanni
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365174736.47
239 rdf:type schema:Person
240 sg:person.01370265210.76 schema:affiliation grid-institutes:grid.7841.a
241 schema:familyName Ziparo
242 schema:givenName Chiara
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370265210.76
244 rdf:type schema:Person
245 sg:person.0625431413.07 schema:affiliation grid-institutes:grid.7841.a
246 schema:familyName Evangelisti
247 schema:givenName Melania
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625431413.07
249 rdf:type schema:Person
250 sg:person.0635161675.99 schema:affiliation grid-institutes:grid.7841.a
251 schema:familyName Corleto
252 schema:givenName Vito Domenico
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635161675.99
254 rdf:type schema:Person
255 sg:person.0663126607.55 schema:affiliation grid-institutes:None
256 schema:familyName Esposito
257 schema:givenName Francesco
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663126607.55
259 rdf:type schema:Person
260 sg:person.0747261540.14 schema:affiliation grid-institutes:grid.7841.a
261 schema:familyName Parisi
262 schema:givenName Pasquale
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747261540.14
264 rdf:type schema:Person
265 sg:pub.10.1007/bf01316581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004786720
266 https://doi.org/10.1007/bf01316581
267 rdf:type schema:CreativeWork
268 sg:pub.10.1007/s00247-019-04467-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117994952
269 https://doi.org/10.1007/s00247-019-04467-5
270 rdf:type schema:CreativeWork
271 sg:pub.10.1007/s00383-004-1194-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024752593
272 https://doi.org/10.1007/s00383-004-1194-7
273 rdf:type schema:CreativeWork
274 sg:pub.10.1007/s10620-011-1972-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009470868
275 https://doi.org/10.1007/s10620-011-1972-8
276 rdf:type schema:CreativeWork
277 sg:pub.10.1007/s12664-015-0612-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046761904
278 https://doi.org/10.1007/s12664-015-0612-1
279 rdf:type schema:CreativeWork
280 sg:pub.10.1007/s40477-014-0091-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038372690
281 https://doi.org/10.1007/s40477-014-0091-8
282 rdf:type schema:CreativeWork
283 sg:pub.10.1007/s40477-018-00355-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112096486
284 https://doi.org/10.1007/s40477-018-00355-0
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/ajg.2013.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031187212
287 https://doi.org/10.1038/ajg.2013.131
288 rdf:type schema:CreativeWork
289 sg:pub.10.1111/j.1572-0241.1998.176_b.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006858838
290 https://doi.org/10.1111/j.1572-0241.1998.176_b.x
291 rdf:type schema:CreativeWork
292 grid-institutes:None schema:alternateName Pediatric Radiology Unit, Santobono-Pausilipon Children Hospital, Naples, Italy
293 schema:name Pediatric Radiology Unit, Santobono-Pausilipon Children Hospital, Naples, Italy
294 rdf:type schema:Organization
295 grid-institutes:grid.413172.2 schema:alternateName General and Emergency Radiology Unit, Antonio Cardarelli Hospital, Naples, Italy
296 schema:name General and Emergency Radiology Unit, Antonio Cardarelli Hospital, Naples, Italy
297 rdf:type schema:Organization
298 grid-institutes:grid.7841.a schema:alternateName Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant’Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy
299 Gastroenterology and Gastrointestinal Endoscopy Unit, Sapienza University of Rome, Sant’Andrea University Hospital, Rome, Italy
300 schema:name Chair of Pediatrics, NESMOS Department, Sapienza University of Rome, Sant’Andrea University Hospital, Via di Grottarossa 1035-1039, 00189, Rome, Italy
301 Gastroenterology and Gastrointestinal Endoscopy Unit, Sapienza University of Rome, Sant’Andrea University Hospital, Rome, Italy
302 rdf:type schema:Organization
303 grid-institutes:grid.9841.4 schema:alternateName Department of Woman, Child and General and Specialistic Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy
304 schema:name Department of Woman, Child and General and Specialistic Surgery, University of Campania “Luigi Vanvitelli”, Naples, Italy
305 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...