Assessment of Preptin peptide level in the sera of rachitic children and in breast milk of their mothers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Gihan M. Bebars, Salem A. Sallam, Shereen S. Gaber, Alshimaa H. Abdelaziz

ABSTRACT

BACKGROUND: Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis. RESEARCH AIMS: To measure levels of serum Preptin in rachitic children and in breastmilk of their mothers and to compare with levels in healthy non-rachitic children. METHODS: Thirty children with rickets and another 30 non-rachitic age and sex matched controls were subjected to detailed history, physical examination including anthropometric measurements, assessment of signs of rickets and laboratory measurement of serum vitamin D, calcium, phosphorus, alkaline phosphatase and Preptin. Mothers' breast milk Preptin were also measured. RESULTS: Significantly lower serum Preptin (p < 0.001) in rachitic children with a significant negative correlation between serum Preptin and alkaline phosphatase (P < 0.0001). Lower breastmilk Preptin levels in mothers of rachitic children (P < 0.001) with a negative correlation between breastmilk Preptin and both maternal weight and BMI(P < 0.01&P < 0.02). Mothers' milk Preptin is positively correlated with serum Preptin and calcium in non-rachitic children(P < 0.001&0.04), but negatively correlated with their mothers' age (P < 0.01). CONCLUSION: Preptin may play a role in the etiology of rickets in children. Further studies are recommended to evaluate Preptin role in treatment of rickets in children. More... »

PAGES

34

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13052-019-0628-8

DOI

http://dx.doi.org/10.1186/s13052-019-0628-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112606590

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30845974


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Minia University", 
          "id": "https://www.grid.ac/institutes/grid.411806.a", 
          "name": [
            "Faculty of Medicine, Pediatric Department, Minia University, Minia, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bebars", 
        "givenName": "Gihan M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minia University", 
          "id": "https://www.grid.ac/institutes/grid.411806.a", 
          "name": [
            "Faculty of Medicine, Pediatric Department, Minia University, Minia, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sallam", 
        "givenName": "Salem A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minia University", 
          "id": "https://www.grid.ac/institutes/grid.411806.a", 
          "name": [
            "Faculty of Medicine, Biochemistry Department, Minia University, Minia, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaber", 
        "givenName": "Shereen S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Minia General hospital, Minia, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abdelaziz", 
        "givenName": "Alshimaa H.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejm199908193410803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005336213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/14767058.2013.849240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019889222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/b978-0-12-382040-2.10023-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024128349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.00642.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025490630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.2000.tb00329.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028550452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1651-2227.2000.tb00329.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028550452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00774-009-0079-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031216503", 
          "https://doi.org/10.1007/s00774-009-0079-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00774-009-0079-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031216503", 
          "https://doi.org/10.1007/s00774-009-0079-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00774-009-0079-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031216503", 
          "https://doi.org/10.1007/s00774-009-0079-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c6ob01455k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032777104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.peptides.2013.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032989240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2013/236085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033050453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2474-14-49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034672291", 
          "https://doi.org/10.1186/1471-2474-14-49"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00431-012-1699-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050305611", 
          "https://doi.org/10.1007/s00431-012-1699-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/80.5.1415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076963244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077652139", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/07.2012/jcpsp.424427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078585902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.29333/ejgm/82209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100508504"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis.\nRESEARCH AIMS: To measure levels of serum Preptin in rachitic children and in breastmilk of their mothers and to compare with levels in healthy non-rachitic children.\nMETHODS: Thirty children with rickets and another 30 non-rachitic age and sex matched controls were subjected to detailed history, physical examination including anthropometric measurements, assessment of signs of rickets and laboratory measurement of serum vitamin D, calcium, phosphorus, alkaline phosphatase and Preptin. Mothers' breast milk Preptin were also measured.\nRESULTS: Significantly lower serum Preptin (p\u2009<\u20090.001) in rachitic children with a significant negative correlation between serum Preptin and alkaline phosphatase (P\u2009<\u20090.0001). Lower breastmilk Preptin levels in mothers of rachitic children (P\u2009<\u20090.001) with a negative correlation between breastmilk Preptin and both maternal weight and BMI(P\u2009<\u20090.01&P\u2009<\u20090.02). Mothers' milk Preptin is positively correlated with serum Preptin and calcium in non-rachitic children(P\u2009<\u20090.001&0.04), but negatively correlated with their mothers' age (P\u2009<\u20090.01).\nCONCLUSION: Preptin may play a role in the etiology of rickets in children. Further studies are recommended to evaluate Preptin role in treatment of rickets in children.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13052-019-0628-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1320494", 
        "issn": [
          "1720-8424", 
          "1824-7288"
        ], 
        "name": "Italian Journal of Pediatrics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "45"
      }
    ], 
    "name": "Assessment of Preptin peptide level in the sera of rachitic children and in breast milk of their mothers", 
    "pagination": "34", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "049b422d5a80356e7b22f76ccef05d6cf86e7896df696d0529a5c77eb37ec298"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30845974"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101510759"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13052-019-0628-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112606590"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13052-019-0628-8", 
      "https://app.dimensions.ai/details/publication/pub.1112606590"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78947_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13052-019-0628-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13052-019-0628-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13052-019-0628-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13052-019-0628-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13052-019-0628-8'


 

This table displays all metadata directly associated to this object as RDF triples.

136 TRIPLES      21 PREDICATES      44 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13052-019-0628-8 schema:about anzsrc-for:11
2 anzsrc-for:1117
3 schema:author N367ab5790a8c4f5d946cbca09aae0add
4 schema:citation sg:pub.10.1007/s00431-012-1699-3
5 sg:pub.10.1007/s00774-009-0079-1
6 sg:pub.10.1186/1471-2474-14-49
7 https://app.dimensions.ai/details/publication/pub.1077652139
8 https://doi.org/07.2012/jcpsp.424427
9 https://doi.org/10.1016/b978-0-12-382040-2.10023-1
10 https://doi.org/10.1016/j.peptides.2013.09.006
11 https://doi.org/10.1039/c6ob01455k
12 https://doi.org/10.1056/nejm199908193410803
13 https://doi.org/10.1093/ajcn/80.5.1415
14 https://doi.org/10.1111/j.1651-2227.2000.tb00329.x
15 https://doi.org/10.1152/ajpendo.00642.2005
16 https://doi.org/10.1155/2013/236085
17 https://doi.org/10.29333/ejgm/82209
18 https://doi.org/10.3109/14767058.2013.849240
19 schema:datePublished 2019-12
20 schema:datePublishedReg 2019-12-01
21 schema:description BACKGROUND: Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis. RESEARCH AIMS: To measure levels of serum Preptin in rachitic children and in breastmilk of their mothers and to compare with levels in healthy non-rachitic children. METHODS: Thirty children with rickets and another 30 non-rachitic age and sex matched controls were subjected to detailed history, physical examination including anthropometric measurements, assessment of signs of rickets and laboratory measurement of serum vitamin D, calcium, phosphorus, alkaline phosphatase and Preptin. Mothers' breast milk Preptin were also measured. RESULTS: Significantly lower serum Preptin (p < 0.001) in rachitic children with a significant negative correlation between serum Preptin and alkaline phosphatase (P < 0.0001). Lower breastmilk Preptin levels in mothers of rachitic children (P < 0.001) with a negative correlation between breastmilk Preptin and both maternal weight and BMI(P < 0.01&P < 0.02). Mothers' milk Preptin is positively correlated with serum Preptin and calcium in non-rachitic children(P < 0.001&0.04), but negatively correlated with their mothers' age (P < 0.01). CONCLUSION: Preptin may play a role in the etiology of rickets in children. Further studies are recommended to evaluate Preptin role in treatment of rickets in children.
22 schema:genre research_article
23 schema:inLanguage en
24 schema:isAccessibleForFree false
25 schema:isPartOf N4f8979527a244d6e8a05a59bad894516
26 N6ad9468c1a3941ef92176f827560047c
27 sg:journal.1320494
28 schema:name Assessment of Preptin peptide level in the sera of rachitic children and in breast milk of their mothers
29 schema:pagination 34
30 schema:productId N063c953381aa417d83defabcf1a7e24a
31 N6160b97ca00d484da2c158b19456fa66
32 N8a89b6329ff94d669368aca847847f99
33 Nb8bf84f5f0d8491fb5f2e237274ee64c
34 Ndc0d654f42ba476ab85e2c9b93221ca5
35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112606590
36 https://doi.org/10.1186/s13052-019-0628-8
37 schema:sdDatePublished 2019-04-11T13:18
38 schema:sdLicense https://scigraph.springernature.com/explorer/license/
39 schema:sdPublisher N0a225af32ab142d6b495932563920d1e
40 schema:url https://link.springer.com/10.1186%2Fs13052-019-0628-8
41 sgo:license sg:explorer/license/
42 sgo:sdDataset articles
43 rdf:type schema:ScholarlyArticle
44 N063c953381aa417d83defabcf1a7e24a schema:name pubmed_id
45 schema:value 30845974
46 rdf:type schema:PropertyValue
47 N0a225af32ab142d6b495932563920d1e schema:name Springer Nature - SN SciGraph project
48 rdf:type schema:Organization
49 N35fe0e9f43d44d76b63bfd6c7cb7311e rdf:first N3cbb920c6a324703a321b94ba994362b
50 rdf:rest N851e97339ce142cfa83c111a33f9b314
51 N367ab5790a8c4f5d946cbca09aae0add rdf:first N447f62c1675f4ba492f2e0bcd2cff2c7
52 rdf:rest N35fe0e9f43d44d76b63bfd6c7cb7311e
53 N37ae80d7d2e64df296074d234161a79c schema:affiliation https://www.grid.ac/institutes/grid.411806.a
54 schema:familyName Gaber
55 schema:givenName Shereen S.
56 rdf:type schema:Person
57 N3cbb920c6a324703a321b94ba994362b schema:affiliation https://www.grid.ac/institutes/grid.411806.a
58 schema:familyName Sallam
59 schema:givenName Salem A.
60 rdf:type schema:Person
61 N447f62c1675f4ba492f2e0bcd2cff2c7 schema:affiliation https://www.grid.ac/institutes/grid.411806.a
62 schema:familyName Bebars
63 schema:givenName Gihan M.
64 rdf:type schema:Person
65 N4f8979527a244d6e8a05a59bad894516 schema:issueNumber 1
66 rdf:type schema:PublicationIssue
67 N6160b97ca00d484da2c158b19456fa66 schema:name nlm_unique_id
68 schema:value 101510759
69 rdf:type schema:PropertyValue
70 N6ad9468c1a3941ef92176f827560047c schema:volumeNumber 45
71 rdf:type schema:PublicationVolume
72 N77b36031cfd84a2b8c856180025df0e0 rdf:first Nc7050293c55d40f9bc96b3896369199b
73 rdf:rest rdf:nil
74 N851e97339ce142cfa83c111a33f9b314 rdf:first N37ae80d7d2e64df296074d234161a79c
75 rdf:rest N77b36031cfd84a2b8c856180025df0e0
76 N8a860c95937a4ccbb1b585c566e301ce schema:name Minia General hospital, Minia, Egypt
77 rdf:type schema:Organization
78 N8a89b6329ff94d669368aca847847f99 schema:name readcube_id
79 schema:value 049b422d5a80356e7b22f76ccef05d6cf86e7896df696d0529a5c77eb37ec298
80 rdf:type schema:PropertyValue
81 Nb8bf84f5f0d8491fb5f2e237274ee64c schema:name doi
82 schema:value 10.1186/s13052-019-0628-8
83 rdf:type schema:PropertyValue
84 Nc7050293c55d40f9bc96b3896369199b schema:affiliation N8a860c95937a4ccbb1b585c566e301ce
85 schema:familyName Abdelaziz
86 schema:givenName Alshimaa H.
87 rdf:type schema:Person
88 Ndc0d654f42ba476ab85e2c9b93221ca5 schema:name dimensions_id
89 schema:value pub.1112606590
90 rdf:type schema:PropertyValue
91 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
92 schema:name Medical and Health Sciences
93 rdf:type schema:DefinedTerm
94 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
95 schema:name Public Health and Health Services
96 rdf:type schema:DefinedTerm
97 sg:journal.1320494 schema:issn 1720-8424
98 1824-7288
99 schema:name Italian Journal of Pediatrics
100 rdf:type schema:Periodical
101 sg:pub.10.1007/s00431-012-1699-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050305611
102 https://doi.org/10.1007/s00431-012-1699-3
103 rdf:type schema:CreativeWork
104 sg:pub.10.1007/s00774-009-0079-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031216503
105 https://doi.org/10.1007/s00774-009-0079-1
106 rdf:type schema:CreativeWork
107 sg:pub.10.1186/1471-2474-14-49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034672291
108 https://doi.org/10.1186/1471-2474-14-49
109 rdf:type schema:CreativeWork
110 https://app.dimensions.ai/details/publication/pub.1077652139 schema:CreativeWork
111 https://doi.org/07.2012/jcpsp.424427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078585902
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1016/b978-0-12-382040-2.10023-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024128349
114 rdf:type schema:CreativeWork
115 https://doi.org/10.1016/j.peptides.2013.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032989240
116 rdf:type schema:CreativeWork
117 https://doi.org/10.1039/c6ob01455k schema:sameAs https://app.dimensions.ai/details/publication/pub.1032777104
118 rdf:type schema:CreativeWork
119 https://doi.org/10.1056/nejm199908193410803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005336213
120 rdf:type schema:CreativeWork
121 https://doi.org/10.1093/ajcn/80.5.1415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076963244
122 rdf:type schema:CreativeWork
123 https://doi.org/10.1111/j.1651-2227.2000.tb00329.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028550452
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1152/ajpendo.00642.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025490630
126 rdf:type schema:CreativeWork
127 https://doi.org/10.1155/2013/236085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033050453
128 rdf:type schema:CreativeWork
129 https://doi.org/10.29333/ejgm/82209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100508504
130 rdf:type schema:CreativeWork
131 https://doi.org/10.3109/14767058.2013.849240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019889222
132 rdf:type schema:CreativeWork
133 https://www.grid.ac/institutes/grid.411806.a schema:alternateName Minia University
134 schema:name Faculty of Medicine, Biochemistry Department, Minia University, Minia, Egypt
135 Faculty of Medicine, Pediatric Department, Minia University, Minia, Egypt
136 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...