Omalizumab in children with severe allergic disease: a case series View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Giuseppe Crisafulli, Lucia Caminiti, Fernanda Chiera, Stefania Arasi, Giuseppina Salzano, Ilenia Panasiti, Andrea Barbalace, Giovanni Battista Pajno

ABSTRACT

BACKGROUND: Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with severe uncontrolled allergic asthma. In recent years there has seen the emergence of an allergic epidemic with increasing food allergy, which represents the main cause of anaphylaxis in children. The standard of care for food allergy is strictly dietary allergen avoidance and emergency treatment, but recent clinical trials have suggested that omalizumab may have a role to play as an adjuvant to oral immunotherapy (OIT). We present a case series of patients treated at our institution with omalizumab for severe allergic asthma and food allergy. METHODS: Patients received omalizumab according to a standard reference nomogram after failing standard therapies. In children with comorbid severe food allergy, omalizumab was administered in conjunction with an oral immunotherapy protocol. RESULTS: Omalizumab was effective in controlling symptoms of allergic asthma, allergic rhinitis and rhinosinusitis, but not eosinophilic esophagitis, while aiding successful oral desensitization of comorbid severe food allergies. CONCLUSIONS: Omalizumab appears to be an excellent therapeutic option in children with inadequately controlled severe allergic asthma, allergic rhinitis and rhinosinusitis, with or without food allergy. More... »

PAGES

13

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13052-019-0602-5

DOI

http://dx.doi.org/10.1186/s13052-019-0602-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111402737

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30642367


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crisafulli", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01065207421.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065207421.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caminiti", 
        "givenName": "Lucia", 
        "id": "sg:person.0603644140.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603644140.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pediatrics, Pediatric Unit, San Giovanni di Dio Hospital, Crotone, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chiera", 
        "givenName": "Fernanda", 
        "id": "sg:person.01051312204.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051312204.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bambino Ges\u00f9 Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414125.7", 
          "name": [
            "Pediatric Allergology Unit, Bambino Ges\u00f9 Hospital (IRCCS), Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arasi", 
        "givenName": "Stefania", 
        "id": "sg:person.0601620706.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601620706.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salzano", 
        "givenName": "Giuseppina", 
        "id": "sg:person.01133322621.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133322621.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Panasiti", 
        "givenName": "Ilenia", 
        "id": "sg:person.0774434045.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774434045.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barbalace", 
        "givenName": "Andrea", 
        "id": "sg:person.011547327220.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011547327220.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pajno", 
        "givenName": "Giovanni Battista", 
        "id": "sg:person.01102144536.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102144536.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa1009705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003923843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2013.09.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005997865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2014.02.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006716266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2015.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009165798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2015.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009165798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2015.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009165798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2015.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009165798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/archdischild-2011-301570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009467809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12016-015-8490-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009522364", 
          "https://doi.org/10.1007/s12016-015-8490-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1939-4551-7-17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009982813", 
          "https://doi.org/10.1186/1939-4551-7-17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1939-4551-7-17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009982813", 
          "https://doi.org/10.1186/1939-4551-7-17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2014.09.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011847751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007995.2010.539502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014654021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2011.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015752934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2004.11.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016241477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007991003771338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018045714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2007.10.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018204075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2010.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020094838"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2222.2009.03214.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020252281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1081-1206(10)62175-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022432057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaip.2014.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022452158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.108.2.e36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022791790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2014.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024893097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/all.12429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025263248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2012.01.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025746326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.10-1194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027934453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.110.5.e55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028583760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd003559.pub4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032018331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/pai.12567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032577565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13052-016-0217-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038511584", 
          "https://doi.org/10.1186/s13052-016-0217-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2009.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038980416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.anai.2010.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040434225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2014.362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041689500", 
          "https://doi.org/10.1038/jid.2014.362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00008115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043279927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00008115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043279927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00008115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043279927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2009.09.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044611800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2014.08.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047866426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aci.0000000000000161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048418172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aci.0000000000000161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048418172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aci.0000000000000161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048418172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1183/09031936.00149812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064123879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4193/rhin09.144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072349244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078588337", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1573398x13666170426094536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085266693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rmed.2017.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090806973"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with severe uncontrolled allergic asthma. In recent years there has seen the emergence of an allergic epidemic with increasing food allergy, which represents the main cause of anaphylaxis in children. The standard of care for food allergy is strictly dietary allergen avoidance and emergency treatment, but recent clinical trials have suggested that omalizumab may have a role to play as an adjuvant to oral immunotherapy (OIT). We present a case series of patients treated at our institution with omalizumab for severe allergic asthma and food allergy.\nMETHODS: Patients received omalizumab according to a standard reference nomogram after failing standard therapies. In children with comorbid severe food allergy, omalizumab was administered in conjunction with an oral immunotherapy protocol.\nRESULTS: Omalizumab was effective in controlling symptoms of allergic asthma, allergic rhinitis and rhinosinusitis, but not eosinophilic esophagitis, while aiding successful oral desensitization of comorbid severe food allergies.\nCONCLUSIONS: Omalizumab appears to be an excellent therapeutic option in children with inadequately controlled severe allergic asthma, allergic rhinitis and rhinosinusitis, with or without food allergy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13052-019-0602-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1320494", 
        "issn": [
          "1720-8424", 
          "1824-7288"
        ], 
        "name": "Italian Journal of Pediatrics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "45"
      }
    ], 
    "name": "Omalizumab in children with severe allergic disease: a case series", 
    "pagination": "13", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "38916ebd8fb7d967a9152a3d0b3a0a9e78f704347273fa3bf88cf16db35ad6c3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30642367"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101510759"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13052-019-0602-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111402737"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13052-019-0602-5", 
      "https://app.dimensions.ai/details/publication/pub.1111402737"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000320_0000000320/records_101387_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13052-019-0602-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13052-019-0602-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13052-019-0602-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13052-019-0602-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13052-019-0602-5'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      21 PREDICATES      67 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13052-019-0602-5 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author Nabbe578c1bab41cea0e77e76d2ba8565
4 schema:citation sg:pub.10.1007/s12016-015-8490-y
5 sg:pub.10.1038/jid.2014.362
6 sg:pub.10.1186/1939-4551-7-17
7 sg:pub.10.1186/s13052-016-0217-z
8 https://app.dimensions.ai/details/publication/pub.1078588337
9 https://doi.org/10.1002/14651858.cd003559.pub4
10 https://doi.org/10.1016/j.anai.2010.03.015
11 https://doi.org/10.1016/j.jaci.2004.11.053
12 https://doi.org/10.1016/j.jaci.2007.10.029
13 https://doi.org/10.1016/j.jaci.2009.09.021
14 https://doi.org/10.1016/j.jaci.2011.04.009
15 https://doi.org/10.1016/j.jaci.2012.01.033
16 https://doi.org/10.1016/j.jaci.2013.09.046
17 https://doi.org/10.1016/j.jaci.2014.02.007
18 https://doi.org/10.1016/j.jaci.2014.09.017
19 https://doi.org/10.1016/j.jaci.2015.03.004
20 https://doi.org/10.1016/j.jaip.2014.10.010
21 https://doi.org/10.1016/j.rmed.2009.06.014
22 https://doi.org/10.1016/j.rmed.2010.04.013
23 https://doi.org/10.1016/j.rmed.2014.02.003
24 https://doi.org/10.1016/j.rmed.2017.07.013
25 https://doi.org/10.1016/s1081-1206(10)62175-8
26 https://doi.org/10.1053/j.gastro.2014.08.028
27 https://doi.org/10.1056/nejmoa1009705
28 https://doi.org/10.1097/aci.0000000000000161
29 https://doi.org/10.1111/all.12429
30 https://doi.org/10.1111/j.1365-2222.2009.03214.x
31 https://doi.org/10.1111/pai.12567
32 https://doi.org/10.1136/archdischild-2011-301570
33 https://doi.org/10.1183/09031936.00008115
34 https://doi.org/10.1183/09031936.00149812
35 https://doi.org/10.1185/03007991003771338
36 https://doi.org/10.1185/03007995.2010.539502
37 https://doi.org/10.1378/chest.10-1194
38 https://doi.org/10.1542/peds.108.2.e36
39 https://doi.org/10.1542/peds.110.5.e55
40 https://doi.org/10.2174/1573398x13666170426094536
41 https://doi.org/10.4193/rhin09.144
42 schema:datePublished 2019-12
43 schema:datePublishedReg 2019-12-01
44 schema:description BACKGROUND: Currently, severe allergic asthma and food allergy in children represent an important public health problem with medical, psychosocial and economic impacts. Omalizumab is a humanized monoclonal anti-IgE antibody, approved for refractory allergic asthma and chronic urticaria. It has been widely used in clinical practice as add-on therapy in patients with severe uncontrolled allergic asthma. In recent years there has seen the emergence of an allergic epidemic with increasing food allergy, which represents the main cause of anaphylaxis in children. The standard of care for food allergy is strictly dietary allergen avoidance and emergency treatment, but recent clinical trials have suggested that omalizumab may have a role to play as an adjuvant to oral immunotherapy (OIT). We present a case series of patients treated at our institution with omalizumab for severe allergic asthma and food allergy. METHODS: Patients received omalizumab according to a standard reference nomogram after failing standard therapies. In children with comorbid severe food allergy, omalizumab was administered in conjunction with an oral immunotherapy protocol. RESULTS: Omalizumab was effective in controlling symptoms of allergic asthma, allergic rhinitis and rhinosinusitis, but not eosinophilic esophagitis, while aiding successful oral desensitization of comorbid severe food allergies. CONCLUSIONS: Omalizumab appears to be an excellent therapeutic option in children with inadequately controlled severe allergic asthma, allergic rhinitis and rhinosinusitis, with or without food allergy.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree true
48 schema:isPartOf N5a43ba0ceb034cc88e8057ecfc6bc840
49 Nc47c97314eba4c2c91972fbac81913f3
50 sg:journal.1320494
51 schema:name Omalizumab in children with severe allergic disease: a case series
52 schema:pagination 13
53 schema:productId N1d1fee57a32e43ff84eb8bc122484939
54 N73e77380ffa04edaaf3f1cd089ab32e9
55 N9c7f6ce4d7bf406eaa204e985bab7b76
56 Nc1cf2c2dec4a4b82bab7108245cd1709
57 Nf305b542c7c94c7dbb62baf78fb1a005
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111402737
59 https://doi.org/10.1186/s13052-019-0602-5
60 schema:sdDatePublished 2019-04-11T08:41
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N7a8933e16db240f8b49f213779f93c68
63 schema:url https://link.springer.com/10.1186%2Fs13052-019-0602-5
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N01363050a94341e28566608245f31dd0 schema:name Department of Pediatrics, Pediatric Unit, San Giovanni di Dio Hospital, Crotone, Italy
68 rdf:type schema:Organization
69 N1d1fee57a32e43ff84eb8bc122484939 schema:name pubmed_id
70 schema:value 30642367
71 rdf:type schema:PropertyValue
72 N20fbc27ff6784fd3af58d530225dce59 rdf:first sg:person.01102144536.74
73 rdf:rest rdf:nil
74 N45cc1b581ed84161a8fbdbb7c2e755f8 rdf:first sg:person.0603644140.73
75 rdf:rest N73b8d6da8bcd4637bd5c60975a24be5c
76 N5a43ba0ceb034cc88e8057ecfc6bc840 schema:volumeNumber 45
77 rdf:type schema:PublicationVolume
78 N6085481c670a4fe98151de6b525a0cc1 rdf:first sg:person.011547327220.25
79 rdf:rest N20fbc27ff6784fd3af58d530225dce59
80 N73b8d6da8bcd4637bd5c60975a24be5c rdf:first sg:person.01051312204.18
81 rdf:rest Nec8b330f0667402ba7de20044360a285
82 N73e77380ffa04edaaf3f1cd089ab32e9 schema:name dimensions_id
83 schema:value pub.1111402737
84 rdf:type schema:PropertyValue
85 N7a6b2326338a4b3694fc7f9b81d47824 rdf:first sg:person.01133322621.53
86 rdf:rest N82d29fc96f564a12bd21a9f2ae3237e9
87 N7a8933e16db240f8b49f213779f93c68 schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 N82d29fc96f564a12bd21a9f2ae3237e9 rdf:first sg:person.0774434045.56
90 rdf:rest N6085481c670a4fe98151de6b525a0cc1
91 N9c7f6ce4d7bf406eaa204e985bab7b76 schema:name readcube_id
92 schema:value 38916ebd8fb7d967a9152a3d0b3a0a9e78f704347273fa3bf88cf16db35ad6c3
93 rdf:type schema:PropertyValue
94 Nabbe578c1bab41cea0e77e76d2ba8565 rdf:first sg:person.01065207421.05
95 rdf:rest N45cc1b581ed84161a8fbdbb7c2e755f8
96 Nc1cf2c2dec4a4b82bab7108245cd1709 schema:name nlm_unique_id
97 schema:value 101510759
98 rdf:type schema:PropertyValue
99 Nc47c97314eba4c2c91972fbac81913f3 schema:issueNumber 1
100 rdf:type schema:PublicationIssue
101 Nec8b330f0667402ba7de20044360a285 rdf:first sg:person.0601620706.08
102 rdf:rest N7a6b2326338a4b3694fc7f9b81d47824
103 Nf305b542c7c94c7dbb62baf78fb1a005 schema:name doi
104 schema:value 10.1186/s13052-019-0602-5
105 rdf:type schema:PropertyValue
106 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
107 schema:name Medical and Health Sciences
108 rdf:type schema:DefinedTerm
109 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
110 schema:name Immunology
111 rdf:type schema:DefinedTerm
112 sg:journal.1320494 schema:issn 1720-8424
113 1824-7288
114 schema:name Italian Journal of Pediatrics
115 rdf:type schema:Periodical
116 sg:person.01051312204.18 schema:affiliation N01363050a94341e28566608245f31dd0
117 schema:familyName Chiera
118 schema:givenName Fernanda
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051312204.18
120 rdf:type schema:Person
121 sg:person.01065207421.05 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
122 schema:familyName Crisafulli
123 schema:givenName Giuseppe
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065207421.05
125 rdf:type schema:Person
126 sg:person.01102144536.74 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
127 schema:familyName Pajno
128 schema:givenName Giovanni Battista
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102144536.74
130 rdf:type schema:Person
131 sg:person.01133322621.53 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
132 schema:familyName Salzano
133 schema:givenName Giuseppina
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133322621.53
135 rdf:type schema:Person
136 sg:person.011547327220.25 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
137 schema:familyName Barbalace
138 schema:givenName Andrea
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011547327220.25
140 rdf:type schema:Person
141 sg:person.0601620706.08 schema:affiliation https://www.grid.ac/institutes/grid.414125.7
142 schema:familyName Arasi
143 schema:givenName Stefania
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601620706.08
145 rdf:type schema:Person
146 sg:person.0603644140.73 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
147 schema:familyName Caminiti
148 schema:givenName Lucia
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603644140.73
150 rdf:type schema:Person
151 sg:person.0774434045.56 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
152 schema:familyName Panasiti
153 schema:givenName Ilenia
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774434045.56
155 rdf:type schema:Person
156 sg:pub.10.1007/s12016-015-8490-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1009522364
157 https://doi.org/10.1007/s12016-015-8490-y
158 rdf:type schema:CreativeWork
159 sg:pub.10.1038/jid.2014.362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041689500
160 https://doi.org/10.1038/jid.2014.362
161 rdf:type schema:CreativeWork
162 sg:pub.10.1186/1939-4551-7-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009982813
163 https://doi.org/10.1186/1939-4551-7-17
164 rdf:type schema:CreativeWork
165 sg:pub.10.1186/s13052-016-0217-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1038511584
166 https://doi.org/10.1186/s13052-016-0217-z
167 rdf:type schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1078588337 schema:CreativeWork
169 https://doi.org/10.1002/14651858.cd003559.pub4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032018331
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.anai.2010.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040434225
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.jaci.2004.11.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016241477
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.jaci.2007.10.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018204075
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.jaci.2009.09.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044611800
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.jaci.2011.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015752934
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.jaci.2012.01.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025746326
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.jaci.2013.09.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005997865
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.jaci.2014.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006716266
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.jaci.2014.09.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011847751
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.jaci.2015.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009165798
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/j.jaip.2014.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022452158
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/j.rmed.2009.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038980416
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.rmed.2010.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020094838
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/j.rmed.2014.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024893097
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.rmed.2017.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090806973
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s1081-1206(10)62175-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022432057
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1053/j.gastro.2014.08.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047866426
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1056/nejmoa1009705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003923843
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1097/aci.0000000000000161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048418172
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1111/all.12429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025263248
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1111/j.1365-2222.2009.03214.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020252281
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1111/pai.12567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032577565
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1136/archdischild-2011-301570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009467809
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1183/09031936.00008115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043279927
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1183/09031936.00149812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064123879
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1185/03007991003771338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018045714
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1185/03007995.2010.539502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014654021
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1378/chest.10-1194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027934453
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1542/peds.108.2.e36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022791790
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1542/peds.110.5.e55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028583760
230 rdf:type schema:CreativeWork
231 https://doi.org/10.2174/1573398x13666170426094536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085266693
232 rdf:type schema:CreativeWork
233 https://doi.org/10.4193/rhin09.144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072349244
234 rdf:type schema:CreativeWork
235 https://www.grid.ac/institutes/grid.10438.3e schema:alternateName University of Messina
236 schema:name Department of Pediatrics, Allergy Unit, University of Messina, Via Consolare Valeria-Gazzi, 98124, Messina, Italy
237 rdf:type schema:Organization
238 https://www.grid.ac/institutes/grid.414125.7 schema:alternateName Bambino Gesù Children's Hospital
239 schema:name Pediatric Allergology Unit, Bambino Gesù Hospital (IRCCS), Rome, Italy
240 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...