Stage 4 s neuroblastoma: features, management and outcome of 268 cases from the Italian Neuroblastoma Registry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Bruno De Bernardi, Andrea Di Cataldo, Alberto Garaventa, Paolo Massirio, Elisabetta Viscardi, Marta Giorgia Podda, Aurora Castellano, Paolo D’Angelo, Elisa Tirtei, Fraia Melchionda, Simona Vetrella, Francesco De Leonardis, Carmelita D’Ippolito, Annalisa Tondo, Antonella Nonnis, Giovanni Erminio, Anna Rita Gigliotti, Katia Mazzocco, Riccardo Haupt

ABSTRACT

BACKGROUND: Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the Italian Neuroblastoma Registry to detect changes over time in presenting features, treatment and outcome. METHODS: Of 3355 subjects aged 0-18 years with previously untreated neuroblastoma diagnosed between 1979 and 2013, a total of 280 infants (8.3%) had stage 4 s characteristics, 268 of whom were eligible for analyses. Three treatment eras were identified on the basis of based diagnostic and chemotherapy adopted. Group 1 patients received upfront chemotherapy; Group 2 and 3 patients underwent observation in the absence of life-threatening symptoms (LTS), except for Group 3 patients with amplified MYCN gene, who received more aggressive therapy. RESULTS: The three groups were comparable, with few exceptions. Ten-year overall survival significantly increased from 76.9 to 89.7% and was worse for male gender, age 0-29 days and presence of selected LTS on diagnosis, elevated LDH, and abnormal biologic features. Infants who underwent primary resection ± chemotherapy did significantly better. On multivariate analysis, treatment eras and the association of hepatomegaly to dyspnea were independently associated with worse outcome. CONCLUSIONS: Our data confirm that stage 4 s neuroblastoma is curable in nearly 90% of cases. Hepatomegaly associated to dyspnea was the most important independent risk factor. The cure rate could be further increased through timely identification of patients at risk who might benefit from surgical techniques, such as intra-arterial chemoembolization and/or liver transplantation, which must be carried out in institutions with specific expertise. More... »

PAGES

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13052-018-0599-1

DOI

http://dx.doi.org/10.1186/s13052-018-0599-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111363965

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30634996


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Hematology-Oncology, IRCCS Istituto Giannina Gaslini, Via Gaslini 5, 16147, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Bernardi", 
        "givenName": "Bruno", 
        "id": "sg:person.01112272011.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112272011.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico Universitario di Catania", 
          "id": "https://www.grid.ac/institutes/grid.412844.f", 
          "name": [
            "Department of Pediatric Hematology-Oncology, University Hospital, Catania, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Cataldo", 
        "givenName": "Andrea", 
        "id": "sg:person.0650411773.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650411773.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Hematology-Oncology, IRCCS Istituto Giannina Gaslini, Via Gaslini 5, 16147, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garaventa", 
        "givenName": "Alberto", 
        "id": "sg:person.01152507233.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152507233.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Hematology-Oncology, IRCCS Istituto Giannina Gaslini, Via Gaslini 5, 16147, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Massirio", 
        "givenName": "Paolo", 
        "id": "sg:person.0774666037.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774666037.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera di Padova", 
          "id": "https://www.grid.ac/institutes/grid.411474.3", 
          "name": [
            "Department of Pediatrics, University Hospital, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viscardi", 
        "givenName": "Elisabetta", 
        "id": "sg:person.01106405125.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106405125.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Department of Oncology, Istituto Nazionale Tumori, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Podda", 
        "givenName": "Marta Giorgia", 
        "id": "sg:person.0675371505.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675371505.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bambino Ges\u00f9 Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414125.7", 
          "name": [
            "Department of Pediatric Oncology, Bambino Ges\u00f9 Children\u2019s Hospital, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castellano", 
        "givenName": "Aurora", 
        "id": "sg:person.01046421466.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046421466.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Palermo", 
          "id": "https://www.grid.ac/institutes/grid.10776.37", 
          "name": [
            "Department of Pediatrics, University of Palermo, Palermo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u2019Angelo", 
        "givenName": "Paolo", 
        "id": "sg:person.0640262243.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640262243.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale Regina Margherita", 
          "id": "https://www.grid.ac/institutes/grid.415778.8", 
          "name": [
            "Department of Pediatric Hematology-Oncology, Regina Margherita Hospital, Torino, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tirtei", 
        "givenName": "Elisa", 
        "id": "sg:person.0704441432.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704441432.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Hematology-Oncology Unit, Sant\u2019Orsola-Malpighi Policlinic, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melchionda", 
        "givenName": "Fraia", 
        "id": "sg:person.0736403230.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736403230.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Santobono Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415247.1", 
          "name": [
            "Department of Hematology-Oncology, Santobono-Pausilipon Children\u2019s Hospital, Naples, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vetrella", 
        "givenName": "Simona", 
        "id": "sg:person.01047375756.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047375756.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pediatrics, University Hospital, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Leonardis", 
        "givenName": "Francesco", 
        "id": "sg:person.01337277526.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337277526.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Spedali Civili di Brescia", 
          "id": "https://www.grid.ac/institutes/grid.412725.7", 
          "name": [
            "Department of Pediatrics, Civic Hospital, Brescia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "D\u2019Ippolito", 
        "givenName": "Carmelita", 
        "id": "sg:person.01024134501.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024134501.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Meyer Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413181.e", 
          "name": [
            "Department of Hematology-Oncology, Anna Meyer Children\u2019s Hospital, Florence, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tondo", 
        "givenName": "Annalisa", 
        "id": "sg:person.0725135437.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725135437.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Pediatric Onco-Hematology, Civic Hospital, Cagliari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nonnis", 
        "givenName": "Antonella", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Giannina Gaslini", 
          "id": "https://www.grid.ac/institutes/grid.419504.d", 
          "name": [
            "Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Erminio", 
        "givenName": "Giovanni", 
        "id": "sg:person.0642174271.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642174271.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Giannina Gaslini", 
          "id": "https://www.grid.ac/institutes/grid.419504.d", 
          "name": [
            "Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gigliotti", 
        "givenName": "Anna Rita", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Giannina Gaslini", 
          "id": "https://www.grid.ac/institutes/grid.419504.d", 
          "name": [
            "Pathology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazzocco", 
        "givenName": "Katia", 
        "id": "sg:person.01052451364.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052451364.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Giannina Gaslini", 
          "id": "https://www.grid.ac/institutes/grid.419504.d", 
          "name": [
            "Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haupt", 
        "givenName": "Riccardo", 
        "id": "sg:person.01304212570.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304212570.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00043426-200202000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004048772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043426-200202000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004048772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043426-200202000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004048772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-911x(199612)27:6<521::aid-mpo3>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004868439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-911x(199612)27:6<521::aid-mpo3>3.0.co;2-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004868439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007272688", 
          "https://doi.org/10.1038/sj.bjc.6601154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007272688", 
          "https://doi.org/10.1038/sj.bjc.6601154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19860715)58:2<372::aid-cncr2820580229>3.0.co;2-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009347779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043426-199508000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009743681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043426-199508000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009743681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.24.8351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010577777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-3468(92)90549-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011546420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.5839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015121232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70012-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019966737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.20080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020234312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(71)91606-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021446396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpedsurg.2010.08.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026805581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.23186", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028734147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.20407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028927032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.20407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028927032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-2495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030952434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035478542", 
          "https://doi.org/10.1038/bjc.1998.370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035478542", 
          "https://doi.org/10.1038/bjc.1998.370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pbc.24391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038249092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mpo.2950190605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040773248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.16.6785", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044073581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19840515)53:10<2083::aid-cncr2820531014>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044859852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molonc.2008.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046316716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.35.9570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046529424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19990715)86:2<364::aid-cncr21>3.0.co;2-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047684161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03260051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047991138", 
          "https://doi.org/10.1007/bf03260051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19800301)45:5<833::aid-cncr2820450502>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050041739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.13.9493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051906145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2012.375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052874118", 
          "https://doi.org/10.1038/bjc.2012.375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19920915)70:6<1625::aid-cncr2820700631>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053362629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043426-198721000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060298133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043426-198721000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060298133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00043426-198721000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060298133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.3.477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074583452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08880018.2016.1266535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079391926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1995.13.4.884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082473757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1993.11.8.1466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082762676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1996.14.5.1537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082882825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.1.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083031465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.6.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083277762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0043-103086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085765503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-017-2761-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100192691", 
          "https://doi.org/10.1007/s00441-017-2761-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000419225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107144412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000419225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1107144412"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Infants diagnosed with stage 4\u2009s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the Italian Neuroblastoma Registry to detect changes over time in presenting features, treatment and outcome.\nMETHODS: Of 3355 subjects aged 0-18\u2009years with previously untreated neuroblastoma diagnosed between 1979 and 2013, a total of 280 infants (8.3%) had stage 4\u2009s characteristics, 268 of whom were eligible for analyses. Three treatment eras were identified on the basis of based diagnostic and chemotherapy adopted. Group 1 patients received upfront chemotherapy; Group 2 and 3 patients underwent observation in the absence of life-threatening symptoms (LTS), except for Group 3 patients with amplified MYCN gene, who received more aggressive therapy.\nRESULTS: The three groups were comparable, with few exceptions. Ten-year overall survival significantly increased from 76.9 to 89.7% and was worse for male gender, age 0-29\u2009days and presence of selected LTS on diagnosis, elevated LDH, and abnormal biologic features. Infants who underwent primary resection \u00b1 chemotherapy did significantly better. On multivariate analysis, treatment eras and the association of hepatomegaly to dyspnea were independently associated with worse outcome.\nCONCLUSIONS: Our data confirm that stage 4\u2009s neuroblastoma is curable in nearly 90% of cases. Hepatomegaly associated to dyspnea was the most important independent risk factor. The cure rate could be further increased through timely identification of patients at risk who might benefit from surgical techniques, such as intra-arterial chemoembolization and/or liver transplantation, which must be carried out in institutions with specific expertise.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13052-018-0599-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1320494", 
        "issn": [
          "1720-8424", 
          "1824-7288"
        ], 
        "name": "Italian Journal of Pediatrics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "45"
      }
    ], 
    "name": "Stage 4 s neuroblastoma: features, management and outcome of 268 cases from the Italian Neuroblastoma Registry", 
    "pagination": "8", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4370412e173593dae8f7f41054c80801f63b22c70a723eab160ebd2bb1a717c8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30634996"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101510759"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13052-018-0599-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111363965"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13052-018-0599-1", 
      "https://app.dimensions.ai/details/publication/pub.1111363965"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:41", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000320_0000000320/records_101401_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13052-018-0599-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0599-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0599-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0599-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0599-1'


 

This table displays all metadata directly associated to this object as RDF triples.

355 TRIPLES      21 PREDICATES      68 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13052-018-0599-1 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nf552c24e7f6a4b07bb77a27e3b4f426f
4 schema:citation sg:pub.10.1007/bf03260051
5 sg:pub.10.1007/s00441-017-2761-2
6 sg:pub.10.1038/bjc.1998.370
7 sg:pub.10.1038/bjc.2012.375
8 sg:pub.10.1038/sj.bjc.6601154
9 https://doi.org/10.1002/(sici)1096-911x(199612)27:6<521::aid-mpo3>3.0.co;2-n
10 https://doi.org/10.1002/(sici)1097-0142(19990715)86:2<364::aid-cncr21>3.0.co;2-7
11 https://doi.org/10.1002/1097-0142(19800301)45:5<833::aid-cncr2820450502>3.0.co;2-u
12 https://doi.org/10.1002/1097-0142(19840515)53:10<2083::aid-cncr2820531014>3.0.co;2-s
13 https://doi.org/10.1002/1097-0142(19860715)58:2<372::aid-cncr2820580229>3.0.co;2-2
14 https://doi.org/10.1002/1097-0142(19920915)70:6<1625::aid-cncr2820700631>3.0.co;2-6
15 https://doi.org/10.1002/mpo.2950190605
16 https://doi.org/10.1002/pbc.20080
17 https://doi.org/10.1002/pbc.20407
18 https://doi.org/10.1002/pbc.23186
19 https://doi.org/10.1002/pbc.24391
20 https://doi.org/10.1016/0022-3468(92)90549-m
21 https://doi.org/10.1016/j.jpedsurg.2010.08.064
22 https://doi.org/10.1016/j.molonc.2008.07.002
23 https://doi.org/10.1016/s0140-6736(71)91606-0
24 https://doi.org/10.1016/s1470-2045(12)70012-8
25 https://doi.org/10.1055/s-0043-103086
26 https://doi.org/10.1080/08880018.2016.1266535
27 https://doi.org/10.1097/00043426-198721000-00002
28 https://doi.org/10.1097/00043426-199508000-00007
29 https://doi.org/10.1097/00043426-200202000-00017
30 https://doi.org/10.1158/1078-0432.ccr-05-2495
31 https://doi.org/10.1159/000419225
32 https://doi.org/10.1200/jco.1993.11.8.1466
33 https://doi.org/10.1200/jco.1995.13.4.884
34 https://doi.org/10.1200/jco.1996.14.5.1537
35 https://doi.org/10.1200/jco.1997.15.1.85
36 https://doi.org/10.1200/jco.1998.16.6.2007
37 https://doi.org/10.1200/jco.2000.18.3.477
38 https://doi.org/10.1200/jco.2007.13.9493
39 https://doi.org/10.1200/jco.2007.14.5839
40 https://doi.org/10.1200/jco.2008.16.6785
41 https://doi.org/10.1200/jco.2009.24.8351
42 https://doi.org/10.1200/jco.2011.35.9570
43 schema:datePublished 2019-12
44 schema:datePublishedReg 2019-12-01
45 schema:description BACKGROUND: Infants diagnosed with stage 4 s neuroblastoma commonly experience spontaneous disease regression, with few succumbing without response to therapy. We analyzed a large cohort of such infants enrolled in the Italian Neuroblastoma Registry to detect changes over time in presenting features, treatment and outcome. METHODS: Of 3355 subjects aged 0-18 years with previously untreated neuroblastoma diagnosed between 1979 and 2013, a total of 280 infants (8.3%) had stage 4 s characteristics, 268 of whom were eligible for analyses. Three treatment eras were identified on the basis of based diagnostic and chemotherapy adopted. Group 1 patients received upfront chemotherapy; Group 2 and 3 patients underwent observation in the absence of life-threatening symptoms (LTS), except for Group 3 patients with amplified MYCN gene, who received more aggressive therapy. RESULTS: The three groups were comparable, with few exceptions. Ten-year overall survival significantly increased from 76.9 to 89.7% and was worse for male gender, age 0-29 days and presence of selected LTS on diagnosis, elevated LDH, and abnormal biologic features. Infants who underwent primary resection ± chemotherapy did significantly better. On multivariate analysis, treatment eras and the association of hepatomegaly to dyspnea were independently associated with worse outcome. CONCLUSIONS: Our data confirm that stage 4 s neuroblastoma is curable in nearly 90% of cases. Hepatomegaly associated to dyspnea was the most important independent risk factor. The cure rate could be further increased through timely identification of patients at risk who might benefit from surgical techniques, such as intra-arterial chemoembolization and/or liver transplantation, which must be carried out in institutions with specific expertise.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree true
49 schema:isPartOf N47721a85599e40bd91d54bd96c270cbd
50 N861e74bcea654c399a9696b7c1174b39
51 sg:journal.1320494
52 schema:name Stage 4 s neuroblastoma: features, management and outcome of 268 cases from the Italian Neuroblastoma Registry
53 schema:pagination 8
54 schema:productId N00ada5b40b11402cb963e89d13695d23
55 N15060bcf737343a2b50e2d55e78d028c
56 N4d821f89c36140f88c6b8f4837431365
57 N6e5b86bbb5d14bdba9f9398a00724689
58 Ncd2fbfb31bf1476091d86451b83029ed
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111363965
60 https://doi.org/10.1186/s13052-018-0599-1
61 schema:sdDatePublished 2019-04-11T08:41
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher Nc506c454e82c4eef860ecfbf1f9a79fc
64 schema:url https://link.springer.com/10.1186%2Fs13052-018-0599-1
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N00ada5b40b11402cb963e89d13695d23 schema:name pubmed_id
69 schema:value 30634996
70 rdf:type schema:PropertyValue
71 N1386931b3f8448b58430f834ffdda1bc schema:name Department of Hematology-Oncology, IRCCS Istituto Giannina Gaslini, Via Gaslini 5, 16147, Genoa, Italy
72 rdf:type schema:Organization
73 N15060bcf737343a2b50e2d55e78d028c schema:name doi
74 schema:value 10.1186/s13052-018-0599-1
75 rdf:type schema:PropertyValue
76 N15e8e5a4199c4d7bb865dee2c44346ce rdf:first sg:person.0736403230.56
77 rdf:rest N5127e513960d45498b805f5e17d6cb60
78 N26d3f995b9fc4c9a96aa01c9893929ae rdf:first sg:person.0774666037.33
79 rdf:rest Nbac61ccc440e428daecee02b5552dc09
80 N26e6661e8d0f402ea7d47dc0fa8f51c9 rdf:first sg:person.0640262243.27
81 rdf:rest N5d622d4eae6d43c9836d2c39ea723d6b
82 N41f0934091524beb91044eda8d96ecae rdf:first sg:person.01337277526.22
83 rdf:rest N6a390c3daf224a9dbb3237f10dd434a5
84 N47721a85599e40bd91d54bd96c270cbd schema:volumeNumber 45
85 rdf:type schema:PublicationVolume
86 N4d821f89c36140f88c6b8f4837431365 schema:name dimensions_id
87 schema:value pub.1111363965
88 rdf:type schema:PropertyValue
89 N5127e513960d45498b805f5e17d6cb60 rdf:first sg:person.01047375756.88
90 rdf:rest N41f0934091524beb91044eda8d96ecae
91 N5d622d4eae6d43c9836d2c39ea723d6b rdf:first sg:person.0704441432.39
92 rdf:rest N15e8e5a4199c4d7bb865dee2c44346ce
93 N5ef1bcd3d37b47deacdcb8ede3ad19a0 rdf:first sg:person.0642174271.72
94 rdf:rest Nc604f63e7ad94845beab23c8481c2f9a
95 N608e874c9e604a71a2fdd0af63bf2c79 rdf:first sg:person.01046421466.71
96 rdf:rest N26e6661e8d0f402ea7d47dc0fa8f51c9
97 N618d19807fb9444eb8b59020868287a5 rdf:first sg:person.01052451364.44
98 rdf:rest Nce861fc40cc649769623458f85c247d8
99 N670f314c7f3a4cdeb07d40ba495f15b9 schema:name Department of Hematology-Oncology, IRCCS Istituto Giannina Gaslini, Via Gaslini 5, 16147, Genoa, Italy
100 rdf:type schema:Organization
101 N6a390c3daf224a9dbb3237f10dd434a5 rdf:first sg:person.01024134501.56
102 rdf:rest Nffac377cd11549d281033d07b10f5939
103 N6e5b86bbb5d14bdba9f9398a00724689 schema:name readcube_id
104 schema:value 4370412e173593dae8f7f41054c80801f63b22c70a723eab160ebd2bb1a717c8
105 rdf:type schema:PropertyValue
106 N6ee1d0690c144b328bacba9600a2e6b2 schema:affiliation Ne207d811948f4a378be2fe15c13723ed
107 schema:familyName Nonnis
108 schema:givenName Antonella
109 rdf:type schema:Person
110 N7f2ad53db33f46b78c2c38e1b6c074a8 schema:name Department of Pediatrics, University Hospital, Bari, Italy
111 rdf:type schema:Organization
112 N861e74bcea654c399a9696b7c1174b39 schema:issueNumber 1
113 rdf:type schema:PublicationIssue
114 N90399f89d952401eaa8ff105a589db0b rdf:first sg:person.01152507233.02
115 rdf:rest N26d3f995b9fc4c9a96aa01c9893929ae
116 Na7d3795b375a43018935c39276b32b37 rdf:first sg:person.0650411773.54
117 rdf:rest N90399f89d952401eaa8ff105a589db0b
118 Nb5f31734e7f34fb58ec00feb289bf7e5 schema:name Hematology-Oncology Unit, Sant’Orsola-Malpighi Policlinic, Bologna, Italy
119 rdf:type schema:Organization
120 Nbac61ccc440e428daecee02b5552dc09 rdf:first sg:person.01106405125.90
121 rdf:rest Nc780d64ca83a42218ba0f46ec4b80ad6
122 Nc506c454e82c4eef860ecfbf1f9a79fc schema:name Springer Nature - SN SciGraph project
123 rdf:type schema:Organization
124 Nc604f63e7ad94845beab23c8481c2f9a rdf:first Nd44232ac919441629750390a2ea797a3
125 rdf:rest N618d19807fb9444eb8b59020868287a5
126 Nc780d64ca83a42218ba0f46ec4b80ad6 rdf:first sg:person.0675371505.83
127 rdf:rest N608e874c9e604a71a2fdd0af63bf2c79
128 Ncbb26047dfc84647befdd62e2c0f240b schema:name Department of Hematology-Oncology, IRCCS Istituto Giannina Gaslini, Via Gaslini 5, 16147, Genoa, Italy
129 rdf:type schema:Organization
130 Ncd2fbfb31bf1476091d86451b83029ed schema:name nlm_unique_id
131 schema:value 101510759
132 rdf:type schema:PropertyValue
133 Nce861fc40cc649769623458f85c247d8 rdf:first sg:person.01304212570.12
134 rdf:rest rdf:nil
135 Nd44232ac919441629750390a2ea797a3 schema:affiliation https://www.grid.ac/institutes/grid.419504.d
136 schema:familyName Gigliotti
137 schema:givenName Anna Rita
138 rdf:type schema:Person
139 Ne207d811948f4a378be2fe15c13723ed schema:name Pediatric Onco-Hematology, Civic Hospital, Cagliari, Italy
140 rdf:type schema:Organization
141 Nf552c24e7f6a4b07bb77a27e3b4f426f rdf:first sg:person.01112272011.79
142 rdf:rest Na7d3795b375a43018935c39276b32b37
143 Nf592738f588842c48614a86c378f65f7 rdf:first N6ee1d0690c144b328bacba9600a2e6b2
144 rdf:rest N5ef1bcd3d37b47deacdcb8ede3ad19a0
145 Nffac377cd11549d281033d07b10f5939 rdf:first sg:person.0725135437.74
146 rdf:rest Nf592738f588842c48614a86c378f65f7
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
151 schema:name Oncology and Carcinogenesis
152 rdf:type schema:DefinedTerm
153 sg:journal.1320494 schema:issn 1720-8424
154 1824-7288
155 schema:name Italian Journal of Pediatrics
156 rdf:type schema:Periodical
157 sg:person.01024134501.56 schema:affiliation https://www.grid.ac/institutes/grid.412725.7
158 schema:familyName D’Ippolito
159 schema:givenName Carmelita
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024134501.56
161 rdf:type schema:Person
162 sg:person.01046421466.71 schema:affiliation https://www.grid.ac/institutes/grid.414125.7
163 schema:familyName Castellano
164 schema:givenName Aurora
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046421466.71
166 rdf:type schema:Person
167 sg:person.01047375756.88 schema:affiliation https://www.grid.ac/institutes/grid.415247.1
168 schema:familyName Vetrella
169 schema:givenName Simona
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047375756.88
171 rdf:type schema:Person
172 sg:person.01052451364.44 schema:affiliation https://www.grid.ac/institutes/grid.419504.d
173 schema:familyName Mazzocco
174 schema:givenName Katia
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052451364.44
176 rdf:type schema:Person
177 sg:person.01106405125.90 schema:affiliation https://www.grid.ac/institutes/grid.411474.3
178 schema:familyName Viscardi
179 schema:givenName Elisabetta
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106405125.90
181 rdf:type schema:Person
182 sg:person.01112272011.79 schema:affiliation Ncbb26047dfc84647befdd62e2c0f240b
183 schema:familyName De Bernardi
184 schema:givenName Bruno
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112272011.79
186 rdf:type schema:Person
187 sg:person.01152507233.02 schema:affiliation N670f314c7f3a4cdeb07d40ba495f15b9
188 schema:familyName Garaventa
189 schema:givenName Alberto
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152507233.02
191 rdf:type schema:Person
192 sg:person.01304212570.12 schema:affiliation https://www.grid.ac/institutes/grid.419504.d
193 schema:familyName Haupt
194 schema:givenName Riccardo
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304212570.12
196 rdf:type schema:Person
197 sg:person.01337277526.22 schema:affiliation N7f2ad53db33f46b78c2c38e1b6c074a8
198 schema:familyName De Leonardis
199 schema:givenName Francesco
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337277526.22
201 rdf:type schema:Person
202 sg:person.0640262243.27 schema:affiliation https://www.grid.ac/institutes/grid.10776.37
203 schema:familyName D’Angelo
204 schema:givenName Paolo
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640262243.27
206 rdf:type schema:Person
207 sg:person.0642174271.72 schema:affiliation https://www.grid.ac/institutes/grid.419504.d
208 schema:familyName Erminio
209 schema:givenName Giovanni
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642174271.72
211 rdf:type schema:Person
212 sg:person.0650411773.54 schema:affiliation https://www.grid.ac/institutes/grid.412844.f
213 schema:familyName Di Cataldo
214 schema:givenName Andrea
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650411773.54
216 rdf:type schema:Person
217 sg:person.0675371505.83 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
218 schema:familyName Podda
219 schema:givenName Marta Giorgia
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675371505.83
221 rdf:type schema:Person
222 sg:person.0704441432.39 schema:affiliation https://www.grid.ac/institutes/grid.415778.8
223 schema:familyName Tirtei
224 schema:givenName Elisa
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704441432.39
226 rdf:type schema:Person
227 sg:person.0725135437.74 schema:affiliation https://www.grid.ac/institutes/grid.413181.e
228 schema:familyName Tondo
229 schema:givenName Annalisa
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725135437.74
231 rdf:type schema:Person
232 sg:person.0736403230.56 schema:affiliation Nb5f31734e7f34fb58ec00feb289bf7e5
233 schema:familyName Melchionda
234 schema:givenName Fraia
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736403230.56
236 rdf:type schema:Person
237 sg:person.0774666037.33 schema:affiliation N1386931b3f8448b58430f834ffdda1bc
238 schema:familyName Massirio
239 schema:givenName Paolo
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774666037.33
241 rdf:type schema:Person
242 sg:pub.10.1007/bf03260051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047991138
243 https://doi.org/10.1007/bf03260051
244 rdf:type schema:CreativeWork
245 sg:pub.10.1007/s00441-017-2761-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100192691
246 https://doi.org/10.1007/s00441-017-2761-2
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/bjc.1998.370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035478542
249 https://doi.org/10.1038/bjc.1998.370
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/bjc.2012.375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052874118
252 https://doi.org/10.1038/bjc.2012.375
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/sj.bjc.6601154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007272688
255 https://doi.org/10.1038/sj.bjc.6601154
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/(sici)1096-911x(199612)27:6<521::aid-mpo3>3.0.co;2-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1004868439
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/(sici)1097-0142(19990715)86:2<364::aid-cncr21>3.0.co;2-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047684161
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/1097-0142(19800301)45:5<833::aid-cncr2820450502>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1050041739
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/1097-0142(19840515)53:10<2083::aid-cncr2820531014>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1044859852
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/1097-0142(19860715)58:2<372::aid-cncr2820580229>3.0.co;2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009347779
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/1097-0142(19920915)70:6<1625::aid-cncr2820700631>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053362629
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/mpo.2950190605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040773248
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1002/pbc.20080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020234312
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/pbc.20407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028927032
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1002/pbc.23186 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028734147
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1002/pbc.24391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038249092
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/0022-3468(92)90549-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1011546420
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.jpedsurg.2010.08.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026805581
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.molonc.2008.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046316716
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0140-6736(71)91606-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021446396
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s1470-2045(12)70012-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019966737
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1055/s-0043-103086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085765503
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1080/08880018.2016.1266535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079391926
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1097/00043426-198721000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060298133
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1097/00043426-199508000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009743681
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1097/00043426-200202000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004048772
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1158/1078-0432.ccr-05-2495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030952434
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1159/000419225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107144412
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1200/jco.1993.11.8.1466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082762676
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1200/jco.1995.13.4.884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082473757
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1200/jco.1996.14.5.1537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082882825
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1200/jco.1997.15.1.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083031465
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1200/jco.1998.16.6.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083277762
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1200/jco.2000.18.3.477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074583452
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1200/jco.2007.13.9493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051906145
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1200/jco.2007.14.5839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015121232
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1200/jco.2008.16.6785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044073581
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1200/jco.2009.24.8351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010577777
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1200/jco.2011.35.9570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046529424
324 rdf:type schema:CreativeWork
325 https://www.grid.ac/institutes/grid.10776.37 schema:alternateName University of Palermo
326 schema:name Department of Pediatrics, University of Palermo, Palermo, Italy
327 rdf:type schema:Organization
328 https://www.grid.ac/institutes/grid.411474.3 schema:alternateName Azienda Ospedaliera di Padova
329 schema:name Department of Pediatrics, University Hospital, Padova, Italy
330 rdf:type schema:Organization
331 https://www.grid.ac/institutes/grid.412725.7 schema:alternateName Spedali Civili di Brescia
332 schema:name Department of Pediatrics, Civic Hospital, Brescia, Italy
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.412844.f schema:alternateName Policlinico Universitario di Catania
335 schema:name Department of Pediatric Hematology-Oncology, University Hospital, Catania, Italy
336 rdf:type schema:Organization
337 https://www.grid.ac/institutes/grid.413181.e schema:alternateName Meyer Children's Hospital
338 schema:name Department of Hematology-Oncology, Anna Meyer Children’s Hospital, Florence, Italy
339 rdf:type schema:Organization
340 https://www.grid.ac/institutes/grid.414125.7 schema:alternateName Bambino Gesù Children's Hospital
341 schema:name Department of Pediatric Oncology, Bambino Gesù Children’s Hospital, Rome, Italy
342 rdf:type schema:Organization
343 https://www.grid.ac/institutes/grid.415247.1 schema:alternateName Santobono Children's Hospital
344 schema:name Department of Hematology-Oncology, Santobono-Pausilipon Children’s Hospital, Naples, Italy
345 rdf:type schema:Organization
346 https://www.grid.ac/institutes/grid.415778.8 schema:alternateName Ospedale Regina Margherita
347 schema:name Department of Pediatric Hematology-Oncology, Regina Margherita Hospital, Torino, Italy
348 rdf:type schema:Organization
349 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
350 schema:name Department of Oncology, Istituto Nazionale Tumori, Milan, Italy
351 rdf:type schema:Organization
352 https://www.grid.ac/institutes/grid.419504.d schema:alternateName Istituto Giannina Gaslini
353 schema:name Epidemiology and Biostatistics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy
354 Pathology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy
355 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...