Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study) View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Stefano Mazzoleni, Giovanna Magni, Daniela Toderini

ABSTRACT

BACKGROUND: The appropriate dose of vitamin D supplementation in children is still debated. We calculated that the recommended dose of 600-1000 IU vitamin D3/day is not sufficient to reach a serum 25-hydroxyvitamin D (25-OH-D) level of at least 30 ng/ml (75 nmol/l) in north Italian children > 12 months. The aim of this study was to analyse the effect of seasonal supplementation with 1500 IU (=37.5 μg) vitamin D3/day. METHODS: DINOS (D-vitamIN Oral Supplementation) study was a pilot, monocentric, non-random case-control register study. It was conducted in a paediatric primary care setting near Padova (North Italy, 45°N latitude). The data of 203 children (girls:boys 1:1,33) aged 2-15 years, collected between November 2010 and January 2015, were analysed. Active group A (n = 82) were given 1500 IU vitamin D3/day from November to April; control Group B (n = 121) received no supplementation. The serum 25-OH-D test was part of a laboratory tests panel and performed using a chemiluminescence immunoassay method. RESULTS: Serum 25-OH-D mean level + standard deviation throughout the period was 32 + 13 ng/ml (80 + 32 nmol/l) in group A vs 22 + 10 ng/ml (55 + 25 nmol/l) in group B. In group A 12% had vitamin D deficiency 25-OH-D < 20 ng/ml (50 nmol/l) and 1.2% severe vitamin D deficiency 25-OH-D < 10 ng/ml (25 nmol/l). In group B 46% had vitamin D deficiency and 9% severe deficiency (P < 0.001). In group A mean levels were normal or near-normal all the year except in May. Group B reached mean 25-OH-D levels close to 30 ng/ml (75 nmol/l) only in late summer. The active group mean 25-OH-D level was normal in preschoolers and schoolers but not in adolescents. Non-white children had a three-times vitamin D deficiency probability despite supplementation. CONCLUSIONS: Vitamin D supplementation with at least 1500 IU vitamin D3/day from November to April was found appropriate for children in North Italy. A prolongation until May could be useful. Higher doses and/or prolonged periods could be more appropriate especially in adolescents and in non-white children. STUDY REGISTRATION: DINOS gained the approval of Padova Ethics Committee (n. 3960/U16/2016). More... »

PAGES

18

References to SciGraph publications

  • 2013-06. Hypovitaminosis D and incidence of obesity: a prospective study in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2012-03. Is vitamin D status known among children living in Northern Italy? in EUROPEAN JOURNAL OF NUTRITION
  • 2015-06. 25-hydroxyvitamin D serum level in children of different ethnicity living in Italy in EUROPEAN JOURNAL OF PEDIATRICS
  • 2006-07. Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr) in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2013-12. Calcium and vitamin D intakes in children: a randomized controlled trial in BMC PEDIATRICS
  • 2012-10. Vitamin D concentration and deficiency across different ages and genders in AGING CLINICAL AND EXPERIMENTAL RESEARCH
  • 2018-12. Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians in ITALIAN JOURNAL OF PEDIATRICS
  • 2016-08. 25-Hydroxyvitamin D insufficiency discriminates cardiovascular risk factors accumulation in peri-pubertal boys undergoing overweight screening in ENDOCRINE
  • 2013-12. Vitamin D status and predictors of hypovitaminosis D in Italian children and adolescents: a cross-sectional study in EUROPEAN JOURNAL OF PEDIATRICS
  • 2011-08. Vitamin D and child health in the 21st century in INDIAN PEDIATRICS
  • 2014-09. Vitamin D levels in a paediatric population of normal weight and obese subjects in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • 2014-12. Prevalence of hypovitaminosis D and predictors of vitamin D status in Italian healthy adolescents in ITALIAN JOURNAL OF PEDIATRICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13052-018-0590-x

    DOI

    http://dx.doi.org/10.1186/s13052-018-0590-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111750581

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30691521


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Primary Care Paediatrician Azienda ULSS 6 Euganea Regione Veneto, Polistudio Pediatrico, via D\u2019Annunzio 3/A, Piove di Sacco, Padova, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mazzoleni", 
            "givenName": "Stefano", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Istituto Oncologico Veneto", 
              "id": "https://www.grid.ac/institutes/grid.419546.b", 
              "name": [
                "Senior Biostatistician, NRC Azienda Ospedaliera Padova, Padova, Italy", 
                "Unit\u00e0 di Ricerca Clinica, Istituto Oncologico Veneto, Padova, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Magni", 
            "givenName": "Giovanna", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Endocrinologist and General Practitioner Azienda ULSS 6 Euganea Regione Veneto, Studio via Benizzi 6, Padova, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Toderini", 
            "givenName": "Daniela", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00431-013-2119-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001911367", 
              "https://doi.org/10.1007/s00431-013-2119-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(15)60745-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003118381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1542/peds.2012-1711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003200278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1542/peds.2008-1862", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004155930"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4081/reumatismo.2011.129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006604613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci29449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007147707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1503/cmaj.1070102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007475368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1503/cmaj.1070102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007475368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bone.2009.08.056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010714275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bpo.0000000000000587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013534795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bpo.0000000000000587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013534795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/bpo.0000000000000587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013534795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00431-014-2451-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015243578", 
              "https://doi.org/10.1007/s00431-014-2451-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3945/jn.110.124891", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015701748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/adc.2009.173195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016218621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.arcped.2011.12.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016272215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13312-011-0107-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018110742", 
              "https://doi.org/10.1007/s13312-011-0107-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/sim.4780111005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018381687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000343446", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019800029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1651-2227.1988.tb10604.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020780725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra070553", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023249044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2431-13-86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024360731", 
              "https://doi.org/10.1186/1471-2431-13-86"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/02640414.2013.847279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025473399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/adc.81.1.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028469805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2011-0385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029888078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40618-014-0108-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030257664", 
              "https://doi.org/10.1007/s40618-014-0108-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1651-2227.2003.tb02535.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030400706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1651-2227.2003.tb02535.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030400706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1753-4887.2008.00100.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031787933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1373/clinchem.2009.139253", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032850219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1824-7288-40-54", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033007974", 
              "https://doi.org/10.1186/1824-7288-40-54"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0007114511003527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033390288"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/nu6104472", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034433144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1542/peds.2014-2173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034946115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/583039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035532522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpg.0b013e31828f3c05", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035559591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mpg.0b013e31828f3c05", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035559591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6281884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036208440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2903/j.efsa.2012.2813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037691216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12020-015-0725-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040362544", 
              "https://doi.org/10.1007/s12020-015-0725-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpedi.158.6.531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040872080"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.arcped.2014.04.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042444258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03344156", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042579000", 
              "https://doi.org/10.1007/bf03344156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejcn.2013.48", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043887477", 
              "https://doi.org/10.1038/ejcn.2013.48"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3945/ajcn.112.046102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045511456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00394-011-0200-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049034304", 
              "https://doi.org/10.1007/s00394-011-0200-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1359/jbmr.060302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049129693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jadohealth.2013.03.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049178086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2007.23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050142805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje-13-0233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052620936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3945/ajcn.115.120873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052796874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2005-1436", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064288674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2007-2530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064290400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2010-2704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064292573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2011-2601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064293170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2013-2728", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064294517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jcem-67-2-373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064315269"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jcem-68-5-882", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064315584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1542/peds.2008-2041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067827306"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1542/peds.2009-0051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067827719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5603/ep.2013.0012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073037486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.9734/bjmmr/2014/4370", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074133429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/86.1.150", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077442447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/87.4.1080s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077631701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/pch/12.7.583", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077813550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.3275/8263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078513705", 
              "https://doi.org/10.3275/8263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078756906", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2017-01179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092017792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13052-018-0488-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103880018", 
              "https://doi.org/10.1186/s13052-018-0488-7"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "BACKGROUND: The appropriate dose of vitamin D supplementation in children is still debated. We calculated that the recommended dose of 600-1000\u2009IU vitamin D3/day is not sufficient to reach a serum 25-hydroxyvitamin D (25-OH-D) level of at least 30\u2009ng/ml (75\u2009nmol/l) in north Italian children >\u200912\u2009months. The aim of this study was to analyse the effect of seasonal supplementation with 1500\u2009IU (=37.5\u2009\u03bcg) vitamin D3/day.\nMETHODS: DINOS (D-vitamIN Oral Supplementation) study was a pilot, monocentric, non-random case-control register study. It was conducted in a paediatric primary care setting near Padova (North Italy, 45\u00b0N latitude). The data of 203 children (girls:boys 1:1,33) aged 2-15\u2009years, collected between November 2010 and January 2015, were analysed. Active group A (n\u2009=\u200982) were given 1500\u2009IU vitamin D3/day from November to April; control Group B (n\u2009=\u2009121) received no supplementation. The serum 25-OH-D test was part of a laboratory tests panel and performed using a chemiluminescence immunoassay method.\nRESULTS: Serum 25-OH-D mean level\u00a0+\u00a0standard deviation throughout the period was 32\u00a0+\u00a013\u2009ng/ml (80\u00a0+\u00a032\u2009nmol/l) in group A vs 22\u00a0+\u00a010\u2009ng/ml (55\u00a0+\u00a025\u2009nmol/l) in group B. In group A 12% had vitamin D deficiency 25-OH-D\u2009<\u200920\u2009ng/ml (50\u2009nmol/l) and 1.2% severe vitamin D deficiency 25-OH-D\u2009<\u200910\u2009ng/ml (25\u2009nmol/l). In group B 46% had vitamin D deficiency and 9% severe deficiency (P\u2009<\u2009\u00a00.001). In group A mean levels were normal or near-normal all the year except in May. Group B reached mean 25-OH-D levels close to 30\u2009ng/ml (75\u2009nmol/l) only in late summer. The active group mean 25-OH-D level was normal in preschoolers and schoolers but not in adolescents. Non-white children had a three-times vitamin D deficiency probability despite supplementation.\nCONCLUSIONS: Vitamin D supplementation with at least 1500\u2009IU vitamin D3/day from November to April was found appropriate for children in North Italy. A prolongation until May could be useful. Higher doses and/or prolonged periods could be more appropriate especially in adolescents and in non-white children.\nSTUDY REGISTRATION: DINOS gained the approval of Padova Ethics Committee (n. 3960/U16/2016).", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/s13052-018-0590-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1320494", 
            "issn": [
              "1720-8424", 
              "1824-7288"
            ], 
            "name": "Italian Journal of Pediatrics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "45"
          }
        ], 
        "name": "Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study)", 
        "pagination": "18", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "3d8a1b306d34af1389f4a90f3ced5a1fcb105e5360734ab99e2e725ca7f6fa71"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30691521"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101510759"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13052-018-0590-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111750581"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13052-018-0590-x", 
          "https://app.dimensions.ai/details/publication/pub.1111750581"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000329_0000000329/records_74683_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1186%2Fs13052-018-0590-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0590-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0590-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0590-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0590-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    288 TRIPLES      21 PREDICATES      93 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13052-018-0590-x schema:about anzsrc-for:11
    2 anzsrc-for:1117
    3 schema:author Nd6291c7a84824a24916544dbdced0722
    4 schema:citation sg:pub.10.1007/bf03344156
    5 sg:pub.10.1007/s00394-011-0200-9
    6 sg:pub.10.1007/s00431-013-2119-z
    7 sg:pub.10.1007/s00431-014-2451-y
    8 sg:pub.10.1007/s12020-015-0725-4
    9 sg:pub.10.1007/s13312-011-0107-9
    10 sg:pub.10.1007/s40618-014-0108-3
    11 sg:pub.10.1038/ejcn.2013.48
    12 sg:pub.10.1186/1471-2431-13-86
    13 sg:pub.10.1186/1824-7288-40-54
    14 sg:pub.10.1186/s13052-018-0488-7
    15 sg:pub.10.3275/8263
    16 https://app.dimensions.ai/details/publication/pub.1078756906
    17 https://doi.org/10.1001/archpedi.158.6.531
    18 https://doi.org/10.1002/sim.4780111005
    19 https://doi.org/10.1016/j.arcped.2011.12.015
    20 https://doi.org/10.1016/j.arcped.2014.04.012
    21 https://doi.org/10.1016/j.bone.2009.08.056
    22 https://doi.org/10.1016/j.jadohealth.2013.03.022
    23 https://doi.org/10.1016/s0140-6736(15)60745-0
    24 https://doi.org/10.1017/s0007114511003527
    25 https://doi.org/10.1038/oby.2007.23
    26 https://doi.org/10.1056/nejmra070553
    27 https://doi.org/10.1080/02640414.2013.847279
    28 https://doi.org/10.1093/ajcn/86.1.150
    29 https://doi.org/10.1093/ajcn/87.4.1080s
    30 https://doi.org/10.1093/pch/12.7.583
    31 https://doi.org/10.1097/bpo.0000000000000587
    32 https://doi.org/10.1097/mpg.0b013e31828f3c05
    33 https://doi.org/10.1111/j.1651-2227.1988.tb10604.x
    34 https://doi.org/10.1111/j.1651-2227.2003.tb02535.x
    35 https://doi.org/10.1111/j.1753-4887.2008.00100.x
    36 https://doi.org/10.1126/science.6281884
    37 https://doi.org/10.1136/adc.2009.173195
    38 https://doi.org/10.1136/adc.81.1.10
    39 https://doi.org/10.1155/2014/583039
    40 https://doi.org/10.1159/000343446
    41 https://doi.org/10.1172/jci29449
    42 https://doi.org/10.1210/jc.2005-1436
    43 https://doi.org/10.1210/jc.2007-2530
    44 https://doi.org/10.1210/jc.2010-2704
    45 https://doi.org/10.1210/jc.2011-0385
    46 https://doi.org/10.1210/jc.2011-2601
    47 https://doi.org/10.1210/jc.2013-2728
    48 https://doi.org/10.1210/jc.2017-01179
    49 https://doi.org/10.1210/jcem-67-2-373
    50 https://doi.org/10.1210/jcem-68-5-882
    51 https://doi.org/10.1359/jbmr.060302
    52 https://doi.org/10.1373/clinchem.2009.139253
    53 https://doi.org/10.1503/cmaj.1070102
    54 https://doi.org/10.1530/eje-13-0233
    55 https://doi.org/10.1542/peds.2008-1862
    56 https://doi.org/10.1542/peds.2008-2041
    57 https://doi.org/10.1542/peds.2009-0051
    58 https://doi.org/10.1542/peds.2012-1711
    59 https://doi.org/10.1542/peds.2014-2173
    60 https://doi.org/10.2903/j.efsa.2012.2813
    61 https://doi.org/10.3390/nu6104472
    62 https://doi.org/10.3945/ajcn.112.046102
    63 https://doi.org/10.3945/ajcn.115.120873
    64 https://doi.org/10.3945/jn.110.124891
    65 https://doi.org/10.4081/reumatismo.2011.129
    66 https://doi.org/10.5603/ep.2013.0012
    67 https://doi.org/10.9734/bjmmr/2014/4370
    68 schema:datePublished 2019-12
    69 schema:datePublishedReg 2019-12-01
    70 schema:description BACKGROUND: The appropriate dose of vitamin D supplementation in children is still debated. We calculated that the recommended dose of 600-1000 IU vitamin D3/day is not sufficient to reach a serum 25-hydroxyvitamin D (25-OH-D) level of at least 30 ng/ml (75 nmol/l) in north Italian children > 12 months. The aim of this study was to analyse the effect of seasonal supplementation with 1500 IU (=37.5 μg) vitamin D3/day. METHODS: DINOS (D-vitamIN Oral Supplementation) study was a pilot, monocentric, non-random case-control register study. It was conducted in a paediatric primary care setting near Padova (North Italy, 45°N latitude). The data of 203 children (girls:boys 1:1,33) aged 2-15 years, collected between November 2010 and January 2015, were analysed. Active group A (n = 82) were given 1500 IU vitamin D3/day from November to April; control Group B (n = 121) received no supplementation. The serum 25-OH-D test was part of a laboratory tests panel and performed using a chemiluminescence immunoassay method. RESULTS: Serum 25-OH-D mean level + standard deviation throughout the period was 32 + 13 ng/ml (80 + 32 nmol/l) in group A vs 22 + 10 ng/ml (55 + 25 nmol/l) in group B. In group A 12% had vitamin D deficiency 25-OH-D < 20 ng/ml (50 nmol/l) and 1.2% severe vitamin D deficiency 25-OH-D < 10 ng/ml (25 nmol/l). In group B 46% had vitamin D deficiency and 9% severe deficiency (P <  0.001). In group A mean levels were normal or near-normal all the year except in May. Group B reached mean 25-OH-D levels close to 30 ng/ml (75 nmol/l) only in late summer. The active group mean 25-OH-D level was normal in preschoolers and schoolers but not in adolescents. Non-white children had a three-times vitamin D deficiency probability despite supplementation. CONCLUSIONS: Vitamin D supplementation with at least 1500 IU vitamin D3/day from November to April was found appropriate for children in North Italy. A prolongation until May could be useful. Higher doses and/or prolonged periods could be more appropriate especially in adolescents and in non-white children. STUDY REGISTRATION: DINOS gained the approval of Padova Ethics Committee (n. 3960/U16/2016).
    71 schema:genre research_article
    72 schema:inLanguage en
    73 schema:isAccessibleForFree true
    74 schema:isPartOf N23dbd014117d4520aa9b62002c6071d0
    75 N69a8b12879e84f0890e107ee6c9f9b55
    76 sg:journal.1320494
    77 schema:name Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study)
    78 schema:pagination 18
    79 schema:productId N13c6a6270a794590988f663dbe0c9a0d
    80 N307e4812159847d0b12ee3d3c67bf268
    81 N3bd0804c638d4e3799b9e46d259ce818
    82 Nc1d5b09b3e5f4141b97352f621639e71
    83 Nd5ccccb3a9954e569f8462f44b906b29
    84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111750581
    85 https://doi.org/10.1186/s13052-018-0590-x
    86 schema:sdDatePublished 2019-04-11T09:00
    87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    88 schema:sdPublisher N7284614edb604ae093228dc7468ae1d2
    89 schema:url https://link.springer.com/10.1186%2Fs13052-018-0590-x
    90 sgo:license sg:explorer/license/
    91 sgo:sdDataset articles
    92 rdf:type schema:ScholarlyArticle
    93 N10fed187ccf44e658535a8e9a3de0414 rdf:first Nf91cd378945f4d6aa8ad7dd40a1d79c2
    94 rdf:rest N9a9c262941d74af294bde6ed80113533
    95 N13c6a6270a794590988f663dbe0c9a0d schema:name doi
    96 schema:value 10.1186/s13052-018-0590-x
    97 rdf:type schema:PropertyValue
    98 N23dbd014117d4520aa9b62002c6071d0 schema:volumeNumber 45
    99 rdf:type schema:PublicationVolume
    100 N307e4812159847d0b12ee3d3c67bf268 schema:name nlm_unique_id
    101 schema:value 101510759
    102 rdf:type schema:PropertyValue
    103 N3228164eb73a4aed92e125f0c2b3d638 schema:name Endocrinologist and General Practitioner Azienda ULSS 6 Euganea Regione Veneto, Studio via Benizzi 6, Padova, Italy
    104 rdf:type schema:Organization
    105 N340a3c26aeee4e08bdf0d9a73dcf2af0 schema:affiliation Nfd262fd652f14f6c83d760461e7ccc7c
    106 schema:familyName Mazzoleni
    107 schema:givenName Stefano
    108 rdf:type schema:Person
    109 N3bd0804c638d4e3799b9e46d259ce818 schema:name readcube_id
    110 schema:value 3d8a1b306d34af1389f4a90f3ced5a1fcb105e5360734ab99e2e725ca7f6fa71
    111 rdf:type schema:PropertyValue
    112 N69a8b12879e84f0890e107ee6c9f9b55 schema:issueNumber 1
    113 rdf:type schema:PublicationIssue
    114 N7284614edb604ae093228dc7468ae1d2 schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 N9a9c262941d74af294bde6ed80113533 rdf:first Na2a8b6723ee44dd7ac77c14f9c2a2fe8
    117 rdf:rest rdf:nil
    118 Na2a8b6723ee44dd7ac77c14f9c2a2fe8 schema:affiliation N3228164eb73a4aed92e125f0c2b3d638
    119 schema:familyName Toderini
    120 schema:givenName Daniela
    121 rdf:type schema:Person
    122 Nc1d5b09b3e5f4141b97352f621639e71 schema:name dimensions_id
    123 schema:value pub.1111750581
    124 rdf:type schema:PropertyValue
    125 Nd5ccccb3a9954e569f8462f44b906b29 schema:name pubmed_id
    126 schema:value 30691521
    127 rdf:type schema:PropertyValue
    128 Nd6291c7a84824a24916544dbdced0722 rdf:first N340a3c26aeee4e08bdf0d9a73dcf2af0
    129 rdf:rest N10fed187ccf44e658535a8e9a3de0414
    130 Nf91cd378945f4d6aa8ad7dd40a1d79c2 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
    131 schema:familyName Magni
    132 schema:givenName Giovanna
    133 rdf:type schema:Person
    134 Nfd262fd652f14f6c83d760461e7ccc7c schema:name Primary Care Paediatrician Azienda ULSS 6 Euganea Regione Veneto, Polistudio Pediatrico, via D’Annunzio 3/A, Piove di Sacco, Padova, Italy
    135 rdf:type schema:Organization
    136 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    137 schema:name Medical and Health Sciences
    138 rdf:type schema:DefinedTerm
    139 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    140 schema:name Public Health and Health Services
    141 rdf:type schema:DefinedTerm
    142 sg:journal.1320494 schema:issn 1720-8424
    143 1824-7288
    144 schema:name Italian Journal of Pediatrics
    145 rdf:type schema:Periodical
    146 sg:pub.10.1007/bf03344156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042579000
    147 https://doi.org/10.1007/bf03344156
    148 rdf:type schema:CreativeWork
    149 sg:pub.10.1007/s00394-011-0200-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049034304
    150 https://doi.org/10.1007/s00394-011-0200-9
    151 rdf:type schema:CreativeWork
    152 sg:pub.10.1007/s00431-013-2119-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1001911367
    153 https://doi.org/10.1007/s00431-013-2119-z
    154 rdf:type schema:CreativeWork
    155 sg:pub.10.1007/s00431-014-2451-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015243578
    156 https://doi.org/10.1007/s00431-014-2451-y
    157 rdf:type schema:CreativeWork
    158 sg:pub.10.1007/s12020-015-0725-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040362544
    159 https://doi.org/10.1007/s12020-015-0725-4
    160 rdf:type schema:CreativeWork
    161 sg:pub.10.1007/s13312-011-0107-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018110742
    162 https://doi.org/10.1007/s13312-011-0107-9
    163 rdf:type schema:CreativeWork
    164 sg:pub.10.1007/s40618-014-0108-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030257664
    165 https://doi.org/10.1007/s40618-014-0108-3
    166 rdf:type schema:CreativeWork
    167 sg:pub.10.1038/ejcn.2013.48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043887477
    168 https://doi.org/10.1038/ejcn.2013.48
    169 rdf:type schema:CreativeWork
    170 sg:pub.10.1186/1471-2431-13-86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024360731
    171 https://doi.org/10.1186/1471-2431-13-86
    172 rdf:type schema:CreativeWork
    173 sg:pub.10.1186/1824-7288-40-54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033007974
    174 https://doi.org/10.1186/1824-7288-40-54
    175 rdf:type schema:CreativeWork
    176 sg:pub.10.1186/s13052-018-0488-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103880018
    177 https://doi.org/10.1186/s13052-018-0488-7
    178 rdf:type schema:CreativeWork
    179 sg:pub.10.3275/8263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078513705
    180 https://doi.org/10.3275/8263
    181 rdf:type schema:CreativeWork
    182 https://app.dimensions.ai/details/publication/pub.1078756906 schema:CreativeWork
    183 https://doi.org/10.1001/archpedi.158.6.531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040872080
    184 rdf:type schema:CreativeWork
    185 https://doi.org/10.1002/sim.4780111005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018381687
    186 rdf:type schema:CreativeWork
    187 https://doi.org/10.1016/j.arcped.2011.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016272215
    188 rdf:type schema:CreativeWork
    189 https://doi.org/10.1016/j.arcped.2014.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042444258
    190 rdf:type schema:CreativeWork
    191 https://doi.org/10.1016/j.bone.2009.08.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010714275
    192 rdf:type schema:CreativeWork
    193 https://doi.org/10.1016/j.jadohealth.2013.03.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049178086
    194 rdf:type schema:CreativeWork
    195 https://doi.org/10.1016/s0140-6736(15)60745-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003118381
    196 rdf:type schema:CreativeWork
    197 https://doi.org/10.1017/s0007114511003527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033390288
    198 rdf:type schema:CreativeWork
    199 https://doi.org/10.1038/oby.2007.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050142805
    200 rdf:type schema:CreativeWork
    201 https://doi.org/10.1056/nejmra070553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023249044
    202 rdf:type schema:CreativeWork
    203 https://doi.org/10.1080/02640414.2013.847279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025473399
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1093/ajcn/86.1.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077442447
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1093/ajcn/87.4.1080s schema:sameAs https://app.dimensions.ai/details/publication/pub.1077631701
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1093/pch/12.7.583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077813550
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1097/bpo.0000000000000587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013534795
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1097/mpg.0b013e31828f3c05 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035559591
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1111/j.1651-2227.1988.tb10604.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020780725
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1111/j.1651-2227.2003.tb02535.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030400706
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1111/j.1753-4887.2008.00100.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031787933
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1126/science.6281884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036208440
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1136/adc.2009.173195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016218621
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1136/adc.81.1.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028469805
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1155/2014/583039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035532522
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1159/000343446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019800029
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1172/jci29449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007147707
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1210/jc.2005-1436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288674
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1210/jc.2007-2530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064290400
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1210/jc.2010-2704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292573
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1210/jc.2011-0385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029888078
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1210/jc.2011-2601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064293170
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1210/jc.2013-2728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064294517
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1210/jc.2017-01179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092017792
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1210/jcem-67-2-373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064315269
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1210/jcem-68-5-882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064315584
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1359/jbmr.060302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049129693
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1373/clinchem.2009.139253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032850219
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1503/cmaj.1070102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007475368
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1530/eje-13-0233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052620936
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1542/peds.2008-1862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004155930
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1542/peds.2008-2041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067827306
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1542/peds.2009-0051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067827719
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1542/peds.2012-1711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003200278
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1542/peds.2014-2173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034946115
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.2903/j.efsa.2012.2813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037691216
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.3390/nu6104472 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034433144
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.3945/ajcn.112.046102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045511456
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.3945/ajcn.115.120873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052796874
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.3945/jn.110.124891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015701748
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.4081/reumatismo.2011.129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006604613
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.5603/ep.2013.0012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073037486
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.9734/bjmmr/2014/4370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074133429
    284 rdf:type schema:CreativeWork
    285 https://www.grid.ac/institutes/grid.419546.b schema:alternateName Istituto Oncologico Veneto
    286 schema:name Senior Biostatistician, NRC Azienda Ospedaliera Padova, Padova, Italy
    287 Unità di Ricerca Clinica, Istituto Oncologico Veneto, Padova, Italy
    288 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...