A comparison of the effect of xinruibai versus filgrastim on hematopoietic reconstruction after allogeneic hematopoietic stem cell transplantation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Qixiang Ye, Hebi Jiang, Hua Jiang

ABSTRACT

BACKGROUND: To compare the effect of xinruibai (Pegfilgrastim) and filgrastim injections on white blood cell and platelet (PLT) recovery, adverse events, post-operative complications, and cost effectiveness after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS: Children who underwent allo-HSCT at our hospital from January 2014 to May 2017 due to thalassemia major, aplastic anemia, leukemia, and mucopolysaccharidosis were included. Among the children, 53 received xinruibai injections and 33 received filgrastim injections. RESULTS: There were no significant differences in the average time to neutrophil and platelet recovery, the incidence of post-operative complications after allo-HSCT, the number of red blood cell and PLT infusions, or the incidence of adverse events related to the injection between two groups (P > 0.05). The pain score was 3.06 (SD 0.41) for the xinruibai group and 25.18 (SD 6.22) for the filgrastim group, indicating significant differences between the two groups (P < 0.001). No difference was found in the hospitalization cost. The cost of the granulocyte-colony stimulating factor (G-CSF) was 257.11 ± 61.87 Euro in the xinruibai group and 214.79 ± 0.00 Euro in the filgrastim group, showing significant difference (P < 0.001). CONCLUSIONS: Xinruibai injection was more convenient, simple, effective, and safer than filgrastim. More... »

PAGES

63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13052-018-0482-0

DOI

http://dx.doi.org/10.1186/s13052-018-0482-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104331315

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29855330


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