Epidemiological and clinical aspects of autoimmune thyroid diseases in children with Down’s syndrome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Tommaso Aversa, Giuseppe Crisafulli, Giuseppina Zirilli, Filippo De Luca, Romina Gallizzi, Mariella Valenzise

ABSTRACT

Aim of this commentary is to report the main peculiarities that have been found to characterize the phenotypic expression of autoimmune thyroid diseases (AITDs) in children with Down's syndrome (DS). According to recent reports, DS children are, per se, more exposed to the risk of both Hashimoto's thyroiditis (HT) and Graves' disease (GD), irrespective of other concomitant risk factors, such as female gender and family antecedents for AITDs. In the context of extra-thyroidal autoimmune disorders, the ones that preferentially aggregate with AITDs in DS children are alopecia areata and vitiligo. Another peculiar aspect, in DS children, is that HT presents with a more severe biochemical picture, which furtherly deteriorates over time. By contrast, GD does not demonstrate a more severe clinical and biochemical picture with respect to that generally observed in patients without DS. Finally, DS children might be at higher risk of progressing from HT toward GD over time. More... »

PAGES

39

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13052-018-0478-9

DOI

http://dx.doi.org/10.1186/s13052-018-0478-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101672026

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29562915


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmune Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comorbidity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Graves Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hashimoto Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Italy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Severity of Illness Index", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aversa", 
        "givenName": "Tommaso", 
        "id": "sg:person.01144253205.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144253205.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crisafulli", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01065207421.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065207421.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zirilli", 
        "givenName": "Giuseppina", 
        "id": "sg:person.01355676043.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355676043.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Luca", 
        "givenName": "Filippo", 
        "id": "sg:person.0661303231.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661303231.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gallizzi", 
        "givenName": "Romina", 
        "id": "sg:person.0731702171.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731702171.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Messina", 
          "id": "https://www.grid.ac/institutes/grid.10438.3e", 
          "name": [
            "Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valenzise", 
        "givenName": "Mariella", 
        "id": "sg:person.0702645621.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702645621.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s13052-015-0146-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002234247", 
          "https://doi.org/10.1186/s13052-015-0146-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13052-015-0146-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002234247", 
          "https://doi.org/10.1186/s13052-015-0146-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13052-015-0197-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004155883", 
          "https://doi.org/10.1186/s13052-015-0197-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-09-0751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009865817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010555834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.27270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010555834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03346582", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012661459", 
          "https://doi.org/10.1007/bf03346582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1824-7288-39-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013493711", 
          "https://doi.org/10.1186/1824-7288-39-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2008.03419.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017073596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11845-013-0994-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019187757", 
          "https://doi.org/10.1007/s11845-013-0994-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11845-013-0994-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019187757", 
          "https://doi.org/10.1007/s11845-013-0994-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00431-008-0736-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023388326", 
          "https://doi.org/10.1007/s00431-008-0736-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1442-200x.2006.02238.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026216909"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/17446651.2015.1063995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029002857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/jpem-2016-0073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029888503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000157874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031731531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bdra.20294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033505666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-5448.2008.00355.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034012580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/pr.2013.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035122476", 
          "https://doi.org/10.1038/pr.2013.26"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)12987-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037058746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)12987-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037058746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc12-1712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037512685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042737-200103000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037911247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00042737-200103000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037911247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ecl.2012.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041090848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1568-9972(03)00006-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041292164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1568-9972(03)00006-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041292164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000313395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043217899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2013.0452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044204449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000334640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045753179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-15-0484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046020820"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13052-016-0322-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053622328", 
          "https://doi.org/10.1186/s13052-016-0322-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13052-016-0322-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053622328", 
          "https://doi.org/10.1186/s13052-016-0322-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2008.1551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059320483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/thy.2012.0374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059321509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.14310/horm.2002.1574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067262490", 
          "https://doi.org/10.14310/horm.2002.1574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3275/6402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077922853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1400742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078944044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1400223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078971816"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "Aim of this commentary is to report the main peculiarities that have been found to characterize the phenotypic expression of autoimmune thyroid diseases (AITDs) in children with Down's syndrome (DS). According to recent reports, DS children are, per se, more exposed to the risk of both Hashimoto's thyroiditis (HT) and Graves' disease (GD), irrespective of other concomitant risk factors, such as female gender and family antecedents for AITDs. In the context of extra-thyroidal autoimmune disorders, the ones that preferentially aggregate with AITDs in DS children are alopecia areata and vitiligo. Another peculiar aspect, in DS children, is that HT presents with a more severe biochemical picture, which furtherly deteriorates over time. By contrast, GD does not demonstrate a more severe clinical and biochemical picture with respect to that generally observed in patients without DS. Finally, DS children might be at higher risk of progressing from HT toward GD over time.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13052-018-0478-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1320494", 
        "issn": [
          "1720-8424", 
          "1824-7288"
        ], 
        "name": "Italian Journal of Pediatrics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "44"
      }
    ], 
    "name": "Epidemiological and clinical aspects of autoimmune thyroid diseases in children with Down\u2019s syndrome", 
    "pagination": "39", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "10ed978e9bf450fbd2e2e4ccb3da238024fc43eca95281486dbac0c777159441"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29562915"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101510759"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13052-018-0478-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101672026"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13052-018-0478-9", 
      "https://app.dimensions.ai/details/publication/pub.1101672026"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:43", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70064_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13052-018-0478-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0478-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0478-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0478-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13052-018-0478-9'


 

This table displays all metadata directly associated to this object as RDF triples.

265 TRIPLES      21 PREDICATES      75 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13052-018-0478-9 schema:about N0733dc43421547daaeeec80aa2a6d071
2 N2541b84c7fdb47f39d5d4cef5d6d7297
3 N270733bbf2c2411a9eb90f21b0569120
4 N27dd3cc1d0dd4164b83654fb21ccf094
5 N2853f5392e14406fadf1edeaffc6f66b
6 N5b9b28c7383542a08e16709bfe30e50b
7 N6d331e760a434913802a4c6bbea913da
8 N88bcd6ff794748cabfd7aeeb23fddfbe
9 N93732ef0a7e849a286255a25fb9a3ebf
10 Na669058bcb4f496cbe0e13a6adead02f
11 Naa040bfe7e534bdeaaabe3c9e67271b1
12 Nbb1b4eb6ddae44f59d7805da8488f67f
13 Nd3a84f42bbdb4893900af3caa3c50d78
14 Ndbeb8f82a907468b86a895a26e511575
15 anzsrc-for:11
16 anzsrc-for:1117
17 schema:author Na69f026637874de79cf92111a609e022
18 schema:citation sg:pub.10.1007/bf03346582
19 sg:pub.10.1007/s00431-008-0736-8
20 sg:pub.10.1007/s11845-013-0994-y
21 sg:pub.10.1038/pr.2013.26
22 sg:pub.10.1186/1824-7288-39-8
23 sg:pub.10.1186/s13052-015-0146-2
24 sg:pub.10.1186/s13052-015-0197-4
25 sg:pub.10.1186/s13052-016-0322-z
26 sg:pub.10.14310/horm.2002.1574
27 https://doi.org/10.1002/art.27270
28 https://doi.org/10.1002/bdra.20294
29 https://doi.org/10.1016/j.ecl.2012.08.008
30 https://doi.org/10.1016/s0140-6736(03)12987-x
31 https://doi.org/10.1016/s1568-9972(03)00006-5
32 https://doi.org/10.1089/thy.2008.1551
33 https://doi.org/10.1089/thy.2012.0374
34 https://doi.org/10.1089/thy.2013.0452
35 https://doi.org/10.1097/00042737-200103000-00008
36 https://doi.org/10.1111/j.1365-2265.2008.03419.x
37 https://doi.org/10.1111/j.1399-5448.2008.00355.x
38 https://doi.org/10.1111/j.1442-200x.2006.02238.x
39 https://doi.org/10.1159/000157874
40 https://doi.org/10.1159/000313395
41 https://doi.org/10.1159/000334640
42 https://doi.org/10.1515/jpem-2016-0073
43 https://doi.org/10.1530/eje-09-0751
44 https://doi.org/10.1530/eje-15-0484
45 https://doi.org/10.1586/17446651.2015.1063995
46 https://doi.org/10.2337/dc12-1712
47 https://doi.org/10.3275/6402
48 https://doi.org/10.4049/jimmunol.1400223
49 https://doi.org/10.4049/jimmunol.1400742
50 schema:datePublished 2018-12
51 schema:datePublishedReg 2018-12-01
52 schema:description Aim of this commentary is to report the main peculiarities that have been found to characterize the phenotypic expression of autoimmune thyroid diseases (AITDs) in children with Down's syndrome (DS). According to recent reports, DS children are, per se, more exposed to the risk of both Hashimoto's thyroiditis (HT) and Graves' disease (GD), irrespective of other concomitant risk factors, such as female gender and family antecedents for AITDs. In the context of extra-thyroidal autoimmune disorders, the ones that preferentially aggregate with AITDs in DS children are alopecia areata and vitiligo. Another peculiar aspect, in DS children, is that HT presents with a more severe biochemical picture, which furtherly deteriorates over time. By contrast, GD does not demonstrate a more severe clinical and biochemical picture with respect to that generally observed in patients without DS. Finally, DS children might be at higher risk of progressing from HT toward GD over time.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N0384c89b2350442d827c0c41ed8e18cd
57 N13ebca49663f43468dbc537a8ed34ac0
58 sg:journal.1320494
59 schema:name Epidemiological and clinical aspects of autoimmune thyroid diseases in children with Down’s syndrome
60 schema:pagination 39
61 schema:productId N2104bbe41b5f4b9ab285a455ec275a88
62 N4f36023c345246d9883bbc9a1a00b2e5
63 N7cc3e33bb42a437dbfdf13c339ef9fdc
64 N7fe58961dbb04600b4b4f3c14273758c
65 N99ec50c9a92b4c018f70d6252e1c196f
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101672026
67 https://doi.org/10.1186/s13052-018-0478-9
68 schema:sdDatePublished 2019-04-11T12:43
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N2017ca908a964e07aefe56eae5f3bbc1
71 schema:url https://link.springer.com/10.1186%2Fs13052-018-0478-9
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0384c89b2350442d827c0c41ed8e18cd schema:volumeNumber 44
76 rdf:type schema:PublicationVolume
77 N0733dc43421547daaeeec80aa2a6d071 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Hashimoto Disease
79 rdf:type schema:DefinedTerm
80 N13ebca49663f43468dbc537a8ed34ac0 schema:issueNumber 1
81 rdf:type schema:PublicationIssue
82 N2017ca908a964e07aefe56eae5f3bbc1 schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N2104bbe41b5f4b9ab285a455ec275a88 schema:name pubmed_id
85 schema:value 29562915
86 rdf:type schema:PropertyValue
87 N2541b84c7fdb47f39d5d4cef5d6d7297 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Prognosis
89 rdf:type schema:DefinedTerm
90 N270733bbf2c2411a9eb90f21b0569120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Comorbidity
92 rdf:type schema:DefinedTerm
93 N27dd3cc1d0dd4164b83654fb21ccf094 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Child
95 rdf:type schema:DefinedTerm
96 N2853f5392e14406fadf1edeaffc6f66b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Female
98 rdf:type schema:DefinedTerm
99 N2dd7f63915fe4838b5a710396e74198d rdf:first sg:person.0661303231.40
100 rdf:rest Nf107bd5032ce48a2a89a931a9e001812
101 N4f36023c345246d9883bbc9a1a00b2e5 schema:name doi
102 schema:value 10.1186/s13052-018-0478-9
103 rdf:type schema:PropertyValue
104 N5b9b28c7383542a08e16709bfe30e50b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Graves Disease
106 rdf:type schema:DefinedTerm
107 N6d331e760a434913802a4c6bbea913da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Italy
109 rdf:type schema:DefinedTerm
110 N7cc3e33bb42a437dbfdf13c339ef9fdc schema:name nlm_unique_id
111 schema:value 101510759
112 rdf:type schema:PropertyValue
113 N7fe58961dbb04600b4b4f3c14273758c schema:name readcube_id
114 schema:value 10ed978e9bf450fbd2e2e4ccb3da238024fc43eca95281486dbac0c777159441
115 rdf:type schema:PropertyValue
116 N88bcd6ff794748cabfd7aeeb23fddfbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Risk Factors
118 rdf:type schema:DefinedTerm
119 N93732ef0a7e849a286255a25fb9a3ebf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Down Syndrome
121 rdf:type schema:DefinedTerm
122 N980d3cb84c3249d1bc6cc8f8704caf43 rdf:first sg:person.01355676043.54
123 rdf:rest N2dd7f63915fe4838b5a710396e74198d
124 N99ec50c9a92b4c018f70d6252e1c196f schema:name dimensions_id
125 schema:value pub.1101672026
126 rdf:type schema:PropertyValue
127 Na669058bcb4f496cbe0e13a6adead02f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Incidence
129 rdf:type schema:DefinedTerm
130 Na69f026637874de79cf92111a609e022 rdf:first sg:person.01144253205.54
131 rdf:rest Nb2a685c38a674057a2ae62c49fa489d2
132 Naa040bfe7e534bdeaaabe3c9e67271b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Humans
134 rdf:type schema:DefinedTerm
135 Nb2a685c38a674057a2ae62c49fa489d2 rdf:first sg:person.01065207421.05
136 rdf:rest N980d3cb84c3249d1bc6cc8f8704caf43
137 Nbb1b4eb6ddae44f59d7805da8488f67f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Autoimmune Diseases
139 rdf:type schema:DefinedTerm
140 Ncbd027eed8c94fbc9dc396b105dadfdd rdf:first sg:person.0702645621.45
141 rdf:rest rdf:nil
142 Nd3a84f42bbdb4893900af3caa3c50d78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Severity of Illness Index
144 rdf:type schema:DefinedTerm
145 Ndbeb8f82a907468b86a895a26e511575 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Male
147 rdf:type schema:DefinedTerm
148 Nf107bd5032ce48a2a89a931a9e001812 rdf:first sg:person.0731702171.48
149 rdf:rest Ncbd027eed8c94fbc9dc396b105dadfdd
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
154 schema:name Public Health and Health Services
155 rdf:type schema:DefinedTerm
156 sg:journal.1320494 schema:issn 1720-8424
157 1824-7288
158 schema:name Italian Journal of Pediatrics
159 rdf:type schema:Periodical
160 sg:person.01065207421.05 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
161 schema:familyName Crisafulli
162 schema:givenName Giuseppe
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065207421.05
164 rdf:type schema:Person
165 sg:person.01144253205.54 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
166 schema:familyName Aversa
167 schema:givenName Tommaso
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144253205.54
169 rdf:type schema:Person
170 sg:person.01355676043.54 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
171 schema:familyName Zirilli
172 schema:givenName Giuseppina
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355676043.54
174 rdf:type schema:Person
175 sg:person.0661303231.40 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
176 schema:familyName De Luca
177 schema:givenName Filippo
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661303231.40
179 rdf:type schema:Person
180 sg:person.0702645621.45 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
181 schema:familyName Valenzise
182 schema:givenName Mariella
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702645621.45
184 rdf:type schema:Person
185 sg:person.0731702171.48 schema:affiliation https://www.grid.ac/institutes/grid.10438.3e
186 schema:familyName Gallizzi
187 schema:givenName Romina
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731702171.48
189 rdf:type schema:Person
190 sg:pub.10.1007/bf03346582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012661459
191 https://doi.org/10.1007/bf03346582
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/s00431-008-0736-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023388326
194 https://doi.org/10.1007/s00431-008-0736-8
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s11845-013-0994-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1019187757
197 https://doi.org/10.1007/s11845-013-0994-y
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/pr.2013.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035122476
200 https://doi.org/10.1038/pr.2013.26
201 rdf:type schema:CreativeWork
202 sg:pub.10.1186/1824-7288-39-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013493711
203 https://doi.org/10.1186/1824-7288-39-8
204 rdf:type schema:CreativeWork
205 sg:pub.10.1186/s13052-015-0146-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002234247
206 https://doi.org/10.1186/s13052-015-0146-2
207 rdf:type schema:CreativeWork
208 sg:pub.10.1186/s13052-015-0197-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004155883
209 https://doi.org/10.1186/s13052-015-0197-4
210 rdf:type schema:CreativeWork
211 sg:pub.10.1186/s13052-016-0322-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1053622328
212 https://doi.org/10.1186/s13052-016-0322-z
213 rdf:type schema:CreativeWork
214 sg:pub.10.14310/horm.2002.1574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067262490
215 https://doi.org/10.14310/horm.2002.1574
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/art.27270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010555834
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/bdra.20294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033505666
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.ecl.2012.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041090848
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0140-6736(03)12987-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037058746
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s1568-9972(03)00006-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041292164
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1089/thy.2008.1551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059320483
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1089/thy.2012.0374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059321509
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1089/thy.2013.0452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044204449
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1097/00042737-200103000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037911247
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/j.1365-2265.2008.03419.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017073596
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1111/j.1399-5448.2008.00355.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034012580
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1111/j.1442-200x.2006.02238.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026216909
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1159/000157874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031731531
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1159/000313395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043217899
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1159/000334640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045753179
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1515/jpem-2016-0073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029888503
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1530/eje-09-0751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009865817
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1530/eje-15-0484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046020820
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1586/17446651.2015.1063995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029002857
254 rdf:type schema:CreativeWork
255 https://doi.org/10.2337/dc12-1712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037512685
256 rdf:type schema:CreativeWork
257 https://doi.org/10.3275/6402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077922853
258 rdf:type schema:CreativeWork
259 https://doi.org/10.4049/jimmunol.1400223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078971816
260 rdf:type schema:CreativeWork
261 https://doi.org/10.4049/jimmunol.1400742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078944044
262 rdf:type schema:CreativeWork
263 https://www.grid.ac/institutes/grid.10438.3e schema:alternateName University of Messina
264 schema:name Department of Human Pathology in Adulthood and Childhood, University of Messina, Via Consolare Valeria, 98124, Messina, Italy
265 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...