Changes in anaesthetic use for trauma patients in German HEMS – a retrospective study over a ten-year period View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Arasch Wafaisade, Michael Caspers, Bertil Bouillon, Matthias Helm, Matthias Ruppert, Michael Gäßler

ABSTRACT

BACKGROUND: Airway management and use of intravenous anaesthetics to facilitate tracheal intubation after major trauma remains controversial. Numerous agents are available and used for pre-hospital rapid-sequence induction (RSI). The aim was to investigate usage and potential changes in administration of intravenous anaesthetics for pre-hospital RSI in trauma patients over a ten-year period. METHODS: Based on a large helicopter emergency medical service (HEMS) database in Germany between 2006 and 2015, a total of 9720 HEMS missions after major trauma leading to RSI on scene were analysed. Administration practice of sedatives and opioids were investigated, while neuromuscular blocking agents were not documented in the database. RESULTS: With respect to administration of sedatives, independent from trauma mechanism and specific injury patterns the use of Etomidate decreased dramatically (52 to 6%) in favour of a more frequent use of Propofol (3 to 32%) and Ketamine (9 to 24%; all p < 0.001) from 2006 to 2015. The use of Benzodiazepines increased slightly, while the utilization rate of Barbiturates remained constant. In patients with Shock Index > 1 at initial contact, the administration rate of Etomidate dropped significantly as well. This decline was mainly substituted by Ketamine and particularly Propofol. In patients with GCS ≤ 8 upon initial contact, a similar distribution compared to the general trauma population could be observed. With respect to opioids, mainly Fentanyl has been administered for RSI in trauma patients (2006: 69,6% to 2015: 60.2%; p < 0.001), while the use of sufentanyl showed a significant increase (0.2 to 8.8%; p < 0.001). CONCLUSIONS: This large study analysed prehospital administration of anaesthetics in trauma patients, showing a substantial change from 2006 to 2015 despite the lack of any high-level evidence. Etomidate has shifted from the main sedative substance to virtual absence, indicating that the recommendation of an established national guideline was transferred into clinical practice, although based on weak evidence as well. The pre-hospital use of Propofol showed a particular increase. Fentanyl has been the main opioid drug for RSI in trauma, however Sufentanyl has become increasingly popular. The mechanisms and advantages of the different substances still have to be elucidated, especially in head injury and bleeding trauma. More... »

PAGES

23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13049-019-0603-9

DOI

http://dx.doi.org/10.1186/s13049-019-0603-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112392812

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30808371


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Witten/Herdecke University", 
          "id": "https://www.grid.ac/institutes/grid.412581.b", 
          "name": [
            "Department of Traumatology and Orthopaedic Surgery, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wafaisade", 
        "givenName": "Arasch", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Witten/Herdecke University", 
          "id": "https://www.grid.ac/institutes/grid.412581.b", 
          "name": [
            "Department of Traumatology and Orthopaedic Surgery, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109, Cologne, Germany", 
            "The Institute for Research in Operative Medicine, Faculty of Health, Department of Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caspers", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Witten/Herdecke University", 
          "id": "https://www.grid.ac/institutes/grid.412581.b", 
          "name": [
            "Department of Traumatology and Orthopaedic Surgery, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109, Cologne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouillon", 
        "givenName": "Bertil", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Armed Forces Medical Centre Ulm, Department of Anaesthesiology and Intensive Care Medicine, Section Emergency Medicine \u2013 HEMS \u201cChristoph 22\u201d, Oberer Eselsberg 40, 89081, Ulm, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Helm", 
        "givenName": "Matthias", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Allgemeiner Deutscher Automobil Club", 
          "id": "https://www.grid.ac/institutes/grid.432059.9", 
          "name": [
            "Department of Medicine \u2013 ADAC Air Rescue Service, Hansastrasse 19, 80686, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ruppert", 
        "givenName": "Matthias", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Allgemeiner Deutscher Automobil Club", 
          "id": "https://www.grid.ac/institutes/grid.432059.9", 
          "name": [
            "Department of Medicine \u2013 ADAC Air Rescue Service, Hansastrasse 19, 80686, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00e4\u00dfler", 
        "givenName": "Michael", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.injury.2014.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000722176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12630-014-0161-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003878495", 
          "https://doi.org/10.1007/s12630-014-0161-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-6576.2008.01673.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007207385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-6576.2008.01673.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007207385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181bbf728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008750728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181bbf728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008750728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181bbf728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008750728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)60949-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009990488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200309000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013441361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200309000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013441361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-200309000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013441361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181a92a70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015172053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181a92a70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015172053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181a92a70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015172053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-004-2550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015414379", 
          "https://doi.org/10.1007/s00134-004-2550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-004-2550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015414379", 
          "https://doi.org/10.1007/s00134-004-2550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/cns.12072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015626554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd010225.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018985251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001503-200110000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021248096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181fec9ba", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025861162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e3181fec9ba", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025861162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ede.0b013e3181577654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027581622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ede.0b013e3181577654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027581622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03011034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027988762", 
          "https://doi.org/10.1007/bf03011034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03011034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027988762", 
          "https://doi.org/10.1007/bf03011034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000044505.24727.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028592997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000044505.24727.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028592997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bja/44.11.1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028899759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199302000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030224906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005373-199302000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030224906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.143.1.62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031328826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/201570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033398912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-197201000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034425268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000542-197201000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034425268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13049-015-0136-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035603860", 
          "https://doi.org/10.1186/s13049-015-0136-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.136.10.1118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036649100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40140-014-0066-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038685240", 
          "https://doi.org/10.1007/s40140-014-0066-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000162491.26292.98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039036539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000162491.26292.98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039036539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000162491.26292.98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039036539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jramc-156-04s-04", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039944736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jramc-156-04s-04", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039944736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0872-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044903714", 
          "https://doi.org/10.1186/s13054-015-0872-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0872-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044903714", 
          "https://doi.org/10.1186/s13054-015-0872-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-015-0872-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044903714", 
          "https://doi.org/10.1186/s13054-015-0872-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1060028013510488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045306472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1060028013510488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045306472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aco.0b013e328362a84c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046910550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aco.0b013e328362a84c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046910550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/postgradmedj-2010-74245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047122811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/postgradmedj-2010-74245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047122811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.annemergmed.2016.08.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048497266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e31815078ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051370306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ta.0b013e31815078ae", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051370306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.annemergmed.2016.03.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052167600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jss.2011.03.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052731957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem-59-6-1143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064313555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3238/arztebl.2012.0849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078665779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082705662", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Airway management and use of intravenous anaesthetics to facilitate tracheal intubation after major trauma remains controversial. Numerous agents are available and used for pre-hospital rapid-sequence induction (RSI). The aim was to investigate usage and potential changes in administration of intravenous anaesthetics for pre-hospital RSI in trauma patients over a ten-year period.\nMETHODS: Based on a large helicopter emergency medical service (HEMS) database in Germany between 2006 and 2015, a total of 9720 HEMS missions after major trauma leading to RSI on scene were analysed. Administration practice of sedatives and opioids were investigated, while neuromuscular blocking agents were not documented in the database.\nRESULTS: With respect to administration of sedatives, independent from trauma mechanism and specific injury patterns the use of Etomidate decreased dramatically (52 to 6%) in favour of a more frequent use of Propofol (3 to 32%) and Ketamine (9 to 24%; all p\u2009<\u20090.001) from 2006 to 2015. The use of Benzodiazepines increased slightly, while the utilization rate of Barbiturates remained constant. In patients with Shock Index >\u20091 at initial contact, the administration rate of Etomidate dropped significantly as well. This decline was mainly substituted by Ketamine and particularly Propofol. In patients with GCS\u2009\u2264\u20098 upon initial contact, a similar distribution compared to the general trauma population could be observed. With respect to opioids, mainly Fentanyl has been administered for RSI in trauma patients (2006: 69,6% to 2015: 60.2%; p\u00a0<\u20090.001), while the use of sufentanyl showed a significant increase (0.2 to 8.8%; p\u00a0<\u20090.001).\nCONCLUSIONS: This large study analysed prehospital administration of anaesthetics in trauma patients, showing a substantial change from 2006 to 2015 despite the lack of any high-level evidence. Etomidate has shifted from the main sedative substance to virtual absence, indicating that the recommendation of an established national guideline was transferred into clinical practice, although based on weak evidence as well. The pre-hospital use of Propofol showed a particular increase. Fentanyl has been the main opioid drug for RSI in trauma, however Sufentanyl has become increasingly popular. The mechanisms and advantages of the different substances still have to be elucidated, especially in head injury and bleeding trauma.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13049-019-0603-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1040201", 
        "issn": [
          "1757-7241"
        ], 
        "name": "Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "27"
      }
    ], 
    "name": "Changes in anaesthetic use for trauma patients in German HEMS \u2013 a retrospective study over a ten-year period", 
    "pagination": "23", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "788e935a8756d0b739f1ce289384651995a27583bb9c27b40ff9cbf4f9ba6b6b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30808371"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101477511"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13049-019-0603-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112392812"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13049-019-0603-9", 
      "https://app.dimensions.ai/details/publication/pub.1112392812"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78950_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13049-019-0603-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13049-019-0603-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13049-019-0603-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13049-019-0603-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13049-019-0603-9'


 

This table displays all metadata directly associated to this object as RDF triples.

216 TRIPLES      21 PREDICATES      65 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13049-019-0603-9 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N8ff9b8836cf44704a8057b0a4e4c393a
4 schema:citation sg:pub.10.1007/bf03011034
5 sg:pub.10.1007/s00134-004-2550-8
6 sg:pub.10.1007/s12630-014-0161-6
7 sg:pub.10.1007/s40140-014-0066-5
8 sg:pub.10.1186/s13049-015-0136-9
9 sg:pub.10.1186/s13054-015-0872-2
10 https://app.dimensions.ai/details/publication/pub.1082705662
11 https://doi.org/10.1001/archsurg.136.10.1118
12 https://doi.org/10.1001/archsurg.143.1.62
13 https://doi.org/10.1002/14651858.cd010225.pub2
14 https://doi.org/10.1016/j.annemergmed.2016.03.041
15 https://doi.org/10.1016/j.annemergmed.2016.08.009
16 https://doi.org/10.1016/j.injury.2014.08.023
17 https://doi.org/10.1016/j.jss.2011.03.044
18 https://doi.org/10.1016/s0140-6736(09)60949-1
19 https://doi.org/10.1093/bja/44.11.1200
20 https://doi.org/10.1097/00000542-197201000-00013
21 https://doi.org/10.1097/00000542-200309000-00016
22 https://doi.org/10.1097/00001503-200110000-00005
23 https://doi.org/10.1097/00005373-199302000-00006
24 https://doi.org/10.1097/01.ccm.0000044505.24727.16
25 https://doi.org/10.1097/01.ccm.0000162491.26292.98
26 https://doi.org/10.1097/aco.0b013e328362a84c
27 https://doi.org/10.1097/ede.0b013e3181577654
28 https://doi.org/10.1097/ta.0b013e31815078ae
29 https://doi.org/10.1097/ta.0b013e3181a92a70
30 https://doi.org/10.1097/ta.0b013e3181bbf728
31 https://doi.org/10.1097/ta.0b013e3181fec9ba
32 https://doi.org/10.1111/cns.12072
33 https://doi.org/10.1111/j.1399-6576.2008.01673.x
34 https://doi.org/10.1136/jramc-156-04s-04
35 https://doi.org/10.1136/postgradmedj-2010-74245
36 https://doi.org/10.1155/2014/201570
37 https://doi.org/10.1177/1060028013510488
38 https://doi.org/10.1210/jcem-59-6-1143
39 https://doi.org/10.3238/arztebl.2012.0849
40 schema:datePublished 2019-12
41 schema:datePublishedReg 2019-12-01
42 schema:description BACKGROUND: Airway management and use of intravenous anaesthetics to facilitate tracheal intubation after major trauma remains controversial. Numerous agents are available and used for pre-hospital rapid-sequence induction (RSI). The aim was to investigate usage and potential changes in administration of intravenous anaesthetics for pre-hospital RSI in trauma patients over a ten-year period. METHODS: Based on a large helicopter emergency medical service (HEMS) database in Germany between 2006 and 2015, a total of 9720 HEMS missions after major trauma leading to RSI on scene were analysed. Administration practice of sedatives and opioids were investigated, while neuromuscular blocking agents were not documented in the database. RESULTS: With respect to administration of sedatives, independent from trauma mechanism and specific injury patterns the use of Etomidate decreased dramatically (52 to 6%) in favour of a more frequent use of Propofol (3 to 32%) and Ketamine (9 to 24%; all p < 0.001) from 2006 to 2015. The use of Benzodiazepines increased slightly, while the utilization rate of Barbiturates remained constant. In patients with Shock Index > 1 at initial contact, the administration rate of Etomidate dropped significantly as well. This decline was mainly substituted by Ketamine and particularly Propofol. In patients with GCS ≤ 8 upon initial contact, a similar distribution compared to the general trauma population could be observed. With respect to opioids, mainly Fentanyl has been administered for RSI in trauma patients (2006: 69,6% to 2015: 60.2%; p < 0.001), while the use of sufentanyl showed a significant increase (0.2 to 8.8%; p < 0.001). CONCLUSIONS: This large study analysed prehospital administration of anaesthetics in trauma patients, showing a substantial change from 2006 to 2015 despite the lack of any high-level evidence. Etomidate has shifted from the main sedative substance to virtual absence, indicating that the recommendation of an established national guideline was transferred into clinical practice, although based on weak evidence as well. The pre-hospital use of Propofol showed a particular increase. Fentanyl has been the main opioid drug for RSI in trauma, however Sufentanyl has become increasingly popular. The mechanisms and advantages of the different substances still have to be elucidated, especially in head injury and bleeding trauma.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N4e5ae6ce8bbc47e681af0223a094c2be
47 N7a45ee6297204186b3b10dd8aa2cc91a
48 sg:journal.1040201
49 schema:name Changes in anaesthetic use for trauma patients in German HEMS – a retrospective study over a ten-year period
50 schema:pagination 23
51 schema:productId N05f40b3a7b5540de8c7247c4b548c3a2
52 N5115a02cb25a4d2285a98f49cbee346b
53 N87c9a05df08e47e8bc72959a80119933
54 Nbc06729475054516a737cbc9d2f96df4
55 Ne9d20fa8075b45518571963e791d1699
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112392812
57 https://doi.org/10.1186/s13049-019-0603-9
58 schema:sdDatePublished 2019-04-11T13:19
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher Nd8d297e424654ef0ad7a97ba6c559476
61 schema:url https://link.springer.com/10.1186%2Fs13049-019-0603-9
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N05f40b3a7b5540de8c7247c4b548c3a2 schema:name doi
66 schema:value 10.1186/s13049-019-0603-9
67 rdf:type schema:PropertyValue
68 N1ca1c2d890574cdd9af1d6f0c30a4944 schema:affiliation https://www.grid.ac/institutes/grid.412581.b
69 schema:familyName Caspers
70 schema:givenName Michael
71 rdf:type schema:Person
72 N20c6355210334b648a6a73579077d0c1 rdf:first N1ca1c2d890574cdd9af1d6f0c30a4944
73 rdf:rest N9b0e885165374cb7ba09a1a0c4d0d89f
74 N28487d2a2c56452eadb9259922bd990d schema:affiliation https://www.grid.ac/institutes/grid.432059.9
75 schema:familyName Gäßler
76 schema:givenName Michael
77 rdf:type schema:Person
78 N30549971c25d431cbe9f73eccb488345 rdf:first N8c02f31d57fd435d845e58774d58a64f
79 rdf:rest N8856cf0cb6534a4189ab82dc53c12bab
80 N307b867a924045b8917f5b8db76cc8b3 schema:affiliation https://www.grid.ac/institutes/grid.412581.b
81 schema:familyName Wafaisade
82 schema:givenName Arasch
83 rdf:type schema:Person
84 N3c0cab1c938744eea4d58fd6152423bc schema:affiliation https://www.grid.ac/institutes/grid.432059.9
85 schema:familyName Ruppert
86 schema:givenName Matthias
87 rdf:type schema:Person
88 N4e5ae6ce8bbc47e681af0223a094c2be schema:volumeNumber 27
89 rdf:type schema:PublicationVolume
90 N5115a02cb25a4d2285a98f49cbee346b schema:name dimensions_id
91 schema:value pub.1112392812
92 rdf:type schema:PropertyValue
93 N7a45ee6297204186b3b10dd8aa2cc91a schema:issueNumber 1
94 rdf:type schema:PublicationIssue
95 N87c9a05df08e47e8bc72959a80119933 schema:name readcube_id
96 schema:value 788e935a8756d0b739f1ce289384651995a27583bb9c27b40ff9cbf4f9ba6b6b
97 rdf:type schema:PropertyValue
98 N8856cf0cb6534a4189ab82dc53c12bab rdf:first N3c0cab1c938744eea4d58fd6152423bc
99 rdf:rest N8adfc8c13b7647ef94552f34a580e223
100 N8adfc8c13b7647ef94552f34a580e223 rdf:first N28487d2a2c56452eadb9259922bd990d
101 rdf:rest rdf:nil
102 N8c02f31d57fd435d845e58774d58a64f schema:affiliation Nd6fd28f6785e464c9d4cd31081baecab
103 schema:familyName Helm
104 schema:givenName Matthias
105 rdf:type schema:Person
106 N8ff9b8836cf44704a8057b0a4e4c393a rdf:first N307b867a924045b8917f5b8db76cc8b3
107 rdf:rest N20c6355210334b648a6a73579077d0c1
108 N9b0e885165374cb7ba09a1a0c4d0d89f rdf:first Nd9e8ba4f61c14a31b5066ccf7a434c51
109 rdf:rest N30549971c25d431cbe9f73eccb488345
110 Nbc06729475054516a737cbc9d2f96df4 schema:name pubmed_id
111 schema:value 30808371
112 rdf:type schema:PropertyValue
113 Nd6fd28f6785e464c9d4cd31081baecab schema:name Armed Forces Medical Centre Ulm, Department of Anaesthesiology and Intensive Care Medicine, Section Emergency Medicine – HEMS “Christoph 22”, Oberer Eselsberg 40, 89081, Ulm, Germany
114 rdf:type schema:Organization
115 Nd8d297e424654ef0ad7a97ba6c559476 schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 Nd9e8ba4f61c14a31b5066ccf7a434c51 schema:affiliation https://www.grid.ac/institutes/grid.412581.b
118 schema:familyName Bouillon
119 schema:givenName Bertil
120 rdf:type schema:Person
121 Ne9d20fa8075b45518571963e791d1699 schema:name nlm_unique_id
122 schema:value 101477511
123 rdf:type schema:PropertyValue
124 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
125 schema:name Medical and Health Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
128 schema:name Clinical Sciences
129 rdf:type schema:DefinedTerm
130 sg:journal.1040201 schema:issn 1757-7241
131 schema:name Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
132 rdf:type schema:Periodical
133 sg:pub.10.1007/bf03011034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027988762
134 https://doi.org/10.1007/bf03011034
135 rdf:type schema:CreativeWork
136 sg:pub.10.1007/s00134-004-2550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015414379
137 https://doi.org/10.1007/s00134-004-2550-8
138 rdf:type schema:CreativeWork
139 sg:pub.10.1007/s12630-014-0161-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003878495
140 https://doi.org/10.1007/s12630-014-0161-6
141 rdf:type schema:CreativeWork
142 sg:pub.10.1007/s40140-014-0066-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038685240
143 https://doi.org/10.1007/s40140-014-0066-5
144 rdf:type schema:CreativeWork
145 sg:pub.10.1186/s13049-015-0136-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035603860
146 https://doi.org/10.1186/s13049-015-0136-9
147 rdf:type schema:CreativeWork
148 sg:pub.10.1186/s13054-015-0872-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044903714
149 https://doi.org/10.1186/s13054-015-0872-2
150 rdf:type schema:CreativeWork
151 https://app.dimensions.ai/details/publication/pub.1082705662 schema:CreativeWork
152 https://doi.org/10.1001/archsurg.136.10.1118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036649100
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1001/archsurg.143.1.62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031328826
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1002/14651858.cd010225.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018985251
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.annemergmed.2016.03.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052167600
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.annemergmed.2016.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048497266
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.injury.2014.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000722176
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.jss.2011.03.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052731957
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/s0140-6736(09)60949-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009990488
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1093/bja/44.11.1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028899759
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1097/00000542-197201000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034425268
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1097/00000542-200309000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013441361
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1097/00001503-200110000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021248096
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1097/00005373-199302000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030224906
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1097/01.ccm.0000044505.24727.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028592997
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1097/01.ccm.0000162491.26292.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039036539
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1097/aco.0b013e328362a84c schema:sameAs https://app.dimensions.ai/details/publication/pub.1046910550
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1097/ede.0b013e3181577654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027581622
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1097/ta.0b013e31815078ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1051370306
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1097/ta.0b013e3181a92a70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015172053
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1097/ta.0b013e3181bbf728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008750728
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1097/ta.0b013e3181fec9ba schema:sameAs https://app.dimensions.ai/details/publication/pub.1025861162
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1111/cns.12072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015626554
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1111/j.1399-6576.2008.01673.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007207385
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1136/jramc-156-04s-04 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039944736
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1136/postgradmedj-2010-74245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047122811
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1155/2014/201570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033398912
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1177/1060028013510488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045306472
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1210/jcem-59-6-1143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064313555
207 rdf:type schema:CreativeWork
208 https://doi.org/10.3238/arztebl.2012.0849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078665779
209 rdf:type schema:CreativeWork
210 https://www.grid.ac/institutes/grid.412581.b schema:alternateName Witten/Herdecke University
211 schema:name Department of Traumatology and Orthopaedic Surgery, Cologne-Merheim Medical Centre (CMMC), Witten/Herdecke University, Campus Cologne-Merheim, Ostmerheimer Str. 200, 51109, Cologne, Germany
212 The Institute for Research in Operative Medicine, Faculty of Health, Department of Medicine, Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany
213 rdf:type schema:Organization
214 https://www.grid.ac/institutes/grid.432059.9 schema:alternateName Allgemeiner Deutscher Automobil Club
215 schema:name Department of Medicine – ADAC Air Rescue Service, Hansastrasse 19, 80686, Munich, Germany
216 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...