Therapeutic hypothermia after nonshockable cardiac arrest: the HYPERION multicenter, randomized, controlled, assessor-blinded, superiority trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Jean Baptiste Lascarrou, Ferhat Meziani, Amélie Le Gouge, Thierry Boulain, Jérôme Bousser, Guillaume Belliard, Pierre Asfar, Jean Pierre Frat, Pierre François Dequin, Jean Paul Gouello, Arnaud Delahaye, Ali Ait Hssain, Jean Charles Chakarian, Nicolas Pichon, Arnaud Desachy, Fréderic Bellec, Didier Thevenin, Jean Pierre Quenot, Michel Sirodot, François Labadie, Gaétan Plantefeve, Dominique Vivier, Patrick Girardie, Bruno Giraudeau, Jean Reignier, for the Clinical Research in Intensive Care and Sepsis (CRICS) Group and the HYPERION Study Group

ABSTRACT

BACKGROUND: Meta-analyses of nonrandomized studies have provided conflicting data on therapeutic hypothermia, or targeted temperature management (TTM), at 33°C in patients successfully resuscitated after nonshockable cardiac arrest. Nevertheless, the latest recommendations issued by the International Liaison Committee on Resuscitation and by the European Resuscitation Council recommend therapeutic hypothermia. New data are available on the adverse effects of therapeutic hypothermia, notably infectious complications. The risk/benefit ratio of therapeutic hypothermia after nonshockable cardiac arrest is unclear. METHODS: HYPERION is a multicenter (22 French ICUs) trial with blinded outcome assessment in which 584 patients with successfully resuscitated nonshockable cardiac arrest are allocated at random to either TTM between 32.5 and 33.5°C (therapeutic hypothermia) or TTM between 36.5 and 37.5°C (therapeutic normothermia) for 24 hours. Both groups are managed with therapeutic normothermia for the next 24 hours. TTM is achieved using locally available equipment. The primary outcome is day-90 neurological status assessed by the Cerebral Performance Categories (CPC) Scale with dichotomization of the results (1 + 2 versus 3 + 4 + 5). The primary outcome is assessed by a blinded psychologist during a semi-structured telephone interview of the patient or next of kin. Secondary outcomes are day-90 mortality, hospital mortality, severe adverse events, infections, and neurocognitive performance. The planned sample size of 584 patients will enable us to detect a 9% absolute difference in day-90 neurological status with 80% power, assuming a 14% event rate in the control group and a two-sided Type 1 error rate of 4.9%. Two interim analyses will be performed, after inclusion of 200 and 400 patients, respectively. DISCUSSION: The HYPERION trial is a multicenter, randomized, controlled, assessor-blinded, superiority trial that may provide an answer to an issue of everyday relevance, namely, whether TTM is beneficial in comatose patients resuscitated after nonshockable cardiac arrest. Furthermore, it will provide new data on the tolerance and adverse events (especially infectious complications) of TTM at 32.5-33.5°C. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01994772 . More... »

PAGES

26

References to SciGraph publications

  • 2010-08. Who benefits most from mild therapeutic hypothermia in coronary intervention era? A retrospective and propensity-matched study in CRITICAL CARE
  • 2012-09. Avis de la CE-SRLF sur la démarche de prise de décision de limitation ou d’arrêt des thérapeutiques chez l’adulte en coma postanoxique après un arrêt cardiaque in MÉDECINE INTENSIVE RÉANIMATION
  • 2013-10. Effects of prehospital epinephrine during out-of-hospital cardiac arrest with initial non-shockable rhythm: an observational cohort study in CRITICAL CARE
  • 2013-05. Therapeutic hypothermia after out-of-hospital cardiac arrest in Finnish intensive care units: the FINNRESUSCI study in INTENSIVE CARE MEDICINE
  • 2013-08. Factors predicting the use of therapeutic hypothermia and survival in unconscious out-of-hospital cardiac arrest patients admitted to the ICU in CRITICAL CARE
  • 2014-08. Effects of prehospital adrenaline administration on out-of-hospital cardiac arrest outcomes: a systematic review and meta-analysis in CRITICAL CARE
  • 2013-08. Invasive versus non-invasive cooling after in- and out-of-hospital cardiac arrest: a randomized trial in CLINICAL RESEARCH IN CARDIOLOGY
  • 2013-05. To cool or not to cool non-shockable cardiac arrest patients: it is time for randomized controlled trials in INTENSIVE CARE MEDICINE
  • 2013-12. A structured approach to neurologic prognostication in clinical cardiac arrest trials in SCANDINAVIAN JOURNAL OF TRAUMA, RESUSCITATION AND EMERGENCY MEDICINE
  • 2014-09. The association of targeted temperature management at 33 and 36 °C with outcome in patients with moderate shock on admission after out-of-hospital cardiac arrest: a post hoc analysis of the Target Temperature Management trial in INTENSIVE CARE MEDICINE
  • 1976-12. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13049-015-0103-5

    DOI

    http://dx.doi.org/10.1186/s13049-015-0103-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036401574

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25882712


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