PD-L1 expression on stromal tumor-infiltrating lymphocytes is a favorable prognostic factor in ovarian serous carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-06-17

AUTHORS

Ki Hyung Kim, Kyung Un Choi, Ahrong Kim, So Jung Lee, Jung Hee Lee, Dong Soo Suh, Byung-su Kwon, Chungsu Hwang

ABSTRACT

BACKGROUND: PD-L1 expression levels determined by immunostaining are known to be related to the survival rate and prognosis of patients with various types of cancers, as well as to the therapeutic response to immune checkpoint inhibitors. Recently, the U.S. Food and Drug Administration approved an immune checkpoint inhibitor for the treatment of non-small cell lung cancer along with the clones used for PD-L1 immunostaining to predict the resulting response. In this study, we performed PD-L1 immunostaining of tissue microarrays from ovarian epithelial cancer using SP263, an approved clone, and examined the effect of PD-L1 expression on survival rate and prognosis. METHODS: Tissue microarrays were constructed from ovarian epithelial cancer tissues of 248 patients and PD-L1 immunostaining was performed using the SP263 clone. PD-L1 expression levels in tumor cells, intraepithelial tumor-infiltrating lymphocytes, and stromal tumor-infiltrating lymphocytes were evaluated, and the effect of PD-L1 expression on survival and prognosis was analyzed. RESULTS: PD-L1 was detected in tumor cells as well as intraepithelial tumor-infiltrating lymphocytes and stromal tumor-infiltrating lymphocytes. It was most frequently expressed in stromal tumor-infiltrating lymphocytes. The Kaplan-Meier curve analysis and log rank test showed that only high stromal PD-L1 expression was associated with increased overall survival in ovarian serous carcinoma. Multivariate and univariate Cox regression analyses revealed that stromal PD-L1 expression was an independent prognostic factor, especially in ovarian serous carcinoma. CONCLUSIONS: PD-L1 immunostaining using SP263 was observed in tumor cells as well as intraepithelial and stromal tumor-infiltrating lymphocytes. PD-L1-expressing stromal tumor-infiltrating lymphocytes were associated with an increased overall survival rate and may serve as a favorable prognostic factor in ovarian cancer, particularly serous carcinoma. More... »

PAGES

56

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13048-019-0526-0

DOI

http://dx.doi.org/10.1186/s13048-019-0526-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117288333

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31208449


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80 ovarian epithelial cancer
81 ovarian epithelial cancer tissues
82 ovarian serous carcinoma
83 overall survival
84 overall survival rate
85 patients
86 prognosis
87 prognosis of patients
88 prognostic factors
89 rank test
90 rate
91 regression analysis
92 response
93 serous carcinoma
94 stromal PD-L1 expression
95 stromal tumor-infiltrating lymphocytes
96 study
97 survival
98 survival rate
99 test
100 therapeutic response
101 tissue
102 tissue microarray
103 treatment
104 tumor cells
105 tumor-infiltrating lymphocytes
106 types
107 types of cancer
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