Ontology type: schema:ScholarlyArticle Open Access: True
2019-06-17
AUTHORSKi Hyung Kim, Kyung Un Choi, Ahrong Kim, So Jung Lee, Jung Hee Lee, Dong Soo Suh, Byung-su Kwon, Chungsu Hwang
ABSTRACTBackgroundPD-L1 expression levels determined by immunostaining are known to be related to the survival rate and prognosis of patients with various types of cancers, as well as to the therapeutic response to immune checkpoint inhibitors. Recently, the U.S. Food and Drug Administration approved an immune checkpoint inhibitor for the treatment of non-small cell lung cancer along with the clones used for PD-L1 immunostaining to predict the resulting response. In this study, we performed PD-L1 immunostaining of tissue microarrays from ovarian epithelial cancer using SP263, an approved clone, and examined the effect of PD-L1 expression on survival rate and prognosis.MethodsTissue microarrays were constructed from ovarian epithelial cancer tissues of 248 patients and PD-L1 immunostaining was performed using the SP263 clone. PD-L1 expression levels in tumor cells, intraepithelial tumor-infiltrating lymphocytes, and stromal tumor-infiltrating lymphocytes were evaluated, and the effect of PD-L1 expression on survival and prognosis was analyzed.ResultsPD-L1 was detected in tumor cells as well as intraepithelial tumor-infiltrating lymphocytes and stromal tumor-infiltrating lymphocytes. It was most frequently expressed in stromal tumor-infiltrating lymphocytes. The Kaplan-Meier curve analysis and log rank test showed that only high stromal PD-L1 expression was associated with increased overall survival in ovarian serous carcinoma. Multivariate and univariate Cox regression analyses revealed that stromal PD-L1 expression was an independent prognostic factor, especially in ovarian serous carcinoma.ConclusionsPD-L1 immunostaining using SP263 was observed in tumor cells as well as intraepithelial and stromal tumor-infiltrating lymphocytes. PD-L1-expressing stromal tumor-infiltrating lymphocytes were associated with an increased overall survival rate and may serve as a favorable prognostic factor in ovarian cancer, particularly serous carcinoma. More... »
PAGES56
http://scigraph.springernature.com/pub.10.1186/s13048-019-0526-0
DOIhttp://dx.doi.org/10.1186/s13048-019-0526-0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1117288333
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/31208449
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "B7-H1 Antigen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Carcinoma, Ovarian Epithelial",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cystadenocarcinoma, Serous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kaplan-Meier Estimate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocytes, Tumor-Infiltrating",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ovarian Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stromal Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Rate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Young Adult",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Obstetrics and Gynecology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea",
"id": "http://www.grid.ac/institutes/grid.412588.2",
"name": [
"Department of Obstetrics and Gynecology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Ki Hyung",
"id": "sg:person.01242727550.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242727550.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea",
"id": "http://www.grid.ac/institutes/grid.412588.2",
"name": [
"Department of Pathology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Choi",
"givenName": "Kyung Un",
"id": "sg:person.01335032703.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335032703.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea",
"id": "http://www.grid.ac/institutes/grid.412588.2",
"name": [
"Department of Pathology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Ahrong",
"id": "sg:person.0722602332.16",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0722602332.16"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea",
"id": "http://www.grid.ac/institutes/grid.412588.2",
"name": [
"Department of Pathology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "So Jung",
"id": "sg:person.0601771572.79",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601771572.79"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Research Institute for Convergence of Biomedical Science and Technology, 20, Geumo-ro, Mulguem-eup, Yangsan-si, Gyeongsangnam-do, South Korea",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Pathology, Pusan National University Yangsan Hospital, 20, Geumo-ro, Mulguem-eup, Yangsan-si, Gyeongsangnam-do, South Korea",
"Research Institute for Convergence of Biomedical Science and Technology, 20, Geumo-ro, Mulguem-eup, Yangsan-si, Gyeongsangnam-do, South Korea"
],
"type": "Organization"
},
"familyName": "Lee",
"givenName": "Jung Hee",
"id": "sg:person.0731265143.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731265143.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Obstetrics and Gynecology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea",
"id": "http://www.grid.ac/institutes/grid.412588.2",
"name": [
"Department of Obstetrics and Gynecology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Suh",
"givenName": "Dong Soo",
"id": "sg:person.01010527607.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010527607.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Obstetrics and Gynecology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea",
"id": "http://www.grid.ac/institutes/grid.412588.2",
"name": [
"Department of Obstetrics and Gynecology, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, 49241, Busan, South Korea"
],
"type": "Organization"
},
"familyName": "Kwon",
"givenName": "Byung-su",
"id": "sg:person.013610746471.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013610746471.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Research Institute for Convergence of Biomedical Science and Technology, 20, Geumo-ro, Mulguem-eup, Yangsan-si, Gyeongsangnam-do, South Korea",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Pathology, Pusan National University Yangsan Hospital, 20, Geumo-ro, Mulguem-eup, Yangsan-si, Gyeongsangnam-do, South Korea",
"Research Institute for Convergence of Biomedical Science and Technology, 20, Geumo-ro, Mulguem-eup, Yangsan-si, Gyeongsangnam-do, South Korea"
],
"type": "Organization"
},
"familyName": "Hwang",
"givenName": "Chungsu",
"id": "sg:person.01305666032.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305666032.42"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s10549-013-2581-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040422873",
"https://doi.org/10.1007/s10549-013-2581-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41416-018-0145-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104893522",
"https://doi.org/10.1038/s41416-018-0145-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00262-006-0266-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018555484",
"https://doi.org/10.1007/s00262-006-0266-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep42929",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084131191",
"https://doi.org/10.1038/srep42929"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41416-018-0144-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104902474",
"https://doi.org/10.1038/s41416-018-0144-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm730",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043110107",
"https://doi.org/10.1038/nm730"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature14011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041312915",
"https://doi.org/10.1038/nature14011"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-06-17",
"datePublishedReg": "2019-06-17",
"description": "BackgroundPD-L1 expression levels determined by immunostaining are known to be related to the survival rate and prognosis of patients with various types of cancers, as well as to the therapeutic response to immune checkpoint inhibitors. Recently, the U.S. Food and Drug Administration approved an immune checkpoint inhibitor for the treatment of non-small cell lung cancer along with the clones used for PD-L1 immunostaining to predict the resulting response. In this study, we performed PD-L1 immunostaining of tissue microarrays from ovarian epithelial cancer using SP263, an approved clone, and examined the effect of PD-L1 expression on survival rate and prognosis.MethodsTissue microarrays were constructed from ovarian epithelial cancer tissues of 248 patients and PD-L1 immunostaining was performed using the SP263 clone. PD-L1 expression levels in tumor cells, intraepithelial tumor-infiltrating lymphocytes, and stromal tumor-infiltrating lymphocytes were evaluated, and the effect of PD-L1 expression on survival and prognosis was analyzed.ResultsPD-L1 was detected in tumor cells as well as intraepithelial tumor-infiltrating lymphocytes and stromal tumor-infiltrating lymphocytes. It was most frequently expressed in stromal tumor-infiltrating lymphocytes. The Kaplan-Meier curve analysis and log rank test showed that only high stromal PD-L1 expression was associated with increased overall survival in ovarian serous carcinoma. Multivariate and univariate Cox regression analyses revealed that stromal PD-L1 expression was an independent prognostic factor, especially in ovarian serous carcinoma.ConclusionsPD-L1 immunostaining using SP263 was observed in tumor cells as well as intraepithelial and stromal tumor-infiltrating lymphocytes. PD-L1-expressing stromal tumor-infiltrating lymphocytes were associated with an increased overall survival rate and may serve as a favorable prognostic factor in ovarian cancer, particularly serous carcinoma.",
"genre": "article",
"id": "sg:pub.10.1186/s13048-019-0526-0",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1040071",
"issn": [
"1757-2215"
],
"name": "Journal of Ovarian Research",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "12"
}
],
"keywords": [
"stromal tumor-infiltrating lymphocytes",
"tumor-infiltrating lymphocytes",
"PD-L1 expression",
"PD-L1 immunostaining",
"intraepithelial tumor-infiltrating lymphocytes",
"stromal PD-L1 expression",
"ovarian serous carcinoma",
"immune checkpoint inhibitors",
"favorable prognostic factor",
"serous carcinoma",
"prognostic factors",
"survival rate",
"checkpoint inhibitors",
"tumor cells",
"non-small cell lung cancer",
"PD-L1 expression levels",
"Kaplan-Meier curve analysis",
"ovarian epithelial cancer tissues",
"prognosis of patients",
"independent prognostic factor",
"overall survival rate",
"Cox regression analysis",
"cell lung cancer",
"log-rank test",
"ovarian epithelial cancer",
"epithelial cancer tissues",
"expression levels",
"types of cancer",
"MethodsTissue microarrays",
"SP263 clone",
"ResultsPD-L1",
"overall survival",
"PD-L1",
"lung cancer",
"therapeutic response",
"ovarian cancer",
"tissue microarray",
"Drug Administration",
"cancer tissues",
"epithelial cancers",
"lymphocytes",
"carcinoma",
"prognosis",
"cancer",
"U.S. Food",
"immunostaining",
"curve analysis",
"SP263",
"rank test",
"patients",
"regression analysis",
"survival",
"inhibitors",
"expression",
"cells",
"microarray",
"factors",
"administration",
"response",
"clones",
"rate",
"levels",
"treatment",
"tissue",
"effect",
"food",
"study",
"test",
"analysis",
"types"
],
"name": "PD-L1 expression on stromal tumor-infiltrating lymphocytes is a favorable prognostic factor in ovarian serous carcinoma",
"pagination": "56",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1117288333"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13048-019-0526-0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"31208449"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13048-019-0526-0",
"https://app.dimensions.ai/details/publication/pub.1117288333"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:36",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_818.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/s13048-019-0526-0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13048-019-0526-0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13048-019-0526-0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13048-019-0526-0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13048-019-0526-0'
This table displays all metadata directly associated to this object as RDF triples.
286 TRIPLES
22 PREDICATES
121 URIs
106 LITERALS
25 BLANK NODES