Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSR. O. A. Benevides, C. C. Vale, J. L. L. Fontelles, L. M. França, T. S. Teófilo, S. N. Silva, A. M. A. Paes, R. S. Gaspar
ABSTRACTBACKGROUND: Obesity is a chronic and multifactorial disease characterized by increased adipose tissue. In females, obesity leads to reduced ovulation and lower chances of conception in diseases like polycystic ovary syndrome, making it important to characterize complementary medicine to attenuate such deleterious effects. Therefore, the aim of this study was to assess the effects of a hydroethanolic extract from Syzigium cumini leaves in female reproductive impairments present in the obesity model of neonatal L-monosodium glutamate injection. METHODS: Newborn Wistar rats received saline (CTRL) or L-monosodium glutamate 4 mg/g BW (MSG). At 90 days of age, CTRL and some MSG rats received saline, while others received hydroethanolic extract of S. cumini leaves (HESc 500 mg/kg/day, MSG-Syz group) for 30 consecutive days. Estrous cycle was determined by daily vaginal washes. On days 26 and 28 of treatment, oral glucose tolerance test and blood collection were performed for biochemical assessment. At the end, animals were euthanized during estrous phase; blood was collected to measure sex hormones and organs collected for weighing and histological evaluation. RESULTS: MSG-Syz showed reduced Lee Index, retroperitoneal fat pads and restored gluco-insulin axis. Moreover, HESc treatment reduced serum cholesterol levels when compared to MSG. Treatment with HESc did not restore the oligociclicity observed in obese animals, though MSG-Syz reestablished ovarian follicle health back to CTRL levels, with proliferating primordial follicles - these effects were followed by a decrease on periovarian adipocyte area. CONCLUSIONS: This is the first report to show the reversibility of the reproductive dysfunctions seen in MSG female rats through ethnopharmacological treatment. Moreover, it expands the use of HESc as a prominent tool to treat metabolic and reproductive disorders. Finally, we provide novel evidence that, without a functioning hypothalamus-pituitary-gonads axis, metabolic improvement is ineffective for estrous cyclicity, but critical for ovarian follicle health. More... »
PAGES13
http://scigraph.springernature.com/pub.10.1186/s13048-019-0490-8
DOIhttp://dx.doi.org/10.1186/s13048-019-0490-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1111910615
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30717749
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Paediatrics and Reproductive Medicine",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Federal University of Maranh\u00e3o",
"id": "https://www.grid.ac/institutes/grid.411204.2",
"name": [
"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"
],
"type": "Organization"
},
"familyName": "Benevides",
"givenName": "R. O. A.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Maranh\u00e3o",
"id": "https://www.grid.ac/institutes/grid.411204.2",
"name": [
"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"
],
"type": "Organization"
},
"familyName": "Vale",
"givenName": "C. C.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Maranh\u00e3o",
"id": "https://www.grid.ac/institutes/grid.411204.2",
"name": [
"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"
],
"type": "Organization"
},
"familyName": "Fontelles",
"givenName": "J. L. L.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Maranh\u00e3o",
"id": "https://www.grid.ac/institutes/grid.411204.2",
"name": [
"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"
],
"type": "Organization"
},
"familyName": "Fran\u00e7a",
"givenName": "L. M.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Universidade Federal Rural do Semi-\u00c1rido",
"id": "https://www.grid.ac/institutes/grid.412393.e",
"name": [
"Departamento de Ci\u00eancias Animais, Universidade Federal Rural do Semi-\u00c1rido, Mossor\u00f3, Rio Grande do Norte, Brazil"
],
"type": "Organization"
},
"familyName": "Te\u00f3filo",
"givenName": "T. S.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Maranh\u00e3o",
"id": "https://www.grid.ac/institutes/grid.411204.2",
"name": [
"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"
],
"type": "Organization"
},
"familyName": "Silva",
"givenName": "S. N.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Federal University of Maranh\u00e3o",
"id": "https://www.grid.ac/institutes/grid.411204.2",
"name": [
"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil"
],
"type": "Organization"
},
"familyName": "Paes",
"givenName": "A. M. A.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Reading",
"id": "https://www.grid.ac/institutes/grid.9435.b",
"name": [
"Departamento de Ci\u00eancias Fisiol\u00f3gicas, Universidade Federal do Maranh\u00e3o, S\u00e3o Lu\u00eds, Maranh\u00e3o, Brazil",
"Institute of Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Harborne Building, Reading, UK"
],
"type": "Organization"
},
"familyName": "Gaspar",
"givenName": "R. S.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s0024-3205(02)01948-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000223543"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/joe-16-0174",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000636663"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0031-9422(01)00365-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002581029"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0031-9422(01)00365-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002581029"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2826.2011.02276.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002686589"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/obr.12229",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003489680"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jep.2016.10.056",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003797935"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.fct.2013.05.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004502000"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1477-7827-9-145",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006163693",
"https://doi.org/10.1186/1477-7827-9-145"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/b978-0-12-411619-1.00006-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007199128"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2017/3795950",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007458232"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1095/biolreprod.111.097808",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007840719"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.carres.2008.03.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008565486"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bpobgyn.2014.12.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008726865"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1933719115578925",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009698251"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1933719115578925",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009698251"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4103/0974-1208.69332",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010191321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.fct.2008.03.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010794166"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.yhbeh.2013.01.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012413085"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3390/nu5114316",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012863437"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ptr.3442",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014951810"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1113/jphysiol.2002.023895",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018109809"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1590/s1519-69842002000400008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018224178"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.phymed.2005.03.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019399552"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.phymed.2005.03.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019399552"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/joe-15-0453",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020225119"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13002-015-0019-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030480296",
"https://doi.org/10.1186/s13002-015-0019-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13002-015-0019-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030480296",
"https://doi.org/10.1186/s13002-015-0019-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1095/biolreprod19.3.597",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030585296"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/humrep/dem371",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036720754"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1677/joe.0.0400527",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042519188"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.metabol.2013.09.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046436353"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db13-1514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049746028"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmra041536",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050370074"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fphar.2016.00048",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052298442"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.164.3880.719",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062497038"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.166.3903.386",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062498120"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1933719116667218",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064079474"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1933719116667218",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064079474"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2012-1385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064251529"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2105/ajph.91.4.642",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068878185"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078854380",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.fertnstert.2017.06.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091393078"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.lfs.2017.10.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092272131"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "BACKGROUND: Obesity is a chronic and multifactorial disease characterized by increased adipose tissue. In females, obesity leads to reduced ovulation and lower chances of conception in diseases like polycystic ovary syndrome, making it important to characterize complementary medicine to attenuate such deleterious effects. Therefore, the aim of this study was to assess the effects of a hydroethanolic extract from Syzigium cumini leaves in female reproductive impairments present in the obesity model of neonatal L-monosodium glutamate injection.\nMETHODS: Newborn Wistar rats received saline (CTRL) or L-monosodium glutamate 4\u2009mg/g BW (MSG). At 90\u2009days of age, CTRL and some MSG rats received saline, while others received hydroethanolic extract of S. cumini leaves (HESc 500\u2009mg/kg/day, MSG-Syz group) for 30 consecutive days. Estrous cycle was determined by daily vaginal washes. On days 26 and 28 of treatment, oral glucose tolerance test and blood collection were performed for biochemical assessment. At the end, animals were euthanized during estrous phase; blood was collected to measure sex hormones and organs collected for weighing and histological evaluation.\nRESULTS: MSG-Syz showed reduced Lee Index, retroperitoneal fat pads and restored gluco-insulin axis. Moreover, HESc treatment reduced serum cholesterol levels when compared to MSG. Treatment with HESc did not restore the oligociclicity observed in obese animals, though MSG-Syz reestablished ovarian follicle health back to CTRL levels, with proliferating primordial follicles - these effects were followed by a decrease on periovarian adipocyte area.\nCONCLUSIONS: This is the first report to show the reversibility of the reproductive dysfunctions seen in MSG female rats through ethnopharmacological treatment. Moreover, it expands the use of HESc as a prominent tool to treat metabolic and reproductive disorders. Finally, we provide novel evidence that, without a functioning hypothalamus-pituitary-gonads axis, metabolic improvement is ineffective for estrous cyclicity, but critical for ovarian follicle health.",
"genre": "research_article",
"id": "sg:pub.10.1186/s13048-019-0490-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1040071",
"issn": [
"1757-2215"
],
"name": "Journal of Ovarian Research",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "12"
}
],
"name": "Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis",
"pagination": "13",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"5462a64b5837895f48e319f010ed5a10d07a680019c2350322d176e049e0ddb7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30717749"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101474849"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13048-019-0490-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1111910615"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13048-019-0490-8",
"https://app.dimensions.ai/details/publication/pub.1111910615"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T09:00",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000329_0000000329/records_74671_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs13048-019-0490-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13048-019-0490-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13048-019-0490-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13048-019-0490-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13048-019-0490-8'
This table displays all metadata directly associated to this object as RDF triples.
234 TRIPLES
21 PREDICATES
68 URIs
21 LITERALS
9 BLANK NODES