Therapeutic potentials of Quercetin in management of polycystic ovarian syndrome using Letrozole induced rat model: a histological and a biochemical ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-03

AUTHORS

Sarwat Jahan, Abira Abid, Sidra Khalid, Tayyaba Afsar, Qurat-Ul-Ain, Ghazala Shaheen, Ali Almajwal, Suhail Razak

ABSTRACT

BackgroundPCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects of quercetin in a letrozole induced rat model of polycystic ovarian syndrome, which displayed both clinical and metabolic features as in PCOS women.MethodsFemale Sprague Dawley (SD) rats were divided into four groups; control group received aqueous solution of carboxymethyl (CMC 0.5%); PCOS group administered with letrozole (1 mg/kg) dissolved in solution (CMC 0.5%); Metformin group given with metformin (20 mg/kg) + letrozole (1 mg/kg); and Quercetin group provided with quercetin (30 mg/kg) + letrozole (1 mg/kg). All doses were given orally via gavage, for 21 consecutive days and colpocytological analysis was carried till end. After 21rst day, blood was taken out, centrifuged and plasma was kept for biochemical analysis (ELISA, anti-oxidant enzymes, lipid profile) and the reproductive organs were dissected out for histopathological evaluation.ResultsQuercetin as a chief member of flavonoid, showed beneficial effects by decreasing body weight, ovarian diameter, cysts and restoring healthy follicles, follicle’s extra-glandular layers, and corpora lutea in contrast to the positive control. Additionally, lipid profile and anti-oxidant status were also maintained to baseline which was very high in diseased rats (p < 0.001).Quercetin depicted a mark regulation in steroidogenesis by decreasing the levels of testosterone (0.78 ng/ml ± 0.14 in quercetin vs. PCOS positive control 1.69 ng/ml ± 0.17, p < 0.001) and estradiol (8.85 pg/ml ± 0.19 in quercetin vs. PCOS positive 1.61 pg/ml ± 0.29) and increasing progesterone levels (34.47 ng/ml ± 1.65 in quercetin vs. 11.08 ng/ml ± 1.17 in PCOS positive). The effects of quercetin were moderately parallel to the standard drug available in market i.e. metformin.ConclusionThe present study has confirmed that quercetin has the potentials to alleviate the hormonal and metabolic disturbances occurring in PCOS. More... »

PAGES

26

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13048-018-0400-5

DOI

http://dx.doi.org/10.1186/s13048-018-0400-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103128431

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29615083


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33 schema:description BackgroundPCOS is a leading endocrinopathy of young women instigating androgens elevation, insulin resistance, obesity, cardiometabolic and menstrual complications. The study investigated the effects of quercetin in a letrozole induced rat model of polycystic ovarian syndrome, which displayed both clinical and metabolic features as in PCOS women.MethodsFemale Sprague Dawley (SD) rats were divided into four groups; control group received aqueous solution of carboxymethyl (CMC 0.5%); PCOS group administered with letrozole (1 mg/kg) dissolved in solution (CMC 0.5%); Metformin group given with metformin (20 mg/kg) + letrozole (1 mg/kg); and Quercetin group provided with quercetin (30 mg/kg) + letrozole (1 mg/kg). All doses were given orally via gavage, for 21 consecutive days and colpocytological analysis was carried till end. After 21rst day, blood was taken out, centrifuged and plasma was kept for biochemical analysis (ELISA, anti-oxidant enzymes, lipid profile) and the reproductive organs were dissected out for histopathological evaluation.ResultsQuercetin as a chief member of flavonoid, showed beneficial effects by decreasing body weight, ovarian diameter, cysts and restoring healthy follicles, follicle’s extra-glandular layers, and corpora lutea in contrast to the positive control. Additionally, lipid profile and anti-oxidant status were also maintained to baseline which was very high in diseased rats (p < 0.001).Quercetin depicted a mark regulation in steroidogenesis by decreasing the levels of testosterone (0.78 ng/ml ± 0.14 in quercetin vs. PCOS positive control 1.69 ng/ml ± 0.17, p < 0.001) and estradiol (8.85 pg/ml ± 0.19 in quercetin vs. PCOS positive 1.61 pg/ml ± 0.29) and increasing progesterone levels (34.47 ng/ml ± 1.65 in quercetin vs. 11.08 ng/ml ± 1.17 in PCOS positive). The effects of quercetin were moderately parallel to the standard drug available in market i.e. metformin.ConclusionThe present study has confirmed that quercetin has the potentials to alleviate the hormonal and metabolic disturbances occurring in PCOS.
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39 schema:keywords ConclusionThe present study
40 Dawley rats
41 MethodsFemale Sprague–Dawley rats
42 PCOS
43 PCOS group
44 PCOS women
45 ResultsQuercetin
46 Sprague-Dawley rats
47 analysis
48 androgen elevation
49 anti-oxidant status
50 aqueous solution
51 baseline
52 beneficial effects
53 biochemical analysis
54 biochemical studies
55 blood
56 body weight
57 carboxymethyl
58 chief member
59 complications
60 consecutive days
61 contrast
62 control
63 control group
64 corpora lutea
65 cysts
66 days
67 diameter
68 diseased rats
69 disturbances
70 doses
71 drugs
72 effect
73 effect of quercetin
74 elevation
75 end
76 endocrinopathies
77 estradiol
78 evaluation
79 features
80 flavonoids
81 follicles
82 gavage
83 group
84 healthy follicles
85 histopathological evaluation
86 i.
87 induced rat model
88 insulin resistance
89 layer
90 letrozole
91 levels
92 levels of testosterone
93 lipid profile
94 lutea
95 management
96 market i.
97 members
98 menstrual complications
99 metabolic disturbances
100 metabolic features
101 metformin
102 metformin group
103 model
104 obesity
105 organs
106 ovarian diameter
107 ovarian syndrome
108 plasma
109 polycystic ovarian syndrome
110 positive control
111 potential
112 present study
113 profile
114 progesterone levels
115 quercetin
116 quercetin group
117 rat model
118 rats
119 regulation
120 reproductive organs
121 resistance
122 solution
123 standard drug
124 status
125 steroidogenesis
126 study
127 syndrome
128 testosterone
129 therapeutic potential
130 weight
131 women
132 young women
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