Luteinizing hormone elevation in ovarian granulosa cell tumor: a case report and review of the literature View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Shengyuan Ran, Qi Yu, Shan Deng, Ling Xu

ABSTRACT

BACKGROUND: Ovarian granulosa cell tumors (GCTs) are the most common type of potentially malignant ovarian sex cord-stromal tumor. GCTs often produce estrogen and/or progesterone; consequently, symptoms related to hyperestrogenism are common at diagnosis. Nonspecific symptoms or signs associated with this neoplasm include amenorrhea and changes in various sex hormone levels, which can be hard to diagnose or explain. The aims of this report were to describe a case of GCT with rare presentations and to review the pertinent literature. CASE PRESENTATION: A 33-year-old woman presented with secondary amenorrhea and elevated LH with normal FSH and low estradiol levels. Laparoscopy revealed an ovarian GCT, and the patient underwent left adnexectomy and platinum-based chemotherapy. Removal of the ovarian GCT resulted in the normalization of LH levels and a return to spontaneous menses. CONCLUSIONS: The mechanisms responsible for elevations in serum LH due to GCTs require further investigation. However, addressing the patient's clinical problems remains the most important treatment consideration. More... »

PAGES

30

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13048-017-0327-2

DOI

http://dx.doi.org/10.1186/s13048-017-0327-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084955197

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28438188


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