Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12-07

AUTHORS

Sarwat Jahan, Faryal Munir, Suhail Razak, Anam Mehboob, Qurat Ul Ain, Hizb Ullah, Tayyaba Afsar, Ghazala Shaheen, Ali Almajwal

ABSTRACT

BackgroundPolycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The study was commenced to assess the favorable effects of Rutin against metabolic, biochemical, histological, and androgenic aspects of polycystic ovary syndrome in rats.MethodsFemale Sprague-Dawley rats were administered letrozole (1 mg/kg) per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of rutin (100 mg/kg and 150 mg/kg, p.o) for 15 days using 0.5% w/v CMC as vehicle. Metformin was also given as a standard control to one of the rat groups.Serum estradiol, progesterone, testosterone, serum lipid parameters, CRP and glucose levels were evaluated. Furthermore, antioxidant activity was tested using superoxide dismutase, catalase, glutathione per-oxidase and reactive-oxygen species level.ResultsRutin flavonoid had a dose-dependent effect on androgenic levels depicting more recovery in the rutin-I treated group, while rutin-II treated groups showed better antioxidant and lipid profiles as compared with PCOS groups. A decrease in the value of C reactive protein (CRP) and a restoration in the proportion of estrous phase smears were observed in the rutin treated groups. Histopathological examination of ovary revealed a significant decrease in the number of cystic follicles in post treated groups. The effects observed with rutin were moderately similar to that with standard metformin, a widely used treatment drug for PCOS.ConclusionThe study provides evidence for the potential ameliorative effects of rutin against clinical and biochemical features of PCOS. More... »

PAGES

86

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13048-016-0295-y

DOI

http://dx.doi.org/10.1186/s13048-016-0295-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018885784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27923406


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aromatase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weights and Measures", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrous Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gonadal Hormones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Letrozole", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metformin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nitriles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxidative Stress", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polycystic Ovary Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reactive Oxygen Species", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rutin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triazoles", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
          "id": "http://www.grid.ac/institutes/grid.412621.2", 
          "name": [
            "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jahan", 
        "givenName": "Sarwat", 
        "id": "sg:person.01145161315.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145161315.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
          "id": "http://www.grid.ac/institutes/grid.412621.2", 
          "name": [
            "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Munir", 
        "givenName": "Faryal", 
        "id": "sg:person.016134524121.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016134524121.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.56302.32", 
          "name": [
            "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
            "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Razak", 
        "givenName": "Suhail", 
        "id": "sg:person.01357705511.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357705511.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
          "id": "http://www.grid.ac/institutes/grid.412621.2", 
          "name": [
            "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mehboob", 
        "givenName": "Anam", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
          "id": "http://www.grid.ac/institutes/grid.412621.2", 
          "name": [
            "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ain", 
        "givenName": "Qurat Ul", 
        "id": "sg:person.012117363073.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012117363073.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
          "id": "http://www.grid.ac/institutes/grid.412621.2", 
          "name": [
            "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ullah", 
        "givenName": "Hizb", 
        "id": "sg:person.0721665472.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721665472.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan", 
          "id": "http://www.grid.ac/institutes/grid.412621.2", 
          "name": [
            "Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Afsar", 
        "givenName": "Tayyaba", 
        "id": "sg:person.01243457111.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243457111.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan", 
          "id": "http://www.grid.ac/institutes/grid.412621.2", 
          "name": [
            "Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shaheen", 
        "givenName": "Ghazala", 
        "id": "sg:person.016066602171.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016066602171.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia", 
          "id": "http://www.grid.ac/institutes/grid.56302.32", 
          "name": [
            "Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Almajwal", 
        "givenName": "Ali", 
        "id": "sg:person.0760740725.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760740725.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1477-7827-3-28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019926167", 
          "https://doi.org/10.1186/1477-7827-3-28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2010.217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024597702", 
          "https://doi.org/10.1038/nrendo.2010.217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02536169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041139261", 
          "https://doi.org/10.1007/bf02536169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4684-5395-9_12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034434352", 
          "https://doi.org/10.1007/978-1-4684-5395-9_12"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12-07", 
    "datePublishedReg": "2016-12-07", 
    "description": "BackgroundPolycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The study was commenced to assess the favorable effects of Rutin against metabolic, biochemical, histological, and androgenic aspects of polycystic ovary syndrome in rats.MethodsFemale Sprague-Dawley rats were administered letrozole (1\u00a0mg/kg) per orally (p.o) for a period of 21\u00a0days for the induction of PCOS, followed by dose of rutin (100\u00a0mg/kg and 150\u00a0mg/kg, p.o) for 15\u00a0days using 0.5%\u00a0w/v CMC as vehicle. Metformin was also given as a standard control to one of the rat groups.Serum estradiol, progesterone, testosterone, serum lipid parameters, CRP and glucose levels were evaluated. Furthermore, antioxidant activity was tested using superoxide dismutase, catalase, glutathione per-oxidase and reactive-oxygen species level.ResultsRutin flavonoid had a dose-dependent effect on androgenic levels depicting more recovery in the rutin-I treated group, while rutin-II treated groups showed better antioxidant and lipid profiles as compared with PCOS groups. A decrease in the value of C reactive protein (CRP) and a restoration in the proportion of estrous phase smears were observed in the rutin treated groups. Histopathological examination of ovary revealed a significant decrease in the number of cystic follicles in post treated groups. The effects observed with rutin were moderately similar to that with standard metformin, a widely used treatment drug for PCOS.ConclusionThe study provides evidence for the potential ameliorative effects of rutin against clinical and biochemical features of PCOS.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13048-016-0295-y", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1040071", 
        "issn": [
          "1757-2215"
        ], 
        "name": "Journal of Ovarian Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "polycystic ovary syndrome", 
      "ovary syndrome", 
      "ameliorative effect", 
      "MethodsFemale Sprague\u2013Dawley rats", 
      "induction of PCOS", 
      "BackgroundPolycystic ovary syndrome", 
      "serum lipid parameters", 
      "Sprague-Dawley rats", 
      "potential ameliorative effects", 
      "dose-dependent effect", 
      "reactive oxygen species levels", 
      "prevalent endocrinopathy", 
      "PCOS group", 
      "serum estradiol", 
      "lipid parameters", 
      "cystic follicles", 
      "histopathological examination", 
      "hormonal disturbances", 
      "reproductive age", 
      "reactive protein", 
      "rat groups", 
      "lipid profile", 
      "glucose levels", 
      "treatment drugs", 
      "PCOS", 
      "standard metformin", 
      "syndrome", 
      "rats", 
      "favorable effect", 
      "significant decrease", 
      "androgenic levels", 
      "superoxide dismutase", 
      "metformin", 
      "biochemical features", 
      "antioxidant activity", 
      "group", 
      "more recovery", 
      "rutin", 
      "standard control", 
      "days", 
      "endocrinopathies", 
      "estradiol", 
      "progesterone", 
      "CRP", 
      "testosterone", 
      "levels", 
      "smears", 
      "follicles", 
      "dose", 
      "women", 
      "drugs", 
      "age", 
      "ovaries", 
      "effect", 
      "decrease", 
      "dismutase", 
      "examination", 
      "study", 
      "induction", 
      "catalase", 
      "glutathione", 
      "flavonoids", 
      "proportion", 
      "biochemical", 
      "evidence", 
      "period", 
      "control", 
      "species level", 
      "activity", 
      "recovery", 
      "protein", 
      "restoration", 
      "post", 
      "oxidase", 
      "disturbances", 
      "profile", 
      "number", 
      "features", 
      "aspects", 
      "values", 
      "parameters", 
      "vehicles", 
      "CMC"
    ], 
    "name": "Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats", 
    "pagination": "86", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018885784"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13048-016-0295-y"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27923406"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13048-016-0295-y", 
      "https://app.dimensions.ai/details/publication/pub.1018885784"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_720.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13048-016-0295-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13048-016-0295-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13048-016-0295-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13048-016-0295-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13048-016-0295-y'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      21 PREDICATES      134 URIs      122 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13048-016-0295-y schema:about N037d25549fc844959ea21691388ec98f
2 N089e0651ed7d47e296200ef8ad090c98
3 N264b2a7852134bb9ab3510ed430d95b6
4 N29cc4b3677534f3a8e62f8f6791218a6
5 N36196710b8df43f3ba7c4c3fed02d9e8
6 N411cfb751ed04dc79cbb4c5f04b80f40
7 N43d262f1038645fc91258c7e3ab79623
8 N45ba643eb3084a8bbbec0370046117b1
9 N45e8b8ba2c784df1adc4e84b80d79127
10 N49cdc58961d14c05b62844e77870e6f5
11 N4c0536d7b1134106b5c6a1dda25a7994
12 N6d39b8a9e31d419b832f85d7174cba24
13 N73fcafa1ab534d57b13adbda37e6b973
14 N924071ad440242c89f5e6c85cfea4461
15 N963739bb1c82430d830dd0b93ed38d0c
16 N9db54240d986424b989c543299885b56
17 Na0fd726e0eec42cd9f38201f024f0d38
18 Ncbbe7c8e826648279cd9dad02cc59f93
19 Ncc05428e35b24af7884eaeae1eb967eb
20 Ndcf3eefeba3e4c21b3a692549f370974
21 Nf17c1451156547948ff702348413b9c6
22 Nfb0979adde1e4d7c891588b6b8cba067
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N186e28c9ccc341e49f8f7f3ab64da65c
26 schema:citation sg:pub.10.1007/978-1-4684-5395-9_12
27 sg:pub.10.1007/bf02536169
28 sg:pub.10.1038/nrendo.2010.217
29 sg:pub.10.1186/1477-7827-3-28
30 schema:datePublished 2016-12-07
31 schema:datePublishedReg 2016-12-07
32 schema:description BackgroundPolycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The study was commenced to assess the favorable effects of Rutin against metabolic, biochemical, histological, and androgenic aspects of polycystic ovary syndrome in rats.MethodsFemale Sprague-Dawley rats were administered letrozole (1 mg/kg) per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of rutin (100 mg/kg and 150 mg/kg, p.o) for 15 days using 0.5% w/v CMC as vehicle. Metformin was also given as a standard control to one of the rat groups.Serum estradiol, progesterone, testosterone, serum lipid parameters, CRP and glucose levels were evaluated. Furthermore, antioxidant activity was tested using superoxide dismutase, catalase, glutathione per-oxidase and reactive-oxygen species level.ResultsRutin flavonoid had a dose-dependent effect on androgenic levels depicting more recovery in the rutin-I treated group, while rutin-II treated groups showed better antioxidant and lipid profiles as compared with PCOS groups. A decrease in the value of C reactive protein (CRP) and a restoration in the proportion of estrous phase smears were observed in the rutin treated groups. Histopathological examination of ovary revealed a significant decrease in the number of cystic follicles in post treated groups. The effects observed with rutin were moderately similar to that with standard metformin, a widely used treatment drug for PCOS.ConclusionThe study provides evidence for the potential ameliorative effects of rutin against clinical and biochemical features of PCOS.
33 schema:genre article
34 schema:isAccessibleForFree true
35 schema:isPartOf N6a6cd8aed52a4ab287c3da47bfdd253c
36 Nb9c60c7317224513a5b7b936bb165d3f
37 sg:journal.1040071
38 schema:keywords BackgroundPolycystic ovary syndrome
39 CMC
40 CRP
41 MethodsFemale Sprague–Dawley rats
42 PCOS
43 PCOS group
44 Sprague-Dawley rats
45 activity
46 age
47 ameliorative effect
48 androgenic levels
49 antioxidant activity
50 aspects
51 biochemical
52 biochemical features
53 catalase
54 control
55 cystic follicles
56 days
57 decrease
58 dismutase
59 disturbances
60 dose
61 dose-dependent effect
62 drugs
63 effect
64 endocrinopathies
65 estradiol
66 evidence
67 examination
68 favorable effect
69 features
70 flavonoids
71 follicles
72 glucose levels
73 glutathione
74 group
75 histopathological examination
76 hormonal disturbances
77 induction
78 induction of PCOS
79 levels
80 lipid parameters
81 lipid profile
82 metformin
83 more recovery
84 number
85 ovaries
86 ovary syndrome
87 oxidase
88 parameters
89 period
90 polycystic ovary syndrome
91 post
92 potential ameliorative effects
93 prevalent endocrinopathy
94 profile
95 progesterone
96 proportion
97 protein
98 rat groups
99 rats
100 reactive oxygen species levels
101 reactive protein
102 recovery
103 reproductive age
104 restoration
105 rutin
106 serum estradiol
107 serum lipid parameters
108 significant decrease
109 smears
110 species level
111 standard control
112 standard metformin
113 study
114 superoxide dismutase
115 syndrome
116 testosterone
117 treatment drugs
118 values
119 vehicles
120 women
121 schema:name Ameliorative effects of rutin against metabolic, biochemical and hormonal disturbances in polycystic ovary syndrome in rats
122 schema:pagination 86
123 schema:productId N374bfceb62bf402f8629f140afc46c34
124 N56a0ac16ac294c3e9fd5b87fae89a596
125 Ndfd1e59b72204239aab9e264caaf8f0d
126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018885784
127 https://doi.org/10.1186/s13048-016-0295-y
128 schema:sdDatePublished 2022-10-01T06:42
129 schema:sdLicense https://scigraph.springernature.com/explorer/license/
130 schema:sdPublisher N1e987e0c2d854a9cb9f95fffd380528b
131 schema:url https://doi.org/10.1186/s13048-016-0295-y
132 sgo:license sg:explorer/license/
133 sgo:sdDataset articles
134 rdf:type schema:ScholarlyArticle
135 N037d25549fc844959ea21691388ec98f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name C-Reactive Protein
137 rdf:type schema:DefinedTerm
138 N089e0651ed7d47e296200ef8ad090c98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Oxidative Stress
140 rdf:type schema:DefinedTerm
141 N0945b3ca800a4a38b08d44e168b4eed2 rdf:first sg:person.0760740725.04
142 rdf:rest rdf:nil
143 N186e28c9ccc341e49f8f7f3ab64da65c rdf:first sg:person.01145161315.83
144 rdf:rest N52a039b324364ee29fe916b04f41ea4c
145 N1e987e0c2d854a9cb9f95fffd380528b schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 N25e7579a65094c5b84c184099b436c3a rdf:first sg:person.012117363073.13
148 rdf:rest N58aad36047924979b1749a1c30c86ebd
149 N264b2a7852134bb9ab3510ed430d95b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Lipids
151 rdf:type schema:DefinedTerm
152 N29cc4b3677534f3a8e62f8f6791218a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Rats
154 rdf:type schema:DefinedTerm
155 N36196710b8df43f3ba7c4c3fed02d9e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Blood Glucose
157 rdf:type schema:DefinedTerm
158 N374bfceb62bf402f8629f140afc46c34 schema:name dimensions_id
159 schema:value pub.1018885784
160 rdf:type schema:PropertyValue
161 N411cfb751ed04dc79cbb4c5f04b80f40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Animals
163 rdf:type schema:DefinedTerm
164 N43d262f1038645fc91258c7e3ab79623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Reactive Oxygen Species
166 rdf:type schema:DefinedTerm
167 N45ba643eb3084a8bbbec0370046117b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Estrous Cycle
169 rdf:type schema:DefinedTerm
170 N45e8b8ba2c784df1adc4e84b80d79127 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Antioxidants
172 rdf:type schema:DefinedTerm
173 N49cdc58961d14c05b62844e77870e6f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Biomarkers
175 rdf:type schema:DefinedTerm
176 N4c0536d7b1134106b5c6a1dda25a7994 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Aromatase Inhibitors
178 rdf:type schema:DefinedTerm
179 N51b7217b290649f2b5b747ed5b9357b8 schema:affiliation grid-institutes:grid.412621.2
180 schema:familyName Mehboob
181 schema:givenName Anam
182 rdf:type schema:Person
183 N52a039b324364ee29fe916b04f41ea4c rdf:first sg:person.016134524121.59
184 rdf:rest Nd564a5548ce34207a042192116879afd
185 N56a0ac16ac294c3e9fd5b87fae89a596 schema:name doi
186 schema:value 10.1186/s13048-016-0295-y
187 rdf:type schema:PropertyValue
188 N58aad36047924979b1749a1c30c86ebd rdf:first sg:person.0721665472.94
189 rdf:rest Nb117a4f57ea143d29d24414e3285c3b4
190 N6a6cd8aed52a4ab287c3da47bfdd253c schema:issueNumber 1
191 rdf:type schema:PublicationIssue
192 N6d39b8a9e31d419b832f85d7174cba24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Letrozole
194 rdf:type schema:DefinedTerm
195 N73a105e71a074201b3f813aacbf52043 rdf:first sg:person.016066602171.18
196 rdf:rest N0945b3ca800a4a38b08d44e168b4eed2
197 N73fcafa1ab534d57b13adbda37e6b973 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Body Weights and Measures
199 rdf:type schema:DefinedTerm
200 N924071ad440242c89f5e6c85cfea4461 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Rutin
202 rdf:type schema:DefinedTerm
203 N963739bb1c82430d830dd0b93ed38d0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Ovary
205 rdf:type schema:DefinedTerm
206 N9db54240d986424b989c543299885b56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Triazoles
208 rdf:type schema:DefinedTerm
209 Na0fd726e0eec42cd9f38201f024f0d38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
210 schema:name Female
211 rdf:type schema:DefinedTerm
212 Nb117a4f57ea143d29d24414e3285c3b4 rdf:first sg:person.01243457111.54
213 rdf:rest N73a105e71a074201b3f813aacbf52043
214 Nb42bf917cda6452088850162ca8682e1 rdf:first N51b7217b290649f2b5b747ed5b9357b8
215 rdf:rest N25e7579a65094c5b84c184099b436c3a
216 Nb9c60c7317224513a5b7b936bb165d3f schema:volumeNumber 9
217 rdf:type schema:PublicationVolume
218 Ncbbe7c8e826648279cd9dad02cc59f93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Gonadal Hormones
220 rdf:type schema:DefinedTerm
221 Ncc05428e35b24af7884eaeae1eb967eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Nitriles
223 rdf:type schema:DefinedTerm
224 Nd564a5548ce34207a042192116879afd rdf:first sg:person.01357705511.88
225 rdf:rest Nb42bf917cda6452088850162ca8682e1
226 Ndcf3eefeba3e4c21b3a692549f370974 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Disease Models, Animal
228 rdf:type schema:DefinedTerm
229 Ndfd1e59b72204239aab9e264caaf8f0d schema:name pubmed_id
230 schema:value 27923406
231 rdf:type schema:PropertyValue
232 Nf17c1451156547948ff702348413b9c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Metformin
234 rdf:type schema:DefinedTerm
235 Nfb0979adde1e4d7c891588b6b8cba067 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
236 schema:name Polycystic Ovary Syndrome
237 rdf:type schema:DefinedTerm
238 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
239 schema:name Medical and Health Sciences
240 rdf:type schema:DefinedTerm
241 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
242 schema:name Clinical Sciences
243 rdf:type schema:DefinedTerm
244 sg:journal.1040071 schema:issn 1757-2215
245 schema:name Journal of Ovarian Research
246 schema:publisher Springer Nature
247 rdf:type schema:Periodical
248 sg:person.01145161315.83 schema:affiliation grid-institutes:grid.412621.2
249 schema:familyName Jahan
250 schema:givenName Sarwat
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145161315.83
252 rdf:type schema:Person
253 sg:person.012117363073.13 schema:affiliation grid-institutes:grid.412621.2
254 schema:familyName Ain
255 schema:givenName Qurat Ul
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012117363073.13
257 rdf:type schema:Person
258 sg:person.01243457111.54 schema:affiliation grid-institutes:grid.412621.2
259 schema:familyName Afsar
260 schema:givenName Tayyaba
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243457111.54
262 rdf:type schema:Person
263 sg:person.01357705511.88 schema:affiliation grid-institutes:grid.56302.32
264 schema:familyName Razak
265 schema:givenName Suhail
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357705511.88
267 rdf:type schema:Person
268 sg:person.016066602171.18 schema:affiliation grid-institutes:grid.412621.2
269 schema:familyName Shaheen
270 schema:givenName Ghazala
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016066602171.18
272 rdf:type schema:Person
273 sg:person.016134524121.59 schema:affiliation grid-institutes:grid.412621.2
274 schema:familyName Munir
275 schema:givenName Faryal
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016134524121.59
277 rdf:type schema:Person
278 sg:person.0721665472.94 schema:affiliation grid-institutes:grid.412621.2
279 schema:familyName Ullah
280 schema:givenName Hizb
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721665472.94
282 rdf:type schema:Person
283 sg:person.0760740725.04 schema:affiliation grid-institutes:grid.56302.32
284 schema:familyName Almajwal
285 schema:givenName Ali
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760740725.04
287 rdf:type schema:Person
288 sg:pub.10.1007/978-1-4684-5395-9_12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034434352
289 https://doi.org/10.1007/978-1-4684-5395-9_12
290 rdf:type schema:CreativeWork
291 sg:pub.10.1007/bf02536169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041139261
292 https://doi.org/10.1007/bf02536169
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nrendo.2010.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024597702
295 https://doi.org/10.1038/nrendo.2010.217
296 rdf:type schema:CreativeWork
297 sg:pub.10.1186/1477-7827-3-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019926167
298 https://doi.org/10.1186/1477-7827-3-28
299 rdf:type schema:CreativeWork
300 grid-institutes:grid.412621.2 schema:alternateName Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
301 Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan
302 schema:name Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan
303 Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan
304 rdf:type schema:Organization
305 grid-institutes:grid.56302.32 schema:alternateName Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
306 schema:name Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
307 Reproductive Physiology Laboratory, Department Of Animal Sciences, Quaid-i-Azam University, Islamabad, Pakistan
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...