The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patient‐derived ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-05-11

AUTHORS

Alessandro De Vita, Federica Recine, Giacomo Miserocchi, Federica Pieri, Chiara Spadazzi, Claudia Cocchi, Silvia Vanni, Chiara Liverani, Anna Farnedi, Francesco Fabbri, Valentina Fausti, Roberto Casadei, Francesca Brandolini, Giorgio Ercolani, Davide Cavaliere, Alberto Bongiovanni, Nada Riva, Lorena Gurrieri, Giandomenico Di Menna, Sebastiano Calpona, Silvia Angela Debonis, Laura Mercatali, Toni Ibrahim

ABSTRACT

BackgroundSoft tissue sarcomas (STS) are a rare group of solid neoplasm including among others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic sarcoma (UPS) entities. The current first-line treatment is represented by anthracycline based- regimens, second-line may include trabectedin. Currently the activity of trabectedin and its mechanism of action is not completely elucidated.MethodsTaking the advantages of our 3D patient-derived primary culture translational model we performed genomic-, chemobiogram, proteomic- and in vivo analysis in a UPS culture (S1). Furthermore pharmacological profiling of a UPS and L-sarcoma patient-derived case series and in silico analysis were carried out.ResultsTrabectedin exhibited an increased activity in 3D respect to 2D cultures suggesting an extracellular matrix (ECM) and timp1 involvement in its mechanism of action. Moreover 3D S1 xenotranspanted zebrafish model showed an increased sensitivity to trabectedin. Finally the results were further validated in a UPS and L-sarcoma case series.ConclusionsTaken together these results confirmed the activity of trabectedin in these STS histotypes. Moreover the data underline the ECM involvement in the cytotoxic effect mediated by trabectedin and could open the door for researches aimed to focus on the patient setting that could benefit from this agent. More... »

PAGES

165

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13046-021-01963-1

DOI

http://dx.doi.org/10.1186/s13046-021-01963-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1137907446

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33975637


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents, Alkylating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Extracellular Matrix", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trabectedin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zebrafish", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Vita", 
        "givenName": "Alessandro", 
        "id": "sg:person.01211336200.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211336200.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Oncology Unit, San Camillo de Lellis Hospital, Rieti, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
            "Medical Oncology Unit, San Camillo de Lellis Hospital, Rieti, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Recine", 
        "givenName": "Federica", 
        "id": "sg:person.011025327675.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011025327675.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miserocchi", 
        "givenName": "Giacomo", 
        "id": "sg:person.011622710275.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011622710275.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathology Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy", 
          "id": "http://www.grid.ac/institutes/grid.415079.e", 
          "name": [
            "Pathology Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pieri", 
        "givenName": "Federica", 
        "id": "sg:person.0726705540.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726705540.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spadazzi", 
        "givenName": "Chiara", 
        "id": "sg:person.01075107600.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075107600.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cocchi", 
        "givenName": "Claudia", 
        "id": "sg:person.011401677751.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011401677751.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vanni", 
        "givenName": "Silvia", 
        "id": "sg:person.01057433056.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057433056.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liverani", 
        "givenName": "Chiara", 
        "id": "sg:person.01165115340.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165115340.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathology Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy", 
          "id": "http://www.grid.ac/institutes/grid.415079.e", 
          "name": [
            "Pathology Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Farnedi", 
        "givenName": "Anna", 
        "id": "sg:person.0770015575.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770015575.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biosciences Laboratory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/grid.419563.c", 
          "name": [
            "Biosciences Laboratory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fabbri", 
        "givenName": "Francesco", 
        "id": "sg:person.01257517274.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257517274.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fausti", 
        "givenName": "Valentina", 
        "id": "sg:person.07770210627.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07770210627.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Orthopedic Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy", 
          "id": "http://www.grid.ac/institutes/grid.415079.e", 
          "name": [
            "Orthopedic Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Casadei", 
        "givenName": "Roberto", 
        "id": "sg:person.010347170674.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347170674.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Orthopedic Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy", 
          "id": "http://www.grid.ac/institutes/grid.415079.e", 
          "name": [
            "Orthopedic Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brandolini", 
        "givenName": "Francesca", 
        "id": "sg:person.012504173051.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012504173051.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medical and Surgical Sciences - DIMEC, University of Bologna, Bologna, Italy", 
          "id": "http://www.grid.ac/institutes/grid.6292.f", 
          "name": [
            "General and Oncologic Surgery Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy", 
            "Department of Medical and Surgical Sciences - DIMEC, University of Bologna, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ercolani", 
        "givenName": "Giorgio", 
        "id": "sg:person.01000444470.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000444470.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "General and Oncologic Surgery Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy", 
          "id": "http://www.grid.ac/institutes/grid.415079.e", 
          "name": [
            "General and Oncologic Surgery Unit, Morgagni-Pierantoni Hospital, Forl\u00ec, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cavaliere", 
        "givenName": "Davide", 
        "id": "sg:person.01243162472.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243162472.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bongiovanni", 
        "givenName": "Alberto", 
        "id": "sg:person.0650273700.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650273700.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riva", 
        "givenName": "Nada", 
        "id": "sg:person.01043134140.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043134140.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gurrieri", 
        "givenName": "Lorena", 
        "id": "sg:person.01316656070.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316656070.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Menna", 
        "givenName": "Giandomenico", 
        "id": "sg:person.014576371263.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576371263.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Calpona", 
        "givenName": "Sebastiano", 
        "id": "sg:person.01335655773.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335655773.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Debonis", 
        "givenName": "Silvia Angela", 
        "id": "sg:person.011231511467.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011231511467.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mercatali", 
        "givenName": "Laura", 
        "id": "sg:person.0777236312.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777236312.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) \u201cDino Amadori\u201d, Meldola, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ibrahim", 
        "givenName": "Toni", 
        "id": "sg:person.0620211740.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620211740.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.2014.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006338022", 
          "https://doi.org/10.1038/bjc.2014.149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12195-017-0483-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084034408", 
          "https://doi.org/10.1007/s12195-017-0483-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12967-017-1328-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092576442", 
          "https://doi.org/10.1186/s12967-017-1328-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-021-84492-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1135875214", 
          "https://doi.org/10.1038/s41598-021-84492-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-019-48701-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1120500693", 
          "https://doi.org/10.1038/s41598-019-48701-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11202860-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002180227", 
          "https://doi.org/10.2165/11202860-000000000-00000"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2021-05-11", 
    "datePublishedReg": "2021-05-11", 
    "description": "BackgroundSoft tissue sarcomas (STS) are a rare group of solid neoplasm including among others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic sarcoma (UPS) entities. The current first-line treatment is represented by anthracycline based- regimens, second-line may include trabectedin. Currently the activity of trabectedin and its mechanism of action is not completely elucidated.MethodsTaking the advantages of our 3D patient-derived primary culture translational model we performed genomic-, chemobiogram, proteomic- and in vivo analysis in a UPS culture (S1). Furthermore pharmacological profiling of a UPS and L-sarcoma patient-derived case series and in silico analysis were carried out.ResultsTrabectedin exhibited an increased activity in 3D respect to 2D cultures suggesting an extracellular matrix (ECM) and timp1 involvement in its mechanism of action. Moreover 3D S1 xenotranspanted zebrafish model showed an increased sensitivity to trabectedin. Finally the results were further validated in a UPS and L-sarcoma case series.ConclusionsTaken together these results confirmed the activity of trabectedin in these STS histotypes. Moreover the data underline the ECM involvement in the cytotoxic effect mediated by trabectedin and could open the door for researches aimed to focus on the patient setting that could benefit from this agent.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/s13046-021-01963-1", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1094159", 
        "issn": [
          "0392-9078", 
          "1756-9966"
        ], 
        "name": "Journal of Experimental & Clinical Cancer Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "keywords": [
      "activity of trabectedin", 
      "case series", 
      "mechanism of action", 
      "current first-line treatment", 
      "BackgroundSoft tissue sarcomas", 
      "first-line treatment", 
      "tissue sarcomas", 
      "patient setting", 
      "L-sarcoma", 
      "extracellular matrix", 
      "solid neoplasms", 
      "trabectedin", 
      "sarcoma entities", 
      "pharmacological profiling", 
      "rare group", 
      "translational model", 
      "zebrafish model", 
      "cytotoxic effects", 
      "potential role", 
      "vivo analysis", 
      "involvement", 
      "leiomyosarcoma", 
      "sarcoma", 
      "liposarcoma", 
      "neoplasms", 
      "anthracyclines", 
      "activity", 
      "silico analysis", 
      "ConclusionsTaken", 
      "treatment", 
      "action", 
      "group", 
      "culture", 
      "agents", 
      "mechanism", 
      "setting", 
      "evidence", 
      "entities", 
      "series", 
      "role", 
      "profiling", 
      "sensitivity", 
      "STS", 
      "analysis", 
      "effect", 
      "results", 
      "proteomics", 
      "S1", 
      "data", 
      "model", 
      "research", 
      "door", 
      "genomics", 
      "respect", 
      "advantages", 
      "matrix", 
      "UPS"
    ], 
    "name": "The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patient\u2010derived primary culture case series in tridimensional and zebrafish models", 
    "pagination": "165", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1137907446"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13046-021-01963-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33975637"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13046-021-01963-1", 
      "https://app.dimensions.ai/details/publication/pub.1137907446"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_880.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/s13046-021-01963-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13046-021-01963-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13046-021-01963-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13046-021-01963-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13046-021-01963-1'


 

This table displays all metadata directly associated to this object as RDF triples.

344 TRIPLES      21 PREDICATES      96 URIs      82 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13046-021-01963-1 schema:about N03319db7f51b41d4a6c27368f050769a
2 N1d1aa98b79ca44fa907c750d477c4c8c
3 N6d7412ed31dc4c02bac88347d0e2ec4a
4 N7093ff34106b449883b7207a64da141a
5 N70a857b41ec845598762770812d23848
6 Nbaa53a1a1ab944fd9c8aa387cf46d4f9
7 Nc051623e72e74c839652dd8297fd7836
8 Nca8962eb09b149e6892954a7b3c6614e
9 anzsrc-for:11
10 anzsrc-for:1112
11 schema:author N6fa02b6238b948e49fe3b4f2500b4233
12 schema:citation sg:pub.10.1007/s12195-017-0483-x
13 sg:pub.10.1038/bjc.2014.149
14 sg:pub.10.1038/s41598-019-48701-4
15 sg:pub.10.1038/s41598-021-84492-3
16 sg:pub.10.1186/s12967-017-1328-z
17 sg:pub.10.2165/11202860-000000000-00000
18 schema:datePublished 2021-05-11
19 schema:datePublishedReg 2021-05-11
20 schema:description BackgroundSoft tissue sarcomas (STS) are a rare group of solid neoplasm including among others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic sarcoma (UPS) entities. The current first-line treatment is represented by anthracycline based- regimens, second-line may include trabectedin. Currently the activity of trabectedin and its mechanism of action is not completely elucidated.MethodsTaking the advantages of our 3D patient-derived primary culture translational model we performed genomic-, chemobiogram, proteomic- and in vivo analysis in a UPS culture (S1). Furthermore pharmacological profiling of a UPS and L-sarcoma patient-derived case series and in silico analysis were carried out.ResultsTrabectedin exhibited an increased activity in 3D respect to 2D cultures suggesting an extracellular matrix (ECM) and timp1 involvement in its mechanism of action. Moreover 3D S1 xenotranspanted zebrafish model showed an increased sensitivity to trabectedin. Finally the results were further validated in a UPS and L-sarcoma case series.ConclusionsTaken together these results confirmed the activity of trabectedin in these STS histotypes. Moreover the data underline the ECM involvement in the cytotoxic effect mediated by trabectedin and could open the door for researches aimed to focus on the patient setting that could benefit from this agent.
21 schema:genre article
22 schema:isAccessibleForFree true
23 schema:isPartOf N5c6748ca2c53490bad6727a7121ef5bd
24 Ndb44dadbb0704efe8c0d371d36536672
25 sg:journal.1094159
26 schema:keywords BackgroundSoft tissue sarcomas
27 ConclusionsTaken
28 L-sarcoma
29 S1
30 STS
31 UPS
32 action
33 activity
34 activity of trabectedin
35 advantages
36 agents
37 analysis
38 anthracyclines
39 case series
40 culture
41 current first-line treatment
42 cytotoxic effects
43 data
44 door
45 effect
46 entities
47 evidence
48 extracellular matrix
49 first-line treatment
50 genomics
51 group
52 involvement
53 leiomyosarcoma
54 liposarcoma
55 matrix
56 mechanism
57 mechanism of action
58 model
59 neoplasms
60 patient setting
61 pharmacological profiling
62 potential role
63 profiling
64 proteomics
65 rare group
66 research
67 respect
68 results
69 role
70 sarcoma
71 sarcoma entities
72 sensitivity
73 series
74 setting
75 silico analysis
76 solid neoplasms
77 tissue sarcomas
78 trabectedin
79 translational model
80 treatment
81 vivo analysis
82 zebrafish model
83 schema:name The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patient‐derived primary culture case series in tridimensional and zebrafish models
84 schema:pagination 165
85 schema:productId N3d8924bcbb96406c816d6abace897365
86 N478397746d634deeb849c57c521326fa
87 Nb644aa0fbda4418ebf158761b41a4cef
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1137907446
89 https://doi.org/10.1186/s13046-021-01963-1
90 schema:sdDatePublished 2022-12-01T06:42
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N300eb1884bde46679a6cd196b2c52533
93 schema:url https://doi.org/10.1186/s13046-021-01963-1
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N03319db7f51b41d4a6c27368f050769a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Extracellular Matrix
99 rdf:type schema:DefinedTerm
100 N1037685a2be54476b839de083be9a665 rdf:first sg:person.014576371263.73
101 rdf:rest N4731e3ce08874f0b89690d3ad0da1d48
102 N1d1aa98b79ca44fa907c750d477c4c8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Animals
104 rdf:type schema:DefinedTerm
105 N300eb1884bde46679a6cd196b2c52533 schema:name Springer Nature - SN SciGraph project
106 rdf:type schema:Organization
107 N320025e39a1848d4bd20508bcdce5fed rdf:first sg:person.011025327675.99
108 rdf:rest Na168bc4854b04ea8baa9d27b0e59b588
109 N3ccbe6f1ca8b472fa67ca6f1d4079714 rdf:first sg:person.01043134140.04
110 rdf:rest N50b34b59d49b437f9f1cb4f550aaa2cb
111 N3d8924bcbb96406c816d6abace897365 schema:name doi
112 schema:value 10.1186/s13046-021-01963-1
113 rdf:type schema:PropertyValue
114 N4731e3ce08874f0b89690d3ad0da1d48 rdf:first sg:person.01335655773.98
115 rdf:rest Nb74f427e87714e65b31f50fa62d0286e
116 N478397746d634deeb849c57c521326fa schema:name dimensions_id
117 schema:value pub.1137907446
118 rdf:type schema:PropertyValue
119 N50b34b59d49b437f9f1cb4f550aaa2cb rdf:first sg:person.01316656070.51
120 rdf:rest N1037685a2be54476b839de083be9a665
121 N576dab38e0844936b1eb9429c0198496 rdf:first sg:person.0726705540.65
122 rdf:rest Nf13ea98850b2457db73c59560c103704
123 N5c6748ca2c53490bad6727a7121ef5bd schema:volumeNumber 40
124 rdf:type schema:PublicationVolume
125 N5ff8f81017d44824a4c0b23950b6dbbb rdf:first sg:person.010347170674.75
126 rdf:rest N789afcc2766c4bcf973fd0ec74d840dd
127 N6d7412ed31dc4c02bac88347d0e2ec4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Antineoplastic Agents, Alkylating
129 rdf:type schema:DefinedTerm
130 N6fa02b6238b948e49fe3b4f2500b4233 rdf:first sg:person.01211336200.97
131 rdf:rest N320025e39a1848d4bd20508bcdce5fed
132 N7093ff34106b449883b7207a64da141a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Trabectedin
134 rdf:type schema:DefinedTerm
135 N70a857b41ec845598762770812d23848 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Disease Models, Animal
137 rdf:type schema:DefinedTerm
138 N789afcc2766c4bcf973fd0ec74d840dd rdf:first sg:person.012504173051.69
139 rdf:rest Nfc9f74be7abb4133b768815393a26755
140 N81d85d2dc3604a038916ae9245322534 rdf:first sg:person.01243162472.01
141 rdf:rest Nb7755daa3b5d4d0a91cb47d0d898fe93
142 N877bdc0561a34298afb6a9b07abc8a19 rdf:first sg:person.0770015575.54
143 rdf:rest Nff65d6a7ebaf46f78cc00533b06c12fb
144 N93e3bc5b95fd417c8ee61aefaae8ac9f rdf:first sg:person.0620211740.11
145 rdf:rest rdf:nil
146 Na168bc4854b04ea8baa9d27b0e59b588 rdf:first sg:person.011622710275.31
147 rdf:rest N576dab38e0844936b1eb9429c0198496
148 Naad38f9ecf1a4e84bd49b78c8583c8c7 rdf:first sg:person.01165115340.31
149 rdf:rest N877bdc0561a34298afb6a9b07abc8a19
150 Nb644aa0fbda4418ebf158761b41a4cef schema:name pubmed_id
151 schema:value 33975637
152 rdf:type schema:PropertyValue
153 Nb74f427e87714e65b31f50fa62d0286e rdf:first sg:person.011231511467.75
154 rdf:rest Nb7cd1c930f324f5ca157d6a22b09cb93
155 Nb7755daa3b5d4d0a91cb47d0d898fe93 rdf:first sg:person.0650273700.27
156 rdf:rest N3ccbe6f1ca8b472fa67ca6f1d4079714
157 Nb7cd1c930f324f5ca157d6a22b09cb93 rdf:first sg:person.0777236312.69
158 rdf:rest N93e3bc5b95fd417c8ee61aefaae8ac9f
159 Nbaa53a1a1ab944fd9c8aa387cf46d4f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Zebrafish
161 rdf:type schema:DefinedTerm
162 Nc051623e72e74c839652dd8297fd7836 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Sarcoma
164 rdf:type schema:DefinedTerm
165 Nc09afeb068914eb79c236a39bd8f4f15 rdf:first sg:person.011401677751.29
166 rdf:rest Nc2ec4a2c94b3490691d73e8a3176ac35
167 Nc2ec4a2c94b3490691d73e8a3176ac35 rdf:first sg:person.01057433056.24
168 rdf:rest Naad38f9ecf1a4e84bd49b78c8583c8c7
169 Nca8962eb09b149e6892954a7b3c6614e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Humans
171 rdf:type schema:DefinedTerm
172 Ndb44dadbb0704efe8c0d371d36536672 schema:issueNumber 1
173 rdf:type schema:PublicationIssue
174 Ne0fe8eb0e7734528a1392873fbc47240 rdf:first sg:person.07770210627.28
175 rdf:rest N5ff8f81017d44824a4c0b23950b6dbbb
176 Nf13ea98850b2457db73c59560c103704 rdf:first sg:person.01075107600.67
177 rdf:rest Nc09afeb068914eb79c236a39bd8f4f15
178 Nfc9f74be7abb4133b768815393a26755 rdf:first sg:person.01000444470.53
179 rdf:rest N81d85d2dc3604a038916ae9245322534
180 Nff65d6a7ebaf46f78cc00533b06c12fb rdf:first sg:person.01257517274.41
181 rdf:rest Ne0fe8eb0e7734528a1392873fbc47240
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
186 schema:name Oncology and Carcinogenesis
187 rdf:type schema:DefinedTerm
188 sg:journal.1094159 schema:issn 0392-9078
189 1756-9966
190 schema:name Journal of Experimental & Clinical Cancer Research
191 schema:publisher Springer Nature
192 rdf:type schema:Periodical
193 sg:person.01000444470.53 schema:affiliation grid-institutes:grid.6292.f
194 schema:familyName Ercolani
195 schema:givenName Giorgio
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000444470.53
197 rdf:type schema:Person
198 sg:person.010347170674.75 schema:affiliation grid-institutes:grid.415079.e
199 schema:familyName Casadei
200 schema:givenName Roberto
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010347170674.75
202 rdf:type schema:Person
203 sg:person.01043134140.04 schema:affiliation grid-institutes:None
204 schema:familyName Riva
205 schema:givenName Nada
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043134140.04
207 rdf:type schema:Person
208 sg:person.01057433056.24 schema:affiliation grid-institutes:None
209 schema:familyName Vanni
210 schema:givenName Silvia
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057433056.24
212 rdf:type schema:Person
213 sg:person.01075107600.67 schema:affiliation grid-institutes:None
214 schema:familyName Spadazzi
215 schema:givenName Chiara
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075107600.67
217 rdf:type schema:Person
218 sg:person.011025327675.99 schema:affiliation grid-institutes:None
219 schema:familyName Recine
220 schema:givenName Federica
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011025327675.99
222 rdf:type schema:Person
223 sg:person.011231511467.75 schema:affiliation grid-institutes:None
224 schema:familyName Debonis
225 schema:givenName Silvia Angela
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011231511467.75
227 rdf:type schema:Person
228 sg:person.011401677751.29 schema:affiliation grid-institutes:None
229 schema:familyName Cocchi
230 schema:givenName Claudia
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011401677751.29
232 rdf:type schema:Person
233 sg:person.011622710275.31 schema:affiliation grid-institutes:None
234 schema:familyName Miserocchi
235 schema:givenName Giacomo
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011622710275.31
237 rdf:type schema:Person
238 sg:person.01165115340.31 schema:affiliation grid-institutes:None
239 schema:familyName Liverani
240 schema:givenName Chiara
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165115340.31
242 rdf:type schema:Person
243 sg:person.01211336200.97 schema:affiliation grid-institutes:None
244 schema:familyName De Vita
245 schema:givenName Alessandro
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211336200.97
247 rdf:type schema:Person
248 sg:person.01243162472.01 schema:affiliation grid-institutes:grid.415079.e
249 schema:familyName Cavaliere
250 schema:givenName Davide
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243162472.01
252 rdf:type schema:Person
253 sg:person.012504173051.69 schema:affiliation grid-institutes:grid.415079.e
254 schema:familyName Brandolini
255 schema:givenName Francesca
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012504173051.69
257 rdf:type schema:Person
258 sg:person.01257517274.41 schema:affiliation grid-institutes:grid.419563.c
259 schema:familyName Fabbri
260 schema:givenName Francesco
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257517274.41
262 rdf:type schema:Person
263 sg:person.01316656070.51 schema:affiliation grid-institutes:None
264 schema:familyName Gurrieri
265 schema:givenName Lorena
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316656070.51
267 rdf:type schema:Person
268 sg:person.01335655773.98 schema:affiliation grid-institutes:None
269 schema:familyName Calpona
270 schema:givenName Sebastiano
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335655773.98
272 rdf:type schema:Person
273 sg:person.014576371263.73 schema:affiliation grid-institutes:None
274 schema:familyName Di Menna
275 schema:givenName Giandomenico
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014576371263.73
277 rdf:type schema:Person
278 sg:person.0620211740.11 schema:affiliation grid-institutes:None
279 schema:familyName Ibrahim
280 schema:givenName Toni
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620211740.11
282 rdf:type schema:Person
283 sg:person.0650273700.27 schema:affiliation grid-institutes:None
284 schema:familyName Bongiovanni
285 schema:givenName Alberto
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650273700.27
287 rdf:type schema:Person
288 sg:person.0726705540.65 schema:affiliation grid-institutes:grid.415079.e
289 schema:familyName Pieri
290 schema:givenName Federica
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726705540.65
292 rdf:type schema:Person
293 sg:person.0770015575.54 schema:affiliation grid-institutes:grid.415079.e
294 schema:familyName Farnedi
295 schema:givenName Anna
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770015575.54
297 rdf:type schema:Person
298 sg:person.07770210627.28 schema:affiliation grid-institutes:None
299 schema:familyName Fausti
300 schema:givenName Valentina
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07770210627.28
302 rdf:type schema:Person
303 sg:person.0777236312.69 schema:affiliation grid-institutes:None
304 schema:familyName Mercatali
305 schema:givenName Laura
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777236312.69
307 rdf:type schema:Person
308 sg:pub.10.1007/s12195-017-0483-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1084034408
309 https://doi.org/10.1007/s12195-017-0483-x
310 rdf:type schema:CreativeWork
311 sg:pub.10.1038/bjc.2014.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006338022
312 https://doi.org/10.1038/bjc.2014.149
313 rdf:type schema:CreativeWork
314 sg:pub.10.1038/s41598-019-48701-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1120500693
315 https://doi.org/10.1038/s41598-019-48701-4
316 rdf:type schema:CreativeWork
317 sg:pub.10.1038/s41598-021-84492-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1135875214
318 https://doi.org/10.1038/s41598-021-84492-3
319 rdf:type schema:CreativeWork
320 sg:pub.10.1186/s12967-017-1328-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1092576442
321 https://doi.org/10.1186/s12967-017-1328-z
322 rdf:type schema:CreativeWork
323 sg:pub.10.2165/11202860-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002180227
324 https://doi.org/10.2165/11202860-000000000-00000
325 rdf:type schema:CreativeWork
326 grid-institutes:None schema:alternateName Medical Oncology Unit, San Camillo de Lellis Hospital, Rieti, Italy
327 Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) “Dino Amadori”, Meldola, Italy
328 schema:name Medical Oncology Unit, San Camillo de Lellis Hospital, Rieti, Italy
329 Osteoncology and Rare Tumors Center, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) “Dino Amadori”, Meldola, Italy
330 rdf:type schema:Organization
331 grid-institutes:grid.415079.e schema:alternateName General and Oncologic Surgery Unit, Morgagni-Pierantoni Hospital, Forlì, Italy
332 Orthopedic Unit, Morgagni-Pierantoni Hospital, Forlì, Italy
333 Pathology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy
334 schema:name General and Oncologic Surgery Unit, Morgagni-Pierantoni Hospital, Forlì, Italy
335 Orthopedic Unit, Morgagni-Pierantoni Hospital, Forlì, Italy
336 Pathology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy
337 rdf:type schema:Organization
338 grid-institutes:grid.419563.c schema:alternateName Biosciences Laboratory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) “Dino Amadori”, Meldola, Italy
339 schema:name Biosciences Laboratory, IRCCS Istituto Romagnolo Per Lo Studio Dei Tumori (IRST) “Dino Amadori”, Meldola, Italy
340 rdf:type schema:Organization
341 grid-institutes:grid.6292.f schema:alternateName Department of Medical and Surgical Sciences - DIMEC, University of Bologna, Bologna, Italy
342 schema:name Department of Medical and Surgical Sciences - DIMEC, University of Bologna, Bologna, Italy
343 General and Oncologic Surgery Unit, Morgagni-Pierantoni Hospital, Forlì, Italy
344 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...