3D models in the new era of immune oncology: focus on T cells, CAF and ECM View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-12

AUTHORS

Francesca Di Modugno, Cristina Colosi, Paola Trono, Giuseppe Antonacci, Giancarlo Ruocco, Paola Nisticò

ABSTRACT

Immune checkpoint inhibitor therapy has changed clinical practice for patients with different cancers, since these agents have demonstrated a significant improvement of overall survival and are effective in many patients. However, an intrinsic or acquired resistance frequently occur and biomarkers predictive of responsiveness should help in patient selection and in defining the adequate treatment options. A deep analysis of the complexity of the tumor microenvironment is likely to further advance the field and hopefully identify more effective combined immunotherapeutic strategies. Here we review the current knowledge on tumor microenvironment, focusing on T cells, cancer associated fibroblasts and extracellular matrix. The use of 3D cell culture models to resemble tumor microenvironment landscape and to screen immunomodulatory drugs is also reviewed. More... »

PAGES

117

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13046-019-1086-2

    DOI

    http://dx.doi.org/10.1186/s13046-019-1086-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112926645

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30898166


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