MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer View Full Text


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Article Info

DATE

2019-02-04

AUTHORS

Lu Zhang, Yi Liao, Liling Tang

ABSTRACT

MicroRNA-34 (miR-34) has been reported to be dysregulated in various human cancers and regarded as a tumor suppressive microRNA because of its synergistic effect with the well-known tumor suppressor p53. Along with the application of MRX34, the first tumor-targeted microRNA drug which based on miR-34a mimics, on phase I clinical trial (NCT01829971), the significance of miR-34 is increasingly recognized. miR-34 plays a crucial role on repressing tumor progression by involving in epithelial-mesenchymal transition (EMT) via EMT- transcription factors, p53 and some important signal pathways. Not only that, numerous preclinical researches revealed the giant potential of miR-34a on cancer therapy through diversiform nano-scaled delivery systems. Here, we provide an overview about the function of miR-34 in various cancers and the mechanism of miR-34 in tumor-associated EMT. Furthermore, its potential role as a microRNA therapeutic candidate is also discussed. Notwithstanding some obstacles existed, the extensive application prospect of miR-34 on oncotherapy cannot be neglected. More... »

PAGES

53

References to SciGraph publications

  • 2018-01-26. miR-34a is involved in CSE-induced apoptosis of human pulmonary microvascular endothelial cells by targeting Notch-1 receptor protein in RESPIRATORY RESEARCH
  • 2012-09-04. EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2012-09-24. MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1 in ONCOGENE
  • 2013-09-28. miR-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells in TUMOR BIOLOGY
  • 2011-01-16. Identification of miR-34a as a potent inhibitor of prostate cancer progenitor cells and metastasis by directly repressing CD44 in NATURE MEDICINE
  • 2011-01-12. Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas in VIRCHOWS ARCHIV
  • 2015-09-01. Principles of nanoparticle design for overcoming biological barriers to drug delivery in NATURE BIOTECHNOLOGY
  • 2017-12-19. Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1 in SCIENTIFIC REPORTS
  • 2013-01-06. Oncolytic adenovirus co-expressing miRNA-34a and IL-24 induces superior antitumor activity in experimental tumor model in JOURNAL OF MOLECULAR MEDICINE
  • 2016-12-05. Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors in INVESTIGATIONAL NEW DRUGS
  • 2012-09-19. Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2018-02-02. miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding in LEUKEMIA
  • 2015. A qRT-PCR Method for Determining the Biodistribution Profile of a miR-34a Mimic in GENE THERAPY OF SOLID CANCERS
  • 2017-12-20. Evidence of novel miR-34a-based therapeutic approaches for multiple myeloma treatment in SCIENTIFIC REPORTS
  • 2013-11-09. MicroRNA expression profile in head and neck cancer: HOX-cluster embedded microRNA-196a and microRNA-10b dysregulation implicated in cell proliferation in BMC CANCER
  • 2013-12-27. Dysregulation of MicroRNA-34a Expression in Colorectal Cancer Inhibits the Phosphorylation of FAK Via VEGF in DIGESTIVE DISEASES AND SCIENCES
  • 2015-06-16. microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway in BMC CANCER
  • 2017-08-28. Analysis of the miR-34 family functions in breast cancer reveals annotation error of miR-34b in SCIENTIFIC REPORTS
  • 2017-02-17. MicroRNA therapeutics: towards a new era for the management of cancer and other diseases in NATURE REVIEWS DRUG DISCOVERY
  • 2010-04-27. Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma in BMC SYSTEMS BIOLOGY
  • 2017-03-09. The microRNA expression signature of small cell lung cancer: tumor suppressors of miR-27a-5p and miR-34b-3p and their targeted oncogenes in JOURNAL OF HUMAN GENETICS
  • 2012-08-17. MicroRNAs in the p53 network: micromanagement of tumour suppression in NATURE REVIEWS CANCER
  • 2014-09-01. A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer in ONCOGENE
  • 2018-08-09. Dual role for miR-34a in the control of early progenitor proliferation and commitment in the mammary gland and in breast cancer in ONCOGENE
  • 2013-01-24. Regulatory networks defining EMT during cancer initiation and progression in NATURE REVIEWS CANCER
  • 2016-12-15. Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis in VIRCHOWS ARCHIV
  • 2018-12-12. Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer in CLINICAL EPIGENETICS
  • 2012-05-05. The quantitative analysis by stem-loop real-time PCR revealed the microRNA-34a, microRNA-155 and microRNA-200c overexpression in human colorectal cancer in MEDICAL ONCOLOGY
  • 2014-11-11. Expression of miRNAs in non-small-cell lung carcinomas and their association with clinicopathological features in TUMOR BIOLOGY
  • 2017-07-18. miR-34a attenuates glioma cells progression and chemoresistance via targeting PD-L1 in BIOTECHNOLOGY LETTERS
  • 2018-04-27. Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation in NATURE COMMUNICATIONS
  • 2016-03-21. miR-34 activity is modulated through 5′-end phosphorylation in response to DNA damage in NATURE COMMUNICATIONS
  • 2016-02-15. Expression and promotor hypermethylation of miR-34a in the various histological subtypes of ovarian cancer in BMC CANCER
  • 2016-04-28. The orphan nuclear receptor NR4A2 is part of a p53–microRNA-34 network in SCIENTIFIC REPORTS
  • 2014-07-26. Expression of miR-34c induces G2/M cell cycle arrest in breast cancer cells in BMC CANCER
  • 2012-01-14. MicroRNA-34a affects the occurrence of laryngeal squamous cell carcinoma by targeting the antiapoptotic gene survivin in MEDICAL ONCOLOGY
  • 2016-08-30. Interplay Between Transcription Factors and MicroRNAs Regulating Epithelial-Mesenchymal Transitions in Colorectal Cancer in NON-CODING RNAS IN COLORECTAL CANCER
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    http://scigraph.springernature.com/pub.10.1186/s13046-019-1059-5

    DOI

    http://dx.doi.org/10.1186/s13046-019-1059-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111917444

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30717802


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