Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Wei Xiao, Zhiyong Gao, Yixing Duan, Wuxiong Yuan, Yang Ke

ABSTRACT

BACKGROUND: Cancer stem cells (CSCs) are correlated with the initiation, chemoresistance and relapse of tumors. Notch pathway has been reported to function in CSCs maintenance, but whether it is involved in renal cell carcinoma (RCC) CSCs maintaining stemness remain unclear. This study aims to explore the effect of Notch pathway on stemness of CSCs in RCC and the underlying mechanisms. METHODS: The CD133+/CD24+ cells were isolated from RCC ACHN and Caki-1 cell line using Magnetic-activated cell sorting and identified by Flow cytometry analysis. RT-PCR and immunoblot analyses were used for determining the stemness maker expression. The effect of Notch pathway on function of CSCs was assessed by self-renewal ability, chemosensitivity, invasive and migratory ability tumorigenicity in vivo using soft agar colony formation assay, sphere-forming assay, MTT assay, Transwell assay. RESULTS: Here, we found that the sorted CD133+/CD24+cells possessed elevated stemness maker CTR2, BCL-2, MDR1, OCT-4, KLF4, compared with parental cells, as well as enhanced self-renewal ability, stronger resistance to cisplatin and sorafenib, increased invasion and migration, and higher tumorigenesis in vivo, suggesting the CD133+/CD24+ cells have the stem-like characteristics of CSCs and thus identified as RCC CSCs. Then the enhanced notch1, notch2, Jagged1, Jagged2, DLL1 and DLL4 expression were detected in RCC CSCs and blockage of Notch1 or notch2 using pharmacological inhibitor MRK-003 or its endogenous inhibitor Numb resulted in loss of its stemness features: self-renewal, chemoresistance, invasive and migratory potential, and tumorigenesis in vivo. Moreover, it is confirmed that overexpression of notch1 up-regulated CXCR4 inRCC CSCs and augmented SDF-1-induced chemotaxis in RCC CSCs in vitro, which could be rescued when treatment of CXCR4 inhibitor, suggesting that notch signaling promotes the chemotaxis of RCC CSCs by SDF-1/CXCR4 axis. CONCLUSIONS: Our results provide a new mechanism of RCC CSCs maintaining stemness via notch pathway as well as a potential therapeutic target in human RCC. More... »

PAGES

41

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13046-017-0507-3

DOI

http://dx.doi.org/10.1186/s13046-017-0507-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084251908

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28279221


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AC133 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD24 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Renal Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Self Renewal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotaxis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Notch", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hunan Provincial People 's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.477407.7", 
          "name": [
            "Department of Urology, Hunan Provincial People\u2019s Hospital, JiefangWest Road 61, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xiao", 
        "givenName": "Wei", 
        "id": "sg:person.0656050035.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656050035.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Provincial People 's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.477407.7", 
          "name": [
            "Department of Urology, Hunan Provincial People\u2019s Hospital, JiefangWest Road 61, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Zhiyong", 
        "id": "sg:person.0724163235.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724163235.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Provincial People 's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.477407.7", 
          "name": [
            "Department of Urology, Hunan Provincial People\u2019s Hospital, JiefangWest Road 61, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duan", 
        "givenName": "Yixing", 
        "id": "sg:person.0772276435.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772276435.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Provincial People 's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.477407.7", 
          "name": [
            "Department of Urology, Hunan Provincial People\u2019s Hospital, JiefangWest Road 61, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Wuxiong", 
        "id": "sg:person.01040411635.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040411635.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hunan Provincial People 's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.477407.7", 
          "name": [
            "Department of Urology, Hunan Provincial People\u2019s Hospital, JiefangWest Road 61, Changsha, Hunan, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ke", 
        "givenName": "Yang", 
        "id": "sg:person.01106525035.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106525035.84"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/s13287-015-0177-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001812749", 
          "https://doi.org/10.1186/s13287-015-0177-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4614-0899-4_13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002803694", 
          "https://doi.org/10.1007/978-1-4614-0899-4_13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2007.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005961010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006704451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006704451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.1407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008030710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2014.06.070", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009457701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0377-4929.41641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009915935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms9989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010712336", 
          "https://doi.org/10.1038/ncomms9989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.30396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010747990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2012.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010772995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011389076", 
          "https://doi.org/10.1038/sj.bjc.6600221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6600221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011389076", 
          "https://doi.org/10.1038/sj.bjc.6600221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0068293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012491807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e3282f9782b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012922901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e3282f9782b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012922901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e3282f9782b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012922901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-5-56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014243009", 
          "https://doi.org/10.1186/1476-4598-5-56"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci81979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016503570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.6266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017137041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.291004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018043420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.mvr.2015.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020517049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023311546", 
          "https://doi.org/10.1038/onc.2013.537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/abbs/gmt123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023613501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.6560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026533569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-005-0058-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030696378", 
          "https://doi.org/10.1007/s00432-005-0058-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-005-0058-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030696378", 
          "https://doi.org/10.1007/s00432-005-0058-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5966/sctm.2015-0168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031963195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.eururo.2011.06.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032436422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2016/6439864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032708680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-016-2985-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036852336", 
          "https://doi.org/10.1186/s12885-016-2985-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-016-2985-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036852336", 
          "https://doi.org/10.1186/s12885-016-2985-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellimm.2013.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037087054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/etm.2014.2141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038977789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/etm.2014.2141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038977789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.060020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040229320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000189115.94847.f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043029394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000189115.94847.f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043029394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000189115.94847.f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043029394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.6672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047455863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1206400109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047806439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0215(20001201)88:5<726::aid-ijc7>3.0.co;2-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047826072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccell.2015.10.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049022197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyq205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050225469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.23820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053270050"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/oncsis.2015.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053596349", 
          "https://doi.org/10.1038/oncsis.2015.35"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.284.5415.770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062565091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v20.i36.13105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071371512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2014.2498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071513551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo.2014.2498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071513551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2011.368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071525298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077298508", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079171713", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Cancer stem cells (CSCs) are correlated with the initiation, chemoresistance and relapse of tumors. Notch pathway has been reported to function in CSCs maintenance, but whether it is involved in renal cell carcinoma (RCC) CSCs maintaining stemness remain unclear. This study aims to explore the effect of Notch pathway on stemness of CSCs in RCC and the underlying mechanisms.\nMETHODS: The CD133+/CD24+ cells were isolated from RCC ACHN and Caki-1 cell line using Magnetic-activated cell sorting and identified by Flow cytometry analysis. RT-PCR and immunoblot analyses were used for determining the stemness maker expression. The effect of Notch pathway on function of CSCs was assessed by self-renewal ability, chemosensitivity, invasive and migratory ability tumorigenicity in vivo using soft agar colony formation assay, sphere-forming assay, MTT assay, Transwell assay.\nRESULTS: Here, we found that the sorted CD133+/CD24+cells possessed elevated stemness maker CTR2, BCL-2, MDR1, OCT-4, KLF4, compared with parental cells, as well as enhanced self-renewal ability, stronger resistance to cisplatin and sorafenib, increased invasion and migration, and higher tumorigenesis in vivo, suggesting the CD133+/CD24+ cells have the stem-like characteristics of CSCs and thus identified as RCC CSCs. Then the enhanced notch1, notch2, Jagged1, Jagged2, DLL1 and DLL4 expression were detected in RCC CSCs and blockage of Notch1 or notch2 using pharmacological inhibitor MRK-003 or its endogenous inhibitor Numb resulted in loss of its stemness features: self-renewal, chemoresistance, invasive and migratory potential, and tumorigenesis in vivo. Moreover, it is confirmed that overexpression of notch1 up-regulated CXCR4 inRCC CSCs and augmented SDF-1-induced chemotaxis in RCC CSCs in vitro, which could be rescued when treatment of CXCR4 inhibitor, suggesting that notch signaling promotes the chemotaxis of RCC CSCs by SDF-1/CXCR4 axis.\nCONCLUSIONS: Our results provide a new mechanism of RCC CSCs maintaining stemness via notch pathway as well as a potential therapeutic target in human RCC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13046-017-0507-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1094159", 
        "issn": [
          "0392-9078", 
          "1756-9966"
        ], 
        "name": "Journal of Experimental & Clinical Cancer Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma", 
    "pagination": "41", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "116f50e8193d0feb4aa4a0847374344ac4637b8c2c5eab4c48308fbe01576958"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28279221"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8308647"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13046-017-0507-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1084251908"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13046-017-0507-3", 
      "https://app.dimensions.ai/details/publication/pub.1084251908"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000346_0000000346/records_99833_00000004.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13046-017-0507-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13046-017-0507-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13046-017-0507-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13046-017-0507-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13046-017-0507-3'


 

This table displays all metadata directly associated to this object as RDF triples.

296 TRIPLES      21 PREDICATES      88 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13046-017-0507-3 schema:about N02bd34a5766e400482ccc2f5df0eea51
2 N07cc1a7fef3f4dc0a3a72e7acee5a99b
3 N147ca640d3984253a17eeaa54ffc9bda
4 N15d37e08d6284282b75701983ef208b8
5 N1f4ebb41c9534d30a2af23a671ce5527
6 N1f71c1f2f763495298ac99f47bef4ba7
7 N34d6e8b2bf8343e8a3458b580b3b3e0b
8 N36b046555df74264a82f1c171c60b5ce
9 N500e5a72a6bf4824b7248fe9da5a2d63
10 N59440f2245694d4b8bcd8ff793c24475
11 N788fc60c0e67419691c92f937a878bd1
12 N7be5e5882f2a4321b37dc963385173c9
13 Nb90e746c3e1b4cbaadf4f56dd3a7dff1
14 Nf4b779fa5d0c47af96ff29755d9d3e29
15 Nfe7f469e86c94f618a36c67780f154a2
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author Ndff2c7cf7ac040208e0a865a34ca340d
19 schema:citation sg:pub.10.1007/978-1-4614-0899-4_13
20 sg:pub.10.1007/s00432-005-0058-4
21 sg:pub.10.1038/ncomms9989
22 sg:pub.10.1038/onc.2013.537
23 sg:pub.10.1038/oncsis.2015.35
24 sg:pub.10.1038/sj.bjc.6600221
25 sg:pub.10.1186/1476-4598-5-56
26 sg:pub.10.1186/s12885-016-2985-7
27 sg:pub.10.1186/s13287-015-0177-z
28 https://app.dimensions.ai/details/publication/pub.1077298508
29 https://app.dimensions.ai/details/publication/pub.1079171713
30 https://doi.org/10.1002/1097-0215(20001201)88:5<726::aid-ijc7>3.0.co;2-h
31 https://doi.org/10.1002/hed.23820
32 https://doi.org/10.1002/ijc.30396
33 https://doi.org/10.1002/stem.1407
34 https://doi.org/10.1016/j.canlet.2012.05.007
35 https://doi.org/10.1016/j.ccell.2015.10.008
36 https://doi.org/10.1016/j.cellimm.2013.02.001
37 https://doi.org/10.1016/j.ctrv.2007.12.001
38 https://doi.org/10.1016/j.ejca.2005.06.025
39 https://doi.org/10.1016/j.eururo.2011.06.049
40 https://doi.org/10.1016/j.juro.2014.06.070
41 https://doi.org/10.1016/j.mvr.2015.12.001
42 https://doi.org/10.1073/pnas.1206400109
43 https://doi.org/10.1093/abbs/gmt123
44 https://doi.org/10.1093/jjco/hyq205
45 https://doi.org/10.1097/01.sla.0000189115.94847.f1
46 https://doi.org/10.1097/cco.0b013e3282f9782b
47 https://doi.org/10.1101/gad.291004
48 https://doi.org/10.1126/science.284.5415.770
49 https://doi.org/10.1155/2016/6439864
50 https://doi.org/10.1172/jci32086
51 https://doi.org/10.1172/jci81979
52 https://doi.org/10.1242/dev.060020
53 https://doi.org/10.1371/journal.pone.0068293
54 https://doi.org/10.18632/oncotarget.6266
55 https://doi.org/10.18632/oncotarget.6560
56 https://doi.org/10.18632/oncotarget.6672
57 https://doi.org/10.3748/wjg.v20.i36.13105
58 https://doi.org/10.3892/etm.2014.2141
59 https://doi.org/10.3892/ijo.2014.2498
60 https://doi.org/10.3892/ol.2011.368
61 https://doi.org/10.4103/0377-4929.41641
62 https://doi.org/10.5966/sctm.2015-0168
63 schema:datePublished 2017-12
64 schema:datePublishedReg 2017-12-01
65 schema:description BACKGROUND: Cancer stem cells (CSCs) are correlated with the initiation, chemoresistance and relapse of tumors. Notch pathway has been reported to function in CSCs maintenance, but whether it is involved in renal cell carcinoma (RCC) CSCs maintaining stemness remain unclear. This study aims to explore the effect of Notch pathway on stemness of CSCs in RCC and the underlying mechanisms. METHODS: The CD133+/CD24+ cells were isolated from RCC ACHN and Caki-1 cell line using Magnetic-activated cell sorting and identified by Flow cytometry analysis. RT-PCR and immunoblot analyses were used for determining the stemness maker expression. The effect of Notch pathway on function of CSCs was assessed by self-renewal ability, chemosensitivity, invasive and migratory ability tumorigenicity in vivo using soft agar colony formation assay, sphere-forming assay, MTT assay, Transwell assay. RESULTS: Here, we found that the sorted CD133+/CD24+cells possessed elevated stemness maker CTR2, BCL-2, MDR1, OCT-4, KLF4, compared with parental cells, as well as enhanced self-renewal ability, stronger resistance to cisplatin and sorafenib, increased invasion and migration, and higher tumorigenesis in vivo, suggesting the CD133+/CD24+ cells have the stem-like characteristics of CSCs and thus identified as RCC CSCs. Then the enhanced notch1, notch2, Jagged1, Jagged2, DLL1 and DLL4 expression were detected in RCC CSCs and blockage of Notch1 or notch2 using pharmacological inhibitor MRK-003 or its endogenous inhibitor Numb resulted in loss of its stemness features: self-renewal, chemoresistance, invasive and migratory potential, and tumorigenesis in vivo. Moreover, it is confirmed that overexpression of notch1 up-regulated CXCR4 inRCC CSCs and augmented SDF-1-induced chemotaxis in RCC CSCs in vitro, which could be rescued when treatment of CXCR4 inhibitor, suggesting that notch signaling promotes the chemotaxis of RCC CSCs by SDF-1/CXCR4 axis. CONCLUSIONS: Our results provide a new mechanism of RCC CSCs maintaining stemness via notch pathway as well as a potential therapeutic target in human RCC.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf N188ab1142d5644dab0cfa8682b6c5b68
70 Na99c1babe08b41f4bb6dfe8141c07826
71 sg:journal.1094159
72 schema:name Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma
73 schema:pagination 41
74 schema:productId N08b21dc4180d41c3b41952fdccef4686
75 N1306e39d8df54a4ea717d90ddcddd224
76 N3ab3217e7e444e85ac73a7166e7a280c
77 N4293fe0e99f64dce9ab383c9d3af9203
78 N94e9ee7dc87249b48009e090c099a8c3
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084251908
80 https://doi.org/10.1186/s13046-017-0507-3
81 schema:sdDatePublished 2019-04-11T09:39
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N1dc07f13a1ad4b31885b29894bd65566
84 schema:url https://link.springer.com/10.1186%2Fs13046-017-0507-3
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N02bd34a5766e400482ccc2f5df0eea51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Signal Transduction
90 rdf:type schema:DefinedTerm
91 N07cc1a7fef3f4dc0a3a72e7acee5a99b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Humans
93 rdf:type schema:DefinedTerm
94 N08b21dc4180d41c3b41952fdccef4686 schema:name doi
95 schema:value 10.1186/s13046-017-0507-3
96 rdf:type schema:PropertyValue
97 N0c05248c77d345e39f61610e0bb652ca rdf:first sg:person.0724163235.49
98 rdf:rest Ne509899e7e6a4dbb8151564511ae24e8
99 N1306e39d8df54a4ea717d90ddcddd224 schema:name nlm_unique_id
100 schema:value 8308647
101 rdf:type schema:PropertyValue
102 N147ca640d3984253a17eeaa54ffc9bda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Chemotaxis
104 rdf:type schema:DefinedTerm
105 N15d37e08d6284282b75701983ef208b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Biomarkers, Tumor
107 rdf:type schema:DefinedTerm
108 N188ab1142d5644dab0cfa8682b6c5b68 schema:issueNumber 1
109 rdf:type schema:PublicationIssue
110 N1dc07f13a1ad4b31885b29894bd65566 schema:name Springer Nature - SN SciGraph project
111 rdf:type schema:Organization
112 N1f4ebb41c9534d30a2af23a671ce5527 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Mice
114 rdf:type schema:DefinedTerm
115 N1f71c1f2f763495298ac99f47bef4ba7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Animals
117 rdf:type schema:DefinedTerm
118 N34d6e8b2bf8343e8a3458b580b3b3e0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Cell Line, Tumor
120 rdf:type schema:DefinedTerm
121 N36b046555df74264a82f1c171c60b5ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Neoplastic Stem Cells
123 rdf:type schema:DefinedTerm
124 N3ab3217e7e444e85ac73a7166e7a280c schema:name pubmed_id
125 schema:value 28279221
126 rdf:type schema:PropertyValue
127 N4293fe0e99f64dce9ab383c9d3af9203 schema:name readcube_id
128 schema:value 116f50e8193d0feb4aa4a0847374344ac4637b8c2c5eab4c48308fbe01576958
129 rdf:type schema:PropertyValue
130 N500e5a72a6bf4824b7248fe9da5a2d63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name CD24 Antigen
132 rdf:type schema:DefinedTerm
133 N59440f2245694d4b8bcd8ff793c24475 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Self Renewal
135 rdf:type schema:DefinedTerm
136 N788fc60c0e67419691c92f937a878bd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Receptors, Notch
138 rdf:type schema:DefinedTerm
139 N7be5e5882f2a4321b37dc963385173c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name AC133 Antigen
141 rdf:type schema:DefinedTerm
142 N94e9ee7dc87249b48009e090c099a8c3 schema:name dimensions_id
143 schema:value pub.1084251908
144 rdf:type schema:PropertyValue
145 Na99c1babe08b41f4bb6dfe8141c07826 schema:volumeNumber 36
146 rdf:type schema:PublicationVolume
147 Nb2f2b0d39e5d43eea91708d3a120f47a rdf:first sg:person.01106525035.84
148 rdf:rest rdf:nil
149 Nb90e746c3e1b4cbaadf4f56dd3a7dff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Kidney Neoplasms
151 rdf:type schema:DefinedTerm
152 Ncabf37cc1f744b0988858d546006c751 rdf:first sg:person.01040411635.88
153 rdf:rest Nb2f2b0d39e5d43eea91708d3a120f47a
154 Ndff2c7cf7ac040208e0a865a34ca340d rdf:first sg:person.0656050035.06
155 rdf:rest N0c05248c77d345e39f61610e0bb652ca
156 Ne509899e7e6a4dbb8151564511ae24e8 rdf:first sg:person.0772276435.27
157 rdf:rest Ncabf37cc1f744b0988858d546006c751
158 Nf4b779fa5d0c47af96ff29755d9d3e29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Carcinoma, Renal Cell
160 rdf:type schema:DefinedTerm
161 Nfe7f469e86c94f618a36c67780f154a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Neoplasm Invasiveness
163 rdf:type schema:DefinedTerm
164 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
165 schema:name Medical and Health Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
168 schema:name Oncology and Carcinogenesis
169 rdf:type schema:DefinedTerm
170 sg:journal.1094159 schema:issn 0392-9078
171 1756-9966
172 schema:name Journal of Experimental & Clinical Cancer Research
173 rdf:type schema:Periodical
174 sg:person.01040411635.88 schema:affiliation https://www.grid.ac/institutes/grid.477407.7
175 schema:familyName Yuan
176 schema:givenName Wuxiong
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040411635.88
178 rdf:type schema:Person
179 sg:person.01106525035.84 schema:affiliation https://www.grid.ac/institutes/grid.477407.7
180 schema:familyName Ke
181 schema:givenName Yang
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106525035.84
183 rdf:type schema:Person
184 sg:person.0656050035.06 schema:affiliation https://www.grid.ac/institutes/grid.477407.7
185 schema:familyName Xiao
186 schema:givenName Wei
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656050035.06
188 rdf:type schema:Person
189 sg:person.0724163235.49 schema:affiliation https://www.grid.ac/institutes/grid.477407.7
190 schema:familyName Gao
191 schema:givenName Zhiyong
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724163235.49
193 rdf:type schema:Person
194 sg:person.0772276435.27 schema:affiliation https://www.grid.ac/institutes/grid.477407.7
195 schema:familyName Duan
196 schema:givenName Yixing
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772276435.27
198 rdf:type schema:Person
199 sg:pub.10.1007/978-1-4614-0899-4_13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002803694
200 https://doi.org/10.1007/978-1-4614-0899-4_13
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/s00432-005-0058-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030696378
203 https://doi.org/10.1007/s00432-005-0058-4
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/ncomms9989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010712336
206 https://doi.org/10.1038/ncomms9989
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/onc.2013.537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023311546
209 https://doi.org/10.1038/onc.2013.537
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/oncsis.2015.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053596349
212 https://doi.org/10.1038/oncsis.2015.35
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/sj.bjc.6600221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011389076
215 https://doi.org/10.1038/sj.bjc.6600221
216 rdf:type schema:CreativeWork
217 sg:pub.10.1186/1476-4598-5-56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014243009
218 https://doi.org/10.1186/1476-4598-5-56
219 rdf:type schema:CreativeWork
220 sg:pub.10.1186/s12885-016-2985-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036852336
221 https://doi.org/10.1186/s12885-016-2985-7
222 rdf:type schema:CreativeWork
223 sg:pub.10.1186/s13287-015-0177-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1001812749
224 https://doi.org/10.1186/s13287-015-0177-z
225 rdf:type schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1077298508 schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1079171713 schema:CreativeWork
228 https://doi.org/10.1002/1097-0215(20001201)88:5<726::aid-ijc7>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1047826072
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1002/hed.23820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053270050
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/ijc.30396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010747990
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/stem.1407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008030710
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.canlet.2012.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010772995
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.ccell.2015.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049022197
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.cellimm.2013.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037087054
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.ctrv.2007.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005961010
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/j.ejca.2005.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006704451
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.eururo.2011.06.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032436422
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.juro.2014.06.070 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009457701
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.mvr.2015.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020517049
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1073/pnas.1206400109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047806439
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/abbs/gmt123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023613501
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1093/jjco/hyq205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050225469
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/01.sla.0000189115.94847.f1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043029394
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1097/cco.0b013e3282f9782b schema:sameAs https://app.dimensions.ai/details/publication/pub.1012922901
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1101/gad.291004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018043420
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1126/science.284.5415.770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062565091
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1155/2016/6439864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032708680
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1172/jci32086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416957
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1172/jci81979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016503570
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1242/dev.060020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040229320
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1371/journal.pone.0068293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012491807
275 rdf:type schema:CreativeWork
276 https://doi.org/10.18632/oncotarget.6266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017137041
277 rdf:type schema:CreativeWork
278 https://doi.org/10.18632/oncotarget.6560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026533569
279 rdf:type schema:CreativeWork
280 https://doi.org/10.18632/oncotarget.6672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047455863
281 rdf:type schema:CreativeWork
282 https://doi.org/10.3748/wjg.v20.i36.13105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071371512
283 rdf:type schema:CreativeWork
284 https://doi.org/10.3892/etm.2014.2141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038977789
285 rdf:type schema:CreativeWork
286 https://doi.org/10.3892/ijo.2014.2498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071513551
287 rdf:type schema:CreativeWork
288 https://doi.org/10.3892/ol.2011.368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071525298
289 rdf:type schema:CreativeWork
290 https://doi.org/10.4103/0377-4929.41641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009915935
291 rdf:type schema:CreativeWork
292 https://doi.org/10.5966/sctm.2015-0168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031963195
293 rdf:type schema:CreativeWork
294 https://www.grid.ac/institutes/grid.477407.7 schema:alternateName Hunan Provincial People 's Hospital
295 schema:name Department of Urology, Hunan Provincial People’s Hospital, JiefangWest Road 61, Changsha, Hunan, China
296 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...