Second-line chemotherapy in advanced biliary cancer progressed to first-line platinum-gemcitabine combination: a multicenter survey and pooled analysis with published data View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Lorenzo Fornaro, Caterina Vivaldi, Stefano Cereda, Francesco Leone, Giuseppe Aprile, Sara Lonardi, Nicola Silvestris, Daniele Santini, Michele Milella, Chiara Caparello, Gianna Musettini, Giulia Pasquini, Alfredo Falcone, Giovanni Brandi, Isabella Sperduti, Enrico Vasile, on behalf of the GICO group (Gruppo Italiano COlangiocarcinoma)

ABSTRACT

BACKGROUND: After progression to a standard first-line platinum and gemcitabine combination (GP), there is no established second-line therapy for patients with advanced biliary tract cancers (aBTC). Indeed, literature data suggest limited activity of most second-line agents evaluated so far. METHODS: We collected a large retrospective series of aBTC patients treated with second-line chemotherapy after progression to a first-line GP regimen at different Italian institutions. We then pooled the data with those reported in previous studies, which were identified with a Medline search and the on-line abstract datasets of major international oncology meetings. RESULTS: A total of 174 patients were included in the multicenter survey: response rate (RR) with second-line chemotherapy was low (3.4 %), with median PFS and OS of 3.0 months and 6.6 months, respectively. At multivariate analysis, preserved performance status, low CA19.9 levels and absence of distant metastases were favorable prognostic factors. Data from other five presented or published series were identified, for a total of 499 patients included in the pooled analysis. The results confirmed marginal activity of second-line chemotherapy (RR: 10.2 %), with limited efficacy in unselected patient populations (median PFS: 3.1 months; median OS: 6.3 months). CONCLUSIONS: The current analysis highlights the limited value of second-line chemotherapy after a first-line GP combination in aBTC. While waiting for effective biologic agents in this setting, ongoing randomized trials will identify the optimal second-line chemotherapy regimen and validate prognostic factors for individual patient management. More... »

PAGES

156

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13046-015-0267-x

DOI

http://dx.doi.org/10.1186/s13046-015-0267-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011416946

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26693938


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biliary Tract Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxycytidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organoplatinum Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fornaro", 
        "givenName": "Lorenzo", 
        "id": "sg:person.01164506727.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164506727.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vivaldi", 
        "givenName": "Caterina", 
        "id": "sg:person.01014265067.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014265067.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Medical Oncology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cereda", 
        "givenName": "Stefano", 
        "id": "sg:person.01210713123.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210713123.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Medical Oncology, Institute for Cancer Research and Treatment IRCCS, Strada provinciale 142, 10060, Candiolo, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leone", 
        "givenName": "Francesco", 
        "id": "sg:person.0636227045.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636227045.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology, University and General Hospital, P.le S. Maria della Misericordia 15, 33100, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aprile", 
        "givenName": "Giuseppe", 
        "id": "sg:person.01150115462.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150115462.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Oncologico Veneto", 
          "id": "https://www.grid.ac/institutes/grid.419546.b", 
          "name": [
            "Unit of Medical Oncology 1, Istituto Oncologico Veneto, IRCCS, Via Gattamelata 64, 35138, Padova, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lonardi", 
        "givenName": "Sara", 
        "id": "sg:person.01155122733.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155122733.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Unit of Medical Oncology, National Cancer Institute Giovanni Paolo II, V.le Orazio Flacco 65, 70124, Bari, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silvestris", 
        "givenName": "Nicola", 
        "id": "sg:person.01041520726.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041520726.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e0 Campus Bio-Medico", 
          "id": "https://www.grid.ac/institutes/grid.9657.d", 
          "name": [
            "Department of Medical Oncology, University Campus Bio-Medico, via Alvaro del Portillo 21, 00128, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Santini", 
        "givenName": "Daniele", 
        "id": "sg:person.0700665677.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700665677.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituti Fisioterapici Ospitalieri", 
          "id": "https://www.grid.ac/institutes/grid.417520.5", 
          "name": [
            "Medical Oncology A, Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Milella", 
        "givenName": "Michele", 
        "id": "sg:person.0603452144.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603452144.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caparello", 
        "givenName": "Chiara", 
        "id": "sg:person.01012133613.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012133613.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Musettini", 
        "givenName": "Gianna", 
        "id": "sg:person.01035150246.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035150246.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pasquini", 
        "givenName": "Giulia", 
        "id": "sg:person.01077752605.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077752605.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falcone", 
        "givenName": "Alfredo", 
        "id": "sg:person.01006230145.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Unit of Medical Oncology, Sant\u2019Orsola Malpighi Hospital, University of Bologna, Via Albertoni 15, 40138, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brandi", 
        "givenName": "Giovanni", 
        "id": "sg:person.0717165510.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717165510.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituti Fisioterapici Ospitalieri", 
          "id": "https://www.grid.ac/institutes/grid.417520.5", 
          "name": [
            "Biostatistical Unit, Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144, Rome, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sperduti", 
        "givenName": "Isabella", 
        "id": "sg:person.01323700675.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323700675.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Azienda Ospedaliera Universitaria Pisana", 
          "id": "https://www.grid.ac/institutes/grid.144189.1", 
          "name": [
            "Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vasile", 
        "givenName": "Enrico", 
        "id": "sg:person.01006607213.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006607213.66"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "on behalf of the GICO group (Gruppo Italiano COlangiocarcinoma)", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/hep.26890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001307790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-9966-28-62", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001482353", 
          "https://doi.org/10.1186/1756-9966-28-62"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1004135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003098211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00280-015-2919-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005869890", 
          "https://doi.org/10.1007/s00280-015-2919-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13046-014-0103-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007845551", 
          "https://doi.org/10.1186/s13046-014-0103-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13046-014-0103-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007845551", 
          "https://doi.org/10.1186/s13046-014-0103-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.29.3605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010772163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2012.11.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018562403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.29471", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018966068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000205388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019614581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2013.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025860285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0908721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027685512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdv035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028177866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.annonc.a010676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031986367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199910283411807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033083074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035031344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.4200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036369271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037652459", 
          "https://doi.org/10.1038/sj.bjc.6605779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1179/1973947813y.0000000133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040002897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2014.190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040427383", 
          "https://doi.org/10.1038/bjc.2014.190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13046-015-0221-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041453748", 
          "https://doi.org/10.1186/s13046-015-0221-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041938462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdu162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048732055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-230x-14-143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050610794", 
          "https://doi.org/10.1186/1471-230x-14-143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1406766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051743411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-200008000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060114053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-200008000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060114053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000421-200008000-00023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060114053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v21.i7.2096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079048942"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: After progression to a standard first-line platinum and gemcitabine combination (GP), there is no established second-line therapy for patients with advanced biliary tract cancers (aBTC). Indeed, literature data suggest limited activity of most second-line agents evaluated so far.\nMETHODS: We collected a large retrospective series of aBTC patients treated with second-line chemotherapy after progression to a first-line GP regimen at different Italian institutions. We then pooled the data with those reported in previous studies, which were identified with a Medline search and the on-line abstract datasets of major international oncology meetings.\nRESULTS: A total of 174 patients were included in the multicenter survey: response rate (RR) with second-line chemotherapy was low (3.4 %), with median PFS and OS of 3.0 months and 6.6 months, respectively. At multivariate analysis, preserved performance status, low CA19.9 levels and absence of distant metastases were favorable prognostic factors. Data from other five presented or published series were identified, for a total of 499 patients included in the pooled analysis. The results confirmed marginal activity of second-line chemotherapy (RR: 10.2 %), with limited efficacy in unselected patient populations (median PFS: 3.1 months; median OS: 6.3 months).\nCONCLUSIONS: The current analysis highlights the limited value of second-line chemotherapy after a first-line GP combination in aBTC. While waiting for effective biologic agents in this setting, ongoing randomized trials will identify the optimal second-line chemotherapy regimen and validate prognostic factors for individual patient management.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13046-015-0267-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1094159", 
        "issn": [
          "0392-9078", 
          "1756-9966"
        ], 
        "name": "Journal of Experimental & Clinical Cancer Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "Second-line chemotherapy in advanced biliary cancer progressed to first-line platinum-gemcitabine combination: a multicenter survey and pooled analysis with published data", 
    "pagination": "156", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "36651ad0bf618e6f30e3360da4b2ad53fbd2124f8296db6452e02fe1da80cf8c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26693938"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8308647"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13046-015-0267-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011416946"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13046-015-0267-x", 
      "https://app.dimensions.ai/details/publication/pub.1011416946"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13046-015-0267-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0267-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0267-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0267-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0267-x'


 

This table displays all metadata directly associated to this object as RDF triples.

341 TRIPLES      21 PREDICATES      69 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13046-015-0267-x schema:about N0eb1481989784b3783fe85258e8da2fb
2 N24daeb5aee994107a759e7ddbc492ca2
3 N401f3b04d1f14f06affc6350bb04920d
4 N577d24eb859e4c21973823c914b2ef0b
5 N5e1a1ce9a45c47f2bbd630c8e9c9eead
6 N81ce8bffcf80441db6fe5f2d0125169c
7 N89fc71f62a0745fd899429f0aac9e221
8 N97be6fc33787493395552008af47f2a6
9 Ndac7368cc2ef41e1ab91cf0a90b3b168
10 Ne3b55481a70f42698a5854fc8991bac6
11 Nea85c1f3683b4a6b9ef867aaee496207
12 Nf5b9f0d9738b4a8d84271d321c973ef5
13 Nfa736042fa6048279bf0fc8e0104e5d7
14 Nfb4f46698c8e4dce9204e053af6ba3e2
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N4e56021953614f5ebfd31830837a7669
18 schema:citation sg:pub.10.1007/s00280-015-2919-0
19 sg:pub.10.1038/bjc.2014.190
20 sg:pub.10.1038/sj.bjc.6605779
21 sg:pub.10.1186/1471-230x-14-143
22 sg:pub.10.1186/1756-9966-28-62
23 sg:pub.10.1186/s13046-014-0103-8
24 sg:pub.10.1186/s13046-015-0221-y
25 https://doi.org/10.1002/cncr.29471
26 https://doi.org/10.1002/gcc.22212
27 https://doi.org/10.1002/hep.26890
28 https://doi.org/10.1002/sim.4200
29 https://doi.org/10.1016/j.critrevonc.2013.05.010
30 https://doi.org/10.1016/j.ejca.2012.11.024
31 https://doi.org/10.1056/nejm199910283411807
32 https://doi.org/10.1056/nejmoa0908721
33 https://doi.org/10.1056/nejmoa1406766
34 https://doi.org/10.1093/annonc/mdu162
35 https://doi.org/10.1093/annonc/mdu379
36 https://doi.org/10.1093/annonc/mdv035
37 https://doi.org/10.1093/oxfordjournals.annonc.a010676
38 https://doi.org/10.1097/00000421-200008000-00023
39 https://doi.org/10.1159/000205388
40 https://doi.org/10.1179/1973947813y.0000000133
41 https://doi.org/10.1200/jco.2010.29.3605
42 https://doi.org/10.1371/journal.pgen.1004135
43 https://doi.org/10.3748/wjg.v21.i7.2096
44 schema:datePublished 2015-12
45 schema:datePublishedReg 2015-12-01
46 schema:description BACKGROUND: After progression to a standard first-line platinum and gemcitabine combination (GP), there is no established second-line therapy for patients with advanced biliary tract cancers (aBTC). Indeed, literature data suggest limited activity of most second-line agents evaluated so far. METHODS: We collected a large retrospective series of aBTC patients treated with second-line chemotherapy after progression to a first-line GP regimen at different Italian institutions. We then pooled the data with those reported in previous studies, which were identified with a Medline search and the on-line abstract datasets of major international oncology meetings. RESULTS: A total of 174 patients were included in the multicenter survey: response rate (RR) with second-line chemotherapy was low (3.4 %), with median PFS and OS of 3.0 months and 6.6 months, respectively. At multivariate analysis, preserved performance status, low CA19.9 levels and absence of distant metastases were favorable prognostic factors. Data from other five presented or published series were identified, for a total of 499 patients included in the pooled analysis. The results confirmed marginal activity of second-line chemotherapy (RR: 10.2 %), with limited efficacy in unselected patient populations (median PFS: 3.1 months; median OS: 6.3 months). CONCLUSIONS: The current analysis highlights the limited value of second-line chemotherapy after a first-line GP combination in aBTC. While waiting for effective biologic agents in this setting, ongoing randomized trials will identify the optimal second-line chemotherapy regimen and validate prognostic factors for individual patient management.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf N432ada033003480b9e29f795377bdbd2
51 N4bfa7d451f944099be92064a5a15964a
52 sg:journal.1094159
53 schema:name Second-line chemotherapy in advanced biliary cancer progressed to first-line platinum-gemcitabine combination: a multicenter survey and pooled analysis with published data
54 schema:pagination 156
55 schema:productId N0f2c5506f0434bd79b6f4b26732b4c43
56 N8bbaafbe33b343cdabbd5b844f4b2290
57 N9dd1e8f7ec584f618b209a138d75c374
58 Nb3690dc11790443aaca60e3986097954
59 Nd8c8e3476c2e4f4cbd571ea939b739a4
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011416946
61 https://doi.org/10.1186/s13046-015-0267-x
62 schema:sdDatePublished 2019-04-10T17:31
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N4d9a20f3fa134292be3f3c1b4dc091aa
65 schema:url http://link.springer.com/10.1186%2Fs13046-015-0267-x
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N069481b6e0b84c8cad1d0342e3d01e26 schema:familyName on behalf of the GICO group (Gruppo Italiano COlangiocarcinoma)
70 rdf:type schema:Person
71 N0e791902462642daba66979d0e97cc7b rdf:first sg:person.01150115462.24
72 rdf:rest N5257b89b180040b39eb82ec59cf7aa05
73 N0eb1481989784b3783fe85258e8da2fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Middle Aged
75 rdf:type schema:DefinedTerm
76 N0f2c5506f0434bd79b6f4b26732b4c43 schema:name dimensions_id
77 schema:value pub.1011416946
78 rdf:type schema:PropertyValue
79 N12f2099b941e48ba8821b21867447029 rdf:first sg:person.0603452144.38
80 rdf:rest Ne4aa19e9ba5a4b40b3c0f3ff6181b226
81 N13d87ec161bf49a4b98a49372b9112e0 rdf:first sg:person.01014265067.53
82 rdf:rest Na35ba26273ac41429ea09cdab0cfa30e
83 N24daeb5aee994107a759e7ddbc492ca2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Male
85 rdf:type schema:DefinedTerm
86 N25e12a4102b149e3b73152d4ab9b7e2e rdf:first sg:person.01323700675.54
87 rdf:rest N8cd66b79b46e45619b97514c222ce4a0
88 N27c37c3830d443748637fb24552a01ff rdf:first sg:person.0636227045.64
89 rdf:rest N0e791902462642daba66979d0e97cc7b
90 N373a95cee09a48dbb44ae3d9cb77af4b rdf:first sg:person.01035150246.23
91 rdf:rest Nb3769fd76ec843b3962ee0ed730ffa37
92 N3c90ec3eb8d146dc8a74816d4a3455d0 rdf:first sg:person.0700665677.08
93 rdf:rest N12f2099b941e48ba8821b21867447029
94 N3dfc8e154e344bec9a3262d8e1fb5c72 schema:name Unit of Medical Oncology, Institute for Cancer Research and Treatment IRCCS, Strada provinciale 142, 10060, Candiolo, Italy
95 rdf:type schema:Organization
96 N401f3b04d1f14f06affc6350bb04920d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Deoxycytidine
98 rdf:type schema:DefinedTerm
99 N432ada033003480b9e29f795377bdbd2 schema:issueNumber 1
100 rdf:type schema:PublicationIssue
101 N4bfa7d451f944099be92064a5a15964a schema:volumeNumber 34
102 rdf:type schema:PublicationVolume
103 N4d9a20f3fa134292be3f3c1b4dc091aa schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N4e56021953614f5ebfd31830837a7669 rdf:first sg:person.01164506727.84
106 rdf:rest N13d87ec161bf49a4b98a49372b9112e0
107 N5257b89b180040b39eb82ec59cf7aa05 rdf:first sg:person.01155122733.59
108 rdf:rest N6fd225d02a8a41b090e567db042172af
109 N528f142cd22e4ef7a3869e35ed36c397 schema:name Unit of Medical Oncology, Sant’Orsola Malpighi Hospital, University of Bologna, Via Albertoni 15, 40138, Bologna, Italy
110 rdf:type schema:Organization
111 N577d24eb859e4c21973823c914b2ef0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Treatment Outcome
113 rdf:type schema:DefinedTerm
114 N5dc9b0c0c05046bea9919e78d35b170a rdf:first sg:person.0717165510.72
115 rdf:rest N25e12a4102b149e3b73152d4ab9b7e2e
116 N5e1a1ce9a45c47f2bbd630c8e9c9eead schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Organoplatinum Compounds
118 rdf:type schema:DefinedTerm
119 N6fd225d02a8a41b090e567db042172af rdf:first sg:person.01041520726.09
120 rdf:rest N3c90ec3eb8d146dc8a74816d4a3455d0
121 N81ce8bffcf80441db6fe5f2d0125169c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Adult
123 rdf:type schema:DefinedTerm
124 N89fc71f62a0745fd899429f0aac9e221 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Cisplatin
126 rdf:type schema:DefinedTerm
127 N8bbaafbe33b343cdabbd5b844f4b2290 schema:name readcube_id
128 schema:value 36651ad0bf618e6f30e3360da4b2ad53fbd2124f8296db6452e02fe1da80cf8c
129 rdf:type schema:PropertyValue
130 N8cd66b79b46e45619b97514c222ce4a0 rdf:first sg:person.01006607213.66
131 rdf:rest Nb07efa5b39f9451eb0983fe7756ae764
132 N97be6fc33787493395552008af47f2a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Retrospective Studies
134 rdf:type schema:DefinedTerm
135 N9dd1e8f7ec584f618b209a138d75c374 schema:name nlm_unique_id
136 schema:value 8308647
137 rdf:type schema:PropertyValue
138 Na35ba26273ac41429ea09cdab0cfa30e rdf:first sg:person.01210713123.27
139 rdf:rest N27c37c3830d443748637fb24552a01ff
140 Nab6b45f94fbf48a78384899a0d397387 schema:name Department of Oncology, University and General Hospital, P.le S. Maria della Misericordia 15, 33100, Udine, Italy
141 rdf:type schema:Organization
142 Nb07efa5b39f9451eb0983fe7756ae764 rdf:first N069481b6e0b84c8cad1d0342e3d01e26
143 rdf:rest rdf:nil
144 Nb3690dc11790443aaca60e3986097954 schema:name pubmed_id
145 schema:value 26693938
146 rdf:type schema:PropertyValue
147 Nb3769fd76ec843b3962ee0ed730ffa37 rdf:first sg:person.01077752605.19
148 rdf:rest Nbb9a68db1e824ad7b6ba133689d8f285
149 Nbb9a68db1e824ad7b6ba133689d8f285 rdf:first sg:person.01006230145.44
150 rdf:rest N5dc9b0c0c05046bea9919e78d35b170a
151 Nd8c8e3476c2e4f4cbd571ea939b739a4 schema:name doi
152 schema:value 10.1186/s13046-015-0267-x
153 rdf:type schema:PropertyValue
154 Ndac7368cc2ef41e1ab91cf0a90b3b168 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Female
156 rdf:type schema:DefinedTerm
157 Ne3b55481a70f42698a5854fc8991bac6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Antineoplastic Combined Chemotherapy Protocols
159 rdf:type schema:DefinedTerm
160 Ne4aa19e9ba5a4b40b3c0f3ff6181b226 rdf:first sg:person.01012133613.37
161 rdf:rest N373a95cee09a48dbb44ae3d9cb77af4b
162 Nea85c1f3683b4a6b9ef867aaee496207 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Biliary Tract Neoplasms
164 rdf:type schema:DefinedTerm
165 Nf5b9f0d9738b4a8d84271d321c973ef5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Humans
167 rdf:type schema:DefinedTerm
168 Nfa736042fa6048279bf0fc8e0104e5d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Disease-Free Survival
170 rdf:type schema:DefinedTerm
171 Nfb4f46698c8e4dce9204e053af6ba3e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Aged
173 rdf:type schema:DefinedTerm
174 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
175 schema:name Medical and Health Sciences
176 rdf:type schema:DefinedTerm
177 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
178 schema:name Oncology and Carcinogenesis
179 rdf:type schema:DefinedTerm
180 sg:journal.1094159 schema:issn 0392-9078
181 1756-9966
182 schema:name Journal of Experimental & Clinical Cancer Research
183 rdf:type schema:Periodical
184 sg:person.01006230145.44 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
185 schema:familyName Falcone
186 schema:givenName Alfredo
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006230145.44
188 rdf:type schema:Person
189 sg:person.01006607213.66 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
190 schema:familyName Vasile
191 schema:givenName Enrico
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006607213.66
193 rdf:type schema:Person
194 sg:person.01012133613.37 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
195 schema:familyName Caparello
196 schema:givenName Chiara
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012133613.37
198 rdf:type schema:Person
199 sg:person.01014265067.53 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
200 schema:familyName Vivaldi
201 schema:givenName Caterina
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014265067.53
203 rdf:type schema:Person
204 sg:person.01035150246.23 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
205 schema:familyName Musettini
206 schema:givenName Gianna
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035150246.23
208 rdf:type schema:Person
209 sg:person.01041520726.09 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
210 schema:familyName Silvestris
211 schema:givenName Nicola
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041520726.09
213 rdf:type schema:Person
214 sg:person.01077752605.19 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
215 schema:familyName Pasquini
216 schema:givenName Giulia
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077752605.19
218 rdf:type schema:Person
219 sg:person.01150115462.24 schema:affiliation Nab6b45f94fbf48a78384899a0d397387
220 schema:familyName Aprile
221 schema:givenName Giuseppe
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150115462.24
223 rdf:type schema:Person
224 sg:person.01155122733.59 schema:affiliation https://www.grid.ac/institutes/grid.419546.b
225 schema:familyName Lonardi
226 schema:givenName Sara
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155122733.59
228 rdf:type schema:Person
229 sg:person.01164506727.84 schema:affiliation https://www.grid.ac/institutes/grid.144189.1
230 schema:familyName Fornaro
231 schema:givenName Lorenzo
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164506727.84
233 rdf:type schema:Person
234 sg:person.01210713123.27 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
235 schema:familyName Cereda
236 schema:givenName Stefano
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210713123.27
238 rdf:type schema:Person
239 sg:person.01323700675.54 schema:affiliation https://www.grid.ac/institutes/grid.417520.5
240 schema:familyName Sperduti
241 schema:givenName Isabella
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323700675.54
243 rdf:type schema:Person
244 sg:person.0603452144.38 schema:affiliation https://www.grid.ac/institutes/grid.417520.5
245 schema:familyName Milella
246 schema:givenName Michele
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603452144.38
248 rdf:type schema:Person
249 sg:person.0636227045.64 schema:affiliation N3dfc8e154e344bec9a3262d8e1fb5c72
250 schema:familyName Leone
251 schema:givenName Francesco
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636227045.64
253 rdf:type schema:Person
254 sg:person.0700665677.08 schema:affiliation https://www.grid.ac/institutes/grid.9657.d
255 schema:familyName Santini
256 schema:givenName Daniele
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700665677.08
258 rdf:type schema:Person
259 sg:person.0717165510.72 schema:affiliation N528f142cd22e4ef7a3869e35ed36c397
260 schema:familyName Brandi
261 schema:givenName Giovanni
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717165510.72
263 rdf:type schema:Person
264 sg:pub.10.1007/s00280-015-2919-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005869890
265 https://doi.org/10.1007/s00280-015-2919-0
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/bjc.2014.190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040427383
268 https://doi.org/10.1038/bjc.2014.190
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/sj.bjc.6605779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037652459
271 https://doi.org/10.1038/sj.bjc.6605779
272 rdf:type schema:CreativeWork
273 sg:pub.10.1186/1471-230x-14-143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050610794
274 https://doi.org/10.1186/1471-230x-14-143
275 rdf:type schema:CreativeWork
276 sg:pub.10.1186/1756-9966-28-62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001482353
277 https://doi.org/10.1186/1756-9966-28-62
278 rdf:type schema:CreativeWork
279 sg:pub.10.1186/s13046-014-0103-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007845551
280 https://doi.org/10.1186/s13046-014-0103-8
281 rdf:type schema:CreativeWork
282 sg:pub.10.1186/s13046-015-0221-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1041453748
283 https://doi.org/10.1186/s13046-015-0221-y
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1002/cncr.29471 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018966068
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1002/gcc.22212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041938462
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1002/hep.26890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001307790
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1002/sim.4200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036369271
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.critrevonc.2013.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025860285
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.ejca.2012.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018562403
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1056/nejm199910283411807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033083074
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1056/nejmoa0908721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027685512
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1056/nejmoa1406766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051743411
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/annonc/mdu162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048732055
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1093/annonc/mdu379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035031344
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1093/annonc/mdv035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028177866
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1093/oxfordjournals.annonc.a010676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031986367
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1097/00000421-200008000-00023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060114053
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1159/000205388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019614581
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1179/1973947813y.0000000133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040002897
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1200/jco.2010.29.3605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010772163
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1371/journal.pgen.1004135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003098211
320 rdf:type schema:CreativeWork
321 https://doi.org/10.3748/wjg.v21.i7.2096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079048942
322 rdf:type schema:CreativeWork
323 https://www.grid.ac/institutes/grid.144189.1 schema:alternateName Azienda Ospedaliera Universitaria Pisana
324 schema:name Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
327 schema:name Department of Medical Oncology, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.417520.5 schema:alternateName Istituti Fisioterapici Ospitalieri
330 schema:name Biostatistical Unit, Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144, Rome, Italy
331 Medical Oncology A, Regina Elena National Cancer Institute, Via E. Chianesi 53, 00144, Rome, Italy
332 rdf:type schema:Organization
333 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
334 schema:name Unit of Medical Oncology, National Cancer Institute Giovanni Paolo II, V.le Orazio Flacco 65, 70124, Bari, Italy
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.419546.b schema:alternateName Istituto Oncologico Veneto
337 schema:name Unit of Medical Oncology 1, Istituto Oncologico Veneto, IRCCS, Via Gattamelata 64, 35138, Padova, Italy
338 rdf:type schema:Organization
339 https://www.grid.ac/institutes/grid.9657.d schema:alternateName Università Campus Bio-Medico
340 schema:name Department of Medical Oncology, University Campus Bio-Medico, via Alvaro del Portillo 21, 00128, Rome, Italy
341 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...