Hematopoietic neoplasms in Prkar2a-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Emmanouil Saloustros, Paraskevi Salpea, Chen-Feng Qi, Lina A. Gugliotti, Kitman Tsang, Sisi Liu, Matthew F. Starost, Herbert C. Morse, Constantine A. Stratakis

ABSTRACT

BACKGROUND: Protein kinase A (PKA) is a holoenzyme that consists of a dimer of regulatory subunits and two inactive catalytic subunits that bind to the regulatory subunit dimer. Four regulatory subunits (RIα, RIβ, RIIα, RIIβ) and four catalytic subunits (Cα, Cβ, Cγ, Prkx) have been described in the human and mouse genomes. Previous studies showed that complete inactivation of the Prkar1a subunit (coding for RIα) in the germline leads to embryonic lethality, while Prkar1a-deficient mice are viable and develop schwannomas, thyroid, and bone neoplasms, and rarely lymphomas and sarcomas. Mice with inactivation of the Prkar2a and Prkar2b genes (coding for RIIα and RIIβ, respectively) are also viable but have not been studied for their susceptibility to any tumors. METHODS: Cohorts of Prkar1a (+/-) , Prkar2a (+/-) , Prkar2a (-/-) , Prkar2b (+/-) and wild type (WT) mice have been observed between 5 and 25 months of age for the development of hematologic malignancies. Tissues were studied by immunohistochemistry; tumor-specific markers were also used as indicated. Cell sorting and protein studies were also performed. RESULTS: Both Prkar2a (-/-) and Prkar2a (+/-) mice frequently developed hematopoietic neoplasms dominated by histiocytic sarcomas (HS) with rare diffuse large B cell lymphomas (DLBCL). Southern blot analysis confirmed that the tumors diagnosed histologically as DLBCL were clonal B cell neoplasms. Mice with other genotypes did not develop a significant number of similar neoplasms. CONCLUSIONS: Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIα's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms. More... »

PAGES

143

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z

DOI

http://dx.doi.org/10.1186/s13046-015-0257-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034909616

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26608815


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP-Dependent Protein Kinase RIalpha Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Association Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematologic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institute of Child Health and Human Development", 
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saloustros", 
        "givenName": "Emmanouil", 
        "id": "sg:person.01105002423.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105002423.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Child Health and Human Development", 
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salpea", 
        "givenName": "Paraskevi", 
        "id": "sg:person.01177543040.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177543040.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, 20852, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qi", 
        "givenName": "Chen-Feng", 
        "id": "sg:person.011237370437.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011237370437.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Child Health and Human Development", 
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Program in Genomics and Differentiation, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gugliotti", 
        "givenName": "Lina A.", 
        "id": "sg:person.01104031357.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104031357.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Child Health and Human Development", 
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsang", 
        "givenName": "Kitman", 
        "id": "sg:person.013406564777.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013406564777.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Child Health and Human Development", 
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Sisi", 
        "id": "sg:person.011552000037.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011552000037.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Office of the Director", 
          "id": "https://www.grid.ac/institutes/grid.453125.4", 
          "name": [
            "Division of Veterinary Resources, Office of the Director (OD), National Institutes of Health, 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Starost", 
        "givenName": "Matthew F.", 
        "id": "sg:person.01156104242.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156104242.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Allergy and Infectious Diseases", 
          "id": "https://www.grid.ac/institutes/grid.419681.3", 
          "name": [
            "Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, 20852, Rockville, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morse", 
        "givenName": "Herbert C.", 
        "id": "sg:person.011265750357.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011265750357.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Child Health and Human Development", 
          "id": "https://www.grid.ac/institutes/grid.420089.7", 
          "name": [
            "Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), 20892, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stratakis", 
        "givenName": "Constantine A.", 
        "id": "sg:person.011151216517.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151216517.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1097/01.gim.0000196821.87655.d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000288901", 
          "https://doi.org/10.1097/01.gim.0000196821.87655.d0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/01.gim.0000196821.87655.d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000288901", 
          "https://doi.org/10.1097/01.gim.0000196821.87655.d0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/01.gim.0000196821.87655.d0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000288901", 
          "https://doi.org/10.1097/01.gim.0000196821.87655.d0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0405535101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003890846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0300985810363705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004594731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0300985810363705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004594731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65327-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007249082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-1561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008657577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.20.11067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011289200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v100.1.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013665881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0888-7543(89)90342-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020341068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.15.5192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020446885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-9966-28-116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027098559", 
          "https://doi.org/10.1186/1756-9966-28-116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3780020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028440930", 
          "https://doi.org/10.1038/labinvest.3780020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/labinvest.3780020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028440930", 
          "https://doi.org/10.1038/labinvest.3780020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.174813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028740701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.174813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028740701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v100.1.238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028951807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.34.24131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032075590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2002.tb04328.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033552107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2002.tb04328.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033552107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/79238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034260511", 
          "https://doi.org/10.1038/79238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/79238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034260511", 
          "https://doi.org/10.1038/79238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1989.tb00251.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036381282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0609033103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038313489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2011-01-293050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038858270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200102000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040570114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200102000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040570114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0580", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042369061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-3620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042916926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.26.15736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046628308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.2012.072470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046639166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cancergen.2010.12.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047462818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-3253", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049894307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050729897", 
          "https://doi.org/10.1038/nature08645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050729897", 
          "https://doi.org/10.1038/nature08645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0192623311431467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051119723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0192623311431467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051119723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-2200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051763756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/skalhegg", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070918540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074649178", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076244911", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077252657", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077286117", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083228089", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Protein kinase A (PKA) is a holoenzyme that consists of a dimer of regulatory subunits and two inactive catalytic subunits that bind to the regulatory subunit dimer. Four regulatory subunits (RI\u03b1, RI\u03b2, RII\u03b1, RII\u03b2) and four catalytic subunits (C\u03b1, C\u03b2, C\u03b3, Prkx) have been described in the human and mouse genomes. Previous studies showed that complete inactivation of the Prkar1a subunit (coding for RI\u03b1) in the germline leads to embryonic lethality, while Prkar1a-deficient mice are viable and develop schwannomas, thyroid, and bone neoplasms, and rarely lymphomas and sarcomas. Mice with inactivation of the Prkar2a and Prkar2b genes (coding for RII\u03b1 and RII\u03b2, respectively) are also viable but have not been studied for their susceptibility to any tumors.\nMETHODS: Cohorts of Prkar1a (+/-) , Prkar2a (+/-) , Prkar2a (-/-) , Prkar2b (+/-) and wild type (WT) mice have been observed between 5 and 25 months of age for the development of hematologic malignancies. Tissues were studied by immunohistochemistry; tumor-specific markers were also used as indicated. Cell sorting and protein studies were also performed.\nRESULTS: Both Prkar2a (-/-) and Prkar2a (+/-) mice frequently developed hematopoietic neoplasms dominated by histiocytic sarcomas (HS) with rare diffuse large B cell lymphomas (DLBCL). Southern blot analysis confirmed that the tumors diagnosed histologically as DLBCL were clonal B cell neoplasms. Mice with other genotypes did not develop a significant number of similar neoplasms.\nCONCLUSIONS: Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RII\u03b1's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13046-015-0257-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2723240", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2725681", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2723122", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1094159", 
        "issn": [
          "0392-9078", 
          "1756-9966"
        ], 
        "name": "Journal of Experimental & Clinical Cancer Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "Hematopoietic neoplasms in Prkar2a-deficient mice", 
    "pagination": "143", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a64c07c1b3a6bd109fb4cdf9244bdc48c33369e05d3a501981a9b7fc5291cba5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26608815"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8308647"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13046-015-0257-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034909616"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13046-015-0257-z", 
      "https://app.dimensions.ai/details/publication/pub.1034909616"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13046-015-0257-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      79 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13046-015-0257-z schema:about N54ecb28915b34be3af40f6caf948d685
2 N627b91d43c7f4aa4a72c0e3f15ca27d4
3 N727c1a96f8aa4940a1898bc8ab6c1c86
4 N7bd0f7220fef4752a6e4c0ed228cb50f
5 N7e99b045014c49278610813db839e465
6 N833a6b75576640cf8515ed21bee53d85
7 Na38fad26381a4a8eae4e60d6fae271ef
8 Na5bbcba685e548f5bfda883b9a9e48b2
9 Nb134a727104b43339d0c366bc43aaf92
10 Nbeaa869482ba48aab96d14745226bd48
11 Ne389dfe1b766432d8a7f85fea95cce1e
12 Ne4c16822eb3944a6a77445e4ac4e22c8
13 Nf7ac7fe6ff13436c8d8708d40454d62a
14 Nfcb03e2fe4e24f88bef8638535d4103c
15 Nfe944126df694ee08583fa9057eaea6e
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N63db0a5f55034834bd541ed855ff219f
19 schema:citation sg:pub.10.1038/79238
20 sg:pub.10.1038/labinvest.3780020
21 sg:pub.10.1038/nature08645
22 sg:pub.10.1097/01.gim.0000196821.87655.d0
23 sg:pub.10.1186/1756-9966-28-116
24 https://app.dimensions.ai/details/publication/pub.1074649178
25 https://app.dimensions.ai/details/publication/pub.1076244911
26 https://app.dimensions.ai/details/publication/pub.1077252657
27 https://app.dimensions.ai/details/publication/pub.1077286117
28 https://app.dimensions.ai/details/publication/pub.1083228089
29 https://doi.org/10.1016/0888-7543(89)90342-x
30 https://doi.org/10.1016/j.cancergen.2010.12.010
31 https://doi.org/10.1016/s0002-9440(10)65327-8
32 https://doi.org/10.1073/pnas.0405535101
33 https://doi.org/10.1073/pnas.0609033103
34 https://doi.org/10.1073/pnas.84.15.5192
35 https://doi.org/10.1073/pnas.94.20.11067
36 https://doi.org/10.1074/jbc.271.26.15736
37 https://doi.org/10.1074/jbc.274.34.24131
38 https://doi.org/10.1097/00000478-200102000-00004
39 https://doi.org/10.1111/j.1365-2141.1989.tb00251.x
40 https://doi.org/10.1111/j.1749-6632.2002.tb04328.x
41 https://doi.org/10.1158/0008-5472.can-03-3253
42 https://doi.org/10.1158/0008-5472.can-04-3620
43 https://doi.org/10.1158/0008-5472.can-05-0580
44 https://doi.org/10.1158/0008-5472.can-06-1561
45 https://doi.org/10.1158/0008-5472.can-06-2200
46 https://doi.org/10.1161/circresaha.108.174813
47 https://doi.org/10.1177/0192623311431467
48 https://doi.org/10.1177/0300985810363705
49 https://doi.org/10.1182/blood-2011-01-293050
50 https://doi.org/10.1182/blood.v100.1.238
51 https://doi.org/10.1182/blood.v100.1.246
52 https://doi.org/10.2741/skalhegg
53 https://doi.org/10.3324/haematol.2012.072470
54 schema:datePublished 2015-12
55 schema:datePublishedReg 2015-12-01
56 schema:description BACKGROUND: Protein kinase A (PKA) is a holoenzyme that consists of a dimer of regulatory subunits and two inactive catalytic subunits that bind to the regulatory subunit dimer. Four regulatory subunits (RIα, RIβ, RIIα, RIIβ) and four catalytic subunits (Cα, Cβ, Cγ, Prkx) have been described in the human and mouse genomes. Previous studies showed that complete inactivation of the Prkar1a subunit (coding for RIα) in the germline leads to embryonic lethality, while Prkar1a-deficient mice are viable and develop schwannomas, thyroid, and bone neoplasms, and rarely lymphomas and sarcomas. Mice with inactivation of the Prkar2a and Prkar2b genes (coding for RIIα and RIIβ, respectively) are also viable but have not been studied for their susceptibility to any tumors. METHODS: Cohorts of Prkar1a (+/-) , Prkar2a (+/-) , Prkar2a (-/-) , Prkar2b (+/-) and wild type (WT) mice have been observed between 5 and 25 months of age for the development of hematologic malignancies. Tissues were studied by immunohistochemistry; tumor-specific markers were also used as indicated. Cell sorting and protein studies were also performed. RESULTS: Both Prkar2a (-/-) and Prkar2a (+/-) mice frequently developed hematopoietic neoplasms dominated by histiocytic sarcomas (HS) with rare diffuse large B cell lymphomas (DLBCL). Southern blot analysis confirmed that the tumors diagnosed histologically as DLBCL were clonal B cell neoplasms. Mice with other genotypes did not develop a significant number of similar neoplasms. CONCLUSIONS: Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIα's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N4ca7918044f142c68689de85fce04a33
61 N7c989359df9043698b67e9b623993fe5
62 sg:journal.1094159
63 schema:name Hematopoietic neoplasms in Prkar2a-deficient mice
64 schema:pagination 143
65 schema:productId N1e179c52af5b44248eeb8d0019742bc1
66 N382313bc431c4081aab28c79f0a38590
67 N459c197f7dc24dda903b0eabe0bb7450
68 N4b506e61ba6142e5805ed59505b23ed0
69 Nea2b38205ea24453b791ef451080b036
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034909616
71 https://doi.org/10.1186/s13046-015-0257-z
72 schema:sdDatePublished 2019-04-11T00:16
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N969099c2efdb489a8bf1ced862392f9a
75 schema:url http://link.springer.com/10.1186%2Fs13046-015-0257-z
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N08dda867e7fe4beb8a8814b9f7f19683 rdf:first sg:person.011237370437.06
80 rdf:rest N1e3c1623008c46b195507dd6da5765c7
81 N0c13d4aa080b42b9a03e24f2ec86e932 rdf:first sg:person.011265750357.58
82 rdf:rest N234ef7da4f6d4d43b391b562fbff35e6
83 N1e179c52af5b44248eeb8d0019742bc1 schema:name pubmed_id
84 schema:value 26608815
85 rdf:type schema:PropertyValue
86 N1e3c1623008c46b195507dd6da5765c7 rdf:first sg:person.01104031357.13
87 rdf:rest Ne3f03e89f0724e7aae77a477a70eba79
88 N21415f9c115b412eb1afb177e91fbfc7 rdf:first sg:person.011552000037.67
89 rdf:rest N643bbb3bea3b4549a4486f0139b13d0c
90 N234ef7da4f6d4d43b391b562fbff35e6 rdf:first sg:person.011151216517.08
91 rdf:rest rdf:nil
92 N382313bc431c4081aab28c79f0a38590 schema:name readcube_id
93 schema:value a64c07c1b3a6bd109fb4cdf9244bdc48c33369e05d3a501981a9b7fc5291cba5
94 rdf:type schema:PropertyValue
95 N459c197f7dc24dda903b0eabe0bb7450 schema:name doi
96 schema:value 10.1186/s13046-015-0257-z
97 rdf:type schema:PropertyValue
98 N4b506e61ba6142e5805ed59505b23ed0 schema:name nlm_unique_id
99 schema:value 8308647
100 rdf:type schema:PropertyValue
101 N4ca7918044f142c68689de85fce04a33 schema:volumeNumber 34
102 rdf:type schema:PublicationVolume
103 N54ecb28915b34be3af40f6caf948d685 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mice
105 rdf:type schema:DefinedTerm
106 N5dbc85f7b6414a4eb5aede22e9f6cd8b rdf:first sg:person.01177543040.12
107 rdf:rest N08dda867e7fe4beb8a8814b9f7f19683
108 N627b91d43c7f4aa4a72c0e3f15ca27d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mice, Knockout
110 rdf:type schema:DefinedTerm
111 N63db0a5f55034834bd541ed855ff219f rdf:first sg:person.01105002423.24
112 rdf:rest N5dbc85f7b6414a4eb5aede22e9f6cd8b
113 N643bbb3bea3b4549a4486f0139b13d0c rdf:first sg:person.01156104242.51
114 rdf:rest N0c13d4aa080b42b9a03e24f2ec86e932
115 N727c1a96f8aa4940a1898bc8ab6c1c86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Genotype
117 rdf:type schema:DefinedTerm
118 N7bd0f7220fef4752a6e4c0ed228cb50f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Phenotype
120 rdf:type schema:DefinedTerm
121 N7c989359df9043698b67e9b623993fe5 schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N7e99b045014c49278610813db839e465 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
125 rdf:type schema:DefinedTerm
126 N833a6b75576640cf8515ed21bee53d85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Genetic Association Studies
128 rdf:type schema:DefinedTerm
129 N969099c2efdb489a8bf1ced862392f9a schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 Na38fad26381a4a8eae4e60d6fae271ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Time Factors
133 rdf:type schema:DefinedTerm
134 Na5bbcba685e548f5bfda883b9a9e48b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Hematologic Neoplasms
136 rdf:type schema:DefinedTerm
137 Nb134a727104b43339d0c366bc43aaf92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cell Transformation, Neoplastic
139 rdf:type schema:DefinedTerm
140 Nbeaa869482ba48aab96d14745226bd48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit
142 rdf:type schema:DefinedTerm
143 Ne389dfe1b766432d8a7f85fea95cce1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Disease Models, Animal
145 rdf:type schema:DefinedTerm
146 Ne3f03e89f0724e7aae77a477a70eba79 rdf:first sg:person.013406564777.27
147 rdf:rest N21415f9c115b412eb1afb177e91fbfc7
148 Ne4c16822eb3944a6a77445e4ac4e22c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Immunophenotyping
150 rdf:type schema:DefinedTerm
151 Nea2b38205ea24453b791ef451080b036 schema:name dimensions_id
152 schema:value pub.1034909616
153 rdf:type schema:PropertyValue
154 Nf7ac7fe6ff13436c8d8708d40454d62a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit
156 rdf:type schema:DefinedTerm
157 Nfcb03e2fe4e24f88bef8638535d4103c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Genetic Predisposition to Disease
159 rdf:type schema:DefinedTerm
160 Nfe944126df694ee08583fa9057eaea6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Animals
162 rdf:type schema:DefinedTerm
163 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
164 schema:name Biological Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
167 schema:name Biochemistry and Cell Biology
168 rdf:type schema:DefinedTerm
169 sg:grant.2723122 http://pending.schema.org/fundedItem sg:pub.10.1186/s13046-015-0257-z
170 rdf:type schema:MonetaryGrant
171 sg:grant.2723240 http://pending.schema.org/fundedItem sg:pub.10.1186/s13046-015-0257-z
172 rdf:type schema:MonetaryGrant
173 sg:grant.2725681 http://pending.schema.org/fundedItem sg:pub.10.1186/s13046-015-0257-z
174 rdf:type schema:MonetaryGrant
175 sg:journal.1094159 schema:issn 0392-9078
176 1756-9966
177 schema:name Journal of Experimental & Clinical Cancer Research
178 rdf:type schema:Periodical
179 sg:person.01104031357.13 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
180 schema:familyName Gugliotti
181 schema:givenName Lina A.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104031357.13
183 rdf:type schema:Person
184 sg:person.01105002423.24 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
185 schema:familyName Saloustros
186 schema:givenName Emmanouil
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105002423.24
188 rdf:type schema:Person
189 sg:person.011151216517.08 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
190 schema:familyName Stratakis
191 schema:givenName Constantine A.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011151216517.08
193 rdf:type schema:Person
194 sg:person.011237370437.06 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
195 schema:familyName Qi
196 schema:givenName Chen-Feng
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011237370437.06
198 rdf:type schema:Person
199 sg:person.011265750357.58 schema:affiliation https://www.grid.ac/institutes/grid.419681.3
200 schema:familyName Morse
201 schema:givenName Herbert C.
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011265750357.58
203 rdf:type schema:Person
204 sg:person.011552000037.67 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
205 schema:familyName Liu
206 schema:givenName Sisi
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011552000037.67
208 rdf:type schema:Person
209 sg:person.01156104242.51 schema:affiliation https://www.grid.ac/institutes/grid.453125.4
210 schema:familyName Starost
211 schema:givenName Matthew F.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156104242.51
213 rdf:type schema:Person
214 sg:person.01177543040.12 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
215 schema:familyName Salpea
216 schema:givenName Paraskevi
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177543040.12
218 rdf:type schema:Person
219 sg:person.013406564777.27 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
220 schema:familyName Tsang
221 schema:givenName Kitman
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013406564777.27
223 rdf:type schema:Person
224 sg:pub.10.1038/79238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034260511
225 https://doi.org/10.1038/79238
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/labinvest.3780020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028440930
228 https://doi.org/10.1038/labinvest.3780020
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nature08645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050729897
231 https://doi.org/10.1038/nature08645
232 rdf:type schema:CreativeWork
233 sg:pub.10.1097/01.gim.0000196821.87655.d0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000288901
234 https://doi.org/10.1097/01.gim.0000196821.87655.d0
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/1756-9966-28-116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027098559
237 https://doi.org/10.1186/1756-9966-28-116
238 rdf:type schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1074649178 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1076244911 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1077252657 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1077286117 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1083228089 schema:CreativeWork
244 https://doi.org/10.1016/0888-7543(89)90342-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020341068
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.cancergen.2010.12.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047462818
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s0002-9440(10)65327-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007249082
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1073/pnas.0405535101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003890846
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1073/pnas.0609033103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038313489
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1073/pnas.84.15.5192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020446885
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1073/pnas.94.20.11067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011289200
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1074/jbc.271.26.15736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046628308
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1074/jbc.274.34.24131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032075590
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1097/00000478-200102000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040570114
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1111/j.1365-2141.1989.tb00251.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036381282
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/j.1749-6632.2002.tb04328.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033552107
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1158/0008-5472.can-03-3253 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049894307
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1158/0008-5472.can-04-3620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042916926
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1158/0008-5472.can-05-0580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042369061
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1158/0008-5472.can-06-1561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008657577
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1158/0008-5472.can-06-2200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051763756
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1161/circresaha.108.174813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028740701
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1177/0192623311431467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051119723
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1177/0300985810363705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004594731
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1182/blood-2011-01-293050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038858270
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1182/blood.v100.1.238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028951807
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1182/blood.v100.1.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013665881
289 rdf:type schema:CreativeWork
290 https://doi.org/10.2741/skalhegg schema:sameAs https://app.dimensions.ai/details/publication/pub.1070918540
291 rdf:type schema:CreativeWork
292 https://doi.org/10.3324/haematol.2012.072470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046639166
293 rdf:type schema:CreativeWork
294 https://www.grid.ac/institutes/grid.419681.3 schema:alternateName National Institute of Allergy and Infectious Diseases
295 schema:name Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, 20852, Rockville, MD, USA
296 rdf:type schema:Organization
297 https://www.grid.ac/institutes/grid.420089.7 schema:alternateName National Institute of Child Health and Human Development
298 schema:name Program in Genomics and Differentiation, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), 20892, Bethesda, MD, USA
299 Section on Endocrinology and Genetics, Program on Developmental Endocrinology & Genetics (PDEGEN) & Pediatric Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), 20892, Bethesda, MD, USA
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.453125.4 schema:alternateName Office of the Director
302 schema:name Division of Veterinary Resources, Office of the Director (OD), National Institutes of Health, 20892, Bethesda, MD, USA
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...