Ontology type: schema:ScholarlyArticle Open Access: True
2015-12
AUTHORSEmmanouil Saloustros, Paraskevi Salpea, Chen-Feng Qi, Lina A. Gugliotti, Kitman Tsang, Sisi Liu, Matthew F. Starost, Herbert C. Morse, Constantine A. Stratakis
ABSTRACTBACKGROUND: Protein kinase A (PKA) is a holoenzyme that consists of a dimer of regulatory subunits and two inactive catalytic subunits that bind to the regulatory subunit dimer. Four regulatory subunits (RIα, RIβ, RIIα, RIIβ) and four catalytic subunits (Cα, Cβ, Cγ, Prkx) have been described in the human and mouse genomes. Previous studies showed that complete inactivation of the Prkar1a subunit (coding for RIα) in the germline leads to embryonic lethality, while Prkar1a-deficient mice are viable and develop schwannomas, thyroid, and bone neoplasms, and rarely lymphomas and sarcomas. Mice with inactivation of the Prkar2a and Prkar2b genes (coding for RIIα and RIIβ, respectively) are also viable but have not been studied for their susceptibility to any tumors. METHODS: Cohorts of Prkar1a (+/-) , Prkar2a (+/-) , Prkar2a (-/-) , Prkar2b (+/-) and wild type (WT) mice have been observed between 5 and 25 months of age for the development of hematologic malignancies. Tissues were studied by immunohistochemistry; tumor-specific markers were also used as indicated. Cell sorting and protein studies were also performed. RESULTS: Both Prkar2a (-/-) and Prkar2a (+/-) mice frequently developed hematopoietic neoplasms dominated by histiocytic sarcomas (HS) with rare diffuse large B cell lymphomas (DLBCL). Southern blot analysis confirmed that the tumors diagnosed histologically as DLBCL were clonal B cell neoplasms. Mice with other genotypes did not develop a significant number of similar neoplasms. CONCLUSIONS: Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RIIα's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms. More... »
PAGES143
http://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z
DOIhttp://dx.doi.org/10.1186/s13046-015-0257-z
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"description": "BACKGROUND: Protein kinase A (PKA) is a holoenzyme that consists of a dimer of regulatory subunits and two inactive catalytic subunits that bind to the regulatory subunit dimer. Four regulatory subunits (RI\u03b1, RI\u03b2, RII\u03b1, RII\u03b2) and four catalytic subunits (C\u03b1, C\u03b2, C\u03b3, Prkx) have been described in the human and mouse genomes. Previous studies showed that complete inactivation of the Prkar1a subunit (coding for RI\u03b1) in the germline leads to embryonic lethality, while Prkar1a-deficient mice are viable and develop schwannomas, thyroid, and bone neoplasms, and rarely lymphomas and sarcomas. Mice with inactivation of the Prkar2a and Prkar2b genes (coding for RII\u03b1 and RII\u03b2, respectively) are also viable but have not been studied for their susceptibility to any tumors.\nMETHODS: Cohorts of Prkar1a (+/-) , Prkar2a (+/-) , Prkar2a (-/-) , Prkar2b (+/-) and wild type (WT) mice have been observed between 5 and 25 months of age for the development of hematologic malignancies. Tissues were studied by immunohistochemistry; tumor-specific markers were also used as indicated. Cell sorting and protein studies were also performed.\nRESULTS: Both Prkar2a (-/-) and Prkar2a (+/-) mice frequently developed hematopoietic neoplasms dominated by histiocytic sarcomas (HS) with rare diffuse large B cell lymphomas (DLBCL). Southern blot analysis confirmed that the tumors diagnosed histologically as DLBCL were clonal B cell neoplasms. Mice with other genotypes did not develop a significant number of similar neoplasms.\nCONCLUSIONS: Prkar2a deficiency predisposes to hematopoietic malignancies in vivo. RII\u03b1's likely association with HS and DLBCL was hitherto unrecognized and may lead to better understanding of these rare neoplasms.",
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"type": "PropertyValue",
"value": [
"8308647"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13046-015-0257-z"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1034909616"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13046-015-0257-z",
"https://app.dimensions.ai/details/publication/pub.1034909616"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T00:16",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000514.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2Fs13046-015-0257-z"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0257-z'
This table displays all metadata directly associated to this object as RDF triples.
303 TRIPLES
21 PREDICATES
79 URIs
36 LITERALS
24 BLANK NODES