Endothelial follicle-stimulating hormone receptor expression in invasive breast cancer and vascular remodeling at tumor periphery View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

François Planeix, Mohammad-Ahsan Siraj, François-Clément Bidard, Blaise Robin, Christophe Pichon, Xavier Sastre-Garau, Martine Antoine, Nicolae Ghinea

ABSTRACT

BACKGROUND: Follicle-stimulating hormone receptor (FSHR) is expressed on the endothelial surface of blood vessels associated with solid tumor periphery, where angiogenesis is known to occur. The correlation between FSHR expression and formation of new peritumoral vessels has not been previously investigated. METHODS: We used immunohistochemical techniques involving specific antibodies to detect FSHR and the endothelial markers (CD34, VEGFR2, and D2-40) in tissue samples from 83 patients with lymph node-negative, invasive breast cancer representing four main clinical treatment groups: HR+/HER2-, HR+/HER2+, HR-/HER2+ and triple-negative. RESULTS: The FSHR+ vessels were exclusively located at breast cancer periphery, in a layer that extended 2 mm into and 5 mm outside of the tumor. The percentage of blood vessels expressing FSHR reached a maximum of 100% at the demarcation line between the tumor and the normal tissue. Common among FSHR+ vessels, regardless of breast cancer type, were the high densities of arterioles and venules (6.4 ± 1.4 and 13.9 ± 2.1 vessels/mm(2), respectively). These values were 3-fold higher that those noticed for CD34+ arterioles and venules associated with normal breast tissue located at a distance greater than 10 mm outside the tumors. The average density of FSHR+ and CD34+ blood vessels as well as of D2-40+ lymphatic vessels did not differ significantly among breast cancer subgroups. FSHR+ vessels did not express VEGFR2. The endothelial FSHR expression correlated significantly with the peritumoral CD34+ vessels' density (p < 0.001) and tumor size (p = 0.01). CONCLUSION: Endothelial FSHR expression in breast cancer is associated with vascular remodeling at tumor periphery. More... »

PAGES

12

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13046-015-0128-7

DOI

http://dx.doi.org/10.1186/s13046-015-0128-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042925985

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25652007


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, FSH", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Remodeling", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "INSERM \u201cTumoral Angiogenesis\u201d Laboratory, Curie Institute, Research Center, Translational Research Department, 26 rue d\u2019Ulm, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Planeix", 
        "givenName": "Fran\u00e7ois", 
        "id": "sg:person.01024160663.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024160663.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "INSERM \u201cTumoral Angiogenesis\u201d Laboratory, Curie Institute, Research Center, Translational Research Department, 26 rue d\u2019Ulm, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Siraj", 
        "givenName": "Mohammad-Ahsan", 
        "id": "sg:person.01071406035.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071406035.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Curie Hospital, Oncology Department, 26 rue d\u2019Ulm, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bidard", 
        "givenName": "Fran\u00e7ois-Cl\u00e9ment", 
        "id": "sg:person.01134552110.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134552110.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "INSERM \u201cTumoral Angiogenesis\u201d Laboratory, Curie Institute, Research Center, Translational Research Department, 26 rue d\u2019Ulm, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robin", 
        "givenName": "Blaise", 
        "id": "sg:person.01205634435.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205634435.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "INSERM \u201cTumoral Angiogenesis\u201d Laboratory, Curie Institute, Research Center, Translational Research Department, 26 rue d\u2019Ulm, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pichon", 
        "givenName": "Christophe", 
        "id": "sg:person.01161675610.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161675610.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Curie Hospital, Pathology Department, 26 rue d\u2019Ulm, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sastre-Garau", 
        "givenName": "Xavier", 
        "id": "sg:person.01354335252.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354335252.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tenon Hospital", 
          "id": "https://www.grid.ac/institutes/grid.413483.9", 
          "name": [
            "Tenon Hospital, Pathology Department, 4 rue de la Chine, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Antoine", 
        "givenName": "Martine", 
        "id": "sg:person.01351724057.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351724057.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "INSERM \u201cTumoral Angiogenesis\u201d Laboratory, Curie Institute, Research Center, Translational Research Department, 26 rue d\u2019Ulm, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ghinea", 
        "givenName": "Nicolae", 
        "id": "sg:person.012333015764.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012333015764.80"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.molonc.2010.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000679392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-012-9500-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001482728", 
          "https://doi.org/10.1007/s10585-012-9500-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005674252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005867939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03009734.2012.660550", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016651957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.28914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017254547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.24.9284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018661827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019725986", 
          "https://doi.org/10.1038/nrc2895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2895", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019725986", 
          "https://doi.org/10.1038/nrc2895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022080605", 
          "https://doi.org/10.1038/nrc1627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022080605", 
          "https://doi.org/10.1038/nrc1627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022080605", 
          "https://doi.org/10.1038/nrc1627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-349-06859-3_9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023010460", 
          "https://doi.org/10.1007/978-1-349-06859-3_9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-12-2217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028218137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11307-013-0688-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030682404", 
          "https://doi.org/10.1007/s11307-013-0688-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1113205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031166230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35021093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033846543", 
          "https://doi.org/10.1038/35021093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2012.12.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036026674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-0642-03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036285197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039488853", 
          "https://doi.org/10.1038/nrc3261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-13-246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039514859", 
          "https://doi.org/10.1186/1471-2407-13-246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002800050885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039532839", 
          "https://doi.org/10.1007/s002800050885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.21208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041182772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyt201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043467979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1001283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044439463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa020989", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044831647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.1370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045851448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65006-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048305964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049222218", 
          "https://doi.org/10.1038/nature11154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/82.1.4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051237830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.36.1105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053069814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi952290f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055211023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi952290f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055211023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3798106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062621480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v19.i5.769", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071370192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4183/aeb.2010.507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072347324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082466764", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083050708", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Follicle-stimulating hormone receptor (FSHR) is expressed on the endothelial surface of blood vessels associated with solid tumor periphery, where angiogenesis is known to occur. The correlation between FSHR expression and formation of new peritumoral vessels has not been previously investigated.\nMETHODS: We used immunohistochemical techniques involving specific antibodies to detect FSHR and the endothelial markers (CD34, VEGFR2, and D2-40) in tissue samples from 83 patients with lymph node-negative, invasive breast cancer representing four main clinical treatment groups: HR+/HER2-, HR+/HER2+, HR-/HER2+ and triple-negative.\nRESULTS: The FSHR+ vessels were exclusively located at breast cancer periphery, in a layer that extended 2\u00a0mm into and 5\u00a0mm outside of the tumor. The percentage of blood vessels expressing FSHR reached a maximum of 100% at the demarcation line between the tumor and the normal tissue. Common among FSHR+ vessels, regardless of breast cancer type, were the high densities of arterioles and venules (6.4\u2009\u00b1\u20091.4 and 13.9\u2009\u00b1\u20092.1 vessels/mm(2), respectively). These values were 3-fold higher that those noticed for CD34+ arterioles and venules associated with normal breast tissue located at a distance greater than 10\u00a0mm outside the tumors. The average density of FSHR+ and CD34+ blood vessels as well as of D2-40+ lymphatic vessels did not differ significantly among breast cancer subgroups. FSHR+ vessels did not express VEGFR2. The endothelial FSHR expression correlated significantly with the peritumoral CD34+ vessels' density (p\u2009<\u20090.001) and tumor size (p\u2009=\u20090.01).\nCONCLUSION: Endothelial FSHR expression in breast cancer is associated with vascular remodeling at tumor periphery.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13046-015-0128-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1094159", 
        "issn": [
          "0392-9078", 
          "1756-9966"
        ], 
        "name": "Journal of Experimental & Clinical Cancer Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "34"
      }
    ], 
    "name": "Endothelial follicle-stimulating hormone receptor expression in invasive breast cancer and vascular remodeling at tumor periphery", 
    "pagination": "12", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cc78bf66d874abf84f42fbae107e10b2ef0d421d08899a57610f3909445c5bcd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25652007"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8308647"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13046-015-0128-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042925985"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13046-015-0128-7", 
      "https://app.dimensions.ai/details/publication/pub.1042925985"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88255_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13046-015-0128-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0128-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0128-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0128-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13046-015-0128-7'


 

This table displays all metadata directly associated to this object as RDF triples.

279 TRIPLES      21 PREDICATES      74 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13046-015-0128-7 schema:about N088fad2a02b04428a3b878b757ef7ce3
2 N18858d3fe47f4aba83a08f8ca3ebd2df
3 N4764b925b7f44832b6a2b0c644a9c9d1
4 N768c29200a434198b978444c586787bf
5 N7ba9faae834b437d9cbec6209a316121
6 N9524ed157c0c4755880155897d6ee3d4
7 Nac3fe7aaeb5841fbab83537a68ed6445
8 Nce2422d784d04cd088a44210e87b509f
9 Nde1fdd81950e4c3b8459bb13122b56c0
10 Ne31dd45c17f54eb4bf7d8394e1c75e92
11 Ned8be80af8154b9c884c15ab2f3ff55c
12 anzsrc-for:11
13 anzsrc-for:1112
14 schema:author Ndc3f7b2dfae94131b30b533eed62221b
15 schema:citation sg:pub.10.1007/978-1-349-06859-3_9
16 sg:pub.10.1007/s002800050885
17 sg:pub.10.1007/s10585-012-9500-6
18 sg:pub.10.1007/s11307-013-0688-x
19 sg:pub.10.1038/35021093
20 sg:pub.10.1038/nature11154
21 sg:pub.10.1038/nrc1627
22 sg:pub.10.1038/nrc2895
23 sg:pub.10.1038/nrc3261
24 sg:pub.10.1186/1471-2407-13-246
25 https://app.dimensions.ai/details/publication/pub.1082466764
26 https://app.dimensions.ai/details/publication/pub.1083050708
27 https://doi.org/10.1002/cncr.20299
28 https://doi.org/10.1002/cncr.22618
29 https://doi.org/10.1002/cncr.28914
30 https://doi.org/10.1016/j.ejca.2012.12.027
31 https://doi.org/10.1016/j.molonc.2010.11.003
32 https://doi.org/10.1016/s0002-9440(10)65006-7
33 https://doi.org/10.1021/bi952290f
34 https://doi.org/10.1056/nejmoa020989
35 https://doi.org/10.1056/nejmoa1001283
36 https://doi.org/10.1056/nejmoa1113205
37 https://doi.org/10.1093/jjco/hyt201
38 https://doi.org/10.1093/jnci/82.1.4
39 https://doi.org/10.1126/science.3798106
40 https://doi.org/10.1158/0008-5472.can-12-2217
41 https://doi.org/10.1158/1078-0432.ccr-0642-03
42 https://doi.org/10.1200/jco.2008.18.1370
43 https://doi.org/10.1200/jco.2009.24.9284
44 https://doi.org/10.1200/jco.2011.36.1105
45 https://doi.org/10.3109/03009734.2012.660550
46 https://doi.org/10.3322/caac.21208
47 https://doi.org/10.3748/wjg.v19.i5.769
48 https://doi.org/10.4183/aeb.2010.507
49 schema:datePublished 2015-12
50 schema:datePublishedReg 2015-12-01
51 schema:description BACKGROUND: Follicle-stimulating hormone receptor (FSHR) is expressed on the endothelial surface of blood vessels associated with solid tumor periphery, where angiogenesis is known to occur. The correlation between FSHR expression and formation of new peritumoral vessels has not been previously investigated. METHODS: We used immunohistochemical techniques involving specific antibodies to detect FSHR and the endothelial markers (CD34, VEGFR2, and D2-40) in tissue samples from 83 patients with lymph node-negative, invasive breast cancer representing four main clinical treatment groups: HR+/HER2-, HR+/HER2+, HR-/HER2+ and triple-negative. RESULTS: The FSHR+ vessels were exclusively located at breast cancer periphery, in a layer that extended 2 mm into and 5 mm outside of the tumor. The percentage of blood vessels expressing FSHR reached a maximum of 100% at the demarcation line between the tumor and the normal tissue. Common among FSHR+ vessels, regardless of breast cancer type, were the high densities of arterioles and venules (6.4 ± 1.4 and 13.9 ± 2.1 vessels/mm(2), respectively). These values were 3-fold higher that those noticed for CD34+ arterioles and venules associated with normal breast tissue located at a distance greater than 10 mm outside the tumors. The average density of FSHR+ and CD34+ blood vessels as well as of D2-40+ lymphatic vessels did not differ significantly among breast cancer subgroups. FSHR+ vessels did not express VEGFR2. The endothelial FSHR expression correlated significantly with the peritumoral CD34+ vessels' density (p < 0.001) and tumor size (p = 0.01). CONCLUSION: Endothelial FSHR expression in breast cancer is associated with vascular remodeling at tumor periphery.
52 schema:genre research_article
53 schema:inLanguage en
54 schema:isAccessibleForFree true
55 schema:isPartOf N185fd4bda12e43bebc6b4d78ba3aa4f5
56 Ncf183cb49a694d199c359e44834d9dbf
57 sg:journal.1094159
58 schema:name Endothelial follicle-stimulating hormone receptor expression in invasive breast cancer and vascular remodeling at tumor periphery
59 schema:pagination 12
60 schema:productId N22113f9ee9e941a2bee1efac7988e962
61 N9cff4058874c41479ba97db9988ee8c1
62 Na95ac582860a494a90ca6bb8829438af
63 Nbd2cccc721034f84b194dfb13995d53e
64 Nebf3f58c4dc84d29894b5ff1839e5a28
65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042925985
66 https://doi.org/10.1186/s13046-015-0128-7
67 schema:sdDatePublished 2019-04-11T13:11
68 schema:sdLicense https://scigraph.springernature.com/explorer/license/
69 schema:sdPublisher Nd42a4b1e250246e981bd74acd65295d2
70 schema:url http://link.springer.com/10.1186%2Fs13046-015-0128-7
71 sgo:license sg:explorer/license/
72 sgo:sdDataset articles
73 rdf:type schema:ScholarlyArticle
74 N088fad2a02b04428a3b878b757ef7ce3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Humans
76 rdf:type schema:DefinedTerm
77 N185fd4bda12e43bebc6b4d78ba3aa4f5 schema:volumeNumber 34
78 rdf:type schema:PublicationVolume
79 N18858d3fe47f4aba83a08f8ca3ebd2df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Endothelial Cells
81 rdf:type schema:DefinedTerm
82 N22113f9ee9e941a2bee1efac7988e962 schema:name doi
83 schema:value 10.1186/s13046-015-0128-7
84 rdf:type schema:PropertyValue
85 N3996f671b07b49f38fea73eaeb026a88 schema:name Curie Hospital, Oncology Department, 26 rue d’Ulm, Paris, France
86 rdf:type schema:Organization
87 N40720f346da4423e8d34c0cddf0ab1a9 rdf:first sg:person.01205634435.87
88 rdf:rest Ndd1c792f9cc4471493e8fcdc8ce86bc4
89 N42efdc7801684a1a811f717114e510f8 rdf:first sg:person.012333015764.80
90 rdf:rest rdf:nil
91 N4764b925b7f44832b6a2b0c644a9c9d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Female
93 rdf:type schema:DefinedTerm
94 N56e3cc00e8794b929a3e9d11bad4f3e2 rdf:first sg:person.01071406035.85
95 rdf:rest Ncbe1a548ea3d410a8da35366cdeed438
96 N768c29200a434198b978444c586787bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Neoplasm Grading
98 rdf:type schema:DefinedTerm
99 N7ba9faae834b437d9cbec6209a316121 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Gene Expression
101 rdf:type schema:DefinedTerm
102 N9524ed157c0c4755880155897d6ee3d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Biomarkers
104 rdf:type schema:DefinedTerm
105 N9cff4058874c41479ba97db9988ee8c1 schema:name nlm_unique_id
106 schema:value 8308647
107 rdf:type schema:PropertyValue
108 Na95ac582860a494a90ca6bb8829438af schema:name dimensions_id
109 schema:value pub.1042925985
110 rdf:type schema:PropertyValue
111 Nac3fe7aaeb5841fbab83537a68ed6445 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Breast Neoplasms
113 rdf:type schema:DefinedTerm
114 Nbd2cccc721034f84b194dfb13995d53e schema:name pubmed_id
115 schema:value 25652007
116 rdf:type schema:PropertyValue
117 Ncbad397d5ad145859857e3e3643ccd62 rdf:first sg:person.01354335252.66
118 rdf:rest Nef53f5bfd6114c26a825e14e1ad00b0e
119 Ncbe1a548ea3d410a8da35366cdeed438 rdf:first sg:person.01134552110.75
120 rdf:rest N40720f346da4423e8d34c0cddf0ab1a9
121 Nce2422d784d04cd088a44210e87b509f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Vascular Remodeling
123 rdf:type schema:DefinedTerm
124 Ncf183cb49a694d199c359e44834d9dbf schema:issueNumber 1
125 rdf:type schema:PublicationIssue
126 Nd42a4b1e250246e981bd74acd65295d2 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 Ndc3f7b2dfae94131b30b533eed62221b rdf:first sg:person.01024160663.84
129 rdf:rest N56e3cc00e8794b929a3e9d11bad4f3e2
130 Ndd1c792f9cc4471493e8fcdc8ce86bc4 rdf:first sg:person.01161675610.44
131 rdf:rest Ncbad397d5ad145859857e3e3643ccd62
132 Nde1fdd81950e4c3b8459bb13122b56c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Neovascularization, Pathologic
134 rdf:type schema:DefinedTerm
135 Ne31dd45c17f54eb4bf7d8394e1c75e92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Immunohistochemistry
137 rdf:type schema:DefinedTerm
138 Ne33206cb3dc446e987774f439cbf7efb schema:name Curie Hospital, Pathology Department, 26 rue d’Ulm, Paris, France
139 rdf:type schema:Organization
140 Nebf3f58c4dc84d29894b5ff1839e5a28 schema:name readcube_id
141 schema:value cc78bf66d874abf84f42fbae107e10b2ef0d421d08899a57610f3909445c5bcd
142 rdf:type schema:PropertyValue
143 Ned8be80af8154b9c884c15ab2f3ff55c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Receptors, FSH
145 rdf:type schema:DefinedTerm
146 Nef53f5bfd6114c26a825e14e1ad00b0e rdf:first sg:person.01351724057.36
147 rdf:rest N42efdc7801684a1a811f717114e510f8
148 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
149 schema:name Medical and Health Sciences
150 rdf:type schema:DefinedTerm
151 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
152 schema:name Oncology and Carcinogenesis
153 rdf:type schema:DefinedTerm
154 sg:journal.1094159 schema:issn 0392-9078
155 1756-9966
156 schema:name Journal of Experimental & Clinical Cancer Research
157 rdf:type schema:Periodical
158 sg:person.01024160663.84 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
159 schema:familyName Planeix
160 schema:givenName François
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024160663.84
162 rdf:type schema:Person
163 sg:person.01071406035.85 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
164 schema:familyName Siraj
165 schema:givenName Mohammad-Ahsan
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071406035.85
167 rdf:type schema:Person
168 sg:person.01134552110.75 schema:affiliation N3996f671b07b49f38fea73eaeb026a88
169 schema:familyName Bidard
170 schema:givenName François-Clément
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134552110.75
172 rdf:type schema:Person
173 sg:person.01161675610.44 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
174 schema:familyName Pichon
175 schema:givenName Christophe
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161675610.44
177 rdf:type schema:Person
178 sg:person.01205634435.87 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
179 schema:familyName Robin
180 schema:givenName Blaise
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205634435.87
182 rdf:type schema:Person
183 sg:person.012333015764.80 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
184 schema:familyName Ghinea
185 schema:givenName Nicolae
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012333015764.80
187 rdf:type schema:Person
188 sg:person.01351724057.36 schema:affiliation https://www.grid.ac/institutes/grid.413483.9
189 schema:familyName Antoine
190 schema:givenName Martine
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351724057.36
192 rdf:type schema:Person
193 sg:person.01354335252.66 schema:affiliation Ne33206cb3dc446e987774f439cbf7efb
194 schema:familyName Sastre-Garau
195 schema:givenName Xavier
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354335252.66
197 rdf:type schema:Person
198 sg:pub.10.1007/978-1-349-06859-3_9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023010460
199 https://doi.org/10.1007/978-1-349-06859-3_9
200 rdf:type schema:CreativeWork
201 sg:pub.10.1007/s002800050885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039532839
202 https://doi.org/10.1007/s002800050885
203 rdf:type schema:CreativeWork
204 sg:pub.10.1007/s10585-012-9500-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001482728
205 https://doi.org/10.1007/s10585-012-9500-6
206 rdf:type schema:CreativeWork
207 sg:pub.10.1007/s11307-013-0688-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030682404
208 https://doi.org/10.1007/s11307-013-0688-x
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/35021093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033846543
211 https://doi.org/10.1038/35021093
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/nature11154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049222218
214 https://doi.org/10.1038/nature11154
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/nrc1627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022080605
217 https://doi.org/10.1038/nrc1627
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/nrc2895 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019725986
220 https://doi.org/10.1038/nrc2895
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nrc3261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039488853
223 https://doi.org/10.1038/nrc3261
224 rdf:type schema:CreativeWork
225 sg:pub.10.1186/1471-2407-13-246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039514859
226 https://doi.org/10.1186/1471-2407-13-246
227 rdf:type schema:CreativeWork
228 https://app.dimensions.ai/details/publication/pub.1082466764 schema:CreativeWork
229 https://app.dimensions.ai/details/publication/pub.1083050708 schema:CreativeWork
230 https://doi.org/10.1002/cncr.20299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005867939
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1002/cncr.22618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005674252
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1002/cncr.28914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017254547
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.ejca.2012.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036026674
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.molonc.2010.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000679392
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0002-9440(10)65006-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048305964
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1021/bi952290f schema:sameAs https://app.dimensions.ai/details/publication/pub.1055211023
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1056/nejmoa020989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044831647
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejmoa1001283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044439463
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1056/nejmoa1113205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031166230
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/jjco/hyt201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043467979
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1093/jnci/82.1.4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051237830
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1126/science.3798106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621480
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1158/0008-5472.can-12-2217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028218137
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1158/1078-0432.ccr-0642-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036285197
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1200/jco.2008.18.1370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045851448
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1200/jco.2009.24.9284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018661827
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1200/jco.2011.36.1105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053069814
265 rdf:type schema:CreativeWork
266 https://doi.org/10.3109/03009734.2012.660550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016651957
267 rdf:type schema:CreativeWork
268 https://doi.org/10.3322/caac.21208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041182772
269 rdf:type schema:CreativeWork
270 https://doi.org/10.3748/wjg.v19.i5.769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071370192
271 rdf:type schema:CreativeWork
272 https://doi.org/10.4183/aeb.2010.507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072347324
273 rdf:type schema:CreativeWork
274 https://www.grid.ac/institutes/grid.413483.9 schema:alternateName Tenon Hospital
275 schema:name Tenon Hospital, Pathology Department, 4 rue de la Chine, Paris, France
276 rdf:type schema:Organization
277 https://www.grid.ac/institutes/grid.418596.7 schema:alternateName Institute Curie
278 schema:name INSERM “Tumoral Angiogenesis” Laboratory, Curie Institute, Research Center, Translational Research Department, 26 rue d’Ulm, Paris, France
279 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...