Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Jiang Lv, Ruocong Zhao, Di Wu, Diwei Zheng, Zhiping Wu, Jingxuan Shi, Xinru Wei, Qiting Wu, Youguo Long, Simiao Lin, Suna Wang, Zhi Wang, Yang Li, Yantao Chen, Qing He, Suimin Chen, Huihui Yao, Zixia Liu, Zhaoyang Tang, Yao Yao, Duanqing Pei, Pentao Liu, Xuchao Zhang, Zhenfeng Zhang, Shuzhong Cui, Ren Chen, Peng Li

ABSTRACT

BACKGROUND: Gastric cancer (GC) is a common cancer in Asia and currently lacks a targeted therapy approach. Mesothelin (MSLN) has been reported to be expressed in GC tissue and could be targeted by chimeric antigen receptor (CAR) T cells. Mesothelin targeting CAR-T has been reported in mesothelioma, lung cancer, breast cancer, and pancreas cancer. However, the feasibility of using anti-MSLN CAR T cells to treat GC remains to be studied. METHODS: We verified MSLN expression in primary human GC tissues and GC cell lines and then redirected T cells with a CAR containing the MSLN scFv (single-chain variable fragment), CD3ζ, CD28, and DAP10 intracellular signaling domain (M28z10) to target MSLN. We evaluated the function of these CAR T cells in vitro in terms of cytotoxicity, cytokine secretion, and surface phenotype changes when they encountered MSLN+ GC cells. We also established four different xenograft GC mouse models to assess in vivo antitumor activity. RESULTS: M28z10 T cells exhibited strong cytotoxicity and cytokine-secreting ability against GC cells in vitro. In addition, cell surface phenotyping suggested significant activation of M28z10 T cells upon target cell stimulation. M28z10 T cells induced GC regression in different xenograft mouse models and prolonged the survival of these mice compared with GFP-transduced T cells in the intraperitoneal and pulmonary metastatic GC models. Importantly, peritumoral delivery strategy can lead to improved CAR-T cells infiltration into tumor tissue and significantly suppress the growth of GC in a subcutaneous GC model. CONCLUSION: These results demonstrate that M28z10 T cells possess strong antitumor activity and represent a promising therapeutic approach to GC. More... »

PAGES

18

References to SciGraph publications

  • 2015-12. Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2017-12. Incorporation of functional elements enhances the antitumor capacity of CAR T cells in EXPERIMENTAL HEMATOLOGY & ONCOLOGY
  • 2017-12. Chimeric antigen receptor T cells: a novel therapy for solid tumors in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2016-12. Efficacy and safety of angiogenesis inhibitors in advanced gastric cancer: a systematic review and meta-analysis in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2012-12. Novel targeted agents for gastric cancer in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2016-09. Engineered T cells: the promise and challenges of cancer immunotherapy in NATURE REVIEWS CANCER
  • 2018-08-13. Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo in NATURE BIOTECHNOLOGY
  • 2018-12. Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2017-12. PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2017-12. Clinical trials of CAR-T cells in China in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2018-03. Toll-like receptor 2 costimulation potentiates the antitumor efficacy of CAR T Cells in LEUKEMIA
  • 2014-03. Biomarkers for gastric cancer: prognostic, predictive or targets of therapy? in VIRCHOWS ARCHIV
  • 2012-04. Combining immunotherapy and targeted therapies in cancer treatment in NATURE REVIEWS CANCER
  • 2018-12. Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients in JOURNAL OF HEMATOLOGY & ONCOLOGY
  • 2016-05. Regional CAR-T cell infusions for peritoneal carcinomatosis are superior to systemic delivery in CANCER GENE THERAPY
  • 2018-06. Interleukin-armed chimeric antigen receptor-modified T cells for cancer immunotherapy in GENE THERAPY
  • 2017-12. Engineering CAR-T cells in BIOMARKER RESEARCH
  • 2017-01. Driving gene-engineered T cell immunotherapy of cancer in CELL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13045-019-0704-y

    DOI

    http://dx.doi.org/10.1186/s13045-019-0704-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112217459

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30777106


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    62 schema:description BACKGROUND: Gastric cancer (GC) is a common cancer in Asia and currently lacks a targeted therapy approach. Mesothelin (MSLN) has been reported to be expressed in GC tissue and could be targeted by chimeric antigen receptor (CAR) T cells. Mesothelin targeting CAR-T has been reported in mesothelioma, lung cancer, breast cancer, and pancreas cancer. However, the feasibility of using anti-MSLN CAR T cells to treat GC remains to be studied. METHODS: We verified MSLN expression in primary human GC tissues and GC cell lines and then redirected T cells with a CAR containing the MSLN scFv (single-chain variable fragment), CD3ζ, CD28, and DAP10 intracellular signaling domain (M28z10) to target MSLN. We evaluated the function of these CAR T cells in vitro in terms of cytotoxicity, cytokine secretion, and surface phenotype changes when they encountered MSLN+ GC cells. We also established four different xenograft GC mouse models to assess in vivo antitumor activity. RESULTS: M28z10 T cells exhibited strong cytotoxicity and cytokine-secreting ability against GC cells in vitro. In addition, cell surface phenotyping suggested significant activation of M28z10 T cells upon target cell stimulation. M28z10 T cells induced GC regression in different xenograft mouse models and prolonged the survival of these mice compared with GFP-transduced T cells in the intraperitoneal and pulmonary metastatic GC models. Importantly, peritumoral delivery strategy can lead to improved CAR-T cells infiltration into tumor tissue and significantly suppress the growth of GC in a subcutaneous GC model. CONCLUSION: These results demonstrate that M28z10 T cells possess strong antitumor activity and represent a promising therapeutic approach to GC.
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