Prognostic or predictive value of circulating cytokines and angiogenic factors for initial treatment of multiple myeloma in the GIMEMA MM0305 ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-01-09

AUTHORS

Ilaria Saltarella, Fortunato Morabito, Nicola Giuliani, Carolina Terragna, Paola Omedè, Antonio Palumbo, Sara Bringhen, Lorenzo De Paoli, Enrica Martino, Alessandra Larocca, Massimo Offidani, Francesca Patriarca, Chiara Nozzoli, Tommasina Guglielmelli, Giulia Benevolo, Vincenzo Callea, Luca Baldini, Mariella Grasso, Giovanna Leonardi, Manuela Rizzo, Antonietta Pia Falcone, Daniela Gottardi, Vittorio Montefusco, Pellegrino Musto, Maria Teresa Petrucci, Franco Dammacco, Mario Boccadoro, Angelo Vacca, Roberto Ria

ABSTRACT

BACKGROUND: Several new drugs are approved for treatment of patients with multiple myeloma (MM), but no validated biomarkers are available for the prediction of a clinical outcome. We aimed to establish whether pretreatment blood and bone marrow plasma concentrations of major cytokines and angiogenic factors (CAFs) of patients from a phase 3 trial of a MM treatment could have a prognostic and predictive value in terms of response to therapy and progression-free and overall survival and whether these patients could be stratified for their prognosis. METHODS: Blood and bone marrow plasma levels of Ang-2, FGF-2, HGF, VEGF, PDGF-β, IL-8, TNF-α, TIMP-1, and TIMP-2 were determined at diagnosis in MM patients enrolled in the GIMEMA MM0305 randomized controlled trial by an enzyme-linked immunosorbent assay (ELISA). These levels were correlated both reciprocally and with the type of therapy and patients' characteristics and with a group of non-MM patients as controls. RESULTS: No significant differences were detected between the blood and bone marrow plasma levels of angiogenic cytokines. A cutoff for each CAF was established. The therapeutic response of patients with blood plasma levels of CAFs lower than the cutoff was better than the response of those with higher levels in terms of percentage of responding patients and quality of response. CONCLUSION: FGF-2, HGF, VEGF, and PDGF-β plasma levels at diagnosis have predictive significance for response to treatment. The stratification of patients based on the levels of CAFs at diagnosis and their variations after therapy is useful to characterize different risk groups concerning outcome and response to therapy. TRIAL REGISTRATION: Clinical trial information can be found at the following link: NCT01063179. More... »

PAGES

4

Journal

TITLE

Journal of Hematology & Oncology

ISSUE

1

VOLUME

12

Author Affiliations

  • Department of Biomedical Science and Human Oncology, University of Bari “Aldo Moro” Medical School, Bari, Italy
  • Hemato-oncology Department Augusta Victoria Hospital, Jerusalem, Israel
  • Department of Clinical and Experimental Medicine, Myeloma Unit, University of Parma, Parma, Italy
  • Seràgnoli” Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University School of Medicine, Bologna, Italy
  • Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy
  • Università degli Studi del Piemonte Orientale, Novara, Italy
  • Division of Hematology, AOU “Policlinico-Vittorio Emanuele”, Catania, Italy
  • Hematology Unit A.O.U. Ospedali Riuniti, Ancona, Italy
  • DAME, University of Udine, Udine, Italy
  • Cellular Therapies and Transfusion Medicine Unit, AOU Careggi, Florence, Italy
  • A.O. San Luigi, Gonzaga, Orbassano, Turin, Italy
  • SC Hematology AO Città della Salute e della Scienza, Turin, Italy
  • Divisione di Ematologia, Ospedali Riuniti, Reggio di Calabria, Italy
  • Hematology Unit, Fondazione IRCCS, Cà Granda, OM Policlinico, DIPO, University of Milan, Milan, Italy
  • A.O. S. Croce e Carle, Cuneo, Italy
  • Department of Oncology and Hematology AOU, Hematology Unit, Modena, Italy
  • University Tor Vergata, Rome, Italy
  • IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
  • A.O.U. S. Giovanni Battista A.O. Mauriziano-Umberto I, Turin, Italy
  • IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
  • IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy
  • Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy
  • Internal Medicine “G. Baccelli”, Myeloma Unit, University of Bari “Aldo Moro” Medical School, Azienda Ospedaliero-Universitaria Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13045-018-0691-4

    DOI

    http://dx.doi.org/10.1186/s13045-018-0691-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1111308965

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30626425


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Becaplermin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Marrow", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibroblast Growth Factor 2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Follow-Up Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hepatocyte Growth Factor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Logistic Models", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multiple Myeloma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Progression-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "ROC Curve", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vascular Endothelial Growth Factor A", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Science and Human Oncology, University of Bari \u201cAldo Moro\u201d Medical School, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Department of Biomedical Science and Human Oncology, University of Bari \u201cAldo Moro\u201d Medical School, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Saltarella", 
            "givenName": "Ilaria", 
            "id": "sg:person.01120436010.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120436010.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hemato-oncology Department Augusta Victoria Hospital, Jerusalem, Israel", 
              "id": "http://www.grid.ac/institutes/grid.427551.0", 
              "name": [
                "Biothecnology Research Unit, Aprigliano, Cosenza Italy", 
                "Hemato-oncology Department Augusta Victoria Hospital, Jerusalem, Israel"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morabito", 
            "givenName": "Fortunato", 
            "id": "sg:person.01121703012.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121703012.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Clinical and Experimental Medicine, Myeloma Unit, University of Parma, Parma, Italy", 
              "id": "http://www.grid.ac/institutes/grid.10383.39", 
              "name": [
                "Department of Clinical and Experimental Medicine, Myeloma Unit, University of Parma, Parma, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giuliani", 
            "givenName": "Nicola", 
            "id": "sg:person.01350052015.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350052015.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ser\u00e0gnoli\u201d Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University School of Medicine, Bologna, Italy", 
              "id": "http://www.grid.ac/institutes/grid.6292.f", 
              "name": [
                "Ser\u00e0gnoli\u201d Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University School of Medicine, Bologna, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Terragna", 
            "givenName": "Carolina", 
            "id": "sg:person.01105531766.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105531766.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/grid.432329.d", 
              "name": [
                "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Omed\u00e8", 
            "givenName": "Paola", 
            "id": "sg:person.012161416633.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012161416633.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/grid.432329.d", 
              "name": [
                "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Palumbo", 
            "givenName": "Antonio", 
            "id": "sg:person.01070504363.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070504363.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/grid.432329.d", 
              "name": [
                "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bringhen", 
            "givenName": "Sara", 
            "id": "sg:person.01271315542.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271315542.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e0 degli Studi del Piemonte Orientale, Novara, Italy", 
              "id": "http://www.grid.ac/institutes/grid.16563.37", 
              "name": [
                "Universit\u00e0 degli Studi del Piemonte Orientale, Novara, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "De Paoli", 
            "givenName": "Lorenzo", 
            "id": "sg:person.0632344475.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632344475.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, AOU \u201cPoliclinico-Vittorio Emanuele\u201d, Catania, Italy", 
              "id": "http://www.grid.ac/institutes/grid.412844.f", 
              "name": [
                "Division of Hematology, AOU \u201cPoliclinico-Vittorio Emanuele\u201d, Catania, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martino", 
            "givenName": "Enrica", 
            "id": "sg:person.014632213344.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014632213344.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/grid.432329.d", 
              "name": [
                "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Larocca", 
            "givenName": "Alessandra", 
            "id": "sg:person.01277165465.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277165465.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Unit A.O.U. Ospedali Riuniti, Ancona, Italy", 
              "id": "http://www.grid.ac/institutes/grid.415845.9", 
              "name": [
                "Hematology Unit A.O.U. Ospedali Riuniti, Ancona, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Offidani", 
            "givenName": "Massimo", 
            "id": "sg:person.01017273566.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017273566.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "DAME, University of Udine, Udine, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5390.f", 
              "name": [
                "DAME, University of Udine, Udine, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Patriarca", 
            "givenName": "Francesca", 
            "id": "sg:person.01170027372.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170027372.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cellular Therapies and Transfusion Medicine Unit, AOU Careggi, Florence, Italy", 
              "id": "http://www.grid.ac/institutes/grid.24704.35", 
              "name": [
                "Cellular Therapies and Transfusion Medicine Unit, AOU Careggi, Florence, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nozzoli", 
            "givenName": "Chiara", 
            "id": "sg:person.01041204476.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041204476.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "A.O. San Luigi, Gonzaga, Orbassano, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "A.O. San Luigi, Gonzaga, Orbassano, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guglielmelli", 
            "givenName": "Tommasina", 
            "id": "sg:person.01353526135.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353526135.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "SC Hematology AO Citt\u00e0 della Salute e della Scienza, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "SC Hematology AO Citt\u00e0 della Salute e della Scienza, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benevolo", 
            "givenName": "Giulia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Divisione di Ematologia, Ospedali Riuniti, Reggio di Calabria, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Divisione di Ematologia, Ospedali Riuniti, Reggio di Calabria, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Callea", 
            "givenName": "Vincenzo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology Unit, Fondazione IRCCS, C\u00e0 Granda, OM Policlinico, DIPO, University of Milan, Milan, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Hematology Unit, Fondazione IRCCS, C\u00e0 Granda, OM Policlinico, DIPO, University of Milan, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baldini", 
            "givenName": "Luca", 
            "id": "sg:person.07531210100.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531210100.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "A.O. S. Croce e Carle, Cuneo, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "A.O. S. Croce e Carle, Cuneo, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grasso", 
            "givenName": "Mariella", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Oncology and Hematology AOU, Hematology Unit, Modena, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Oncology and Hematology AOU, Hematology Unit, Modena, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leonardi", 
            "givenName": "Giovanna", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Tor Vergata, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.6530.0", 
              "name": [
                "University Tor Vergata, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rizzo", 
            "givenName": "Manuela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy", 
              "id": "http://www.grid.ac/institutes/grid.413503.0", 
              "name": [
                "IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Falcone", 
            "givenName": "Antonietta Pia", 
            "id": "sg:person.01251764203.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251764203.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "A.O.U. S. Giovanni Battista A.O. Mauriziano-Umberto I, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "A.O.U. S. Giovanni Battista A.O. Mauriziano-Umberto I, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gottardi", 
            "givenName": "Daniela", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy", 
              "id": "http://www.grid.ac/institutes/grid.417893.0", 
              "name": [
                "IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Montefusco", 
            "givenName": "Vittorio", 
            "id": "sg:person.0617665742.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617665742.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy", 
              "id": "http://www.grid.ac/institutes/grid.418322.e", 
              "name": [
                "IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Musto", 
            "givenName": "Pellegrino", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7841.a", 
              "name": [
                "Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Petrucci", 
            "givenName": "Maria Teresa", 
            "id": "sg:person.01046625545.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046625545.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Science and Human Oncology, University of Bari \u201cAldo Moro\u201d Medical School, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Department of Biomedical Science and Human Oncology, University of Bari \u201cAldo Moro\u201d Medical School, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dammacco", 
            "givenName": "Franco", 
            "id": "sg:person.01144606055.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144606055.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy", 
              "id": "http://www.grid.ac/institutes/grid.432329.d", 
              "name": [
                "Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boccadoro", 
            "givenName": "Mario", 
            "id": "sg:person.0605336206.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605336206.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Science and Human Oncology, University of Bari \u201cAldo Moro\u201d Medical School, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Department of Biomedical Science and Human Oncology, University of Bari \u201cAldo Moro\u201d Medical School, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vacca", 
            "givenName": "Angelo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Internal Medicine \u201cG. Baccelli\u201d, Myeloma Unit, University of Bari \u201cAldo Moro\u201d Medical School, Azienda Ospedaliero-Universitaria Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Department of Biomedical Science and Human Oncology, University of Bari \u201cAldo Moro\u201d Medical School, Bari, Italy", 
                "Internal Medicine \u201cG. Baccelli\u201d, Myeloma Unit, University of Bari \u201cAldo Moro\u201d Medical School, Azienda Ospedaliero-Universitaria Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ria", 
            "givenName": "Roberto", 
            "id": "sg:person.0606000302.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606000302.74"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.14310/horm.2002.11177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067262147", 
              "https://doi.org/10.14310/horm.2002.11177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35025220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043028620", 
              "https://doi.org/10.1038/35025220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10238-008-0170-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011144038", 
              "https://doi.org/10.1007/s10238-008-0170-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/leu.2013.247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016945153", 
              "https://doi.org/10.1038/leu.2013.247"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-01-09", 
        "datePublishedReg": "2019-01-09", 
        "description": "BACKGROUND: Several new drugs are approved for treatment of patients with multiple myeloma (MM), but no validated biomarkers are available for the prediction of a clinical outcome. We aimed to establish whether pretreatment blood and bone marrow plasma concentrations of major cytokines and angiogenic factors (CAFs) of patients from a phase 3 trial of a MM treatment could have a prognostic and predictive value in terms of response to therapy and progression-free and overall survival and whether these patients could be stratified for their prognosis.\nMETHODS: Blood and bone marrow plasma levels of Ang-2, FGF-2, HGF, VEGF, PDGF-\u03b2, IL-8, TNF-\u03b1, TIMP-1, and TIMP-2 were determined at diagnosis in MM patients enrolled in the GIMEMA MM0305 randomized controlled trial by an enzyme-linked immunosorbent assay (ELISA). These levels were correlated both reciprocally and with the type of therapy and patients' characteristics and with a group of non-MM patients as controls.\nRESULTS: No significant differences were detected between the blood and bone marrow plasma levels of angiogenic cytokines. A cutoff for each CAF was established. The therapeutic response of patients with blood plasma levels of CAFs lower than the cutoff was better than the response of those with higher levels in terms of percentage of responding patients and quality of response.\nCONCLUSION: FGF-2, HGF, VEGF, and PDGF-\u03b2 plasma levels at diagnosis have predictive significance for response to treatment. The stratification of patients based on the levels of CAFs at diagnosis and their variations after therapy is useful to characterize different risk groups concerning outcome and response to therapy.\nTRIAL REGISTRATION: Clinical trial information can be found at the following link: NCT01063179.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/s13045-018-0691-4", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1039771", 
            "issn": [
              "1756-8722"
            ], 
            "name": "Journal of Hematology & Oncology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "keywords": [
          "bone marrow plasma levels", 
          "plasma levels", 
          "multiple myeloma", 
          "enzyme-linked immunosorbent assay", 
          "MM patients", 
          "predictive value", 
          "angiogenic factors", 
          "phase 3 trial", 
          "treatment of patients", 
          "stratification of patients", 
          "type of therapy", 
          "different risk groups", 
          "FGF-2", 
          "clinical trial information", 
          "blood plasma levels", 
          "levels of CAF", 
          "pretreatment blood", 
          "overall survival", 
          "patient characteristics", 
          "clinical outcomes", 
          "initial treatment", 
          "IL-8", 
          "therapeutic response", 
          "plasma concentrations", 
          "Ang-2", 
          "risk groups", 
          "major cytokine", 
          "patients", 
          "TIMP-1", 
          "angiogenic cytokines", 
          "predictive significance", 
          "TIMP-2", 
          "therapy", 
          "trial information", 
          "MM treatment", 
          "immunosorbent assay", 
          "cytokines", 
          "new drugs", 
          "terms of response", 
          "diagnosis", 
          "quality of response", 
          "blood", 
          "trials", 
          "significant differences", 
          "myeloma", 
          "treatment", 
          "VEGF", 
          "HGF", 
          "PDGF", 
          "outcomes", 
          "CAF", 
          "terms of percentage", 
          "response", 
          "high levels", 
          "levels", 
          "prognosis", 
          "group", 
          "TNF", 
          "cutoff", 
          "biomarkers", 
          "drugs", 
          "survival", 
          "factors", 
          "assays", 
          "stratification", 
          "percentage", 
          "differences", 
          "control", 
          "significance", 
          "concentration", 
          "characteristics", 
          "values", 
          "quality", 
          "types", 
          "following link", 
          "information", 
          "terms", 
          "link", 
          "variation", 
          "prediction", 
          "bone marrow plasma concentrations", 
          "marrow plasma concentrations", 
          "marrow plasma levels", 
          "GIMEMA MM0305", 
          "MM0305", 
          "NCT01063179"
        ], 
        "name": "Prognostic or predictive value of circulating cytokines and angiogenic factors for initial treatment of multiple myeloma in the GIMEMA MM0305 randomized controlled trial", 
        "pagination": "4", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1111308965"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/s13045-018-0691-4"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30626425"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/s13045-018-0691-4", 
          "https://app.dimensions.ai/details/publication/pub.1111308965"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-12-01T19:43", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_814.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/s13045-018-0691-4"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13045-018-0691-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13045-018-0691-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13045-018-0691-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13045-018-0691-4'


     

    This table displays all metadata directly associated to this object as RDF triples.

    495 TRIPLES      22 PREDICATES      137 URIs      123 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/s13045-018-0691-4 schema:about N16c9b1918adb4a8c9109034130ed7075
    2 N22ed0ff754e1405c91637d1328bf201d
    3 N245d3cabadb3422dbd58b5b889715b12
    4 N500a2171ecab41aa92d69971371f5944
    5 N59a8d8b738d94ed0bd9377dd8feb6b07
    6 N6ef25a0a7b1e4265a0b0f82b22dc46be
    7 N6f9d9fef5b2342c5bc4f2429c6501509
    8 N7b62ad6b3fcf482f8ab95caedbbd7050
    9 N87c65922d998425cb38f57a39db1002d
    10 N981ae93bc5af44b4af5a3ed1f157d709
    11 N986d66aca62a4fee8c5257c9f7473fb2
    12 N9afcbf9b190341699915394ef7d64989
    13 Nc4cbbc13853a4d23b905d9bdc07004b0
    14 Nd1984e1fcc3e4a57b909ad102e03b9d0
    15 Ndf99c72a42534e82bd04a3315b84e6c0
    16 Ne72d3d5c05c94236901b7e7bbe4d7ae5
    17 Nec49aea66f5d4b39bc216aa898668006
    18 Nf90a8b0d5fe7435192e965f0953f16e6
    19 Nfc7ba0f2387e439ba694f1bc99a02e4a
    20 anzsrc-for:11
    21 anzsrc-for:1102
    22 anzsrc-for:1103
    23 anzsrc-for:1112
    24 schema:author Nbc602c2fc3cc49dd8eeab0cf3e55544a
    25 schema:citation sg:pub.10.1007/s10238-008-0170-2
    26 sg:pub.10.1038/35025220
    27 sg:pub.10.1038/leu.2013.247
    28 sg:pub.10.14310/horm.2002.11177
    29 schema:datePublished 2019-01-09
    30 schema:datePublishedReg 2019-01-09
    31 schema:description BACKGROUND: Several new drugs are approved for treatment of patients with multiple myeloma (MM), but no validated biomarkers are available for the prediction of a clinical outcome. We aimed to establish whether pretreatment blood and bone marrow plasma concentrations of major cytokines and angiogenic factors (CAFs) of patients from a phase 3 trial of a MM treatment could have a prognostic and predictive value in terms of response to therapy and progression-free and overall survival and whether these patients could be stratified for their prognosis. METHODS: Blood and bone marrow plasma levels of Ang-2, FGF-2, HGF, VEGF, PDGF-β, IL-8, TNF-α, TIMP-1, and TIMP-2 were determined at diagnosis in MM patients enrolled in the GIMEMA MM0305 randomized controlled trial by an enzyme-linked immunosorbent assay (ELISA). These levels were correlated both reciprocally and with the type of therapy and patients' characteristics and with a group of non-MM patients as controls. RESULTS: No significant differences were detected between the blood and bone marrow plasma levels of angiogenic cytokines. A cutoff for each CAF was established. The therapeutic response of patients with blood plasma levels of CAFs lower than the cutoff was better than the response of those with higher levels in terms of percentage of responding patients and quality of response. CONCLUSION: FGF-2, HGF, VEGF, and PDGF-β plasma levels at diagnosis have predictive significance for response to treatment. The stratification of patients based on the levels of CAFs at diagnosis and their variations after therapy is useful to characterize different risk groups concerning outcome and response to therapy. TRIAL REGISTRATION: Clinical trial information can be found at the following link: NCT01063179.
    32 schema:genre article
    33 schema:inLanguage en
    34 schema:isAccessibleForFree true
    35 schema:isPartOf N1d7ab68679e24e07a15661a44bdc6c69
    36 Nb511aba896144098b42b3d4811f0a6f6
    37 sg:journal.1039771
    38 schema:keywords Ang-2
    39 CAF
    40 FGF-2
    41 GIMEMA MM0305
    42 HGF
    43 IL-8
    44 MM patients
    45 MM treatment
    46 MM0305
    47 NCT01063179
    48 PDGF
    49 TIMP-1
    50 TIMP-2
    51 TNF
    52 VEGF
    53 angiogenic cytokines
    54 angiogenic factors
    55 assays
    56 biomarkers
    57 blood
    58 blood plasma levels
    59 bone marrow plasma concentrations
    60 bone marrow plasma levels
    61 characteristics
    62 clinical outcomes
    63 clinical trial information
    64 concentration
    65 control
    66 cutoff
    67 cytokines
    68 diagnosis
    69 differences
    70 different risk groups
    71 drugs
    72 enzyme-linked immunosorbent assay
    73 factors
    74 following link
    75 group
    76 high levels
    77 immunosorbent assay
    78 information
    79 initial treatment
    80 levels
    81 levels of CAF
    82 link
    83 major cytokine
    84 marrow plasma concentrations
    85 marrow plasma levels
    86 multiple myeloma
    87 myeloma
    88 new drugs
    89 outcomes
    90 overall survival
    91 patient characteristics
    92 patients
    93 percentage
    94 phase 3 trial
    95 plasma concentrations
    96 plasma levels
    97 prediction
    98 predictive significance
    99 predictive value
    100 pretreatment blood
    101 prognosis
    102 quality
    103 quality of response
    104 response
    105 risk groups
    106 significance
    107 significant differences
    108 stratification
    109 stratification of patients
    110 survival
    111 terms
    112 terms of percentage
    113 terms of response
    114 therapeutic response
    115 therapy
    116 treatment
    117 treatment of patients
    118 trial information
    119 trials
    120 type of therapy
    121 types
    122 values
    123 variation
    124 schema:name Prognostic or predictive value of circulating cytokines and angiogenic factors for initial treatment of multiple myeloma in the GIMEMA MM0305 randomized controlled trial
    125 schema:pagination 4
    126 schema:productId N24230e690a23411aa1f47221ab14ac23
    127 N63e62f8f81d746398193fc34f2c01e8f
    128 Nbc99f8eebdbc4167a44e35d2fa547e5b
    129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111308965
    130 https://doi.org/10.1186/s13045-018-0691-4
    131 schema:sdDatePublished 2021-12-01T19:43
    132 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    133 schema:sdPublisher Nc845fcbd3bca4298a2bd1bbcacdc13b2
    134 schema:url https://doi.org/10.1186/s13045-018-0691-4
    135 sgo:license sg:explorer/license/
    136 sgo:sdDataset articles
    137 rdf:type schema:ScholarlyArticle
    138 N0703b843c488482fa1082e53314ae0b8 rdf:first sg:person.07531210100.55
    139 rdf:rest Nb5bc21241c404d1ebbc80ce614afc921
    140 N0fa9bc921bfc4b369e9f7f2e51b5c6b4 schema:affiliation grid-institutes:None
    141 schema:familyName Callea
    142 schema:givenName Vincenzo
    143 rdf:type schema:Person
    144 N16c9b1918adb4a8c9109034130ed7075 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Prognosis
    146 rdf:type schema:DefinedTerm
    147 N1c585dedafa04ec0bd4bd0b2a31b0f04 rdf:first sg:person.01041204476.23
    148 rdf:rest Na7f36134a87f41e4b6c5301998e45bba
    149 N1d7ab68679e24e07a15661a44bdc6c69 schema:volumeNumber 12
    150 rdf:type schema:PublicationVolume
    151 N22ed0ff754e1405c91637d1328bf201d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Becaplermin
    153 rdf:type schema:DefinedTerm
    154 N234681e07918442899e5ab1f11b00d4a rdf:first sg:person.012161416633.73
    155 rdf:rest N8d339fc835634a82a5e6f675e6608e25
    156 N24230e690a23411aa1f47221ab14ac23 schema:name dimensions_id
    157 schema:value pub.1111308965
    158 rdf:type schema:PropertyValue
    159 N245d3cabadb3422dbd58b5b889715b12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Progression-Free Survival
    161 rdf:type schema:DefinedTerm
    162 N2815ae5619d942c9be623e35de0b73b2 schema:affiliation grid-institutes:grid.6530.0
    163 schema:familyName Rizzo
    164 schema:givenName Manuela
    165 rdf:type schema:Person
    166 N2c999f87ecf54ea8933118653f80297e rdf:first sg:person.01017273566.69
    167 rdf:rest N92c7a4635c2b4185b4ab652be1a5659b
    168 N344f9a798793409798891409149b26e5 rdf:first sg:person.01350052015.51
    169 rdf:rest Nee26232da468493e90c5a4c973a1c422
    170 N393bc9350e344870a72effa1e274544a schema:affiliation grid-institutes:None
    171 schema:familyName Gottardi
    172 schema:givenName Daniela
    173 rdf:type schema:Person
    174 N396511bb5e9e4eaf849ffa79810b4e06 rdf:first Na11f47ec32d34b56a46e7a1e98598026
    175 rdf:rest N3d38d03d510245e1a8a1bedd175f4e9f
    176 N3d38d03d510245e1a8a1bedd175f4e9f rdf:first N2815ae5619d942c9be623e35de0b73b2
    177 rdf:rest Nec305630e7cb4fa9b4bd0b4b5de0453e
    178 N3fd28badb49141bb9c2ec195b0807775 rdf:first sg:person.01121703012.16
    179 rdf:rest N344f9a798793409798891409149b26e5
    180 N459c862dabe24832a8fd14240be46257 rdf:first sg:person.0606000302.74
    181 rdf:rest rdf:nil
    182 N4dcc40d36ed1413bbce1efcf2f4385c5 rdf:first sg:person.0605336206.28
    183 rdf:rest N51ddaf3f6e6f4505b1dd38320d75f3a8
    184 N4e0cb6ee6db04c41b701e7c43d76a03d schema:affiliation grid-institutes:None
    185 schema:familyName Benevolo
    186 schema:givenName Giulia
    187 rdf:type schema:Person
    188 N500a2171ecab41aa92d69971371f5944 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Aged, 80 and over
    190 rdf:type schema:DefinedTerm
    191 N51ddaf3f6e6f4505b1dd38320d75f3a8 rdf:first N8228964570ac4d9fabd43622df66b28c
    192 rdf:rest N459c862dabe24832a8fd14240be46257
    193 N59a8d8b738d94ed0bd9377dd8feb6b07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Female
    195 rdf:type schema:DefinedTerm
    196 N63e62f8f81d746398193fc34f2c01e8f schema:name doi
    197 schema:value 10.1186/s13045-018-0691-4
    198 rdf:type schema:PropertyValue
    199 N666445e124a0411f93f2b229cbe6c438 rdf:first sg:person.014632213344.14
    200 rdf:rest Ne024ce6b595a49a7b509ec6d291fecbb
    201 N6d0528f128414750b121ab0d5b97b426 rdf:first N0fa9bc921bfc4b369e9f7f2e51b5c6b4
    202 rdf:rest N0703b843c488482fa1082e53314ae0b8
    203 N6ef25a0a7b1e4265a0b0f82b22dc46be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Fibroblast Growth Factor 2
    205 rdf:type schema:DefinedTerm
    206 N6f9d9fef5b2342c5bc4f2429c6501509 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Biomarkers, Tumor
    208 rdf:type schema:DefinedTerm
    209 N7b62ad6b3fcf482f8ab95caedbbd7050 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Male
    211 rdf:type schema:DefinedTerm
    212 N8228964570ac4d9fabd43622df66b28c schema:affiliation grid-institutes:grid.7644.1
    213 schema:familyName Vacca
    214 schema:givenName Angelo
    215 rdf:type schema:Person
    216 N82ed157b5df24e2aaff841342824a27c schema:affiliation grid-institutes:grid.418322.e
    217 schema:familyName Musto
    218 schema:givenName Pellegrino
    219 rdf:type schema:Person
    220 N87c65922d998425cb38f57a39db1002d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Antineoplastic Combined Chemotherapy Protocols
    222 rdf:type schema:DefinedTerm
    223 N8d339fc835634a82a5e6f675e6608e25 rdf:first sg:person.01070504363.90
    224 rdf:rest Nb31e700c09cc4acb93d29b3eb6348d7f
    225 N92c7a4635c2b4185b4ab652be1a5659b rdf:first sg:person.01170027372.44
    226 rdf:rest N1c585dedafa04ec0bd4bd0b2a31b0f04
    227 N981ae93bc5af44b4af5a3ed1f157d709 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    228 schema:name Middle Aged
    229 rdf:type schema:DefinedTerm
    230 N986d66aca62a4fee8c5257c9f7473fb2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Humans
    232 rdf:type schema:DefinedTerm
    233 N98956ae8d6224591a386b009f03fdc8e rdf:first N4e0cb6ee6db04c41b701e7c43d76a03d
    234 rdf:rest N6d0528f128414750b121ab0d5b97b426
    235 N9afcbf9b190341699915394ef7d64989 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    236 schema:name Logistic Models
    237 rdf:type schema:DefinedTerm
    238 Na11f47ec32d34b56a46e7a1e98598026 schema:affiliation grid-institutes:None
    239 schema:familyName Leonardi
    240 schema:givenName Giovanna
    241 rdf:type schema:Person
    242 Na7f36134a87f41e4b6c5301998e45bba rdf:first sg:person.01353526135.31
    243 rdf:rest N98956ae8d6224591a386b009f03fdc8e
    244 Na999ba5313c54c34ac9afa45753ab120 rdf:first sg:person.01046625545.78
    245 rdf:rest Nb530151d8e084af5a8e126ac74f66283
    246 Nb2f02e38907f4ea4910bdb6d8593d576 schema:affiliation grid-institutes:None
    247 schema:familyName Grasso
    248 schema:givenName Mariella
    249 rdf:type schema:Person
    250 Nb31e700c09cc4acb93d29b3eb6348d7f rdf:first sg:person.01271315542.71
    251 rdf:rest Ne80fabc47004492f8f63a43235d50ff5
    252 Nb511aba896144098b42b3d4811f0a6f6 schema:issueNumber 1
    253 rdf:type schema:PublicationIssue
    254 Nb530151d8e084af5a8e126ac74f66283 rdf:first sg:person.01144606055.57
    255 rdf:rest N4dcc40d36ed1413bbce1efcf2f4385c5
    256 Nb5bc21241c404d1ebbc80ce614afc921 rdf:first Nb2f02e38907f4ea4910bdb6d8593d576
    257 rdf:rest N396511bb5e9e4eaf849ffa79810b4e06
    258 Nbc602c2fc3cc49dd8eeab0cf3e55544a rdf:first sg:person.01120436010.20
    259 rdf:rest N3fd28badb49141bb9c2ec195b0807775
    260 Nbc99f8eebdbc4167a44e35d2fa547e5b schema:name pubmed_id
    261 schema:value 30626425
    262 rdf:type schema:PropertyValue
    263 Nc4cbbc13853a4d23b905d9bdc07004b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    264 schema:name Follow-Up Studies
    265 rdf:type schema:DefinedTerm
    266 Nc845fcbd3bca4298a2bd1bbcacdc13b2 schema:name Springer Nature - SN SciGraph project
    267 rdf:type schema:Organization
    268 Nd1984e1fcc3e4a57b909ad102e03b9d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    269 schema:name Aged
    270 rdf:type schema:DefinedTerm
    271 Nd420fbb500484bdfb1db7a3b45f27701 rdf:first sg:person.0617665742.30
    272 rdf:rest Ndc586aaa0de14bb180a6840307e31287
    273 Ndc586aaa0de14bb180a6840307e31287 rdf:first N82ed157b5df24e2aaff841342824a27c
    274 rdf:rest Na999ba5313c54c34ac9afa45753ab120
    275 Ndf99c72a42534e82bd04a3315b84e6c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    276 schema:name Multiple Myeloma
    277 rdf:type schema:DefinedTerm
    278 Ne024ce6b595a49a7b509ec6d291fecbb rdf:first sg:person.01277165465.91
    279 rdf:rest N2c999f87ecf54ea8933118653f80297e
    280 Ne72d3d5c05c94236901b7e7bbe4d7ae5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    281 schema:name ROC Curve
    282 rdf:type schema:DefinedTerm
    283 Ne80fabc47004492f8f63a43235d50ff5 rdf:first sg:person.0632344475.32
    284 rdf:rest N666445e124a0411f93f2b229cbe6c438
    285 Nec305630e7cb4fa9b4bd0b4b5de0453e rdf:first sg:person.01251764203.22
    286 rdf:rest Nfea7f95e2f3a4b3b9e3f73967ae36e81
    287 Nec49aea66f5d4b39bc216aa898668006 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    288 schema:name Vascular Endothelial Growth Factor A
    289 rdf:type schema:DefinedTerm
    290 Nee26232da468493e90c5a4c973a1c422 rdf:first sg:person.01105531766.61
    291 rdf:rest N234681e07918442899e5ab1f11b00d4a
    292 Nf90a8b0d5fe7435192e965f0953f16e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    293 schema:name Hepatocyte Growth Factor
    294 rdf:type schema:DefinedTerm
    295 Nfc7ba0f2387e439ba694f1bc99a02e4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    296 schema:name Bone Marrow
    297 rdf:type schema:DefinedTerm
    298 Nfea7f95e2f3a4b3b9e3f73967ae36e81 rdf:first N393bc9350e344870a72effa1e274544a
    299 rdf:rest Nd420fbb500484bdfb1db7a3b45f27701
    300 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    301 schema:name Medical and Health Sciences
    302 rdf:type schema:DefinedTerm
    303 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    304 schema:name Cardiorespiratory Medicine and Haematology
    305 rdf:type schema:DefinedTerm
    306 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    307 schema:name Clinical Sciences
    308 rdf:type schema:DefinedTerm
    309 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    310 schema:name Oncology and Carcinogenesis
    311 rdf:type schema:DefinedTerm
    312 sg:journal.1039771 schema:issn 1756-8722
    313 schema:name Journal of Hematology & Oncology
    314 schema:publisher Springer Nature
    315 rdf:type schema:Periodical
    316 sg:person.01017273566.69 schema:affiliation grid-institutes:grid.415845.9
    317 schema:familyName Offidani
    318 schema:givenName Massimo
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017273566.69
    320 rdf:type schema:Person
    321 sg:person.01041204476.23 schema:affiliation grid-institutes:grid.24704.35
    322 schema:familyName Nozzoli
    323 schema:givenName Chiara
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041204476.23
    325 rdf:type schema:Person
    326 sg:person.01046625545.78 schema:affiliation grid-institutes:grid.7841.a
    327 schema:familyName Petrucci
    328 schema:givenName Maria Teresa
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046625545.78
    330 rdf:type schema:Person
    331 sg:person.01070504363.90 schema:affiliation grid-institutes:grid.432329.d
    332 schema:familyName Palumbo
    333 schema:givenName Antonio
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070504363.90
    335 rdf:type schema:Person
    336 sg:person.01105531766.61 schema:affiliation grid-institutes:grid.6292.f
    337 schema:familyName Terragna
    338 schema:givenName Carolina
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105531766.61
    340 rdf:type schema:Person
    341 sg:person.01120436010.20 schema:affiliation grid-institutes:grid.7644.1
    342 schema:familyName Saltarella
    343 schema:givenName Ilaria
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120436010.20
    345 rdf:type schema:Person
    346 sg:person.01121703012.16 schema:affiliation grid-institutes:grid.427551.0
    347 schema:familyName Morabito
    348 schema:givenName Fortunato
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121703012.16
    350 rdf:type schema:Person
    351 sg:person.01144606055.57 schema:affiliation grid-institutes:grid.7644.1
    352 schema:familyName Dammacco
    353 schema:givenName Franco
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144606055.57
    355 rdf:type schema:Person
    356 sg:person.01170027372.44 schema:affiliation grid-institutes:grid.5390.f
    357 schema:familyName Patriarca
    358 schema:givenName Francesca
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170027372.44
    360 rdf:type schema:Person
    361 sg:person.012161416633.73 schema:affiliation grid-institutes:grid.432329.d
    362 schema:familyName Omedè
    363 schema:givenName Paola
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012161416633.73
    365 rdf:type schema:Person
    366 sg:person.01251764203.22 schema:affiliation grid-institutes:grid.413503.0
    367 schema:familyName Falcone
    368 schema:givenName Antonietta Pia
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251764203.22
    370 rdf:type schema:Person
    371 sg:person.01271315542.71 schema:affiliation grid-institutes:grid.432329.d
    372 schema:familyName Bringhen
    373 schema:givenName Sara
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271315542.71
    375 rdf:type schema:Person
    376 sg:person.01277165465.91 schema:affiliation grid-institutes:grid.432329.d
    377 schema:familyName Larocca
    378 schema:givenName Alessandra
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277165465.91
    380 rdf:type schema:Person
    381 sg:person.01350052015.51 schema:affiliation grid-institutes:grid.10383.39
    382 schema:familyName Giuliani
    383 schema:givenName Nicola
    384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350052015.51
    385 rdf:type schema:Person
    386 sg:person.01353526135.31 schema:affiliation grid-institutes:None
    387 schema:familyName Guglielmelli
    388 schema:givenName Tommasina
    389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353526135.31
    390 rdf:type schema:Person
    391 sg:person.014632213344.14 schema:affiliation grid-institutes:grid.412844.f
    392 schema:familyName Martino
    393 schema:givenName Enrica
    394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014632213344.14
    395 rdf:type schema:Person
    396 sg:person.0605336206.28 schema:affiliation grid-institutes:grid.432329.d
    397 schema:familyName Boccadoro
    398 schema:givenName Mario
    399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605336206.28
    400 rdf:type schema:Person
    401 sg:person.0606000302.74 schema:affiliation grid-institutes:grid.7644.1
    402 schema:familyName Ria
    403 schema:givenName Roberto
    404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606000302.74
    405 rdf:type schema:Person
    406 sg:person.0617665742.30 schema:affiliation grid-institutes:grid.417893.0
    407 schema:familyName Montefusco
    408 schema:givenName Vittorio
    409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617665742.30
    410 rdf:type schema:Person
    411 sg:person.0632344475.32 schema:affiliation grid-institutes:grid.16563.37
    412 schema:familyName De Paoli
    413 schema:givenName Lorenzo
    414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632344475.32
    415 rdf:type schema:Person
    416 sg:person.07531210100.55 schema:affiliation grid-institutes:None
    417 schema:familyName Baldini
    418 schema:givenName Luca
    419 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07531210100.55
    420 rdf:type schema:Person
    421 sg:pub.10.1007/s10238-008-0170-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011144038
    422 https://doi.org/10.1007/s10238-008-0170-2
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/35025220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043028620
    425 https://doi.org/10.1038/35025220
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/leu.2013.247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016945153
    428 https://doi.org/10.1038/leu.2013.247
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.14310/horm.2002.11177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067262147
    431 https://doi.org/10.14310/horm.2002.11177
    432 rdf:type schema:CreativeWork
    433 grid-institutes:None schema:alternateName A.O. S. Croce e Carle, Cuneo, Italy
    434 A.O. San Luigi, Gonzaga, Orbassano, Turin, Italy
    435 A.O.U. S. Giovanni Battista A.O. Mauriziano-Umberto I, Turin, Italy
    436 Department of Oncology and Hematology AOU, Hematology Unit, Modena, Italy
    437 Divisione di Ematologia, Ospedali Riuniti, Reggio di Calabria, Italy
    438 Hematology Unit, Fondazione IRCCS, Cà Granda, OM Policlinico, DIPO, University of Milan, Milan, Italy
    439 SC Hematology AO Città della Salute e della Scienza, Turin, Italy
    440 schema:name A.O. S. Croce e Carle, Cuneo, Italy
    441 A.O. San Luigi, Gonzaga, Orbassano, Turin, Italy
    442 A.O.U. S. Giovanni Battista A.O. Mauriziano-Umberto I, Turin, Italy
    443 Department of Oncology and Hematology AOU, Hematology Unit, Modena, Italy
    444 Divisione di Ematologia, Ospedali Riuniti, Reggio di Calabria, Italy
    445 Hematology Unit, Fondazione IRCCS, Cà Granda, OM Policlinico, DIPO, University of Milan, Milan, Italy
    446 SC Hematology AO Città della Salute e della Scienza, Turin, Italy
    447 rdf:type schema:Organization
    448 grid-institutes:grid.10383.39 schema:alternateName Department of Clinical and Experimental Medicine, Myeloma Unit, University of Parma, Parma, Italy
    449 schema:name Department of Clinical and Experimental Medicine, Myeloma Unit, University of Parma, Parma, Italy
    450 rdf:type schema:Organization
    451 grid-institutes:grid.16563.37 schema:alternateName Università degli Studi del Piemonte Orientale, Novara, Italy
    452 schema:name Università degli Studi del Piemonte Orientale, Novara, Italy
    453 rdf:type schema:Organization
    454 grid-institutes:grid.24704.35 schema:alternateName Cellular Therapies and Transfusion Medicine Unit, AOU Careggi, Florence, Italy
    455 schema:name Cellular Therapies and Transfusion Medicine Unit, AOU Careggi, Florence, Italy
    456 rdf:type schema:Organization
    457 grid-institutes:grid.412844.f schema:alternateName Division of Hematology, AOU “Policlinico-Vittorio Emanuele”, Catania, Italy
    458 schema:name Division of Hematology, AOU “Policlinico-Vittorio Emanuele”, Catania, Italy
    459 rdf:type schema:Organization
    460 grid-institutes:grid.413503.0 schema:alternateName IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    461 schema:name IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    462 rdf:type schema:Organization
    463 grid-institutes:grid.415845.9 schema:alternateName Hematology Unit A.O.U. Ospedali Riuniti, Ancona, Italy
    464 schema:name Hematology Unit A.O.U. Ospedali Riuniti, Ancona, Italy
    465 rdf:type schema:Organization
    466 grid-institutes:grid.417893.0 schema:alternateName IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    467 schema:name IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    468 rdf:type schema:Organization
    469 grid-institutes:grid.418322.e schema:alternateName IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy
    470 schema:name IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Italy
    471 rdf:type schema:Organization
    472 grid-institutes:grid.427551.0 schema:alternateName Hemato-oncology Department Augusta Victoria Hospital, Jerusalem, Israel
    473 schema:name Biothecnology Research Unit, Aprigliano, Cosenza Italy
    474 Hemato-oncology Department Augusta Victoria Hospital, Jerusalem, Israel
    475 rdf:type schema:Organization
    476 grid-institutes:grid.432329.d schema:alternateName Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy
    477 schema:name Division of Hematology, University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy
    478 rdf:type schema:Organization
    479 grid-institutes:grid.5390.f schema:alternateName DAME, University of Udine, Udine, Italy
    480 schema:name DAME, University of Udine, Udine, Italy
    481 rdf:type schema:Organization
    482 grid-institutes:grid.6292.f schema:alternateName Seràgnoli” Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University School of Medicine, Bologna, Italy
    483 schema:name Seràgnoli” Institute of Hematology, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University School of Medicine, Bologna, Italy
    484 rdf:type schema:Organization
    485 grid-institutes:grid.6530.0 schema:alternateName University Tor Vergata, Rome, Italy
    486 schema:name University Tor Vergata, Rome, Italy
    487 rdf:type schema:Organization
    488 grid-institutes:grid.7644.1 schema:alternateName Department of Biomedical Science and Human Oncology, University of Bari “Aldo Moro” Medical School, Bari, Italy
    489 Internal Medicine “G. Baccelli”, Myeloma Unit, University of Bari “Aldo Moro” Medical School, Azienda Ospedaliero-Universitaria Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    490 schema:name Department of Biomedical Science and Human Oncology, University of Bari “Aldo Moro” Medical School, Bari, Italy
    491 Internal Medicine “G. Baccelli”, Myeloma Unit, University of Bari “Aldo Moro” Medical School, Azienda Ospedaliero-Universitaria Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    492 rdf:type schema:Organization
    493 grid-institutes:grid.7841.a schema:alternateName Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy
    494 schema:name Hematology, Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Rome, Italy
    495 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...