LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing View Full Text


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Article Info

DATE

2019-12

AUTHORS

Michinori Koebis, Shinji Urata, Yo Shinoda, Shigeo Okabe, Tatsuya Yamasoba, Kazuki Nakao, Atsu Aiba, Teiichi Furuichi

ABSTRACT

Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. Here we focus on the prominent expression of LAMP5 in the brainstem and spinal cord and suggest a role for LAMP5 in these brain regions. LAMP5 was highly expressed in several brainstem nuclei involved with auditory processing including the cochlear nuclei, the superior olivary complex, nuclei of the lateral lemniscus and grey matter in the spinal cord. It was localized exclusively in inhibitory synaptic terminals, as has been reported in the forebrain. In the absence of LAMP5, localization of the vesicular inhibitory amino acid transporter (VIAAT) was unaltered in the lateral superior olive and the ventral cochlear nuclei, arguing against a conserved role for LAMP5 in trafficking VIAAT. Lamp5 knockout mice showed no overt behavioral abnormality but an increased startle response to auditory and tactile stimuli. In addition, LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. Our results indicate that LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. More... »

PAGES

20

References to SciGraph publications

  • 2015-09. Electroporation enables the efficient mRNA delivery into the mouse zygotes and facilitates CRISPR/Cas9-based genome editing in SCIENTIFIC REPORTS
  • 2017-05-11. Autophagy is essential for hearing in mice in CELL DEATH & DISEASE
  • 2004-04. Role of the PAR-3–KIF3 complex in the establishment of neuronal polarity in NATURE CELL BIOLOGY
  • 1994-06. A missense mutation in the gene encoding the α1 subunit of the inhibitory glycine receptor in the spasmodic mouse in NATURE GENETICS
  • 2012-07. NIH Image to ImageJ: 25 years of image analysis in NATURE METHODS
  • 1994-06. Glycine receptor β–subunit gene mutation in spastic mouse associated with LINE–1 element insertion in NATURE GENETICS
  • 2016-11. CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3–CA1 synapses in adult hippocampus in SCIENTIFIC REPORTS
  • 2012-12. Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx in BMC BIOLOGY
  • 2008-08. Models and mechanisms of anxiety: evidence from startle studies in PSYCHOPHARMACOLOGY
  • 1961-12. Mode of Action of the Efferent Olivo-Cochlear Bundle on the Inner Ear in NATURE
  • 2007-01. Genome-wide atlas of gene expression in the adult mouse brain in NATURE
  • 2016-01-20. ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes in NATURE COMMUNICATIONS
  • 2007-07. UNC-46 is required for trafficking of the vesicular GABA transporter in NATURE NEUROSCIENCE
  • 2012-10. Molecular machines governing exocytosis of synaptic vesicles in NATURE
  • 1993-12. Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons in NATURE
  • 2006-09. SNAREs — engines for membrane fusion in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13041-019-0437-4

    DOI

    http://dx.doi.org/10.1186/s13041-019-0437-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112739179

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30867010


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13041-019-0437-4'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13041-019-0437-4'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13041-019-0437-4'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13041-019-0437-4'


     

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