Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06-08

AUTHORS

Virginie Dinet, Giuseppe D. Ciccotosto, Kimberley Delaunay, Céline Borras, Isabelle Ranchon-Cole, Corinne Kostic, Michèle Savoldelli, Mohamed El Sanharawi, Laurent Jonet, Caroline Pirou, Na An, Marc Abitbol, Yvan Arsenijevic, Francine Behar-Cohen, Roberto Cappai, Frédéric Mascarelli

ABSTRACT

BackgroundAmyloid precursor protein knockout mice (APP-KO) have impaired differentiation of amacrine and horizontal cells. APP is part of a gene family and its paralogue amyloid precursor-like protein 2 (APLP2) has both shared as well as distinct expression patterns to APP, including in the retina. Given the impact of APP in the retina we investigated how APLP2 expression affected the retina using APLP2 knockout mice (APLP2-KO).ResultsUsing histology, morphometric analysis with noninvasive imaging technique and electron microscopy, we showed that APLP2-KO retina displayed abnormal formation of the outer synaptic layer, accompanied with greatly impaired photoreceptor ribbon synapses in adults. Moreover, APLP2-KO displayed a significant decease in ON-bipolar, rod bipolar and type 2 OFF-cone bipolar cells (36, 21 and 63 %, respectively). Reduction of the number of bipolar cells was accompanied with disrupted dendrites, reduced expression of metabotropic glutamate receptor 6 at the dendritic tips and alteration of axon terminals in the OFF laminae of the inner plexiform layer. In contrast, the APP-KO photoreceptor ribbon synapses and bipolar cells were intact. The APLP2-KO retina displayed numerous phenotypic similarities with the congenital stationary night blindness, a non-progressive retinal degeneration disease characterized by the loss of night vision. The pathological phenotypes in the APLP2-KO mouse correlated to altered transcription of genes involved in pre- and postsynatic structure/function, including CACNA1F, GRM6, TRMP1 and Gα0, and a normal scotopic a-wave electroretinogram amplitude, markedly reduced scotopic electroretinogram b-wave and modestly reduced photopic cone response. This confirmed the impaired function of the photoreceptor ribbon synapses and retinal bipolar cells, as is also observed in congenital stationary night blindness. Since congenital stationary night blindness present at birth, we extended our analysis to retinal differentiation and showed impaired differentiation of different bipolar cell subtypes and an altered temporal sequence of development from OFF to ON laminae in the inner plexiform layer. This was associated with the altered expression patterns of bipolar cell generation and differentiation factors, including MATH3, CHX10, VSX1 and OTX2.ConclusionsThese findings demonstrate that APLP2 couples retina development and synaptic genes and present the first evidence that APLP2 expression may be linked to synaptic disease. More... »

PAGES

64

References to SciGraph publications

  • 2007-08-31. Delineating the Mechanism of Alzheimer’s Disease Aβ Peptide Neurotoxicity in NEUROCHEMICAL RESEARCH
  • 1998-07. Loss-of-function mutations in a calcium-channel α1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindness in NATURE GENETICS
  • 2015-09-23. Rac1 plays an essential role in axon growth and guidance and in neuronal survival in the central and peripheral nervous systems in NEURAL DEVELOPMENT
  • 2010-10-27. APP involvement in retinogenesis of mice in ACTA NEUROPATHOLOGICA
  • 1996-04. Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation in NATURE GENETICS
  • 1984-05. Close genetic linkage between X-linked retinitis pigmentosa and a restriction fragment length polymorphism identified by recombinant DNA probe L1.28 in NATURE
  • 1998-07. An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness in NATURE GENETICS
  • 2011-03-24. Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex in BMC GENOMICS
  • 2012-06-29. Outer retinal structural anomaly due to frameshift mutation in CACNA1F gene in EYE
  • 1996-09. On- and off-responses in the photopic electroretinogram in complete-type congenital stationary night blindness in DOCUMENTA OPHTHALMOLOGICA
  • 2011-11-11. Congenital Stationary Night Blindness: Mutation Update and Clinical Variability in RETINAL DEGENERATIVE DISEASES
  • 2000-11. The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich repeat protein in NATURE GENETICS
  • 2000-11. Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindness in NATURE GENETICS
  • 2011-09-20. Functions of the APP gene family in the nervous system: insights from mouse models in EXPERIMENTAL BRAIN RESEARCH
  • 2009-10-27. Ectopic synaptic ribbons in dendrites of mouse retinal ON- and OFF-bipolar cells in CELL AND TISSUE RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13041-016-0245-z

    DOI

    http://dx.doi.org/10.1186/s13041-016-0245-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028802033

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27267879


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