Ontology type: schema:ScholarlyArticle Open Access: True
2015-12
AUTHORSKang-Ho Choi, Man-Seok Park, Hyung-Seok Kim, Kyung-Tae Kim, Hyeon-Sik Kim, Joon-Tae Kim, Byeong-Chae Kim, Myeong-Kyu Kim, Jong-Tae Park, Ki-Hyun Cho
ABSTRACTThe antioxidant properties of alpha-lipoic acid (aLA) correlate with its ability to promote neuroproliferation. However, there have been no comprehensive studies examining the neurorestorative effects of aLA administration after the onset of ischemia. The middle cerebral artery (MCA) of adult rats was occluded for 2 hours and then reperfused. aLA (20 mg/kg) was administered in 71 animals (aLA group) through the left external jugular vein immediately after reperfusion. An equivalent volume of vehicle was administered to 71 animals (control group). Functional outcome, levels of endogenous neural precursors with neurogenesis, glial cell activation, and brain metabolism were evaluated. Immediate aLA administration after reperfusion resulted in significantly reduced mortality, infarct size, and neurological deficit score (NDS) in the test group compared to the control group. Long-term functional outcomes, measured by the rotarod test, were markedly improved by aLA treatment. There was a significant increase in the number of cells expressing nestin and GFAP in the boundary zone and infarct core regions after aLA treatment. Furthermore, significantly more BrdU/GFAP, BrdU/DCX, and BrdU/NeuN double-labeled cells were observed along the boundary zone of the aLA group on days 7, 14, and 28 days, respectively. And brain metabolism using (18)F-FDG microPET imaging was markedly improved in aLA group. The effects of aLA was blocked by insulin receptor inhibitor, HNMPA (AM)3. These results indicate that immediate treatment with aLA after ischemic injury may have significant neurorestorative effects mediated at least partially via insulin receptor activation. Thus, aLA may be useful for the treatment of acute ischemic stroke. More... »
PAGES9
http://scigraph.springernature.com/pub.10.1186/s13041-015-0101-6
DOIhttp://dx.doi.org/10.1186/s13041-015-0101-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1049017076
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25761600
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain Infarction",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bromodeoxyuridine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Proliferation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glial Fibrillary Acidic Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glucose",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infarction, Middle Cerebral Artery",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Inflammation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nestin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Positron-Emission Tomography",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Messenger",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Sprague-Dawley",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recovery of Function",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "SOXB1 Transcription Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Staining and Labeling",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Stroke",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tetrazolium Salts",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Thioctic Acid",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Chonnam National University",
"id": "https://www.grid.ac/institutes/grid.14005.30",
"name": [
"Department of Neurology, Chonnam National University Hwasun Hospital, Hwasun, Korea",
"Department of Neurology, Chonnam National University Medical School, 8 Hak-dong, 501-757, Gwangju, Dong-gu, Korea"
],
"type": "Organization"
},
"familyName": "Choi",
"givenName": "Kang-Ho",
"id": "sg:person.0742202174.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742202174.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chonnam National University",
"id": "https://www.grid.ac/institutes/grid.14005.30",
"name": [
"Department of Neurology, Chonnam National University Medical School, 8 Hak-dong, 501-757, Gwangju, Dong-gu, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Man-Seok",
"id": "sg:person.01232633576.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232633576.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chonnam National University",
"id": "https://www.grid.ac/institutes/grid.14005.30",
"name": [
"Department of Forensic medicine, Chonnam National University Medical School, 8 Hak-dong, 501-757, Gwangju, Dong-gu, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Hyung-Seok",
"id": "sg:person.011626707760.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011626707760.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Inje University Ilsan Paik Hospital",
"id": "https://www.grid.ac/institutes/grid.411633.2",
"name": [
"Department of Anesthesiology and Pain Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Kyung-Tae",
"id": "sg:person.0775643612.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775643612.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chonnam National University Hwasun Hospital",
"id": "https://www.grid.ac/institutes/grid.411602.0",
"name": [
"Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Hyeon-Sik",
"id": "sg:person.01337252352.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337252352.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chonnam National University",
"id": "https://www.grid.ac/institutes/grid.14005.30",
"name": [
"Department of Neurology, Chonnam National University Medical School, 8 Hak-dong, 501-757, Gwangju, Dong-gu, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Joon-Tae",
"id": "sg:person.01116405176.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116405176.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chonnam National University",
"id": "https://www.grid.ac/institutes/grid.14005.30",
"name": [
"Department of Neurology, Chonnam National University Medical School, 8 Hak-dong, 501-757, Gwangju, Dong-gu, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Byeong-Chae",
"id": "sg:person.01172657174.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172657174.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chonnam National University",
"id": "https://www.grid.ac/institutes/grid.14005.30",
"name": [
"Department of Neurology, Chonnam National University Medical School, 8 Hak-dong, 501-757, Gwangju, Dong-gu, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Myeong-Kyu",
"id": "sg:person.01240772374.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240772374.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chonnam National University",
"id": "https://www.grid.ac/institutes/grid.14005.30",
"name": [
"Department of Forensic medicine, Chonnam National University Medical School, 8 Hak-dong, 501-757, Gwangju, Dong-gu, Korea"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Jong-Tae",
"id": "sg:person.01120342105.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120342105.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Chonnam National University",
"id": "https://www.grid.ac/institutes/grid.14005.30",
"name": [
"Department of Neurology, Chonnam National University Medical School, 8 Hak-dong, 501-757, Gwangju, Dong-gu, Korea"
],
"type": "Organization"
},
"familyName": "Cho",
"givenName": "Ki-Hyun",
"id": "sg:person.0762423300.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762423300.10"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.4161/oxim.2.1.7985",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000079568"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbagen.2009.07.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002736744"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12929-014-0092-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005722188",
"https://doi.org/10.1186/s12929-014-0092-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12929-014-0092-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005722188",
"https://doi.org/10.1186/s12929-014-0092-0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11064-004-6880-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006660526",
"https://doi.org/10.1007/s11064-004-6880-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1471-4159.2008.05287.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007760046"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2013/634598",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008245009"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.0000252156.65953.a9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008489892"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.0000252156.65953.a9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008489892"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.17.3.472",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009574090"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.brainres.2009.07.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009915265"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/417039a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009958221",
"https://doi.org/10.1038/417039a"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/417039a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009958221",
"https://doi.org/10.1038/417039a"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1213/01.ane.0000087800.56290.2e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011394180"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1213/01.ane.0000087800.56290.2e",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011394180"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ana.10782",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012410010"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2011-01-330050",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012493058"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.brainres.2013.04.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014535902"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ana.410350414",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014628947"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12031-012-9884-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015074533",
"https://doi.org/10.1007/s12031-012-9884-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00221-007-1050-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015205285",
"https://doi.org/10.1007/s00221-007-1050-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00221-007-1050-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015205285",
"https://doi.org/10.1007/s00221-007-1050-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-510x(93)90099-k",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020266717"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0022-510x(93)90099-k",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020266717"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.111.635185",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020534064"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.111.635185",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020534064"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/strokeaha.111.635185",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020534064"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11064-010-0256-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022993717",
"https://doi.org/10.1007/s11064-010-0256-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11064-010-0256-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022993717",
"https://doi.org/10.1007/s11064-010-0256-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.nut.2003.08.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023767864"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1016/j.nurt.2010.07.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025388160",
"https://doi.org/10.1016/j.nurt.2010.07.004"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-4886(92)90142-d",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026286858"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1007677003387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026442266",
"https://doi.org/10.1023/a:1007677003387"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0006-8993(97)00588-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026695907"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/glia.20204",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028335105"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/sj.jcbfm.9600546",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028928220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/sj.jcbfm.9600546",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028928220"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/glia.10249",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029092779"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pneurobio.2011.01.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029786278"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2013/507091",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030392667"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jnr.20834",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033844124"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jnr.20834",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033844124"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02736854",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034094035",
"https://doi.org/10.1007/bf02736854"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02736854",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034094035",
"https://doi.org/10.1007/bf02736854"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mehy.2010.11.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035917064"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs20120560",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036907188"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs20120560",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036907188"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/jcbfm.2011.51",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039137435"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/jcbfm.2011.51",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039137435"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.brainres.2010.12.045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039231156"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1097/01.wcb.0000044631.80210.3c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039967141",
"https://doi.org/10.1097/01.wcb.0000044631.80210.3c"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10715769509065257",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039995536"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/taap.2002.9437",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040305109"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0028-3908(95)00172-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043178581"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(90)90662-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043517258"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bja/aen036",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043560872"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3727/000000005783983205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044276209"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3727/000000005783983205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044276209"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1022572304626",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044313280",
"https://doi.org/10.1023/a:1022572304626"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1022385402197",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045058469",
"https://doi.org/10.1023/a:1022385402197"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0891-5849(01)00551-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045920125"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0306-3623(96)00474-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046151356"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1460-9568.2004.03632.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048776831"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00320136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049560089",
"https://doi.org/10.1007/bf00320136"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00320136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049560089",
"https://doi.org/10.1007/bf00320136"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.32.4.1000",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050395604"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.25.4.869",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052621449"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-8993(96)00009-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053604273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi00439a053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055176200"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi602547m",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055206873"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi602547m",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055206873"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004647-200302000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060185049"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004647-200302000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060185049"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004647-200302000-00001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060185049"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.26.8.1438",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063341694"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.str.27.6.1124",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063342010"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/156720210790820208",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069187514"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/ijo.30.3.593",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071516447"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.14670/hh-20.665",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077013695"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077793233",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077879046",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.18-19-07768.1998",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083318031"
],
"type": "CreativeWork"
}
],
"datePublished": "2015-12",
"datePublishedReg": "2015-12-01",
"description": "The antioxidant properties of alpha-lipoic acid (aLA) correlate with its ability to promote neuroproliferation. However, there have been no comprehensive studies examining the neurorestorative effects of aLA administration after the onset of ischemia. The middle cerebral artery (MCA) of adult rats was occluded for 2\u00a0hours and then reperfused. aLA (20\u00a0mg/kg) was administered in 71 animals (aLA group) through the left external jugular vein immediately after reperfusion. An equivalent volume of vehicle was administered to 71 animals (control group). Functional outcome, levels of endogenous neural precursors with neurogenesis, glial cell activation, and brain metabolism were evaluated. Immediate aLA administration after reperfusion resulted in significantly reduced mortality, infarct size, and neurological deficit score (NDS) in the test group compared to the control group. Long-term functional outcomes, measured by the rotarod test, were markedly improved by aLA treatment. There was a significant increase in the number of cells expressing nestin and GFAP in the boundary zone and infarct core regions after aLA treatment. Furthermore, significantly more BrdU/GFAP, BrdU/DCX, and BrdU/NeuN double-labeled cells were observed along the boundary zone of the aLA group on days 7, 14, and 28\u00a0days, respectively. And brain metabolism using (18)F-FDG microPET imaging was markedly improved in aLA group. The effects of aLA was blocked by insulin receptor inhibitor, HNMPA (AM)3. These results indicate that immediate treatment with aLA after ischemic injury may have significant neurorestorative effects mediated at least partially via insulin receptor activation. Thus, aLA may be useful for the treatment of acute ischemic stroke. ",
"genre": "research_article",
"id": "sg:pub.10.1186/s13041-015-0101-6",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1039765",
"issn": [
"1756-6606"
],
"name": "Molecular Brain",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "8"
}
],
"name": "Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats",
"pagination": "9",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"e98264459bac775eabad1894e2fddcd608c83835607e2df4d91b1166dc27331b"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25761600"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101468876"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13041-015-0101-6"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1049017076"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13041-015-0101-6",
"https://app.dimensions.ai/details/publication/pub.1049017076"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:09",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88236_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2Fs13041-015-0101-6"
}
]Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13041-015-0101-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13041-015-0101-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13041-015-0101-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13041-015-0101-6'
This table displays all metadata directly associated to this object as RDF triples.
427 TRIPLES
21 PREDICATES
114 URIs
43 LITERALS
31 BLANK NODES