Cell maps on the human genome View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Christopher Cherniak, Raul Rodriguez-Esteban

ABSTRACT

Background: We have previously described evidence for a statistically significant, global, supra-chromosomal representation of the human body that appears to stretch over the entire genome. Results: Here, we extend the genome mapping model, zooming down to the typical individual animal cell. Its cellular organization appears to be significantly mapped onto the human genome: Evidence is reported for a "cellunculus" - on the model of a homunculus, on the H. sapiens genome. Conclusions: Basic cell structure turns out to map similarly onto the total genome, mirrored via genes that express in particular cell organelles (e.g., "nuclear membrane"). Similar cell maps may also appear on individual chromosomes that map topologically on the dorsoventral body axis. This seems to constitute some of the basic structural and functional organization of nucleus and chromosome architecture. More... »

PAGES

14

References to SciGraph publications

  • 2008-12. Chromosome distribution in human sperm – a 3D multicolor banding-study in MOLECULAR CYTOGENETICS
  • 2013-12. Body maps on the human genome in MOLECULAR CYTOGENETICS
  • Journal

    TITLE

    Molecular Cytogenetics

    ISSUE

    1

    VOLUME

    12

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13039-019-0426-4

    DOI

    http://dx.doi.org/10.1186/s13039-019-0426-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112900289

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30930962


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