Chromoanagenesis: cataclysms behind complex chromosomal rearrangements View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Franck Pellestor

ABSTRACT

Background: During the last decade, genome sequencing projects in cancer genomes as well as in patients with congenital diseases and healthy individuals have led to the identification of new types of massive chromosomal rearrangements arising during single chaotic cellular events. These unanticipated catastrophic phenomenon are termed chromothripsis, chromoanasynthesis and chromoplexis., and are grouped under the name of "chromoanagenesis". Results: For each process, several specific features have been described, allowing each phenomenon to be distinguished from each other and to understand its mechanism of formation and to better understand its aetiology. Thus, chromothripsis derives from chromosome shattering followed by the random restitching of chromosomal fragments with low copy-number change whereas chromoanasynthesis results from erroneous DNA replication of a chromosome through serial fork stalling and template switching with variable copy-number gains, and chromoplexy refers to the occurrence of multiple inter-and intra-chromosomal translocations and deletions with little or no copy-number alterations in prostate cancer. Cumulating data and experimental models have shown that chromothripsis and chromoanasynthesis may essentially result from lagging chromosome encapsulated in micronuclei or telomere attrition and end-to-end telomere fusion. Conclusion: The concept of chromanagenesis has provided new insight into the aetiology of complex structural rearrangements, the connection between defective cell cycle progression and genomic instability, and the complexity of cancer evolution. Increasing reported chromoanagenesis events suggest that these chaotic mechanisms are probably much more frequent than anticipated. More... »

PAGES

6

References to SciGraph publications

  • 2018. Generation of Micronuclei and Detection of Chromosome Pulverization in CHROMOTHRIPSIS
  • 2015-06. Chromothripsis from DNA damage in micronuclei in NATURE
  • 2018. A Role for Retrotransposons in Chromothripsis in CHROMOTHRIPSIS
  • 2018. Genes, Proteins, and Biological Pathways Preventing Chromothripsis in CHROMOTHRIPSIS
  • 2009-05. Recent advance in our understanding of the molecular nature of chromosomal abnormalities in JOURNAL OF HUMAN GENETICS
  • 2016-12. Organization and function of the 3D genome in NATURE REVIEWS GENETICS
  • 2003-06. Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre in NATURE CELL BIOLOGY
  • 2000-01. Environmental genetics: Rapid chromosomal evolution in island mice in NATURE
  • 2014-12. Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens in BMC GENOMICS
  • 2013-12. Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis in LEUKEMIA
  • 2015-12. Chromothripsis with at least 12 breaks at 1p36.33-p35.3 in a boy with multiple congenital anomalies in MOLECULAR GENETICS AND GENOMICS
  • 2016-02-15. The presence of extra chromosomes leads to genomic instability in NATURE COMMUNICATIONS
  • 2014-09-10. Gibbon genome and the fast karyotype evolution of small apes in NATURE
  • 2011-02. Cancer: When catastrophe strikes a cell in NATURE
  • 2012-10. Chromothripsis and cancer: causes and consequences of chromosome shattering in NATURE REVIEWS CANCER
  • 2012-04. Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration in NATURE GENETICS
  • 2008-03. Genome instability: a mechanistic view of its causes and consequences in NATURE REVIEWS GENETICS
  • 2001-04. Chromosome territories, nuclear architecture and gene regulation in mammalian cells in NATURE REVIEWS GENETICS
  • 2012-01-18. DNA breaks and chromosome pulverization from errors in mitosis in NATURE
  • 2017-06-09. Transposable elements in cancer in NATURE REVIEWS CANCER
  • 2016-05. A germline chromothripsis event stably segregating in 11 individuals through three generations in GENETICS IN MEDICINE
  • 2018-09. Nuclear envelope assembly defects link mitotic errors to chromothripsis in NATURE
  • 2012-03. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes in NATURE
  • 1999-10. Transgressive segregation, adaptation and speciation in HEREDITY
  • 2000-11. Surfing the p53 network in NATURE
  • 2018-07. Chromothripsis in acute myeloid leukemia: biological features and impact on survival in LEUKEMIA
  • 2013-10. Pan-cancer patterns of somatic copy number alteration in NATURE GENETICS
  • 2016-11. Impaired nuclear functions in micronuclei results in genome instability and chromothripsis in ARCHIVES OF TOXICOLOGY
  • 2018. Looking for Broken TAD Boundaries and Changes on DNA Interactions: Clinical Guide to 3D Chromatin Change Analysis in Complex Chromosomal Rearrangements and Chromothripsis in CHROMOTHRIPSIS
  • 2018. Experimental Induction of Genome Chaos in CHROMOTHRIPSIS
  • 2018-03. Transposable elements: genome innovation, chromosome diversity, and centromere conflict in CHROMOSOME RESEARCH
  • 2012-11. Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements in NATURE MEDICINE
  • 2017-12. Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells in GENOME MEDICINE
  • 2012-08. Identification of novel CHD1-associated collaborative alterations of genomic structure and functional assessment of CHD1 in prostate cancer in ONCOGENE
  • 2003-12. Control of apoptosis by p53 in ONCOGENE
  • 2017-01. Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining in NATURE CELL BIOLOGY
  • 2017-03. Telomeres in cancer: tumour suppression and genome instability in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2017-12. Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome in GENOME BIOLOGY
  • 2016-10. A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns in NATURE
  • 2012-05. Increased chromosome mobility facilitates homology search during recombination in NATURE CELL BIOLOGY
  • 2012-05. Lagging chromosomes entrapped in micronuclei are not 'lost' by cells in CELL RESEARCH
  • 2017-10. Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis in LEUKEMIA
  • 2018. Clinical Consequences of Chromothripsis and Other Catastrophic Cellular Events in CHROMOTHRIPSIS
  • Journal

    TITLE

    Molecular Cytogenetics

    ISSUE

    1

    VOLUME

    12

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13039-019-0415-7

    DOI

    http://dx.doi.org/10.1186/s13039-019-0415-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112063021

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30805029


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        "description": "Background: During the last decade, genome sequencing projects in cancer genomes as well as in patients with congenital diseases and healthy individuals have led to the identification of new types of massive chromosomal rearrangements arising during single chaotic cellular events. These unanticipated catastrophic phenomenon are termed chromothripsis, chromoanasynthesis and chromoplexis., and are grouped under the name of \"chromoanagenesis\".\nResults: For each process, several specific features have been described, allowing each phenomenon to be distinguished from each other and to understand its mechanism of formation and to better understand its aetiology. Thus, chromothripsis derives from chromosome shattering followed by the random restitching of chromosomal fragments with low copy-number change whereas chromoanasynthesis results from erroneous DNA replication of a chromosome through serial fork stalling and template switching with variable copy-number gains, and chromoplexy refers to the occurrence of multiple inter-and intra-chromosomal translocations and deletions with little or no copy-number alterations in prostate cancer. Cumulating data and experimental models have shown that chromothripsis and chromoanasynthesis may essentially result from lagging chromosome encapsulated in micronuclei or telomere attrition and end-to-end telomere fusion.\nConclusion: The concept of chromanagenesis has provided new insight into the aetiology of complex structural rearrangements, the connection between defective cell cycle progression and genomic instability, and the complexity of cancer evolution. Increasing reported chromoanagenesis events suggest that these chaotic mechanisms are probably much more frequent than anticipated.", 
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