Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Mi-Ok Lee, Kwang Bo Jung, Seong-Jae Jo, Sung-Ae Hyun, Kyoung-Sik Moon, Joung-Wook Seo, Sang-Heon Kim, Mi-Young Son

ABSTRACT

Background: Cardiac fibrosis is the most common pathway of many cardiac diseases. To date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic the complex environment of the human heart. Here, a three-dimensional (3D) cardiac sphere platform of contractile cardiac microtissue, composed of human embryonic stem cell (hESC)-derived cardiomyocytes (CMs) and mesenchymal stem cells (MSCs), is presented to better recapitulate the human heart. Results: We hypothesized that MSCs would develop an in vitro fibrotic reaction in response to treatment with transforming growth factor-β1 (TGF-β1), a primary inducer of cardiac fibrosis. The addition of MSCs improved sarcomeric organization, electrophysiological properties, and the expression of cardiac-specific genes, suggesting their physiological relevance in the generation of human cardiac microtissue model in vitro. MSCs could also generate fibroblasts within 3D cardiac microtissues and, subsequently, these fibroblasts were transdifferentiated into myofibroblasts by the exogenous addition of TGF-β1. Cardiac microtissues displayed fibrotic features such as the deposition of collagen, the presence of numerous apoptotic CMs and the dissolution of mitochondrial networks. Furthermore, treatment with pro-fibrotic substances demonstrated that this model could reproduce key molecular and cellular fibrotic events. Conclusions: This highlights the potential of our 3D cardiac microtissues as a valuable tool for manifesting and evaluating the pro-fibrotic effects of various agents, thereby representing an important step forward towards an in vitro system for the prediction of drug-induced cardiac fibrosis and the study of the pathological changes in human cardiac fibrosis. More... »

PAGES

15

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13036-019-0139-6

DOI

http://dx.doi.org/10.1186/s13036-019-0139-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112119165

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30809271


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Korea Research Institute of Bioscience and Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.249967.7", 
          "name": [
            "Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 341411, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Mi-Ok", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.412786.e", 
          "name": [
            "Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 341411, Daejeon, Republic of Korea", 
            "Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), 34113, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jung", 
        "givenName": "Kwang Bo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.412786.e", 
          "name": [
            "Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 341411, Daejeon, Republic of Korea", 
            "Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), 34113, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jo", 
        "givenName": "Seong-Jae", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Research Group for Safety Pharmacology, Korea Institute of Toxicology, KRICT, 34114, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hyun", 
        "givenName": "Sung-Ae", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Research Group for Safety Pharmacology, Korea Institute of Toxicology, KRICT, 34114, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moon", 
        "givenName": "Kyoung-Sik", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Research Group for Safety Pharmacology, Korea Institute of Toxicology, KRICT, 34114, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seo", 
        "givenName": "Joung-Wook", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.412786.e", 
          "name": [
            "Center for Biomaterials, Korea Institute of Science and Technology (KIST), 02792, Seoul, Republic of Korea", 
            "Department of Biomedical Engineering, KIST school, UST, 34113, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Sang-Heon", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea University of Science and Technology", 
          "id": "https://www.grid.ac/institutes/grid.412786.e", 
          "name": [
            "Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 341411, Daejeon, Republic of Korea", 
            "Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), 34113, Daejeon, Republic of Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Son", 
        "givenName": "Mi-Young", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2015.11.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001239608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2016.08.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001312553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2007-0742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004081827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004338635", 
          "https://doi.org/10.1038/nmeth.2999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hrthm.2011.10.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004647833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0163158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006544568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules19044967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007103466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules19044967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007103466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnh.0000000000000230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007988111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mnh.0000000000000230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007988111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161211798357773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010956717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1415448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013270526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/7651_2014_178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014076087", 
          "https://doi.org/10.1007/7651_2014_178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2016.03.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014090396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/emm.2016.27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014823167", 
          "https://doi.org/10.1038/emm.2016.27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.308139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015417922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.308139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015417922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0344-0338(96)80092-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016783103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.199083", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016851868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2001-1326-1-30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017462523", 
          "https://doi.org/10.1186/2001-1326-1-30"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcyt.2014.01.416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020448737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0166428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020873706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms12260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020999325", 
          "https://doi.org/10.1038/ncomms12260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2006.10.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021854022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1253/circj.cj-16-1003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021968476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrcardio.2012.158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022326948", 
          "https://doi.org/10.1038/nrcardio.2012.158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.357871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022446933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pharmthera.2012.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022503754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fjc.0b013e31821209ee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022889796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fjc.0b013e31821209ee", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022889796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2010.10.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024160072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cels.2015.12.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024709936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a014027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027010017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000085658.98621.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028159916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci46315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028839083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2015.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029712321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajpath.2011.06.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031258934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuro.2010.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033489591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvr061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034310580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2010.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034483916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pharmthera.2009.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035489010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2016.01.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036100988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2008.00457.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038787359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci43230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039016872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2004.08.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039804868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardiores.2006.06.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040129732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/1758-5082/6/4/045009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040779810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11010-014-2030-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044983713", 
          "https://doi.org/10.1007/s11010-014-2030-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045100469", 
          "https://doi.org/10.1038/nmeth.2524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.toxlet.2016.03.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046018545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1504848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046225159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047212186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molmed.2011.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047527482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-0436.1992.tb00675.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047858354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2015.01.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048526357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s000590050024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048830028", 
          "https://doi.org/10.1007/s000590050024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/dvdy.20095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049802773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2015.05.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050148272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2013.04.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050766947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052142938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fjc.0b013e3182116e39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053084397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fjc.0b013e3182116e39", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053084397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.209809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053459843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.109.209809", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053459843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf802357g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055925542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jf802357g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055925542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bsr20160346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056717280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.115.306565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.115.306565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.115.306565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/0929867321666131212152408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069163473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1381612811319270003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069169083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rsif.2016.0877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083830484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/nan.12396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083909380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12265-017-9737-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084034838", 
          "https://doi.org/10.1007/s12265-017-9737-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12265-017-9737-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084034838", 
          "https://doi.org/10.1007/s12265-017-9737-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.143438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084256468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21037/jtd.2017.03.122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084382953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/etm.2017.4224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084442963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adhm.201601434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085390392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c7mb00174f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086115532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-05018-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090342153", 
          "https://doi.org/10.1038/s41598-017-05018-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-06385-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090933039", 
          "https://doi.org/10.1038/s41598-017-06385-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-06385-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090933039", 
          "https://doi.org/10.1038/s41598-017-06385-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2017.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090953080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000477436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090992189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.201700504r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091381792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2017.00777", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092186926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00041.2017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093100894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-018-28393-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105236542", 
          "https://doi.org/10.1038/s41598-018-28393-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-018-05450-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1105886897", 
          "https://doi.org/10.1038/s41467-018-05450-8"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Background: Cardiac fibrosis is the most common pathway of many cardiac diseases. To date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic the complex environment of the human heart. Here, a three-dimensional (3D) cardiac sphere platform of contractile cardiac microtissue, composed of human embryonic stem cell (hESC)-derived cardiomyocytes (CMs) and mesenchymal stem cells (MSCs), is presented to better recapitulate the human heart.\nResults: We hypothesized that MSCs would develop an in vitro fibrotic reaction in response to treatment with transforming growth factor-\u03b21 (TGF-\u03b21), a primary inducer of cardiac fibrosis. The addition of MSCs improved sarcomeric organization, electrophysiological properties, and the expression of cardiac-specific genes, suggesting their physiological relevance in the generation of human cardiac microtissue model in vitro. MSCs could also generate fibroblasts within 3D cardiac microtissues and, subsequently, these fibroblasts were transdifferentiated into myofibroblasts by the exogenous addition of TGF-\u03b21. Cardiac microtissues displayed fibrotic features such as the deposition of collagen, the presence of numerous apoptotic CMs and the dissolution of mitochondrial networks. Furthermore, treatment with pro-fibrotic substances demonstrated that this model could reproduce key molecular and cellular fibrotic events.\nConclusions: This highlights the potential of our 3D cardiac microtissues as a valuable tool for manifesting and evaluating the pro-fibrotic effects of various agents, thereby representing an important step forward towards an in vitro system for the prediction of drug-induced cardiac fibrosis and the study of the pathological changes in human cardiac fibrosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13036-019-0139-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1038668", 
        "issn": [
          "1754-1611"
        ], 
        "name": "Journal of Biological Engineering", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells", 
    "pagination": "15", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "46d87ef5adfc7e281132784b9208af333a0427d44411930d4d953b4edef525db"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30809271"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101306640"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13036-019-0139-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112119165"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13036-019-0139-6", 
      "https://app.dimensions.ai/details/publication/pub.1112119165"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77561_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13036-019-0139-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13036-019-0139-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13036-019-0139-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13036-019-0139-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13036-019-0139-6'


 

This table displays all metadata directly associated to this object as RDF triples.

375 TRIPLES      21 PREDICATES      109 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13036-019-0139-6 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N90fd4820223f4befbbab25521f7741ef
4 schema:citation sg:pub.10.1007/7651_2014_178
5 sg:pub.10.1007/s000590050024
6 sg:pub.10.1007/s11010-014-2030-6
7 sg:pub.10.1007/s12265-017-9737-1
8 sg:pub.10.1038/emm.2016.27
9 sg:pub.10.1038/ncomms12260
10 sg:pub.10.1038/nmeth.2524
11 sg:pub.10.1038/nmeth.2999
12 sg:pub.10.1038/nrcardio.2012.158
13 sg:pub.10.1038/s41467-018-05450-8
14 sg:pub.10.1038/s41598-017-05018-4
15 sg:pub.10.1038/s41598-017-06385-8
16 sg:pub.10.1038/s41598-018-28393-y
17 sg:pub.10.1186/2001-1326-1-30
18 https://doi.org/10.1002/adhm.201601434
19 https://doi.org/10.1002/dvdy.20095
20 https://doi.org/10.1002/path.2281
21 https://doi.org/10.1016/j.addr.2015.05.010
22 https://doi.org/10.1016/j.addr.2015.09.011
23 https://doi.org/10.1016/j.ajpath.2011.06.022
24 https://doi.org/10.1016/j.bbamcr.2015.11.036
25 https://doi.org/10.1016/j.biomaterials.2013.04.034
26 https://doi.org/10.1016/j.biomaterials.2016.08.042
27 https://doi.org/10.1016/j.cardiores.2004.08.020
28 https://doi.org/10.1016/j.cardiores.2006.06.013
29 https://doi.org/10.1016/j.cardiores.2006.10.002
30 https://doi.org/10.1016/j.cels.2015.12.004
31 https://doi.org/10.1016/j.hrthm.2011.10.028
32 https://doi.org/10.1016/j.jcyt.2014.01.416
33 https://doi.org/10.1016/j.molmed.2011.05.001
34 https://doi.org/10.1016/j.neuro.2010.04.001
35 https://doi.org/10.1016/j.pharmthera.2009.05.002
36 https://doi.org/10.1016/j.pharmthera.2012.01.005
37 https://doi.org/10.1016/j.stem.2017.07.011
38 https://doi.org/10.1016/j.toxlet.2016.03.008
39 https://doi.org/10.1016/j.ydbio.2015.01.012
40 https://doi.org/10.1016/j.yexcr.2010.04.004
41 https://doi.org/10.1016/j.yjmcc.2010.10.033
42 https://doi.org/10.1016/j.yjmcc.2016.01.006
43 https://doi.org/10.1016/j.yjmcc.2016.03.005
44 https://doi.org/10.1016/s0344-0338(96)80092-6
45 https://doi.org/10.1021/jf802357g
46 https://doi.org/10.1039/c7mb00174f
47 https://doi.org/10.1042/bsr20160346
48 https://doi.org/10.1056/nejmc1415448
49 https://doi.org/10.1056/nejmc1504848
50 https://doi.org/10.1074/jbc.m112.357871
51 https://doi.org/10.1088/1758-5082/6/4/045009
52 https://doi.org/10.1093/cvr/cvr061
53 https://doi.org/10.1096/fj.201700504r
54 https://doi.org/10.1097/fjc.0b013e3182116e39
55 https://doi.org/10.1097/fjc.0b013e31821209ee
56 https://doi.org/10.1097/mnh.0000000000000230
57 https://doi.org/10.1098/rsif.2016.0877
58 https://doi.org/10.1101/cshperspect.a014027
59 https://doi.org/10.1111/j.1432-0436.1992.tb00675.x
60 https://doi.org/10.1111/j.1582-4934.2008.00457.x
61 https://doi.org/10.1111/nan.12396
62 https://doi.org/10.1152/physiolgenomics.00041.2017
63 https://doi.org/10.1159/000477436
64 https://doi.org/10.1161/01.cir.0000085658.98621.49
65 https://doi.org/10.1161/circresaha.109.209809
66 https://doi.org/10.1161/circresaha.115.306565
67 https://doi.org/10.1161/circresaha.116.308139
68 https://doi.org/10.1172/jci43230
69 https://doi.org/10.1172/jci46315
70 https://doi.org/10.1242/dev.143438
71 https://doi.org/10.1242/jcs.199083
72 https://doi.org/10.1253/circj.cj-16-1003
73 https://doi.org/10.1371/journal.pone.0163158
74 https://doi.org/10.1371/journal.pone.0166428
75 https://doi.org/10.1634/stemcells.2005-0648
76 https://doi.org/10.1634/stemcells.2007-0742
77 https://doi.org/10.21037/jtd.2017.03.122
78 https://doi.org/10.2174/0929867321666131212152408
79 https://doi.org/10.2174/138161211798357773
80 https://doi.org/10.2174/1381612811319270003
81 https://doi.org/10.3389/fphys.2017.00777
82 https://doi.org/10.3390/molecules19044967
83 https://doi.org/10.3892/etm.2017.4224
84 schema:datePublished 2019-12
85 schema:datePublishedReg 2019-12-01
86 schema:description Background: Cardiac fibrosis is the most common pathway of many cardiac diseases. To date, there has been no suitable in vitro cardiac fibrosis model that could sufficiently mimic the complex environment of the human heart. Here, a three-dimensional (3D) cardiac sphere platform of contractile cardiac microtissue, composed of human embryonic stem cell (hESC)-derived cardiomyocytes (CMs) and mesenchymal stem cells (MSCs), is presented to better recapitulate the human heart. Results: We hypothesized that MSCs would develop an in vitro fibrotic reaction in response to treatment with transforming growth factor-β1 (TGF-β1), a primary inducer of cardiac fibrosis. The addition of MSCs improved sarcomeric organization, electrophysiological properties, and the expression of cardiac-specific genes, suggesting their physiological relevance in the generation of human cardiac microtissue model in vitro. MSCs could also generate fibroblasts within 3D cardiac microtissues and, subsequently, these fibroblasts were transdifferentiated into myofibroblasts by the exogenous addition of TGF-β1. Cardiac microtissues displayed fibrotic features such as the deposition of collagen, the presence of numerous apoptotic CMs and the dissolution of mitochondrial networks. Furthermore, treatment with pro-fibrotic substances demonstrated that this model could reproduce key molecular and cellular fibrotic events. Conclusions: This highlights the potential of our 3D cardiac microtissues as a valuable tool for manifesting and evaluating the pro-fibrotic effects of various agents, thereby representing an important step forward towards an in vitro system for the prediction of drug-induced cardiac fibrosis and the study of the pathological changes in human cardiac fibrosis.
87 schema:genre research_article
88 schema:inLanguage en
89 schema:isAccessibleForFree true
90 schema:isPartOf N00f7d06162f34eb8842ef53518a1a087
91 Nbf5b090f235e424493b158fbc3e32056
92 sg:journal.1038668
93 schema:name Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells
94 schema:pagination 15
95 schema:productId N1cf77fde23124ab0a25b9427b06baf04
96 N52aa5bf69ee446c09f51ff8db4ec0a5b
97 Na2654ad9f7aa4c149175837ecd8bda36
98 Nf01db8baf5ce4f5ca35f28bbd2bf5059
99 Nf5fa45f4dc4b44cead9776953db7c431
100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112119165
101 https://doi.org/10.1186/s13036-019-0139-6
102 schema:sdDatePublished 2019-04-11T10:49
103 schema:sdLicense https://scigraph.springernature.com/explorer/license/
104 schema:sdPublisher Nb9d82027cf20427c8e52332d7cf0428c
105 schema:url https://link.springer.com/10.1186%2Fs13036-019-0139-6
106 sgo:license sg:explorer/license/
107 sgo:sdDataset articles
108 rdf:type schema:ScholarlyArticle
109 N00f7d06162f34eb8842ef53518a1a087 schema:issueNumber 1
110 rdf:type schema:PublicationIssue
111 N0f24b42df131466f8016705359ef0a1c schema:name Research Group for Safety Pharmacology, Korea Institute of Toxicology, KRICT, 34114, Daejeon, Republic of Korea
112 rdf:type schema:Organization
113 N1cf77fde23124ab0a25b9427b06baf04 schema:name readcube_id
114 schema:value 46d87ef5adfc7e281132784b9208af333a0427d44411930d4d953b4edef525db
115 rdf:type schema:PropertyValue
116 N242157216cc84683be8a2599e92c8809 rdf:first N3102456b8b3341ab9a771aa1f3bc3d15
117 rdf:rest N8f3bce23423c4a8abfe6f4633fa66a53
118 N2c7a243325f64e4880ac728d4f95a7d4 schema:affiliation https://www.grid.ac/institutes/grid.412786.e
119 schema:familyName Son
120 schema:givenName Mi-Young
121 rdf:type schema:Person
122 N2ccbe9c451994583a23c48b026843c31 schema:affiliation N0f24b42df131466f8016705359ef0a1c
123 schema:familyName Seo
124 schema:givenName Joung-Wook
125 rdf:type schema:Person
126 N3102456b8b3341ab9a771aa1f3bc3d15 schema:affiliation https://www.grid.ac/institutes/grid.412786.e
127 schema:familyName Kim
128 schema:givenName Sang-Heon
129 rdf:type schema:Person
130 N3f54ea8885f74801942ffc2cbba08159 rdf:first Nc1df8c325dae44b280a79dff9730252c
131 rdf:rest N746cd88008b24242a8ecbd32281e0768
132 N4f72a199fbb9440fae5acb96f8e41cb0 rdf:first N83952681d11f46aeb29bc0ee6d2245a6
133 rdf:rest N64886c7b958e48769509e2a17a3933a4
134 N52aa5bf69ee446c09f51ff8db4ec0a5b schema:name pubmed_id
135 schema:value 30809271
136 rdf:type schema:PropertyValue
137 N64886c7b958e48769509e2a17a3933a4 rdf:first Nd6e8bb395ff447998e2c02fad84f2f99
138 rdf:rest N3f54ea8885f74801942ffc2cbba08159
139 N6d9649c8a9874adab3f5e6d99e61d5c8 schema:affiliation https://www.grid.ac/institutes/grid.249967.7
140 schema:familyName Lee
141 schema:givenName Mi-Ok
142 rdf:type schema:Person
143 N746cd88008b24242a8ecbd32281e0768 rdf:first N2ccbe9c451994583a23c48b026843c31
144 rdf:rest N242157216cc84683be8a2599e92c8809
145 N83952681d11f46aeb29bc0ee6d2245a6 schema:affiliation https://www.grid.ac/institutes/grid.412786.e
146 schema:familyName Jo
147 schema:givenName Seong-Jae
148 rdf:type schema:Person
149 N8f3bce23423c4a8abfe6f4633fa66a53 rdf:first N2c7a243325f64e4880ac728d4f95a7d4
150 rdf:rest rdf:nil
151 N90fd4820223f4befbbab25521f7741ef rdf:first N6d9649c8a9874adab3f5e6d99e61d5c8
152 rdf:rest Nf786f14e5f0645f6b2771c706e651d09
153 N9b123f93dfb148d4b9b8375403ab9038 schema:affiliation https://www.grid.ac/institutes/grid.412786.e
154 schema:familyName Jung
155 schema:givenName Kwang Bo
156 rdf:type schema:Person
157 Na2654ad9f7aa4c149175837ecd8bda36 schema:name nlm_unique_id
158 schema:value 101306640
159 rdf:type schema:PropertyValue
160 Nb57685068bbd4f15b6bebe9822eeb149 schema:name Research Group for Safety Pharmacology, Korea Institute of Toxicology, KRICT, 34114, Daejeon, Republic of Korea
161 rdf:type schema:Organization
162 Nb9d82027cf20427c8e52332d7cf0428c schema:name Springer Nature - SN SciGraph project
163 rdf:type schema:Organization
164 Nbc6488d1695746a3bbf4796e4f4b1b9a schema:name Research Group for Safety Pharmacology, Korea Institute of Toxicology, KRICT, 34114, Daejeon, Republic of Korea
165 rdf:type schema:Organization
166 Nbf5b090f235e424493b158fbc3e32056 schema:volumeNumber 13
167 rdf:type schema:PublicationVolume
168 Nc1df8c325dae44b280a79dff9730252c schema:affiliation Nbc6488d1695746a3bbf4796e4f4b1b9a
169 schema:familyName Moon
170 schema:givenName Kyoung-Sik
171 rdf:type schema:Person
172 Nd6e8bb395ff447998e2c02fad84f2f99 schema:affiliation Nb57685068bbd4f15b6bebe9822eeb149
173 schema:familyName Hyun
174 schema:givenName Sung-Ae
175 rdf:type schema:Person
176 Nf01db8baf5ce4f5ca35f28bbd2bf5059 schema:name dimensions_id
177 schema:value pub.1112119165
178 rdf:type schema:PropertyValue
179 Nf5fa45f4dc4b44cead9776953db7c431 schema:name doi
180 schema:value 10.1186/s13036-019-0139-6
181 rdf:type schema:PropertyValue
182 Nf786f14e5f0645f6b2771c706e651d09 rdf:first N9b123f93dfb148d4b9b8375403ab9038
183 rdf:rest N4f72a199fbb9440fae5acb96f8e41cb0
184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medical and Health Sciences
186 rdf:type schema:DefinedTerm
187 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
188 schema:name Cardiorespiratory Medicine and Haematology
189 rdf:type schema:DefinedTerm
190 sg:journal.1038668 schema:issn 1754-1611
191 schema:name Journal of Biological Engineering
192 rdf:type schema:Periodical
193 sg:pub.10.1007/7651_2014_178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014076087
194 https://doi.org/10.1007/7651_2014_178
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s000590050024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048830028
197 https://doi.org/10.1007/s000590050024
198 rdf:type schema:CreativeWork
199 sg:pub.10.1007/s11010-014-2030-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044983713
200 https://doi.org/10.1007/s11010-014-2030-6
201 rdf:type schema:CreativeWork
202 sg:pub.10.1007/s12265-017-9737-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084034838
203 https://doi.org/10.1007/s12265-017-9737-1
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/emm.2016.27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014823167
206 https://doi.org/10.1038/emm.2016.27
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/ncomms12260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020999325
209 https://doi.org/10.1038/ncomms12260
210 rdf:type schema:CreativeWork
211 sg:pub.10.1038/nmeth.2524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045100469
212 https://doi.org/10.1038/nmeth.2524
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/nmeth.2999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004338635
215 https://doi.org/10.1038/nmeth.2999
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/nrcardio.2012.158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022326948
218 https://doi.org/10.1038/nrcardio.2012.158
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/s41467-018-05450-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105886897
221 https://doi.org/10.1038/s41467-018-05450-8
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/s41598-017-05018-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090342153
224 https://doi.org/10.1038/s41598-017-05018-4
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/s41598-017-06385-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090933039
227 https://doi.org/10.1038/s41598-017-06385-8
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/s41598-018-28393-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1105236542
230 https://doi.org/10.1038/s41598-018-28393-y
231 rdf:type schema:CreativeWork
232 sg:pub.10.1186/2001-1326-1-30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017462523
233 https://doi.org/10.1186/2001-1326-1-30
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/adhm.201601434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085390392
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/dvdy.20095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049802773
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/path.2281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052142938
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/j.addr.2015.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050148272
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.addr.2015.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029712321
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.ajpath.2011.06.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031258934
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.bbamcr.2015.11.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001239608
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.biomaterials.2013.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050766947
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.biomaterials.2016.08.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001312553
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.cardiores.2004.08.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039804868
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.cardiores.2006.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040129732
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.cardiores.2006.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021854022
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.cels.2015.12.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024709936
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.hrthm.2011.10.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004647833
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.jcyt.2014.01.416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020448737
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.molmed.2011.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047527482
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.neuro.2010.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033489591
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.pharmthera.2009.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035489010
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.pharmthera.2012.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022503754
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.stem.2017.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090953080
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.toxlet.2016.03.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046018545
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.ydbio.2015.01.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048526357
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.yexcr.2010.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034483916
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.yjmcc.2010.10.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024160072
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.yjmcc.2016.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036100988
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.yjmcc.2016.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014090396
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0344-0338(96)80092-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016783103
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1021/jf802357g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055925542
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1039/c7mb00174f schema:sameAs https://app.dimensions.ai/details/publication/pub.1086115532
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1042/bsr20160346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056717280
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1056/nejmc1415448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013270526
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1056/nejmc1504848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046225159
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1074/jbc.m112.357871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022446933
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1088/1758-5082/6/4/045009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040779810
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/cvr/cvr061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034310580
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1096/fj.201700504r schema:sameAs https://app.dimensions.ai/details/publication/pub.1091381792
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1097/fjc.0b013e3182116e39 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053084397
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1097/fjc.0b013e31821209ee schema:sameAs https://app.dimensions.ai/details/publication/pub.1022889796
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1097/mnh.0000000000000230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007988111
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1098/rsif.2016.0877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083830484
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1101/cshperspect.a014027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027010017
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1111/j.1432-0436.1992.tb00675.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047858354
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1111/j.1582-4934.2008.00457.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038787359
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1111/nan.12396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083909380
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1152/physiolgenomics.00041.2017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093100894
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1159/000477436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090992189
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1161/01.cir.0000085658.98621.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028159916
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1161/circresaha.109.209809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053459843
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1161/circresaha.115.306565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063343766
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1161/circresaha.116.308139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015417922
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1172/jci43230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039016872
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1172/jci46315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028839083
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1242/dev.143438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084256468
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1242/jcs.199083 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016851868
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1253/circj.cj-16-1003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021968476
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1371/journal.pone.0163158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006544568
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1371/journal.pone.0166428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020873706
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1634/stemcells.2005-0648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047212186
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1634/stemcells.2007-0742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004081827
352 rdf:type schema:CreativeWork
353 https://doi.org/10.21037/jtd.2017.03.122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084382953
354 rdf:type schema:CreativeWork
355 https://doi.org/10.2174/0929867321666131212152408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069163473
356 rdf:type schema:CreativeWork
357 https://doi.org/10.2174/138161211798357773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010956717
358 rdf:type schema:CreativeWork
359 https://doi.org/10.2174/1381612811319270003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069169083
360 rdf:type schema:CreativeWork
361 https://doi.org/10.3389/fphys.2017.00777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092186926
362 rdf:type schema:CreativeWork
363 https://doi.org/10.3390/molecules19044967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007103466
364 rdf:type schema:CreativeWork
365 https://doi.org/10.3892/etm.2017.4224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084442963
366 rdf:type schema:CreativeWork
367 https://www.grid.ac/institutes/grid.249967.7 schema:alternateName Korea Research Institute of Bioscience and Biotechnology
368 schema:name Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 341411, Daejeon, Republic of Korea
369 rdf:type schema:Organization
370 https://www.grid.ac/institutes/grid.412786.e schema:alternateName Korea University of Science and Technology
371 schema:name Center for Biomaterials, Korea Institute of Science and Technology (KIST), 02792, Seoul, Republic of Korea
372 Department of Biomedical Engineering, KIST school, UST, 34113, Daejeon, Republic of Korea
373 Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), 34113, Daejeon, Republic of Korea
374 Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 341411, Daejeon, Republic of Korea
375 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...