Interleukin-17F expression is elevated in hepatitis C patients with fibrosis and hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Ming-Sian Wu, Chun-Hsiang Wang, Fan-Chen Tseng, Hsuan-Ju Yang, Yin-Chiu Lo, Yi-Ping Kuo, De-Jiun Tsai, Wan-Ting Tsai, Guann-Yi Yu

ABSTRACT

BACKGROUND: The role of interleukin (IL) 17A in chronic liver diseases had been extensively studied, but the function of IL-17F, which shares a high degree of homology with IL-17A, in the progression of chronic hepatic diseases is poorly understood. The aim of the study was to evaluate the association between IL-17F and liver diseases including, fibrosis and hepatocellular carcinoma (HCC). METHODS: Hepatic tumor samples from both hepatitis C virus (HCV) positive and negative patients (without HBV and HCV, NBNC) were examined with quantitative PCR and immunohistochemistry staining for inflammatory cytokine genes expression. In addition, 250 HCV patients naïve for interferon treatment were also subjected to enzyme-linked immunosorbent Assay (ELISA) for their serum cytokine concentrations. RESULTS: Serum IL-17F concentrations were significantly elevated in HCV patients with severe fibrosis stages. In accordance with serum data, IL-17F expression was also found higher in HCV-associated HCC tissues compared with NBNC HCC tissues at both the mRNA and protein levels. CONCLUSIONS: Our data suggest that IL-17F might be used as a valuable biological marker than IL-17A during chronic fibrosis progression and HCC development in HCV patients. More... »

PAGES

42

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13027-017-0152-7

DOI

http://dx.doi.org/10.1186/s13027-017-0152-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090897850

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28770001


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Health Research Institutes", 
          "id": "https://www.grid.ac/institutes/grid.59784.37", 
          "name": [
            "National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Ming-Sian", 
        "id": "sg:person.0655756465.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655756465.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tainan Municipal Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410770.5", 
          "name": [
            "Division of Gastroenterology, Tainan Municipal Hospital, 70173, Tainan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Chun-Hsiang", 
        "id": "sg:person.0747062601.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747062601.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Health Research Institutes", 
          "id": "https://www.grid.ac/institutes/grid.59784.37", 
          "name": [
            "National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tseng", 
        "givenName": "Fan-Chen", 
        "id": "sg:person.0736546234.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736546234.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tainan Municipal Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410770.5", 
          "name": [
            "Division of Gastroenterology, Tainan Municipal Hospital, 70173, Tainan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Hsuan-Ju", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Health Research Institutes", 
          "id": "https://www.grid.ac/institutes/grid.59784.37", 
          "name": [
            "National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lo", 
        "givenName": "Yin-Chiu", 
        "id": "sg:person.01240721675.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240721675.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Health Research Institutes", 
          "id": "https://www.grid.ac/institutes/grid.59784.37", 
          "name": [
            "National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuo", 
        "givenName": "Yi-Ping", 
        "id": "sg:person.013556067345.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013556067345.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Health Research Institutes", 
          "id": "https://www.grid.ac/institutes/grid.59784.37", 
          "name": [
            "National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsai", 
        "givenName": "De-Jiun", 
        "id": "sg:person.01045101064.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045101064.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Health Research Institutes", 
          "id": "https://www.grid.ac/institutes/grid.59784.37", 
          "name": [
            "National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsai", 
        "givenName": "Wan-Ting", 
        "id": "sg:person.01326114534.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326114534.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cheng Kung University", 
          "id": "https://www.grid.ac/institutes/grid.64523.36", 
          "name": [
            "National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan", 
            "Center of Infectious Disease and Signaling Research, National Cheng-Kung University, 70101, Tainan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Guann-Yi", 
        "id": "sg:person.01067642670.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067642670.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2008.00628.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000506483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000677027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2006.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004052070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000003284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005094568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/md.0000000000003284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005094568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci24282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006469641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2011.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007898556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/155.4.323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008526200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2006.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009201806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0021816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011502390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8278(02)00429-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012389516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8278(02)00429-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012389516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micinf.2009.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012830261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4314/ahs.v15i3.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014937384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4314/ahs.v15i3.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014937384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/345803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018321830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10620-011-1997-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019008049", 
          "https://doi.org/10.1007/s10620-011-1997-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2008.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019039197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20072713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021611842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1872-034x.2007.00040.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024242077"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20071978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024795348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/meth.2001.1262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027621591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.22680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031353408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2008.12.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033844841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2004.09.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035011181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2008.04.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035394013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2011.06782.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036019941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840360710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036634216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.1840360710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036634216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037247321", 
          "https://doi.org/10.1038/nature04753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037247321", 
          "https://doi.org/10.1038/nature04753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.177.1.566", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040036581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaut.2008.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041088665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2012.05.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042801500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.23291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044561011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m705100200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047483488"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0021359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052924649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2014.07.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053118987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v20.i32.11033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071371293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/03353bm03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076572405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1203013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078755172"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: The role of interleukin (IL) 17A in chronic liver diseases had been extensively studied, but the function of IL-17F, which shares a high degree of homology with IL-17A, in the progression of chronic hepatic diseases is poorly understood. The aim of the study was to evaluate the association between IL-17F and liver diseases including, fibrosis and hepatocellular carcinoma (HCC).\nMETHODS: Hepatic tumor samples from both hepatitis C virus (HCV) positive and negative patients (without HBV and HCV, NBNC) were examined with quantitative PCR and immunohistochemistry staining for inflammatory cytokine genes expression. In addition, 250 HCV patients na\u00efve for interferon treatment were also subjected to enzyme-linked immunosorbent Assay (ELISA) for their serum cytokine concentrations.\nRESULTS: Serum IL-17F concentrations were significantly elevated in HCV patients with severe fibrosis stages. In accordance with serum data, IL-17F expression was also found higher in HCV-associated HCC tissues compared with NBNC HCC tissues at both the mRNA and protein levels.\nCONCLUSIONS: Our data suggest that IL-17F might be used as a valuable biological marker than IL-17A during chronic fibrosis progression and HCC development in HCV patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13027-017-0152-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1037008", 
        "issn": [
          "1750-9378"
        ], 
        "name": "Infectious Agents and Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Interleukin-17F expression is elevated in hepatitis C patients with fibrosis and hepatocellular carcinoma", 
    "pagination": "42", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7cdb2a8df84c4cadea3d0ea8f8ff630193b600212e8fa058c8b297299c4176ae"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28770001"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101276559"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13027-017-0152-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1090897850"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13027-017-0152-7", 
      "https://app.dimensions.ai/details/publication/pub.1090897850"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89786_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13027-017-0152-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13027-017-0152-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13027-017-0152-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13027-017-0152-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13027-017-0152-7'


 

This table displays all metadata directly associated to this object as RDF triples.

240 TRIPLES      21 PREDICATES      65 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13027-017-0152-7 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N544ca8ef6c33444294b547adb7f65a9f
4 schema:citation sg:pub.10.1007/s10620-011-1997-z
5 sg:pub.10.1038/nature04753
6 https://doi.org/10.1002/hep.1840360710
7 https://doi.org/10.1002/hep.22680
8 https://doi.org/10.1002/hep.23291
9 https://doi.org/10.1006/meth.2001.1262
10 https://doi.org/10.1016/j.ccr.2009.01.001
11 https://doi.org/10.1016/j.coi.2006.05.003
12 https://doi.org/10.1016/j.immuni.2006.01.001
13 https://doi.org/10.1016/j.immuni.2008.11.009
14 https://doi.org/10.1016/j.immuni.2011.02.012
15 https://doi.org/10.1016/j.jaut.2008.04.017
16 https://doi.org/10.1016/j.jaut.2008.11.001
17 https://doi.org/10.1016/j.jhep.2008.12.033
18 https://doi.org/10.1016/j.jhep.2014.07.027
19 https://doi.org/10.1016/j.micinf.2009.04.003
20 https://doi.org/10.1016/s0168-8278(02)00429-4
21 https://doi.org/10.1053/j.gastro.2004.09.014
22 https://doi.org/10.1053/j.gastro.2012.05.049
23 https://doi.org/10.1074/jbc.m705100200
24 https://doi.org/10.1084/jem.20071978
25 https://doi.org/10.1084/jem.20072713
26 https://doi.org/10.1093/aje/155.4.323
27 https://doi.org/10.1097/md.0000000000003284
28 https://doi.org/10.1111/j.1440-1746.2011.06782.x
29 https://doi.org/10.1111/j.1600-065x.2008.00628.x
30 https://doi.org/10.1111/j.1872-034x.2007.00040.x
31 https://doi.org/10.1155/2011/345803
32 https://doi.org/10.1172/jci24282
33 https://doi.org/10.1371/journal.pone.0021359
34 https://doi.org/10.1371/journal.pone.0021816
35 https://doi.org/10.2144/03353bm03
36 https://doi.org/10.3748/wjg.v20.i32.11033
37 https://doi.org/10.4049/jimmunol.1203013
38 https://doi.org/10.4049/jimmunol.177.1.566
39 https://doi.org/10.4314/ahs.v15i3.3
40 schema:datePublished 2017-12
41 schema:datePublishedReg 2017-12-01
42 schema:description BACKGROUND: The role of interleukin (IL) 17A in chronic liver diseases had been extensively studied, but the function of IL-17F, which shares a high degree of homology with IL-17A, in the progression of chronic hepatic diseases is poorly understood. The aim of the study was to evaluate the association between IL-17F and liver diseases including, fibrosis and hepatocellular carcinoma (HCC). METHODS: Hepatic tumor samples from both hepatitis C virus (HCV) positive and negative patients (without HBV and HCV, NBNC) were examined with quantitative PCR and immunohistochemistry staining for inflammatory cytokine genes expression. In addition, 250 HCV patients naïve for interferon treatment were also subjected to enzyme-linked immunosorbent Assay (ELISA) for their serum cytokine concentrations. RESULTS: Serum IL-17F concentrations were significantly elevated in HCV patients with severe fibrosis stages. In accordance with serum data, IL-17F expression was also found higher in HCV-associated HCC tissues compared with NBNC HCC tissues at both the mRNA and protein levels. CONCLUSIONS: Our data suggest that IL-17F might be used as a valuable biological marker than IL-17A during chronic fibrosis progression and HCC development in HCV patients.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N32f058bc7be6457c8faf8192998332d9
47 N9dc1bc79852a4b3db04d06614d5a5a66
48 sg:journal.1037008
49 schema:name Interleukin-17F expression is elevated in hepatitis C patients with fibrosis and hepatocellular carcinoma
50 schema:pagination 42
51 schema:productId N16e8861b1edd4eb58f63402bf2c9ee2b
52 N3c6d36d7f66042878f3bbffa7b12be0b
53 N4fbabfc172dd4e7d997851dc151c824c
54 N54a3dbdb396845269683510ea97d9292
55 N6302331a545440dc86e823d168321447
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090897850
57 https://doi.org/10.1186/s13027-017-0152-7
58 schema:sdDatePublished 2019-04-11T09:50
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher Neda090e84e284d37ac37e895fd21a5c8
61 schema:url https://link.springer.com/10.1186%2Fs13027-017-0152-7
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N06fde5e79c7641a9bb254258e2ee67bc rdf:first sg:person.01067642670.20
66 rdf:rest rdf:nil
67 N109931cb00804fa58d0e5c33058a3987 rdf:first sg:person.01045101064.86
68 rdf:rest Nd8d64e12a4a94b70a5b20b424d18cfc8
69 N16e8861b1edd4eb58f63402bf2c9ee2b schema:name readcube_id
70 schema:value 7cdb2a8df84c4cadea3d0ea8f8ff630193b600212e8fa058c8b297299c4176ae
71 rdf:type schema:PropertyValue
72 N32f058bc7be6457c8faf8192998332d9 schema:issueNumber 1
73 rdf:type schema:PublicationIssue
74 N3c6d36d7f66042878f3bbffa7b12be0b schema:name nlm_unique_id
75 schema:value 101276559
76 rdf:type schema:PropertyValue
77 N4fbabfc172dd4e7d997851dc151c824c schema:name pubmed_id
78 schema:value 28770001
79 rdf:type schema:PropertyValue
80 N544ca8ef6c33444294b547adb7f65a9f rdf:first sg:person.0655756465.08
81 rdf:rest N9115e45c71f64d3cb045e9a224441fe0
82 N54a3dbdb396845269683510ea97d9292 schema:name doi
83 schema:value 10.1186/s13027-017-0152-7
84 rdf:type schema:PropertyValue
85 N592094e05bef4af9979bc56860056898 rdf:first sg:person.01240721675.64
86 rdf:rest Nf6d2dc217f13436ba36a24ce37b96148
87 N5a15a64d2ce64c088cad2a90e80b7365 rdf:first sg:person.0736546234.56
88 rdf:rest Nafd6f7e76cab4afaa38f8cb0d8bb53ca
89 N6302331a545440dc86e823d168321447 schema:name dimensions_id
90 schema:value pub.1090897850
91 rdf:type schema:PropertyValue
92 N9115e45c71f64d3cb045e9a224441fe0 rdf:first sg:person.0747062601.90
93 rdf:rest N5a15a64d2ce64c088cad2a90e80b7365
94 N9dc1bc79852a4b3db04d06614d5a5a66 schema:volumeNumber 12
95 rdf:type schema:PublicationVolume
96 Nafd6f7e76cab4afaa38f8cb0d8bb53ca rdf:first Nf77a643529e64d739a1f2b60a32b0a2a
97 rdf:rest N592094e05bef4af9979bc56860056898
98 Nd8d64e12a4a94b70a5b20b424d18cfc8 rdf:first sg:person.01326114534.20
99 rdf:rest N06fde5e79c7641a9bb254258e2ee67bc
100 Neda090e84e284d37ac37e895fd21a5c8 schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 Nf6d2dc217f13436ba36a24ce37b96148 rdf:first sg:person.013556067345.31
103 rdf:rest N109931cb00804fa58d0e5c33058a3987
104 Nf77a643529e64d739a1f2b60a32b0a2a schema:affiliation https://www.grid.ac/institutes/grid.410770.5
105 schema:familyName Yang
106 schema:givenName Hsuan-Ju
107 rdf:type schema:Person
108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
109 schema:name Medical and Health Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
112 schema:name Clinical Sciences
113 rdf:type schema:DefinedTerm
114 sg:journal.1037008 schema:issn 1750-9378
115 schema:name Infectious Agents and Cancer
116 rdf:type schema:Periodical
117 sg:person.01045101064.86 schema:affiliation https://www.grid.ac/institutes/grid.59784.37
118 schema:familyName Tsai
119 schema:givenName De-Jiun
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045101064.86
121 rdf:type schema:Person
122 sg:person.01067642670.20 schema:affiliation https://www.grid.ac/institutes/grid.64523.36
123 schema:familyName Yu
124 schema:givenName Guann-Yi
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067642670.20
126 rdf:type schema:Person
127 sg:person.01240721675.64 schema:affiliation https://www.grid.ac/institutes/grid.59784.37
128 schema:familyName Lo
129 schema:givenName Yin-Chiu
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240721675.64
131 rdf:type schema:Person
132 sg:person.01326114534.20 schema:affiliation https://www.grid.ac/institutes/grid.59784.37
133 schema:familyName Tsai
134 schema:givenName Wan-Ting
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326114534.20
136 rdf:type schema:Person
137 sg:person.013556067345.31 schema:affiliation https://www.grid.ac/institutes/grid.59784.37
138 schema:familyName Kuo
139 schema:givenName Yi-Ping
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013556067345.31
141 rdf:type schema:Person
142 sg:person.0655756465.08 schema:affiliation https://www.grid.ac/institutes/grid.59784.37
143 schema:familyName Wu
144 schema:givenName Ming-Sian
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655756465.08
146 rdf:type schema:Person
147 sg:person.0736546234.56 schema:affiliation https://www.grid.ac/institutes/grid.59784.37
148 schema:familyName Tseng
149 schema:givenName Fan-Chen
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736546234.56
151 rdf:type schema:Person
152 sg:person.0747062601.90 schema:affiliation https://www.grid.ac/institutes/grid.410770.5
153 schema:familyName Wang
154 schema:givenName Chun-Hsiang
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747062601.90
156 rdf:type schema:Person
157 sg:pub.10.1007/s10620-011-1997-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1019008049
158 https://doi.org/10.1007/s10620-011-1997-z
159 rdf:type schema:CreativeWork
160 sg:pub.10.1038/nature04753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037247321
161 https://doi.org/10.1038/nature04753
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1002/hep.1840360710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036634216
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1002/hep.22680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031353408
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1002/hep.23291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044561011
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1006/meth.2001.1262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027621591
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.ccr.2009.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000677027
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.coi.2006.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004052070
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/j.immuni.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009201806
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.immuni.2008.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019039197
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.immuni.2011.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007898556
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.jaut.2008.04.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035394013
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.jaut.2008.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041088665
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.jhep.2008.12.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033844841
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.jhep.2014.07.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053118987
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/j.micinf.2009.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012830261
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/s0168-8278(02)00429-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012389516
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1053/j.gastro.2004.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035011181
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1053/j.gastro.2012.05.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042801500
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1074/jbc.m705100200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047483488
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1084/jem.20071978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024795348
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1084/jem.20072713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021611842
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1093/aje/155.4.323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008526200
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1097/md.0000000000003284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005094568
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1111/j.1440-1746.2011.06782.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036019941
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1111/j.1600-065x.2008.00628.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000506483
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1111/j.1872-034x.2007.00040.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024242077
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1155/2011/345803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018321830
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1172/jci24282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006469641
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1371/journal.pone.0021359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052924649
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1371/journal.pone.0021816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011502390
220 rdf:type schema:CreativeWork
221 https://doi.org/10.2144/03353bm03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076572405
222 rdf:type schema:CreativeWork
223 https://doi.org/10.3748/wjg.v20.i32.11033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071371293
224 rdf:type schema:CreativeWork
225 https://doi.org/10.4049/jimmunol.1203013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078755172
226 rdf:type schema:CreativeWork
227 https://doi.org/10.4049/jimmunol.177.1.566 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040036581
228 rdf:type schema:CreativeWork
229 https://doi.org/10.4314/ahs.v15i3.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014937384
230 rdf:type schema:CreativeWork
231 https://www.grid.ac/institutes/grid.410770.5 schema:alternateName Tainan Municipal Hospital
232 schema:name Division of Gastroenterology, Tainan Municipal Hospital, 70173, Tainan, Taiwan
233 rdf:type schema:Organization
234 https://www.grid.ac/institutes/grid.59784.37 schema:alternateName National Health Research Institutes
235 schema:name National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.64523.36 schema:alternateName National Cheng Kung University
238 schema:name Center of Infectious Disease and Signaling Research, National Cheng-Kung University, 70101, Tainan, Taiwan
239 National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, 35053, Miaoli County, Taiwan
240 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...