Predictors of immune reconstitution inflammatory syndrome associated with Kaposi’s sarcoma: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Anna Maria Cattelan, Adriana Mattiolo, Angela Grassi, Maria Assunta Piano, Lolita Sasset, Marco Trevenzoli, Paola Zanovello, Maria Luisa Calabrò

ABSTRACT

We present here a case of immune reconstitution inflammatory syndrome associated with Kaposi's sarcoma (KS-IRIS) developed in an AIDS patient two months after initiation of antiretroviral therapy (ART). Baseline characteristics of this IRIS-KS case, within a cohort of 12 naïve AIDS-KS patients, were analyzed. No statistically significant differences in CD4 cell counts, plasma HIV RNA load, KS clinical staging, human herpesvirus 8 (HHV8) antibody titers and HHV8 load in peripheral blood mononuclear cells and saliva were evidenced. HHV8 load in plasma was found to be significantly higher in the KS-IRIS patient (> 6 log10 genome equivalents/ml, p = 0.01, t-test) compared to the 11 patients with KS regression. This case highlights that measurement of HHV8 load in plasma may be useful to identify patients at risk for KS-IRIS, and that this parameter should be included in the design of larger studies to define KS-IRIS risk predictors. More... »

PAGES

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13027-016-0051-3

DOI

http://dx.doi.org/10.1186/s13027-016-0051-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012338056

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26848307


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