Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, Yoshiaki Furukawa

ABSTRACT

BACKGROUND: Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) gene cause a familial form of amyotrophic lateral sclerosis (SOD1-ALS) with accumulation of misfolded SOD1 proteins as intracellular inclusions in spinal motor neurons. Oligomerization of SOD1 via abnormal disulfide crosslinks has been proposed as one of the misfolding pathways occurring in mutant SOD1; however, the pathological relevance of such oligomerization in the SOD1-ALS cases still remains obscure. METHODS: We prepared antibodies exclusively recognizing the SOD1 oligomers cross-linked via disulfide bonds in vitro. By using those antibodies, immunohistochemical examination and ELISA were mainly performed on the tissue samples of transgenic mice expressing mutant SOD1 proteins and also of human SOD1-ALS cases. RESULTS: We showed the recognition specificity of our antibodies exclusively toward the disulfide-crosslinked SOD1 oligomers by ELISA using various forms of purified SOD1 proteins in conformationally distinct states in vitro. Furthermore, the epitope of those antibodies was buried and inaccessible in the natively folded structure of SOD1. The antibodies were then found to specifically detect the pathological SOD1 species in the spinal motor neurons of the SOD1-ALS patients as well as the transgenic model mice. CONCLUSIONS: Our findings here suggest that the SOD1 oligomerization through the disulfide-crosslinking associates with exposure of the SOD1 structural interior and is a pathological process occurring in the SOD1-ALS cases. More... »

PAGES

2

References to SciGraph publications

  • 1996-05. Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury in NATURE GENETICS
  • 2014-11. The phenotypic variability of amyotrophic lateral sclerosis in NATURE REVIEWS NEUROLOGY
  • 2014-12. In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants in NATURE COMMUNICATIONS
  • 2011-11. Clinical genetics of amyotrophic lateral sclerosis: what do we really know? in NATURE REVIEWS NEUROLOGY
  • 2013-05. Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis in NATURE NEUROSCIENCE
  • 1993-03. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis in NATURE
  • 2007-06. An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS in NATURE MEDICINE
  • 2011-05. Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis in ACTA NEUROPATHOLOGICA
  • 1999-01. Slowing of axonal transport is a very early event in the toxicity of ALS–linked SOD1 mutants to motor neurons in NATURE NEUROSCIENCE
  • 2010-03. Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form in ACTA NEUROPATHOLOGICA
  • 2016-07. Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9 in SCIENTIFIC REPORTS
  • 2008-03. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis in NATURE NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13024-016-0145-9

    DOI

    http://dx.doi.org/10.1186/s13024-016-0145-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1006654931

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28057013


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