Economic burden and health-related quality of life in tenosynovial giant-cell tumour patients in Europe: an observational disease registry View Full Text


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Article Info

DATE

2021-07-02

AUTHORS

J. Lopez-Bastida, I. Aranda-Reneo, B. Rodríguez-Sánchez, L. M. Peña-Longobardo, X. Ye, P. Laeis, E. M. Fronk, E. Palmerini, A. Leithner, M. A. J. Van de Sande

ABSTRACT

BackgroundTenosynovial Giant-Cell Tumour (TGCT) is a benign clonal neoplastic proliferation arising from the synovium, causing a variety of symptoms and often requiring repetitive surgery. This study aims to define the economic burden—from a societal perspective—associated with TGCT patients and their health-related quality of life (HRQOL) in six European countries.MethodsThis article analyses data from a multinational, multicentre, prospective observational registry, the TGCT Observational Platform Project (TOPP), involving hospitals and tertiary sarcoma centres from six European countries (Austria, France, Germany, Italy, the Netherlands, and Spain). It includes information on TGCT patients’ health-related quality of life and healthcare and non-healthcare resources used at baseline (the 12-month period prior to the patients entering the registry) and after 12 months of follow-up.Results146 TGCT patients enrolled for the study, of which 137 fulfilled the inclusion criteria. Their mean age was 44.5 years, and 62% were female. The annual average total costs associated with TGCT were €4866 at baseline and €5160 at the 12-month follow-up visit. The annual average healthcare costs associated with TGCT were €4620 at baseline, of which 67% and 18% corresponded to surgery and medical visits, respectively. At the 12-month follow-up, the mean healthcare costs amounted to €5094, with surgery representing 70% of total costs. Loss of productivity represented, on average, 5% of the total cost at baseline and 1.3% at follow-up. The most-affected HRQOL dimensions, measured with the EQ-5D-5L instrument, were pain or discomfort, mobility, and the performance of usual activities, both at baseline and at the follow-up visit. Regarding HRQOL, patients declared a mean index score of 0.75 at baseline and 0.76 at the 12-month follow-up.ConclusionThe results suggest that TGCT places a heavy burden on its sufferers, which increases after one year of follow-up, mainly due to the healthcare resources required—in particular, surgical procedures. As a result, this condition has a high economic impact on healthcare budgets, while the HRQOL of TGCT patients substantially deteriorates over time. More... »

PAGES

294

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13023-021-01883-5

DOI

http://dx.doi.org/10.1186/s13023-021-01883-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1139345468

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34215312


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35 schema:description BackgroundTenosynovial Giant-Cell Tumour (TGCT) is a benign clonal neoplastic proliferation arising from the synovium, causing a variety of symptoms and often requiring repetitive surgery. This study aims to define the economic burden—from a societal perspective—associated with TGCT patients and their health-related quality of life (HRQOL) in six European countries.MethodsThis article analyses data from a multinational, multicentre, prospective observational registry, the TGCT Observational Platform Project (TOPP), involving hospitals and tertiary sarcoma centres from six European countries (Austria, France, Germany, Italy, the Netherlands, and Spain). It includes information on TGCT patients’ health-related quality of life and healthcare and non-healthcare resources used at baseline (the 12-month period prior to the patients entering the registry) and after 12 months of follow-up.Results146 TGCT patients enrolled for the study, of which 137 fulfilled the inclusion criteria. Their mean age was 44.5 years, and 62% were female. The annual average total costs associated with TGCT were €4866 at baseline and €5160 at the 12-month follow-up visit. The annual average healthcare costs associated with TGCT were €4620 at baseline, of which 67% and 18% corresponded to surgery and medical visits, respectively. At the 12-month follow-up, the mean healthcare costs amounted to €5094, with surgery representing 70% of total costs. Loss of productivity represented, on average, 5% of the total cost at baseline and 1.3% at follow-up. The most-affected HRQOL dimensions, measured with the EQ-5D-5L instrument, were pain or discomfort, mobility, and the performance of usual activities, both at baseline and at the follow-up visit. Regarding HRQOL, patients declared a mean index score of 0.75 at baseline and 0.76 at the 12-month follow-up.ConclusionThe results suggest that TGCT places a heavy burden on its sufferers, which increases after one year of follow-up, mainly due to the healthcare resources required—in particular, surgical procedures. As a result, this condition has a high economic impact on healthcare budgets, while the HRQOL of TGCT patients substantially deteriorates over time.
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41 schema:keywords Disease Registry
42 EQ-5D
43 Europe
44 European countries
45 HRQoL
46 HRQoL dimensions
47 MethodsThis article
48 TGCT
49 TGCT patients
50 activity
51 age
52 annual average total cost
53 article
54 average healthcare costs
55 average total cost
56 baseline
57 benign clonal neoplastic proliferation
58 budget
59 burden
60 center
61 clonal neoplastic proliferation
62 conditions
63 cost
64 countries
65 criteria
66 data
67 dimensions
68 discomfort
69 economic burden
70 economic impact
71 follow
72 giant cell tumor
73 giant-cell tumour patients
74 health-related quality
75 healthcare
76 healthcare budgets
77 healthcare costs
78 healthcare resources
79 heavy burden
80 high economic impact
81 hospital
82 impact
83 inclusion criteria
84 index score
85 information
86 instrument
87 life
88 loss
89 loss of productivity
90 mean age
91 mean healthcare costs
92 mean index score
93 medical visits
94 mobility
95 months
96 multicentre
97 neoplastic proliferation
98 non-healthcare resources
99 observational disease registry
100 observational registry
101 pain
102 patients
103 performance
104 platform project
105 procedure
106 productivity
107 project
108 proliferation
109 prospective observational registry
110 quality
111 registry
112 repetitive surgery
113 resources
114 results
115 sarcoma center
116 scores
117 study
118 sufferers
119 surgery
120 surgical procedures
121 symptoms
122 synovium
123 tertiary sarcoma centre
124 time
125 total cost
126 tumor patients
127 tumors
128 usual activities
129 variety
130 variety of symptoms
131 visits
132 years
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