Down-regulation of miR-9* in the peripheral leukocytes of Huntington’s disease patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Kuo-Hsuan Chang, Yih-Ru Wu, Chiung-Mei Chen

ABSTRACT

BACKGROUND: Huntington's disease (HD), caused by expansion of a polyglutamine tract within HUNTINGTIN (HTT) protein, is an autosomal dominant neurodegenerative disease associated with a progressive neurodegeneration of striatum and cerebral cortex. Although a few studies have identified substantial microRNA (miRNA) alterations in central nervous tissues from HD patients, it will be more accessible to employ these molecular changes in peripheral tissues as biomarkers for HD. METHODS: We examined the expression levels of 13 miRNAs (miR-1, mirR-9, miR-9*, miR-10b, miR-29a, miR-29b, miR-124a, miR-132, miR-155, miR-196a, miR-196b, miR-330 and miR-615), 10 of which previously demonstrated alterations and 3 of which are potential regulators of differentially-expressed genes in brains of HD patients, in the peripheral leukocytes of 36 HD patients, 8 pre-symptomatic HD carriers and 28 healthy controls. RESULTS: We found expression levels of miR-9* was significantly lower in HD patients compared with those in healthy controls, while other miRNAs did not show significant difference between these two groups. However, there was no significant correlation between Unified Huntington's Disease Rating Scales (UHDRS) and levels of miR-9* in peripheral leukocytes of HD patients. CONCLUSION: Our findings indicate the potential of miR-9* in peripheral leukocyte as a signature of neurodegeneration in HD patients. More... »

PAGES

185

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13023-017-0742-x

DOI

http://dx.doi.org/10.1186/s13023-017-0742-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099718938

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29258536


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Huntingtin Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Huntington Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chang", 
        "givenName": "Kuo-Hsuan", 
        "id": "sg:person.01345366440.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345366440.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Yih-Ru", 
        "id": "sg:person.010105624554.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010105624554.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chang Gung University", 
          "id": "https://www.grid.ac/institutes/grid.145695.a", 
          "name": [
            "Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Chiung-Mei", 
        "id": "sg:person.07637400054.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07637400054.41"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/gb-2004-5-3-r13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000703776", 
          "https://doi.org/10.1186/gb-2004-5-3-r13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000758199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2005.03985.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003793489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004126670", 
          "https://doi.org/10.1038/nrn2037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrn2037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004126670", 
          "https://doi.org/10.1038/nrn2037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12015-012-9411-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010497063", 
          "https://doi.org/10.1007/s12015-012-9411-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12015-012-9411-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010497063", 
          "https://doi.org/10.1007/s12015-012-9411-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0508448102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010654253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mds.870110204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011121612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12920-014-0060-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013359370", 
          "https://doi.org/10.1186/s12920-014-0060-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12920-014-0060-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013359370", 
          "https://doi.org/10.1186/s12920-014-0060-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2005-6-3-210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013626539", 
          "https://doi.org/10.1186/gb-2005-6-3-210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkn488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014661090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbi.2014.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014709884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90585-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016075278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0007936", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019708850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.277.5334.1990", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022495827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023682432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2390-08.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024253369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024945277", 
          "https://doi.org/10.1038/nature10323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024945277", 
          "https://doi.org/10.1038/nature10323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2007.05.093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026036156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pneurobio.2007.03.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026731452"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awl027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027277788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/rna.8.4.16019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029031629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12920-015-0083-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030836829", 
          "https://doi.org/10.1186/s12920-015-0083-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12920-015-0083-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030836829", 
          "https://doi.org/10.1186/s12920-015-0083-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1196/annals.1427.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031494030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.b.30223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033300405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.b.30223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033300405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034835522", 
          "https://doi.org/10.1038/13518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/13518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034835522", 
          "https://doi.org/10.1038/13518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20080178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035515725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddr111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035765888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1073858405280639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036407818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1073858405280639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036407818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1073858405280639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036407818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddg046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039296304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0046492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039323961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-013-1062-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042572621", 
          "https://doi.org/10.1007/s11064-013-1062-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.nbd.2007.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043558254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0511041103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046042632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awn212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046141397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048914481", 
          "https://doi.org/10.1038/ng1219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048914481", 
          "https://doi.org/10.1038/ng1219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbadis.2010.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049112410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049280395", 
          "https://doi.org/10.1038/nature08139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049280395", 
          "https://doi.org/10.1038/nature08139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049280395", 
          "https://doi.org/10.1038/nature08139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.2001.00689.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051142210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/pr0700753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056291531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wnr.0000127073.66692.8f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060332509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wnr.0000127073.66692.8f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060332509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.wnr.0000127073.66692.8f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060332509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0630-16.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067642751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/jad-2008-14103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077656852"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078391230", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Huntington's disease (HD), caused by expansion of a polyglutamine tract within HUNTINGTIN (HTT) protein, is an autosomal dominant neurodegenerative disease associated with a progressive neurodegeneration of striatum and cerebral cortex. Although a few studies have identified substantial microRNA (miRNA) alterations in central nervous tissues from HD patients, it will be more accessible to employ these molecular changes in peripheral tissues as biomarkers for HD.\nMETHODS: We examined the expression levels of 13 miRNAs (miR-1, mirR-9, miR-9*, miR-10b, miR-29a, miR-29b, miR-124a, miR-132, miR-155, miR-196a, miR-196b, miR-330 and miR-615), 10 of which previously demonstrated alterations and 3 of which are potential regulators of differentially-expressed genes in brains of HD patients, in the peripheral leukocytes of 36 HD patients, 8 pre-symptomatic HD carriers and 28 healthy controls.\nRESULTS: We found expression levels of miR-9* was significantly lower in HD patients compared with those in healthy controls, while other miRNAs did not show significant difference between these two groups. However, there was no significant correlation between Unified Huntington's Disease Rating Scales (UHDRS) and levels of miR-9* in peripheral leukocytes of HD patients.\nCONCLUSION: Our findings indicate the potential of miR-9* in peripheral leukocyte as a signature of neurodegeneration in HD patients.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13023-017-0742-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036535", 
        "issn": [
          "1750-1172"
        ], 
        "name": "Orphanet Journal of Rare Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Down-regulation of miR-9* in the peripheral leukocytes of Huntington\u2019s disease patients", 
    "pagination": "185", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "411999099df9b4e118fff7c14e475625bf16df464c0fbc902249d0b6ed230076"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29258536"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101266602"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13023-017-0742-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1099718938"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13023-017-0742-x", 
      "https://app.dimensions.ai/details/publication/pub.1099718938"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000502.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s13023-017-0742-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13023-017-0742-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13023-017-0742-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13023-017-0742-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13023-017-0742-x'


 

This table displays all metadata directly associated to this object as RDF triples.

261 TRIPLES      21 PREDICATES      82 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13023-017-0742-x schema:about N1a2122a58b5d4087b74de4034c4b5f57
2 N1e6e86219d244ff8ba4b88c0d0b51079
3 N7b9b2109dd68406d8b1cffa9e6f9e9b0
4 N91adc97f6acc437bb649819305ed0f7f
5 Na1783a458ce24c8b85c4f2ae3ea9295d
6 Na8cc86a0b2b44503abf69997f6c5266d
7 Nb1988da281874947be10565c46c1a15c
8 Nb3c79fdef2f244999580d46973b54302
9 Nbd7728aade394a6191d16560939a8df9
10 Ncdc49d9e592b4853b6908e65703d1f99
11 anzsrc-for:11
12 anzsrc-for:1109
13 schema:author Nc36bdaebb9e84e6cb105900bd4d6b75e
14 schema:citation sg:pub.10.1007/s11064-013-1062-8
15 sg:pub.10.1007/s12015-012-9411-6
16 sg:pub.10.1038/13518
17 sg:pub.10.1038/nature08139
18 sg:pub.10.1038/nature10323
19 sg:pub.10.1038/ng1219
20 sg:pub.10.1038/nrn2037
21 sg:pub.10.1186/gb-2004-5-3-r13
22 sg:pub.10.1186/gb-2005-6-3-210
23 sg:pub.10.1186/s12920-014-0060-2
24 sg:pub.10.1186/s12920-015-0083-3
25 https://app.dimensions.ai/details/publication/pub.1078391230
26 https://doi.org/10.1002/ajmg.b.30223
27 https://doi.org/10.1002/mds.870110204
28 https://doi.org/10.1016/0092-8674(93)90585-e
29 https://doi.org/10.1016/j.bbadis.2010.05.001
30 https://doi.org/10.1016/j.bbi.2014.09.011
31 https://doi.org/10.1016/j.bbrc.2007.05.093
32 https://doi.org/10.1016/j.cell.2009.01.002
33 https://doi.org/10.1016/j.nbd.2007.11.001
34 https://doi.org/10.1016/j.neuron.2011.11.010
35 https://doi.org/10.1016/j.pneurobio.2007.03.004
36 https://doi.org/10.1021/pr0700753
37 https://doi.org/10.1046/j.1471-4159.2001.00689.x
38 https://doi.org/10.1073/pnas.0508448102
39 https://doi.org/10.1073/pnas.0511041103
40 https://doi.org/10.1084/jem.20080178
41 https://doi.org/10.1093/brain/awl027
42 https://doi.org/10.1093/brain/awn212
43 https://doi.org/10.1093/hmg/ddg046
44 https://doi.org/10.1093/hmg/ddr111
45 https://doi.org/10.1093/nar/gkn488
46 https://doi.org/10.1097/01.wnr.0000127073.66692.8f
47 https://doi.org/10.1111/j.1460-9568.2005.03985.x
48 https://doi.org/10.1126/science.277.5334.1990
49 https://doi.org/10.1177/1073858405280639
50 https://doi.org/10.1196/annals.1427.008
51 https://doi.org/10.1371/journal.pone.0007936
52 https://doi.org/10.1371/journal.pone.0046492
53 https://doi.org/10.1523/jneurosci.0630-16.2016
54 https://doi.org/10.1523/jneurosci.2390-08.2008
55 https://doi.org/10.3233/jad-2008-14103
56 https://doi.org/10.4161/rna.8.4.16019
57 schema:datePublished 2017-12
58 schema:datePublishedReg 2017-12-01
59 schema:description BACKGROUND: Huntington's disease (HD), caused by expansion of a polyglutamine tract within HUNTINGTIN (HTT) protein, is an autosomal dominant neurodegenerative disease associated with a progressive neurodegeneration of striatum and cerebral cortex. Although a few studies have identified substantial microRNA (miRNA) alterations in central nervous tissues from HD patients, it will be more accessible to employ these molecular changes in peripheral tissues as biomarkers for HD. METHODS: We examined the expression levels of 13 miRNAs (miR-1, mirR-9, miR-9*, miR-10b, miR-29a, miR-29b, miR-124a, miR-132, miR-155, miR-196a, miR-196b, miR-330 and miR-615), 10 of which previously demonstrated alterations and 3 of which are potential regulators of differentially-expressed genes in brains of HD patients, in the peripheral leukocytes of 36 HD patients, 8 pre-symptomatic HD carriers and 28 healthy controls. RESULTS: We found expression levels of miR-9* was significantly lower in HD patients compared with those in healthy controls, while other miRNAs did not show significant difference between these two groups. However, there was no significant correlation between Unified Huntington's Disease Rating Scales (UHDRS) and levels of miR-9* in peripheral leukocytes of HD patients. CONCLUSION: Our findings indicate the potential of miR-9* in peripheral leukocyte as a signature of neurodegeneration in HD patients.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N4cc8e8d94100405ebbb6d554d521f1d9
64 Nd1e9a0f1d617459abd69d954049d610d
65 sg:journal.1036535
66 schema:name Down-regulation of miR-9* in the peripheral leukocytes of Huntington’s disease patients
67 schema:pagination 185
68 schema:productId N30863208f5d14a05a34450fe651ee3da
69 N41225e63d0614a689234daee99a19ec1
70 N66c25d46c3064d83a697e8321a3fa96d
71 N67804dc9c6d24440ae60d846e739ed29
72 Nda1360917eea4ff58569fb61a184ca23
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099718938
74 https://doi.org/10.1186/s13023-017-0742-x
75 schema:sdDatePublished 2019-04-10T21:34
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N821400a6503641fba7b2c356d98ddef5
78 schema:url http://link.springer.com/10.1186/s13023-017-0742-x
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N1a2122a58b5d4087b74de4034c4b5f57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Humans
84 rdf:type schema:DefinedTerm
85 N1e6e86219d244ff8ba4b88c0d0b51079 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Biomarkers
87 rdf:type schema:DefinedTerm
88 N30863208f5d14a05a34450fe651ee3da schema:name doi
89 schema:value 10.1186/s13023-017-0742-x
90 rdf:type schema:PropertyValue
91 N41225e63d0614a689234daee99a19ec1 schema:name pubmed_id
92 schema:value 29258536
93 rdf:type schema:PropertyValue
94 N4a931f3c39a14d11a7e6c3fb66f0baab rdf:first sg:person.07637400054.41
95 rdf:rest rdf:nil
96 N4cc8e8d94100405ebbb6d554d521f1d9 schema:volumeNumber 12
97 rdf:type schema:PublicationVolume
98 N66c25d46c3064d83a697e8321a3fa96d schema:name dimensions_id
99 schema:value pub.1099718938
100 rdf:type schema:PropertyValue
101 N67804dc9c6d24440ae60d846e739ed29 schema:name nlm_unique_id
102 schema:value 101266602
103 rdf:type schema:PropertyValue
104 N7b9b2109dd68406d8b1cffa9e6f9e9b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Female
106 rdf:type schema:DefinedTerm
107 N821400a6503641fba7b2c356d98ddef5 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N8ddf0eb51ada4f319922e3f9eaebe116 rdf:first sg:person.010105624554.23
110 rdf:rest N4a931f3c39a14d11a7e6c3fb66f0baab
111 N91adc97f6acc437bb649819305ed0f7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Middle Aged
113 rdf:type schema:DefinedTerm
114 Na1783a458ce24c8b85c4f2ae3ea9295d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Leukocytes
116 rdf:type schema:DefinedTerm
117 Na8cc86a0b2b44503abf69997f6c5266d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Huntingtin Protein
119 rdf:type schema:DefinedTerm
120 Nb1988da281874947be10565c46c1a15c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Male
122 rdf:type schema:DefinedTerm
123 Nb3c79fdef2f244999580d46973b54302 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Huntington Disease
125 rdf:type schema:DefinedTerm
126 Nbd7728aade394a6191d16560939a8df9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name MicroRNAs
128 rdf:type schema:DefinedTerm
129 Nc36bdaebb9e84e6cb105900bd4d6b75e rdf:first sg:person.01345366440.55
130 rdf:rest N8ddf0eb51ada4f319922e3f9eaebe116
131 Ncdc49d9e592b4853b6908e65703d1f99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Adult
133 rdf:type schema:DefinedTerm
134 Nd1e9a0f1d617459abd69d954049d610d schema:issueNumber 1
135 rdf:type schema:PublicationIssue
136 Nda1360917eea4ff58569fb61a184ca23 schema:name readcube_id
137 schema:value 411999099df9b4e118fff7c14e475625bf16df464c0fbc902249d0b6ed230076
138 rdf:type schema:PropertyValue
139 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
140 schema:name Medical and Health Sciences
141 rdf:type schema:DefinedTerm
142 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
143 schema:name Neurosciences
144 rdf:type schema:DefinedTerm
145 sg:journal.1036535 schema:issn 1750-1172
146 schema:name Orphanet Journal of Rare Diseases
147 rdf:type schema:Periodical
148 sg:person.010105624554.23 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
149 schema:familyName Wu
150 schema:givenName Yih-Ru
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010105624554.23
152 rdf:type schema:Person
153 sg:person.01345366440.55 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
154 schema:familyName Chang
155 schema:givenName Kuo-Hsuan
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345366440.55
157 rdf:type schema:Person
158 sg:person.07637400054.41 schema:affiliation https://www.grid.ac/institutes/grid.145695.a
159 schema:familyName Chen
160 schema:givenName Chiung-Mei
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07637400054.41
162 rdf:type schema:Person
163 sg:pub.10.1007/s11064-013-1062-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042572621
164 https://doi.org/10.1007/s11064-013-1062-8
165 rdf:type schema:CreativeWork
166 sg:pub.10.1007/s12015-012-9411-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010497063
167 https://doi.org/10.1007/s12015-012-9411-6
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/13518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034835522
170 https://doi.org/10.1038/13518
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/nature08139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049280395
173 https://doi.org/10.1038/nature08139
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/nature10323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024945277
176 https://doi.org/10.1038/nature10323
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/ng1219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048914481
179 https://doi.org/10.1038/ng1219
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nrn2037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004126670
182 https://doi.org/10.1038/nrn2037
183 rdf:type schema:CreativeWork
184 sg:pub.10.1186/gb-2004-5-3-r13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000703776
185 https://doi.org/10.1186/gb-2004-5-3-r13
186 rdf:type schema:CreativeWork
187 sg:pub.10.1186/gb-2005-6-3-210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013626539
188 https://doi.org/10.1186/gb-2005-6-3-210
189 rdf:type schema:CreativeWork
190 sg:pub.10.1186/s12920-014-0060-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013359370
191 https://doi.org/10.1186/s12920-014-0060-2
192 rdf:type schema:CreativeWork
193 sg:pub.10.1186/s12920-015-0083-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030836829
194 https://doi.org/10.1186/s12920-015-0083-3
195 rdf:type schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1078391230 schema:CreativeWork
197 https://doi.org/10.1002/ajmg.b.30223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033300405
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1002/mds.870110204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011121612
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/0092-8674(93)90585-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1016075278
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.bbadis.2010.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049112410
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.bbi.2014.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014709884
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.bbrc.2007.05.093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026036156
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.cell.2009.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023682432
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.nbd.2007.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043558254
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.neuron.2011.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000758199
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.pneurobio.2007.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026731452
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1021/pr0700753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056291531
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1046/j.1471-4159.2001.00689.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051142210
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1073/pnas.0508448102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010654253
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1073/pnas.0511041103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046042632
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1084/jem.20080178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035515725
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1093/brain/awl027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027277788
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/brain/awn212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046141397
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/hmg/ddg046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039296304
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1093/hmg/ddr111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035765888
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1093/nar/gkn488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014661090
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1097/01.wnr.0000127073.66692.8f schema:sameAs https://app.dimensions.ai/details/publication/pub.1060332509
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1111/j.1460-9568.2005.03985.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003793489
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1126/science.277.5334.1990 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022495827
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1177/1073858405280639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036407818
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1196/annals.1427.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031494030
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1371/journal.pone.0007936 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019708850
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1371/journal.pone.0046492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039323961
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1523/jneurosci.0630-16.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067642751
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1523/jneurosci.2390-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024253369
254 rdf:type schema:CreativeWork
255 https://doi.org/10.3233/jad-2008-14103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077656852
256 rdf:type schema:CreativeWork
257 https://doi.org/10.4161/rna.8.4.16019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029031629
258 rdf:type schema:CreativeWork
259 https://www.grid.ac/institutes/grid.145695.a schema:alternateName Chang Gung University
260 schema:name Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and College of Medicine, Chang Gung University, Taoyuan, Taiwan
261 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...