Everolimus safety and efficacy for renal angiomyolipomas associated with tuberous sclerosis complex: a Spanish expanded access trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Nicolás Roberto Robles, Ramón Peces, Álvaro Gómez-Ferrer, Felipe Villacampa, Jose Luis Álvarez-Ossorio, Pedro Pérez-Segura, Juan Morote, Bernardo Herrera-Imbroda, Javier Nieto, Joaquín Carballido, Urbano Anido, Marian Valero, Cristina Meseguer, Roser Torra

ABSTRACT

BACKGROUND: Renal angiomyolipomas (AML) are usual manifestations of tuberous sclerosis complex (TSC) that may cause aneurism-related haemorrhages and renal impairment. Everolimus has emerged as an alternative to surgery/embolization. We provide further insight into everolimus safety and efficacy for TSC-related AML. METHODS: This was a Spanish expanded access trial including patients aged ≥18 years with TSC-related AML. They received 10 mg everolimus once daily until AML progression, unacceptable toxicity, death/withdrawal, commercialisation for TSC-related AML, or 1 year after first patient enrolment. The primary outcome was dose-limiting safety according to grade 3/4 adverse events, serious adverse events, or adverse events leading to treatment modification. Secondary outcomes included overall safety and efficacy. RESULTS: Nineteen patients were enrolled and received everolimus for a median of 6.6 (5.3-10.9) months. Eleven (57.9 %) remained on 10 mg/day throughout the study and eight (42.1 %) required treatment modifications due to adverse events; none permanently discontinued treatment. Adverse events were overall grade 1/2 and most frequently included aphthous stomatitis/mucosal inflammation, hypercholesterolaemia/hypertriglyceridaemia, urinary tract infection, hypertension, dermatitis acneiform, and insomnia. Four (21.1 %) patients experienced grade 3 adverse events, none was grade 4, and only one (5.3 %) was serious (pneumonia). AML volume was reduced ≥30 % in 11 (57.9 %) patients and ≥50 % in 9 (47.4 %); none progressed. Right and left kidney sizes decreased in 16 and 14 patients, respectively. CONCLUSIONS: These findings support the benefit of everolimus for renal AML due to a manageable safety profile accompanied by reduced AML and kidney volumes. TRIAL REGISTRATION: EudraCT number 2012-005397-63 ; date of registration 22 Nov 2012. More... »

PAGES

128

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13023-016-0517-9

DOI

http://dx.doi.org/10.1186/s13023-016-0517-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041836240

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27669821


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Infanta Cristina", 
          "id": "https://www.grid.ac/institutes/grid.411319.f", 
          "name": [
            "Department of Nephrology, Hospital Universitario Infanta Cristina, REDINREN, Avenida de Elvas, S/N, 06006, Badajoz, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robles", 
        "givenName": "Nicol\u00e1s Roberto", 
        "id": "sg:person.0625461101.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625461101.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario La Paz", 
          "id": "https://www.grid.ac/institutes/grid.81821.32", 
          "name": [
            "Department of Nephrology, Hospital Universitario La Paz, REDINREN, Paseo de la Castellana, 261, 28046, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peces", 
        "givenName": "Ram\u00f3n", 
        "id": "sg:person.01036335316.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036335316.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fundaci\u00f3n Instituto Valenciano de Oncolog\u00eda", 
          "id": "https://www.grid.ac/institutes/grid.418082.7", 
          "name": [
            "Department of Urology, Instituto Valenciano de Oncolog\u00eda, Calle del Profesor Beltr\u00e1n B\u00e0guena, 8, 46009, Valencia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00f3mez-Ferrer", 
        "givenName": "\u00c1lvaro", 
        "id": "sg:person.0772152402.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772152402.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario 12 De Octubre", 
          "id": "https://www.grid.ac/institutes/grid.144756.5", 
          "name": [
            "Department of Urology, Hospital Universitario 12 de Octubre, Avenida de C\u00f3rdoba, S/N, 28041, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Villacampa", 
        "givenName": "Felipe", 
        "id": "sg:person.0742020243.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742020243.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta del Mar", 
          "id": "https://www.grid.ac/institutes/grid.411342.1", 
          "name": [
            "Department of Urology, Hospital Universitario Puerta del Mar, Avenida Ana Viya, 21, 11009, C\u00e1diz, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "\u00c1lvarez-Ossorio", 
        "givenName": "Jose Luis", 
        "id": "sg:person.01215272604.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215272604.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Cl\u00ednico San Carlos", 
          "id": "https://www.grid.ac/institutes/grid.411068.a", 
          "name": [
            "Department of Oncology, Hospital Universitario Cl\u00ednico San Carlos, Calle del Profesor Mart\u00edn Lagos, S/N, 28040, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "P\u00e9rez-Segura", 
        "givenName": "Pedro", 
        "id": "sg:person.01102527274.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102527274.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitari Vall d'Hebron", 
          "id": "https://www.grid.ac/institutes/grid.411083.f", 
          "name": [
            "Department of Urology, Hospital Universitario Vall d\u2019Hebron, Paseo de la Vall d\u2019Hebron, 119-129, 08035, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morote", 
        "givenName": "Juan", 
        "id": "sg:person.0737214022.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737214022.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Urology, Hospital Universitario Virgen de la Victoria, Campus de Teatinos, S/N, 29010, M\u00e1laga, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Herrera-Imbroda", 
        "givenName": "Bernardo", 
        "id": "sg:person.01312340333.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312340333.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital General Universitario de Ciudad Real", 
          "id": "https://www.grid.ac/institutes/grid.411096.b", 
          "name": [
            "Department of Nephrology, Hospital General Universitario de Ciudad Real, Calle del Obispo Rafael Torija, S/N, 13005, Ciudad Real, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nieto", 
        "givenName": "Javier", 
        "id": "sg:person.01014652707.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014652707.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario Puerta de Hierro Majadahonda", 
          "id": "https://www.grid.ac/institutes/grid.73221.35", 
          "name": [
            "Department of Urology, Hospital Universitario Puerta de Hierro Majadahonda, Calle de Manuel de Falla, 1, 28222, Majadahonda, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carballido", 
        "givenName": "Joaqu\u00edn", 
        "id": "sg:person.01153763300.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153763300.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Complejo Hospitalario Universitario de Santiago", 
          "id": "https://www.grid.ac/institutes/grid.411048.8", 
          "name": [
            "Department of Oncology, Hospital Cl\u00ednico Universitario de Santiago de Compostela, Traves\u00eda de Choupana, S/N, 15706, Santiago de Compostela, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Anido", 
        "givenName": "Urbano", 
        "id": "sg:person.01277421642.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277421642.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Spain)", 
          "id": "https://www.grid.ac/institutes/grid.476612.0", 
          "name": [
            "Department of Medical Affairs, Novartis Farmac\u00e9utica S.A, Gran Via de les Corts Catalanes, 764, 08013, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valero", 
        "givenName": "Marian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Novartis (Spain)", 
          "id": "https://www.grid.ac/institutes/grid.476612.0", 
          "name": [
            "Department of Medical Affairs, Novartis Farmac\u00e9utica S.A, Gran Via de les Corts Catalanes, 764, 08013, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meseguer", 
        "givenName": "Cristina", 
        "id": "sg:person.012351542501.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012351542501.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Inherited Renal Diseases, Department of Nephrology, Fundaci\u00f3 Puigvert, REDINREN, IIB Sant Pau, Universitat Aut\u00f3noma de Barcelona, Cartagena, 340-350, 08025, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Torra", 
        "givenName": "Roser", 
        "id": "sg:person.01343055165.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343055165.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1111/j.1523-1755.2004.00838.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000003474", 
          "https://doi.org/10.1111/j.1523-1755.2004.00838.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/gfu013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007940610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000350625", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009419063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/088307389801301206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012252699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/088307389801301206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012252699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)61134-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019518465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddi260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021611245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddi260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021611245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-4632.2010.04727.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024763775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-4632.2010.04727.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024763775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1001671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029275718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1750-1172-7-87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030118237", 
          "https://doi.org/10.1186/1750-1172-7-87"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.57.5.662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030501846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(05)64440-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038817341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pediatrneurol.2013.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039003462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1378/chest.14-3095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039621157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.ajkd.2015.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042462028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5201402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043778575", 
          "https://doi.org/10.1038/sj.ejhg.5201402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5201402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043778575", 
          "https://doi.org/10.1038/sj.ejhg.5201402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)61767-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047847005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/bcp.12834", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049738964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.1994.00540130110018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050375025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/316951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058621890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ndt/gfv249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059933146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182815428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182815428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182815428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3182815428", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064357524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1684/bdc.2008.0767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077824622"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-12", 
    "datePublishedReg": "2016-12-01", 
    "description": "BACKGROUND: Renal angiomyolipomas (AML) are usual manifestations of tuberous sclerosis complex (TSC) that may cause aneurism-related haemorrhages and renal impairment. Everolimus has emerged as an alternative to surgery/embolization. We provide further insight into everolimus safety and efficacy for TSC-related AML.\nMETHODS: This was a Spanish expanded access trial including patients aged \u226518\u00a0years with TSC-related AML. They received 10\u00a0mg everolimus once daily until AML progression, unacceptable toxicity, death/withdrawal, commercialisation for TSC-related AML, or 1\u00a0year after first patient enrolment. The primary outcome was dose-limiting safety according to grade 3/4 adverse events, serious adverse events, or adverse events leading to treatment modification. Secondary outcomes included overall safety and efficacy.\nRESULTS: Nineteen patients were enrolled and received everolimus for a median of 6.6 (5.3-10.9) months. Eleven (57.9\u00a0%) remained on 10\u00a0mg/day throughout the study and eight (42.1\u00a0%) required treatment modifications due to adverse events; none permanently discontinued treatment. Adverse events were overall grade 1/2 and most frequently included aphthous stomatitis/mucosal inflammation, hypercholesterolaemia/hypertriglyceridaemia, urinary tract infection, hypertension, dermatitis acneiform, and insomnia. Four (21.1\u00a0%) patients experienced grade 3 adverse events, none was grade 4, and only one (5.3\u00a0%) was serious (pneumonia). AML volume was reduced \u226530\u00a0% in 11 (57.9\u00a0%) patients and \u226550\u00a0% in 9 (47.4\u00a0%); none progressed. Right and left kidney sizes decreased in 16 and 14 patients, respectively.\nCONCLUSIONS: These findings support the benefit of everolimus for renal AML due to a manageable safety profile accompanied by reduced AML and kidney volumes.\nTRIAL REGISTRATION: EudraCT number 2012-005397-63 ; date of registration 22 Nov 2012.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13023-016-0517-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036535", 
        "issn": [
          "1750-1172"
        ], 
        "name": "Orphanet Journal of Rare Diseases", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Everolimus safety and efficacy for renal angiomyolipomas associated with tuberous sclerosis complex: a Spanish expanded access trial", 
    "pagination": "128", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c749f359bce5b6a2449a08a917b28e201604c98bbe2cd0e24ab17ba260585ba5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27669821"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101266602"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13023-016-0517-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1041836240"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13023-016-0517-9", 
      "https://app.dimensions.ai/details/publication/pub.1041836240"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70046_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13023-016-0517-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13023-016-0517-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13023-016-0517-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13023-016-0517-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13023-016-0517-9'


 

This table displays all metadata directly associated to this object as RDF triples.

261 TRIPLES      21 PREDICATES      51 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13023-016-0517-9 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N8b3ee117773840548d15198492601db3
4 schema:citation sg:pub.10.1038/sj.ejhg.5201402
5 sg:pub.10.1111/j.1523-1755.2004.00838.x
6 sg:pub.10.1186/1750-1172-7-87
7 https://doi.org/10.1001/archneur.1994.00540130110018
8 https://doi.org/10.1001/archneur.57.5.662
9 https://doi.org/10.1016/j.pediatrneurol.2013.08.002
10 https://doi.org/10.1016/s0022-5347(05)64440-0
11 https://doi.org/10.1016/s0140-6736(12)61134-9
12 https://doi.org/10.1016/s0140-6736(12)61767-x
13 https://doi.org/10.1053/j.ajkd.2015.05.016
14 https://doi.org/10.1056/nejmoa1001671
15 https://doi.org/10.1086/316951
16 https://doi.org/10.1093/hmg/ddi260
17 https://doi.org/10.1093/ndt/gfu013
18 https://doi.org/10.1093/ndt/gfv249
19 https://doi.org/10.1111/bcp.12834
20 https://doi.org/10.1111/j.1365-4632.2010.04727.x
21 https://doi.org/10.1159/000350625
22 https://doi.org/10.1177/088307389801301206
23 https://doi.org/10.1212/wnl.0b013e3182815428
24 https://doi.org/10.1378/chest.14-3095
25 https://doi.org/10.1684/bdc.2008.0767
26 schema:datePublished 2016-12
27 schema:datePublishedReg 2016-12-01
28 schema:description BACKGROUND: Renal angiomyolipomas (AML) are usual manifestations of tuberous sclerosis complex (TSC) that may cause aneurism-related haemorrhages and renal impairment. Everolimus has emerged as an alternative to surgery/embolization. We provide further insight into everolimus safety and efficacy for TSC-related AML. METHODS: This was a Spanish expanded access trial including patients aged ≥18 years with TSC-related AML. They received 10 mg everolimus once daily until AML progression, unacceptable toxicity, death/withdrawal, commercialisation for TSC-related AML, or 1 year after first patient enrolment. The primary outcome was dose-limiting safety according to grade 3/4 adverse events, serious adverse events, or adverse events leading to treatment modification. Secondary outcomes included overall safety and efficacy. RESULTS: Nineteen patients were enrolled and received everolimus for a median of 6.6 (5.3-10.9) months. Eleven (57.9 %) remained on 10 mg/day throughout the study and eight (42.1 %) required treatment modifications due to adverse events; none permanently discontinued treatment. Adverse events were overall grade 1/2 and most frequently included aphthous stomatitis/mucosal inflammation, hypercholesterolaemia/hypertriglyceridaemia, urinary tract infection, hypertension, dermatitis acneiform, and insomnia. Four (21.1 %) patients experienced grade 3 adverse events, none was grade 4, and only one (5.3 %) was serious (pneumonia). AML volume was reduced ≥30 % in 11 (57.9 %) patients and ≥50 % in 9 (47.4 %); none progressed. Right and left kidney sizes decreased in 16 and 14 patients, respectively. CONCLUSIONS: These findings support the benefit of everolimus for renal AML due to a manageable safety profile accompanied by reduced AML and kidney volumes. TRIAL REGISTRATION: EudraCT number 2012-005397-63 ; date of registration 22 Nov 2012.
29 schema:genre research_article
30 schema:inLanguage en
31 schema:isAccessibleForFree true
32 schema:isPartOf N5a061773da0b4e1185ff635b0b51f183
33 Nf278481d988a4ea7b9b8ac9725c133ee
34 sg:journal.1036535
35 schema:name Everolimus safety and efficacy for renal angiomyolipomas associated with tuberous sclerosis complex: a Spanish expanded access trial
36 schema:pagination 128
37 schema:productId N1b63bdd0cd784615bcf0e3353e6a7b36
38 N7eba8ce130a04a23a492a6522b36984b
39 Nb1bdd4d5834e4d76bff09e020bc4e79f
40 Ne86726114f2842418331b6e588eceace
41 Nfca1dfe8ed7d4e7bb371076e8f418b9a
42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041836240
43 https://doi.org/10.1186/s13023-016-0517-9
44 schema:sdDatePublished 2019-04-11T12:39
45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
46 schema:sdPublisher Na5626d8c9f9746dbb0faf50514a7582b
47 schema:url https://link.springer.com/10.1186%2Fs13023-016-0517-9
48 sgo:license sg:explorer/license/
49 sgo:sdDataset articles
50 rdf:type schema:ScholarlyArticle
51 N08e43ff196014c2698e1a4b1a1e9399b schema:affiliation https://www.grid.ac/institutes/grid.476612.0
52 schema:familyName Valero
53 schema:givenName Marian
54 rdf:type schema:Person
55 N09501f3b09ef46f4b912218482a7a696 rdf:first sg:person.0737214022.52
56 rdf:rest N2c4a7419534845e591bf301b9c9cf6ea
57 N0a54d857f64944ed8c36005d47a73b14 rdf:first sg:person.01014652707.13
58 rdf:rest N0ba3fe1950684e2896bab4f4a3ac76c8
59 N0ba3fe1950684e2896bab4f4a3ac76c8 rdf:first sg:person.01153763300.19
60 rdf:rest Nadcf322213c84aa8af5c373e2c964758
61 N1862edaa9f2c45ee88d5fe666d6281bc rdf:first sg:person.01102527274.29
62 rdf:rest N09501f3b09ef46f4b912218482a7a696
63 N1b63bdd0cd784615bcf0e3353e6a7b36 schema:name readcube_id
64 schema:value c749f359bce5b6a2449a08a917b28e201604c98bbe2cd0e24ab17ba260585ba5
65 rdf:type schema:PropertyValue
66 N2c4a7419534845e591bf301b9c9cf6ea rdf:first sg:person.01312340333.23
67 rdf:rest N0a54d857f64944ed8c36005d47a73b14
68 N3477721daf1b455fa6357020f63bb21e rdf:first N08e43ff196014c2698e1a4b1a1e9399b
69 rdf:rest N5770b8235f1c4e73b5039d9fd6c4ce1b
70 N5770b8235f1c4e73b5039d9fd6c4ce1b rdf:first sg:person.012351542501.12
71 rdf:rest N7fbbd9b111e84879a51c5a2bd987a1b7
72 N5a061773da0b4e1185ff635b0b51f183 schema:issueNumber 1
73 rdf:type schema:PublicationIssue
74 N5e722ea966d44c518610e90656c25c37 schema:name Inherited Renal Diseases, Department of Nephrology, Fundació Puigvert, REDINREN, IIB Sant Pau, Universitat Autónoma de Barcelona, Cartagena, 340-350, 08025, Barcelona, Spain
75 rdf:type schema:Organization
76 N780bcb397e8e4e41880478e8cc0bf532 schema:name Department of Urology, Hospital Universitario Virgen de la Victoria, Campus de Teatinos, S/N, 29010, Málaga, Spain
77 rdf:type schema:Organization
78 N7eba8ce130a04a23a492a6522b36984b schema:name nlm_unique_id
79 schema:value 101266602
80 rdf:type schema:PropertyValue
81 N7fbbd9b111e84879a51c5a2bd987a1b7 rdf:first sg:person.01343055165.74
82 rdf:rest rdf:nil
83 N8b3ee117773840548d15198492601db3 rdf:first sg:person.0625461101.53
84 rdf:rest Neb504ec136844fabada19943476292a0
85 Na12576f77d0b4477901198199902eaf4 rdf:first sg:person.0742020243.95
86 rdf:rest Ne2f8be24fad54930bb587d36b1145828
87 Na5626d8c9f9746dbb0faf50514a7582b schema:name Springer Nature - SN SciGraph project
88 rdf:type schema:Organization
89 Nadcf322213c84aa8af5c373e2c964758 rdf:first sg:person.01277421642.37
90 rdf:rest N3477721daf1b455fa6357020f63bb21e
91 Nb0a6b51add9043f3a652056d242c24c2 rdf:first sg:person.0772152402.65
92 rdf:rest Na12576f77d0b4477901198199902eaf4
93 Nb1bdd4d5834e4d76bff09e020bc4e79f schema:name dimensions_id
94 schema:value pub.1041836240
95 rdf:type schema:PropertyValue
96 Ne2f8be24fad54930bb587d36b1145828 rdf:first sg:person.01215272604.26
97 rdf:rest N1862edaa9f2c45ee88d5fe666d6281bc
98 Ne86726114f2842418331b6e588eceace schema:name pubmed_id
99 schema:value 27669821
100 rdf:type schema:PropertyValue
101 Neb504ec136844fabada19943476292a0 rdf:first sg:person.01036335316.64
102 rdf:rest Nb0a6b51add9043f3a652056d242c24c2
103 Nf278481d988a4ea7b9b8ac9725c133ee schema:volumeNumber 11
104 rdf:type schema:PublicationVolume
105 Nfca1dfe8ed7d4e7bb371076e8f418b9a schema:name doi
106 schema:value 10.1186/s13023-016-0517-9
107 rdf:type schema:PropertyValue
108 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
109 schema:name Medical and Health Sciences
110 rdf:type schema:DefinedTerm
111 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
112 schema:name Clinical Sciences
113 rdf:type schema:DefinedTerm
114 sg:journal.1036535 schema:issn 1750-1172
115 schema:name Orphanet Journal of Rare Diseases
116 rdf:type schema:Periodical
117 sg:person.01014652707.13 schema:affiliation https://www.grid.ac/institutes/grid.411096.b
118 schema:familyName Nieto
119 schema:givenName Javier
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014652707.13
121 rdf:type schema:Person
122 sg:person.01036335316.64 schema:affiliation https://www.grid.ac/institutes/grid.81821.32
123 schema:familyName Peces
124 schema:givenName Ramón
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036335316.64
126 rdf:type schema:Person
127 sg:person.01102527274.29 schema:affiliation https://www.grid.ac/institutes/grid.411068.a
128 schema:familyName Pérez-Segura
129 schema:givenName Pedro
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102527274.29
131 rdf:type schema:Person
132 sg:person.01153763300.19 schema:affiliation https://www.grid.ac/institutes/grid.73221.35
133 schema:familyName Carballido
134 schema:givenName Joaquín
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153763300.19
136 rdf:type schema:Person
137 sg:person.01215272604.26 schema:affiliation https://www.grid.ac/institutes/grid.411342.1
138 schema:familyName Álvarez-Ossorio
139 schema:givenName Jose Luis
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215272604.26
141 rdf:type schema:Person
142 sg:person.012351542501.12 schema:affiliation https://www.grid.ac/institutes/grid.476612.0
143 schema:familyName Meseguer
144 schema:givenName Cristina
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012351542501.12
146 rdf:type schema:Person
147 sg:person.01277421642.37 schema:affiliation https://www.grid.ac/institutes/grid.411048.8
148 schema:familyName Anido
149 schema:givenName Urbano
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277421642.37
151 rdf:type schema:Person
152 sg:person.01312340333.23 schema:affiliation N780bcb397e8e4e41880478e8cc0bf532
153 schema:familyName Herrera-Imbroda
154 schema:givenName Bernardo
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312340333.23
156 rdf:type schema:Person
157 sg:person.01343055165.74 schema:affiliation N5e722ea966d44c518610e90656c25c37
158 schema:familyName Torra
159 schema:givenName Roser
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343055165.74
161 rdf:type schema:Person
162 sg:person.0625461101.53 schema:affiliation https://www.grid.ac/institutes/grid.411319.f
163 schema:familyName Robles
164 schema:givenName Nicolás Roberto
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625461101.53
166 rdf:type schema:Person
167 sg:person.0737214022.52 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
168 schema:familyName Morote
169 schema:givenName Juan
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737214022.52
171 rdf:type schema:Person
172 sg:person.0742020243.95 schema:affiliation https://www.grid.ac/institutes/grid.144756.5
173 schema:familyName Villacampa
174 schema:givenName Felipe
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742020243.95
176 rdf:type schema:Person
177 sg:person.0772152402.65 schema:affiliation https://www.grid.ac/institutes/grid.418082.7
178 schema:familyName Gómez-Ferrer
179 schema:givenName Álvaro
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772152402.65
181 rdf:type schema:Person
182 sg:pub.10.1038/sj.ejhg.5201402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043778575
183 https://doi.org/10.1038/sj.ejhg.5201402
184 rdf:type schema:CreativeWork
185 sg:pub.10.1111/j.1523-1755.2004.00838.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000003474
186 https://doi.org/10.1111/j.1523-1755.2004.00838.x
187 rdf:type schema:CreativeWork
188 sg:pub.10.1186/1750-1172-7-87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030118237
189 https://doi.org/10.1186/1750-1172-7-87
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1001/archneur.1994.00540130110018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050375025
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1001/archneur.57.5.662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030501846
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/j.pediatrneurol.2013.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039003462
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s0022-5347(05)64440-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038817341
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0140-6736(12)61134-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019518465
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s0140-6736(12)61767-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047847005
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1053/j.ajkd.2015.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042462028
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1056/nejmoa1001671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029275718
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1086/316951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058621890
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1093/hmg/ddi260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021611245
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1093/ndt/gfu013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007940610
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1093/ndt/gfv249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059933146
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1111/bcp.12834 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049738964
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/j.1365-4632.2010.04727.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024763775
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1159/000350625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009419063
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1177/088307389801301206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012252699
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1212/wnl.0b013e3182815428 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064357524
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1378/chest.14-3095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039621157
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1684/bdc.2008.0767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077824622
228 rdf:type schema:CreativeWork
229 https://www.grid.ac/institutes/grid.144756.5 schema:alternateName Hospital Universitario 12 De Octubre
230 schema:name Department of Urology, Hospital Universitario 12 de Octubre, Avenida de Córdoba, S/N, 28041, Madrid, Spain
231 rdf:type schema:Organization
232 https://www.grid.ac/institutes/grid.411048.8 schema:alternateName Complejo Hospitalario Universitario de Santiago
233 schema:name Department of Oncology, Hospital Clínico Universitario de Santiago de Compostela, Travesía de Choupana, S/N, 15706, Santiago de Compostela, Spain
234 rdf:type schema:Organization
235 https://www.grid.ac/institutes/grid.411068.a schema:alternateName Hospital Clínico San Carlos
236 schema:name Department of Oncology, Hospital Universitario Clínico San Carlos, Calle del Profesor Martín Lagos, S/N, 28040, Madrid, Spain
237 rdf:type schema:Organization
238 https://www.grid.ac/institutes/grid.411083.f schema:alternateName Hospital Universitari Vall d'Hebron
239 schema:name Department of Urology, Hospital Universitario Vall d’Hebron, Paseo de la Vall d’Hebron, 119-129, 08035, Barcelona, Spain
240 rdf:type schema:Organization
241 https://www.grid.ac/institutes/grid.411096.b schema:alternateName Hospital General Universitario de Ciudad Real
242 schema:name Department of Nephrology, Hospital General Universitario de Ciudad Real, Calle del Obispo Rafael Torija, S/N, 13005, Ciudad Real, Spain
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.411319.f schema:alternateName Hospital Universitario Infanta Cristina
245 schema:name Department of Nephrology, Hospital Universitario Infanta Cristina, REDINREN, Avenida de Elvas, S/N, 06006, Badajoz, Spain
246 rdf:type schema:Organization
247 https://www.grid.ac/institutes/grid.411342.1 schema:alternateName Hospital Universitario Puerta del Mar
248 schema:name Department of Urology, Hospital Universitario Puerta del Mar, Avenida Ana Viya, 21, 11009, Cádiz, Spain
249 rdf:type schema:Organization
250 https://www.grid.ac/institutes/grid.418082.7 schema:alternateName Fundación Instituto Valenciano de Oncología
251 schema:name Department of Urology, Instituto Valenciano de Oncología, Calle del Profesor Beltrán Bàguena, 8, 46009, Valencia, Spain
252 rdf:type schema:Organization
253 https://www.grid.ac/institutes/grid.476612.0 schema:alternateName Novartis (Spain)
254 schema:name Department of Medical Affairs, Novartis Farmacéutica S.A, Gran Via de les Corts Catalanes, 764, 08013, Barcelona, Spain
255 rdf:type schema:Organization
256 https://www.grid.ac/institutes/grid.73221.35 schema:alternateName Hospital Universitario Puerta de Hierro Majadahonda
257 schema:name Department of Urology, Hospital Universitario Puerta de Hierro Majadahonda, Calle de Manuel de Falla, 1, 28222, Majadahonda, Spain
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.81821.32 schema:alternateName Hospital Universitario La Paz
260 schema:name Department of Nephrology, Hospital Universitario La Paz, REDINREN, Paseo de la Castellana, 261, 28046, Madrid, Spain
261 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...