The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation View Full Text


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Article Info

DATE

2019-12

AUTHORS

Haichao Xu, Abudumailamu Abuduwufuer, Wang Lv, Zhenyu Zhou, Yunhai Yang, Chong Zhang, Jian Hu

ABSTRACT

BACKGROUND: Graft function may be affected if the organ is exposed to hypoxia. We hypothesized that bronchiolitis obliterans (BO) after lung transplantation is associated with hypoxia-inducible factor-1α (HIF-1α). This study compares the expression of HIF-1α and its downstream proteins in allograft and isograft to explore the relationship between this pathway and BO in rats. MATERIAL AND METHODS: We performed an orthotopic left pulmonary transplant model using the tri-cuff vascular anastomosis method and evaluated the histopathology, including the severity of fibrosis (SF). The expression of HIF-1α, VEGF-A, and VEGFR-2 was accessed by immunohistochemistry. RESULTS: The imageology and pathology showed that the allogenic model developed BO 90 days after the operation. The percentages of a high expression of HIF-1α, VEGF-A, and VEGFR-2 in the allogeneic group were 77.27, 63.64, and 68.18% higher than in the isogeneic group, respectively. The SF score was highest in the allograft and was positively correlated with the expression of the proteins. CONCLUSION: This model can simulate human BO after lung transplantation. The expression of HIF-1α and its downstream proteins in post-transplantation was up-regulated, suggesting that activation of the HIF-1α-VEGF pathway might be involved in the occurrence and prognosis of BO. More... »

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27

References to SciGraph publications

  • 2004-09. Angiogenesis and organ transplantation in FOLIA MICROBIOLOGICA
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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30696477


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        "description": "BACKGROUND: Graft function may be affected if the organ is exposed to hypoxia. We hypothesized that bronchiolitis obliterans (BO) after lung transplantation is associated with hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1). This study compares the expression of HIF-1\u03b1 and its downstream proteins in allograft and isograft to explore the relationship between this pathway and BO in rats.\nMATERIAL AND METHODS: We performed an orthotopic left pulmonary transplant model using the tri-cuff vascular anastomosis method and evaluated the histopathology, including the severity of fibrosis (SF). The expression of HIF-1\u03b1, VEGF-A, and VEGFR-2 was accessed by immunohistochemistry.\nRESULTS: The imageology and pathology showed that the allogenic model developed BO 90\u2009days after the operation. The percentages of a high expression of HIF-1\u03b1, VEGF-A, and VEGFR-2 in the allogeneic group were 77.27, 63.64, and 68.18% higher than in the isogeneic group, respectively. The SF score was highest in the allograft and was positively correlated with the expression of the proteins.\nCONCLUSION: This model can simulate human BO after lung transplantation. The expression of HIF-1\u03b1 and its downstream proteins in post-transplantation was up-regulated, suggesting that activation of the HIF-1\u03b1-VEGF pathway might be involved in the occurrence and prognosis of BO.", 
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    47 schema:description BACKGROUND: Graft function may be affected if the organ is exposed to hypoxia. We hypothesized that bronchiolitis obliterans (BO) after lung transplantation is associated with hypoxia-inducible factor-1α (HIF-1α). This study compares the expression of HIF-1α and its downstream proteins in allograft and isograft to explore the relationship between this pathway and BO in rats. MATERIAL AND METHODS: We performed an orthotopic left pulmonary transplant model using the tri-cuff vascular anastomosis method and evaluated the histopathology, including the severity of fibrosis (SF). The expression of HIF-1α, VEGF-A, and VEGFR-2 was accessed by immunohistochemistry. RESULTS: The imageology and pathology showed that the allogenic model developed BO 90 days after the operation. The percentages of a high expression of HIF-1α, VEGF-A, and VEGFR-2 in the allogeneic group were 77.27, 63.64, and 68.18% higher than in the isogeneic group, respectively. The SF score was highest in the allograft and was positively correlated with the expression of the proteins. CONCLUSION: This model can simulate human BO after lung transplantation. The expression of HIF-1α and its downstream proteins in post-transplantation was up-regulated, suggesting that activation of the HIF-1α-VEGF pathway might be involved in the occurrence and prognosis of BO.
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