Myocardial inflammation, injury and infarction during on-pump coronary artery bypass graft surgery View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Shirjel R. Alam, Colin Stirrat, Nick Spath, Vipin Zamvar, Renzo Pessotto, Marc R. Dweck, Colin Moore, Scott Semple, Ahmed El-Medany, Divya Manoharan, Nicholas L. Mills, Anoop Shah, Saeed Mirsadraee, David E. Newby, Peter A. Henriksen

ABSTRACT

BACKGROUND: Myocardial inflammation and injury occur during coronary artery bypass graft (CABG) surgery. We aimed to characterise these processes during routine CABG surgery to inform the diagnosis of type 5 myocardial infarction. METHODS: We assessed 87 patients with stable coronary artery disease who underwent elective CABG surgery. Myocardial inflammation, injury and infarction were assessed using plasma inflammatory biomarkers, high-sensitivity cardiac troponin I (hs-cTnI) and cardiac magnetic resonance imaging (CMR) using both late gadolinium enhancement (LGE) and ultrasmall superparamagnetic particles of iron oxide (USPIO). RESULTS: Systemic humoral inflammatory biomarkers (myeloperoxidase, interleukin-6, interleukin-8 and c-reactive protein) increased in the post-operative period with C-reactive protein concentrations plateauing by 48 h (median area under the curve (AUC) 7530 [interquartile range (IQR) 6088 to 9027] mg/L/48 h). USPIO-defined cellular myocardial inflammation ranged from normal to those associated with type 1 myocardial infarction (median 80.2 [IQR 67.4 to 104.8] /s). Plasma hs-cTnI concentrations rose by ≥50-fold from baseline and exceeded 10-fold the upper limit of normal in all patients. Two distinct patterns of peak cTnI release were observed at 6 and 24 h. After CABG surgery, new LGE was seen in 20% (n = 18) of patients although clinical peri-operative type 5 myocardial infarction was diagnosed in only 9% (n = 8). LGE was associated with the delayed 24-h peak in hs-cTnI and its magnitude correlated with AUC plasma hs-cTnI concentrations (r = 0.33, p < 0.01) but not systemic inflammation, myocardial inflammation or bypass time. CONCLUSION: Patients undergoing CABG surgery invariably have plasma hs-cTnI concentrations >10-fold the 99th centile upper limit of normal that is not attributable to inflammatory or ischemic injury alone. Peri-operative type 5 myocardial infarction is often unrecognised and is associated with a delayed 24-h peak in plasma hs-cTnI concentrations. More... »

PAGES

115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13019-017-0681-6

DOI

http://dx.doi.org/10.1186/s13019-017-0681-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099677711

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29246240


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Artery Bypass", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Artery Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Elafin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intraoperative Complications", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging, Cine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardial Reperfusion Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocarditis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protease Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Troponin I", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alam", 
        "givenName": "Shirjel R.", 
        "id": "sg:person.016666460252.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016666460252.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stirrat", 
        "givenName": "Colin", 
        "id": "sg:person.01237521671.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237521671.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spath", 
        "givenName": "Nick", 
        "id": "sg:person.016430600753.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016430600753.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiothoracic Surgery, Edinburgh Heart Centre, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zamvar", 
        "givenName": "Vipin", 
        "id": "sg:person.0620125706.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620125706.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiothoracic Surgery, Edinburgh Heart Centre, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pessotto", 
        "givenName": "Renzo", 
        "id": "sg:person.0611446577.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611446577.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dweck", 
        "givenName": "Marc R.", 
        "id": "sg:person.01320530175.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320530175.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiothoracic Surgery, Edinburgh Heart Centre, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moore", 
        "givenName": "Colin", 
        "id": "sg:person.0576642175.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576642175.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK", 
            "Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Semple", 
        "givenName": "Scott", 
        "id": "sg:person.0751672605.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751672605.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "NHS Lothian", 
          "id": "https://www.grid.ac/institutes/grid.39489.3f", 
          "name": [
            "NHS Lothian, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "El-Medany", 
        "givenName": "Ahmed", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manoharan", 
        "givenName": "Divya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mills", 
        "givenName": "Nicholas L.", 
        "id": "sg:person.01052613263.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052613263.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shah", 
        "givenName": "Anoop", 
        "id": "sg:person.016271553612.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016271553612.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mirsadraee", 
        "givenName": "Saeed", 
        "id": "sg:person.01215571666.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215571666.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Newby", 
        "givenName": "David E.", 
        "id": "sg:person.01334045014.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334045014.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor\u2019s Building, Little France Crescent, EH16 5SA, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henriksen", 
        "givenName": "Peter A.", 
        "id": "sg:person.0756754724.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756754724.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.jacc.2004.11.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001084705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/hrt.2010.213462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002022254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.110.959866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014696894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.110.959866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014696894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(15)00391-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014930766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.112.974907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020003117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.112.974907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020003117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5273(02)00331-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022248870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5273(02)00331-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022248870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.g7873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022804677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2012.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024243590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2011.05.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029145220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/heartjnl-2015-307745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029171782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrm.21478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030501177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.105.602370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031446314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.athoracsur.2004.07.060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036891018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc0402.102975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039853393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5223(95)70028-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042416393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0886-0440.2005.200387.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044506358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1406944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049168609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0008-6363(98)00229-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054580192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1010-7940(01)01099-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054669598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ehj.2004.05.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054732545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4244/eijv6i6a119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072399416"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-12", 
    "datePublishedReg": "2017-12-01", 
    "description": "BACKGROUND: Myocardial inflammation and injury occur during coronary artery bypass graft (CABG) surgery. We aimed to characterise these processes during routine CABG surgery to inform the diagnosis of type 5 myocardial infarction.\nMETHODS: We assessed 87 patients with stable coronary artery disease who underwent elective CABG surgery. Myocardial inflammation, injury and infarction were assessed using plasma inflammatory biomarkers, high-sensitivity cardiac troponin I (hs-cTnI) and cardiac magnetic resonance imaging (CMR) using both late gadolinium enhancement (LGE) and ultrasmall superparamagnetic particles of iron oxide (USPIO).\nRESULTS: Systemic humoral inflammatory biomarkers (myeloperoxidase, interleukin-6, interleukin-8 and c-reactive protein) increased in the post-operative period with C-reactive protein concentrations plateauing by 48\u00a0h (median area under the curve (AUC) 7530 [interquartile range (IQR) 6088 to 9027] mg/L/48\u00a0h). USPIO-defined cellular myocardial inflammation ranged from normal to those associated with type 1 myocardial infarction (median 80.2 [IQR 67.4 to 104.8] /s). Plasma hs-cTnI concentrations rose by \u226550-fold from baseline and exceeded 10-fold the upper limit of normal in all patients. Two distinct patterns of peak cTnI release were observed at 6 and 24\u00a0h. After CABG surgery, new LGE was seen in 20% (n\u2009=\u200918) of patients although clinical peri-operative type 5 myocardial infarction was diagnosed in only 9% (n\u2009=\u20098). LGE was associated with the delayed 24-h peak in hs-cTnI and its magnitude correlated with AUC plasma hs-cTnI concentrations (r\u2009=\u20090.33, p\u2009<\u20090.01) but not systemic inflammation, myocardial inflammation or bypass time.\nCONCLUSION: Patients undergoing CABG surgery invariably have plasma hs-cTnI concentrations >10-fold the 99th centile upper limit of normal that is not attributable to inflammatory or ischemic injury alone. Peri-operative type 5 myocardial infarction is often unrecognised and is associated with a delayed 24-h peak in plasma hs-cTnI concentrations.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13019-017-0681-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5141674", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6798408", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5140171", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2787671", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3957045", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1036453", 
        "issn": [
          "1749-8090"
        ], 
        "name": "Journal of Cardiothoracic Surgery", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Myocardial inflammation, injury and infarction during on-pump coronary artery bypass graft surgery", 
    "pagination": "115", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "20f9d0189b5cc88c290aaa763faebf7ef16f0d69f86c0f43a1c655fcb9472acb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29246240"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101265113"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13019-017-0681-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1099677711"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13019-017-0681-6", 
      "https://app.dimensions.ai/details/publication/pub.1099677711"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000493.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s13019-017-0681-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13019-017-0681-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13019-017-0681-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13019-017-0681-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13019-017-0681-6'


 

This table displays all metadata directly associated to this object as RDF triples.

307 TRIPLES      21 PREDICATES      65 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13019-017-0681-6 schema:about N0ad630cc4f5840ec97f0f1aa05405589
2 N1332a0ef17e2407baf85d8937b2f0a72
3 N1592a8de4c02471e94c29751e610d35b
4 N29d3f028c5ca4862b1ce44f092f78d6b
5 N411369bce2aa48cc92fec87302db5893
6 N444533ef4bef49c58599f81a3ca74f77
7 N634bfc5985e14def948bc56affe89977
8 N716de6a602284541bad8932b72102c9d
9 N81dac2f880cf439482f0419a06809d39
10 N9472e2c788594f89a6495ec2b7b05d05
11 N9737222e3d424073b62a427a6f17a325
12 Nac92202bebb04c3ea6eeb300f3e2474f
13 Nb8b7e65854f44f42b8521d6123393870
14 Nf7efd8594b3e4f8580fbfb92349c275d
15 Nffc9093ba0ea4f1982da5e70b4c0c0cb
16 anzsrc-for:11
17 anzsrc-for:1102
18 schema:author N75179e01e87f4b75ae59b855ececad47
19 schema:citation https://doi.org/10.1002/mrm.21478
20 https://doi.org/10.1016/j.athoracsur.2004.07.060
21 https://doi.org/10.1016/j.athoracsur.2011.05.019
22 https://doi.org/10.1016/j.ehj.2004.05.015
23 https://doi.org/10.1016/j.jacc.2004.11.030
24 https://doi.org/10.1016/j.jacc.2012.08.001
25 https://doi.org/10.1016/s0008-6363(98)00229-6
26 https://doi.org/10.1016/s0022-5223(95)70028-5
27 https://doi.org/10.1016/s0140-6736(15)00391-8
28 https://doi.org/10.1016/s0167-5273(02)00331-5
29 https://doi.org/10.1016/s1010-7940(01)01099-5
30 https://doi.org/10.1056/nejmra1406944
31 https://doi.org/10.1111/j.0886-0440.2005.200387.x
32 https://doi.org/10.1136/bmj.g7873
33 https://doi.org/10.1136/heartjnl-2015-307745
34 https://doi.org/10.1136/hrt.2010.213462
35 https://doi.org/10.1161/circimaging.110.959866
36 https://doi.org/10.1161/circimaging.112.974907
37 https://doi.org/10.1161/circulationaha.105.602370
38 https://doi.org/10.1161/hc0402.102975
39 https://doi.org/10.4244/eijv6i6a119
40 schema:datePublished 2017-12
41 schema:datePublishedReg 2017-12-01
42 schema:description BACKGROUND: Myocardial inflammation and injury occur during coronary artery bypass graft (CABG) surgery. We aimed to characterise these processes during routine CABG surgery to inform the diagnosis of type 5 myocardial infarction. METHODS: We assessed 87 patients with stable coronary artery disease who underwent elective CABG surgery. Myocardial inflammation, injury and infarction were assessed using plasma inflammatory biomarkers, high-sensitivity cardiac troponin I (hs-cTnI) and cardiac magnetic resonance imaging (CMR) using both late gadolinium enhancement (LGE) and ultrasmall superparamagnetic particles of iron oxide (USPIO). RESULTS: Systemic humoral inflammatory biomarkers (myeloperoxidase, interleukin-6, interleukin-8 and c-reactive protein) increased in the post-operative period with C-reactive protein concentrations plateauing by 48 h (median area under the curve (AUC) 7530 [interquartile range (IQR) 6088 to 9027] mg/L/48 h). USPIO-defined cellular myocardial inflammation ranged from normal to those associated with type 1 myocardial infarction (median 80.2 [IQR 67.4 to 104.8] /s). Plasma hs-cTnI concentrations rose by ≥50-fold from baseline and exceeded 10-fold the upper limit of normal in all patients. Two distinct patterns of peak cTnI release were observed at 6 and 24 h. After CABG surgery, new LGE was seen in 20% (n = 18) of patients although clinical peri-operative type 5 myocardial infarction was diagnosed in only 9% (n = 8). LGE was associated with the delayed 24-h peak in hs-cTnI and its magnitude correlated with AUC plasma hs-cTnI concentrations (r = 0.33, p < 0.01) but not systemic inflammation, myocardial inflammation or bypass time. CONCLUSION: Patients undergoing CABG surgery invariably have plasma hs-cTnI concentrations >10-fold the 99th centile upper limit of normal that is not attributable to inflammatory or ischemic injury alone. Peri-operative type 5 myocardial infarction is often unrecognised and is associated with a delayed 24-h peak in plasma hs-cTnI concentrations.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N922e06aa335548a285ac24f7f518affc
47 Ndbff4efd064342378bd7e360d65131ad
48 sg:journal.1036453
49 schema:name Myocardial inflammation, injury and infarction during on-pump coronary artery bypass graft surgery
50 schema:pagination 115
51 schema:productId N596dd2b2ef7a46e0b13dc30b9c2779c1
52 N648a4bec653f47d89c1c8f853221147e
53 Na214eae83b4b490daf148ea44d91aecc
54 Naf5a10d624c343b899dbd674ea0341f5
55 Nfeeb2488b8864603a9407d8df77f1b73
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099677711
57 https://doi.org/10.1186/s13019-017-0681-6
58 schema:sdDatePublished 2019-04-11T01:03
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N5fa033bdc6bc45b88eec20afdc8c4631
61 schema:url http://link.springer.com/10.1186/s13019-017-0681-6
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N035c498ad2b74fdc9ebe9f07a8b0cf65 rdf:first N374bfd1f9e1d45c6a50090b1bf94df0a
66 rdf:rest Nf37e3034a0664e49aeea754dfbe7f6ed
67 N0ad630cc4f5840ec97f0f1aa05405589 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Myocardial Reperfusion Injury
69 rdf:type schema:DefinedTerm
70 N1332a0ef17e2407baf85d8937b2f0a72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Protease Inhibitors
72 rdf:type schema:DefinedTerm
73 N1592a8de4c02471e94c29751e610d35b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Coronary Artery Disease
75 rdf:type schema:DefinedTerm
76 N219aff1ef79f4ec2b508ca1476da45dd rdf:first sg:person.0611446577.54
77 rdf:rest N58bd5f647896479eaed2fa8c0911a590
78 N29d3f028c5ca4862b1ce44f092f78d6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Biomarkers
80 rdf:type schema:DefinedTerm
81 N2be16be5a2444795870a3a7115a3b490 rdf:first sg:person.016430600753.68
82 rdf:rest N63e61e8b38984014bbcb5f5ed389eb1e
83 N2e80db08bd3c414b9e321106bb8ef9d3 rdf:first sg:person.016271553612.76
84 rdf:rest N37a82c1f53d54ffba275f59c3c082b45
85 N374bfd1f9e1d45c6a50090b1bf94df0a schema:affiliation https://www.grid.ac/institutes/grid.4305.2
86 schema:familyName Manoharan
87 schema:givenName Divya
88 rdf:type schema:Person
89 N37a82c1f53d54ffba275f59c3c082b45 rdf:first sg:person.01215571666.10
90 rdf:rest Nf1c7480b31c44fe0b20d5d1a1e948c34
91 N411369bce2aa48cc92fec87302db5893 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Middle Aged
93 rdf:type schema:DefinedTerm
94 N444533ef4bef49c58599f81a3ca74f77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Female
96 rdf:type schema:DefinedTerm
97 N475b933772ef429eb1f83824b96a21c8 schema:affiliation https://www.grid.ac/institutes/grid.39489.3f
98 schema:familyName El-Medany
99 schema:givenName Ahmed
100 rdf:type schema:Person
101 N5177c6a2e33e46bf88c24e25b3f1e3bb schema:name Department of Cardiothoracic Surgery, Edinburgh Heart Centre, Edinburgh, UK
102 rdf:type schema:Organization
103 N58bd5f647896479eaed2fa8c0911a590 rdf:first sg:person.01320530175.66
104 rdf:rest N9f14b8db71a344dca6a8de538358842b
105 N596dd2b2ef7a46e0b13dc30b9c2779c1 schema:name readcube_id
106 schema:value 20f9d0189b5cc88c290aaa763faebf7ef16f0d69f86c0f43a1c655fcb9472acb
107 rdf:type schema:PropertyValue
108 N5fa033bdc6bc45b88eec20afdc8c4631 schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N634bfc5985e14def948bc56affe89977 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Intraoperative Complications
112 rdf:type schema:DefinedTerm
113 N63e61e8b38984014bbcb5f5ed389eb1e rdf:first sg:person.0620125706.35
114 rdf:rest N219aff1ef79f4ec2b508ca1476da45dd
115 N648a4bec653f47d89c1c8f853221147e schema:name dimensions_id
116 schema:value pub.1099677711
117 rdf:type schema:PropertyValue
118 N716de6a602284541bad8932b72102c9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Elafin
120 rdf:type schema:DefinedTerm
121 N75179e01e87f4b75ae59b855ececad47 rdf:first sg:person.016666460252.87
122 rdf:rest Na820091130e24172a6ebbbdddd865123
123 N81dac2f880cf439482f0419a06809d39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Coronary Artery Bypass
125 rdf:type schema:DefinedTerm
126 N922e06aa335548a285ac24f7f518affc schema:volumeNumber 12
127 rdf:type schema:PublicationVolume
128 N9472e2c788594f89a6495ec2b7b05d05 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Aged
130 rdf:type schema:DefinedTerm
131 N9737222e3d424073b62a427a6f17a325 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Myocarditis
133 rdf:type schema:DefinedTerm
134 N9f14b8db71a344dca6a8de538358842b rdf:first sg:person.0576642175.30
135 rdf:rest Naa05811003f84d5fa8ff48bd626476e9
136 Na214eae83b4b490daf148ea44d91aecc schema:name nlm_unique_id
137 schema:value 101265113
138 rdf:type schema:PropertyValue
139 Na820091130e24172a6ebbbdddd865123 rdf:first sg:person.01237521671.95
140 rdf:rest N2be16be5a2444795870a3a7115a3b490
141 Naa05811003f84d5fa8ff48bd626476e9 rdf:first sg:person.0751672605.19
142 rdf:rest Nd752bfbac38a48c28f0ff03ffb13e1b8
143 Nac92202bebb04c3ea6eeb300f3e2474f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Humans
145 rdf:type schema:DefinedTerm
146 Naf5a10d624c343b899dbd674ea0341f5 schema:name pubmed_id
147 schema:value 29246240
148 rdf:type schema:PropertyValue
149 Nb4878a4bfd0447ab97b6c0532219cfe3 rdf:first sg:person.0756754724.30
150 rdf:rest rdf:nil
151 Nb8b7e65854f44f42b8521d6123393870 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Troponin I
153 rdf:type schema:DefinedTerm
154 Nd752bfbac38a48c28f0ff03ffb13e1b8 rdf:first N475b933772ef429eb1f83824b96a21c8
155 rdf:rest N035c498ad2b74fdc9ebe9f07a8b0cf65
156 Ndbff4efd064342378bd7e360d65131ad schema:issueNumber 1
157 rdf:type schema:PublicationIssue
158 Nf1c7480b31c44fe0b20d5d1a1e948c34 rdf:first sg:person.01334045014.42
159 rdf:rest Nb4878a4bfd0447ab97b6c0532219cfe3
160 Nf37e3034a0664e49aeea754dfbe7f6ed rdf:first sg:person.01052613263.54
161 rdf:rest N2e80db08bd3c414b9e321106bb8ef9d3
162 Nf7d27d285a784e2f82180f2e123fd7ea schema:name Department of Cardiothoracic Surgery, Edinburgh Heart Centre, Edinburgh, UK
163 rdf:type schema:Organization
164 Nf7efd8594b3e4f8580fbfb92349c275d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Magnetic Resonance Imaging, Cine
166 rdf:type schema:DefinedTerm
167 Nfc22b7782ec344e1ae5bdb153c01ee17 schema:name Department of Cardiothoracic Surgery, Edinburgh Heart Centre, Edinburgh, UK
168 rdf:type schema:Organization
169 Nfeeb2488b8864603a9407d8df77f1b73 schema:name doi
170 schema:value 10.1186/s13019-017-0681-6
171 rdf:type schema:PropertyValue
172 Nffc9093ba0ea4f1982da5e70b4c0c0cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Male
174 rdf:type schema:DefinedTerm
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
179 schema:name Cardiorespiratory Medicine and Haematology
180 rdf:type schema:DefinedTerm
181 sg:grant.2787671 http://pending.schema.org/fundedItem sg:pub.10.1186/s13019-017-0681-6
182 rdf:type schema:MonetaryGrant
183 sg:grant.3957045 http://pending.schema.org/fundedItem sg:pub.10.1186/s13019-017-0681-6
184 rdf:type schema:MonetaryGrant
185 sg:grant.5140171 http://pending.schema.org/fundedItem sg:pub.10.1186/s13019-017-0681-6
186 rdf:type schema:MonetaryGrant
187 sg:grant.5141674 http://pending.schema.org/fundedItem sg:pub.10.1186/s13019-017-0681-6
188 rdf:type schema:MonetaryGrant
189 sg:grant.6798408 http://pending.schema.org/fundedItem sg:pub.10.1186/s13019-017-0681-6
190 rdf:type schema:MonetaryGrant
191 sg:journal.1036453 schema:issn 1749-8090
192 schema:name Journal of Cardiothoracic Surgery
193 rdf:type schema:Periodical
194 sg:person.01052613263.54 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
195 schema:familyName Mills
196 schema:givenName Nicholas L.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052613263.54
198 rdf:type schema:Person
199 sg:person.01215571666.10 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
200 schema:familyName Mirsadraee
201 schema:givenName Saeed
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215571666.10
203 rdf:type schema:Person
204 sg:person.01237521671.95 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
205 schema:familyName Stirrat
206 schema:givenName Colin
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237521671.95
208 rdf:type schema:Person
209 sg:person.01320530175.66 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
210 schema:familyName Dweck
211 schema:givenName Marc R.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320530175.66
213 rdf:type schema:Person
214 sg:person.01334045014.42 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
215 schema:familyName Newby
216 schema:givenName David E.
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334045014.42
218 rdf:type schema:Person
219 sg:person.016271553612.76 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
220 schema:familyName Shah
221 schema:givenName Anoop
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016271553612.76
223 rdf:type schema:Person
224 sg:person.016430600753.68 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
225 schema:familyName Spath
226 schema:givenName Nick
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016430600753.68
228 rdf:type schema:Person
229 sg:person.016666460252.87 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
230 schema:familyName Alam
231 schema:givenName Shirjel R.
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016666460252.87
233 rdf:type schema:Person
234 sg:person.0576642175.30 schema:affiliation Nf7d27d285a784e2f82180f2e123fd7ea
235 schema:familyName Moore
236 schema:givenName Colin
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576642175.30
238 rdf:type schema:Person
239 sg:person.0611446577.54 schema:affiliation Nfc22b7782ec344e1ae5bdb153c01ee17
240 schema:familyName Pessotto
241 schema:givenName Renzo
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611446577.54
243 rdf:type schema:Person
244 sg:person.0620125706.35 schema:affiliation N5177c6a2e33e46bf88c24e25b3f1e3bb
245 schema:familyName Zamvar
246 schema:givenName Vipin
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620125706.35
248 rdf:type schema:Person
249 sg:person.0751672605.19 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
250 schema:familyName Semple
251 schema:givenName Scott
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751672605.19
253 rdf:type schema:Person
254 sg:person.0756754724.30 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
255 schema:familyName Henriksen
256 schema:givenName Peter A.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756754724.30
258 rdf:type schema:Person
259 https://doi.org/10.1002/mrm.21478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030501177
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.athoracsur.2004.07.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036891018
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.athoracsur.2011.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029145220
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.ehj.2004.05.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054732545
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.jacc.2004.11.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001084705
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.jacc.2012.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024243590
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0008-6363(98)00229-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054580192
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0022-5223(95)70028-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042416393
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0140-6736(15)00391-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014930766
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0167-5273(02)00331-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022248870
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s1010-7940(01)01099-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054669598
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1056/nejmra1406944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049168609
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/j.0886-0440.2005.200387.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044506358
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1136/bmj.g7873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022804677
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1136/heartjnl-2015-307745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029171782
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1136/hrt.2010.213462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002022254
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1161/circimaging.110.959866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014696894
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1161/circimaging.112.974907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020003117
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1161/circulationaha.105.602370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031446314
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1161/hc0402.102975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039853393
298 rdf:type schema:CreativeWork
299 https://doi.org/10.4244/eijv6i6a119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072399416
300 rdf:type schema:CreativeWork
301 https://www.grid.ac/institutes/grid.39489.3f schema:alternateName NHS Lothian
302 schema:name NHS Lothian, Edinburgh, UK
303 rdf:type schema:Organization
304 https://www.grid.ac/institutes/grid.4305.2 schema:alternateName University of Edinburgh
305 schema:name BHF Centre for Cardiovascular Science, University of Edinburgh, The Chancellor’s Building, Little France Crescent, EH16 5SA, Edinburgh, UK
306 Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK
307 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...