Evaluating the bioactivity of a hydroxyapatite-incorporated polyetheretherketone biocomposite View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Rui Ma, Dagang Guo

ABSTRACT

BACKGROUND: Polyetheretherketone (PEEK) exhibits stable chemical properties, excellent biocompatibility, and rational mechanical properties that are similar to those of human cortical bone, but the lack of bioactivity impedes its clinical application. METHODS: In this study, hydroxyapatite (HA) was incorporated into PEEK to fabricate HA/PEEK biocomposite using a compounding and injection-molding technique. The tensile properties of the prepared HA/PEEK composites (HA content from 0 to 40 wt%) were tested to choose an optimal HA content. To evaluate the bioactivity of the composite, the cell attachment, proliferation, spreading and alkaline phosphatase (ALP) activity of MC3T3-E1 cells, and apatite formation after immersion in simulated body fluid (SBF), and osseointegration in a rabbit cranial defect model were investigated. The results were compared to those from ultra-high molecular weight polyethylene (UHMWPE) and pure PEEK. RESULTS: By evaluating the tensile properties and elastic moduli of PEEK composite samples/PEEK composites with different HA contents, the 30 wt% HA/PEEK composite was chosen for use in the subsequent tests. The results of the cell tests demonstrated that PEEK composite samples/PEEK composite exhibited better cell attachment, proliferation, spreading, and higher ALP activity than those of UHMWPE and pure PEEK. Apatite islands formed on the HA/PEEK composite after immersion in SBF for 7 days and grew continuously with longer time periods. Animal tests indicated that bone contact and new bone formation around the HA/PEEK composite were more obvious than those around UHMWPE and pure PEEK. CONCLUSIONS: The HA/PEEK biocomposite created by a compounding and injection-molding technique exhibited enhanced osteogenesis and could be used as a candidate of orthopedic implants. More... »

PAGES

32

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13018-019-1069-1

DOI

http://dx.doi.org/10.1186/s13018-019-1069-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111654826

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30683125


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0912", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Materials Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/09", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Engineering", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Second Affiliated Hospital of Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.452672.0", 
          "name": [
            "Department of Orthopedics, The Second Affiliated Hospital of Xi\u2019an Jiaotong University, 710004, Xi\u2019an, Shaanxi, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Rui", 
        "id": "sg:person.0774712132.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774712132.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xi'an Jiaotong University", 
          "id": "https://www.grid.ac/institutes/grid.43169.39", 
          "name": [
            "State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi\u2019an Jiaotong University, 710049, Xi\u2019an, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Dagang", 
        "id": "sg:person.0775556447.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775556447.18"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jbm.a.32298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004527285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0142-9612(99)00075-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006912506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.matlet.2011.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007183272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/ijms15045426", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007337156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0142-9612(81)90050-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007615207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0142-9612(81)90050-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007615207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0921-5093(02)00289-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008100597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11837-008-0030-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008358212", 
          "https://doi.org/10.1007/s11837-008-0030-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2004.07.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011401913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jor.20305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012661371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0501.1997.080306.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012747769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2005.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012896436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2005.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012896436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1163/156856299x00865", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014186849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2009.02.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015813326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2012.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016024005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2010.07.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016289676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1263/jbb.100.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019530490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/app.37926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019870068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.820050611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021142525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cej.2007.07.076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022801860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.matlet.2013.01.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025846336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.12.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028391893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2006.07.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031433414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/17434440.2.3.303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033755038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2007.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034129798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2012.11.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034714006"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2008.00606.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035572685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11771-001-0015-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037166669", 
          "https://doi.org/10.1007/s11771-001-0015-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2010.08.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037325586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2006.01.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043310296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0142-9612(03)00044-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047382986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0142-9612(03)00044-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047382986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0266-3538(02)00230-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050032261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0266-3538(02)00230-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050032261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jbm.820251105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050415898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10856-005-2539-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052986676", 
          "https://doi.org/10.1007/s10856-005-2539-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10856-005-2539-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052986676", 
          "https://doi.org/10.1007/s10856-005-2539-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198606000-00046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060161676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198606000-00046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060161676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003086-198606000-00046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060161676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077806924", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1098862559", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "BACKGROUND: Polyetheretherketone (PEEK) exhibits stable chemical properties, excellent biocompatibility, and rational mechanical properties that are similar to those of human cortical bone, but the lack of bioactivity impedes its clinical application.\nMETHODS: In this study, hydroxyapatite (HA) was incorporated into PEEK to fabricate HA/PEEK biocomposite using a compounding and injection-molding technique. The tensile properties of the prepared HA/PEEK composites (HA content from 0 to 40\u2009wt%) were tested to choose an optimal HA content. To evaluate the bioactivity of the composite, the cell attachment, proliferation, spreading and alkaline phosphatase (ALP) activity of MC3T3-E1 cells, and apatite formation after immersion in simulated body fluid (SBF), and osseointegration in a rabbit cranial defect model were investigated. The results were compared to those from ultra-high molecular weight polyethylene (UHMWPE) and pure PEEK.\nRESULTS: By evaluating the tensile properties and elastic moduli of PEEK composite samples/PEEK composites with different HA contents, the 30\u2009wt% HA/PEEK composite was chosen for use in the subsequent tests. The results of the cell tests demonstrated that PEEK composite samples/PEEK composite exhibited better cell attachment, proliferation, spreading, and higher ALP activity than those of UHMWPE and pure PEEK. Apatite islands formed on the HA/PEEK composite after immersion in SBF for 7\u2009days and grew continuously with longer time periods. Animal tests indicated that bone contact and new bone formation around the HA/PEEK composite were more obvious than those around UHMWPE and pure PEEK.\nCONCLUSIONS: The HA/PEEK biocomposite created by a compounding and injection-molding technique exhibited enhanced osteogenesis and could be used as a candidate of orthopedic implants.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13018-019-1069-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036452", 
        "issn": [
          "1749-799X"
        ], 
        "name": "Journal of Orthopaedic Surgery and Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Evaluating the bioactivity of a hydroxyapatite-incorporated polyetheretherketone biocomposite", 
    "pagination": "32", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0fec84e0c59ae88cfa37b42eb8b9ae066321e517cc526f79f0b7fd5ae11a880d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30683125"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101265112"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13018-019-1069-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1111654826"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13018-019-1069-1", 
      "https://app.dimensions.ai/details/publication/pub.1111654826"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T08:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000326_0000000326/records_68472_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13018-019-1069-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13018-019-1069-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13018-019-1069-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13018-019-1069-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13018-019-1069-1'


 

This table displays all metadata directly associated to this object as RDF triples.

187 TRIPLES      21 PREDICATES      65 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13018-019-1069-1 schema:about anzsrc-for:09
2 anzsrc-for:0912
3 schema:author N513c7caa8e2f4b5083cd5e5fb84db2c4
4 schema:citation sg:pub.10.1007/s10856-005-2539-z
5 sg:pub.10.1007/s11771-001-0015-6
6 sg:pub.10.1007/s11837-008-0030-2
7 https://app.dimensions.ai/details/publication/pub.1077806924
8 https://app.dimensions.ai/details/publication/pub.1098862559
9 https://doi.org/10.1002/app.37926
10 https://doi.org/10.1002/jbm.820050611
11 https://doi.org/10.1002/jbm.820251105
12 https://doi.org/10.1002/jbm.a.32298
13 https://doi.org/10.1002/jor.20305
14 https://doi.org/10.1016/0142-9612(81)90050-8
15 https://doi.org/10.1016/j.actbio.2009.02.023
16 https://doi.org/10.1016/j.actbio.2012.03.013
17 https://doi.org/10.1016/j.actbio.2012.11.030
18 https://doi.org/10.1016/j.biomaterials.2004.07.028
19 https://doi.org/10.1016/j.biomaterials.2005.07.011
20 https://doi.org/10.1016/j.biomaterials.2006.01.017
21 https://doi.org/10.1016/j.biomaterials.2006.07.027
22 https://doi.org/10.1016/j.biomaterials.2007.07.013
23 https://doi.org/10.1016/j.biomaterials.2009.12.030
24 https://doi.org/10.1016/j.biomaterials.2010.07.054
25 https://doi.org/10.1016/j.biomaterials.2010.08.006
26 https://doi.org/10.1016/j.cej.2007.07.076
27 https://doi.org/10.1016/j.matlet.2011.12.007
28 https://doi.org/10.1016/j.matlet.2013.01.081
29 https://doi.org/10.1016/s0142-9612(03)00044-9
30 https://doi.org/10.1016/s0142-9612(99)00075-7
31 https://doi.org/10.1016/s0266-3538(02)00230-0
32 https://doi.org/10.1016/s0921-5093(02)00289-7
33 https://doi.org/10.1034/j.1600-0501.1997.080306.x
34 https://doi.org/10.1097/00003086-198606000-00046
35 https://doi.org/10.1111/j.1582-4934.2008.00606.x
36 https://doi.org/10.1163/156856299x00865
37 https://doi.org/10.1263/jbb.100.43
38 https://doi.org/10.1586/17434440.2.3.303
39 https://doi.org/10.3390/ijms15045426
40 schema:datePublished 2019-12
41 schema:datePublishedReg 2019-12-01
42 schema:description BACKGROUND: Polyetheretherketone (PEEK) exhibits stable chemical properties, excellent biocompatibility, and rational mechanical properties that are similar to those of human cortical bone, but the lack of bioactivity impedes its clinical application. METHODS: In this study, hydroxyapatite (HA) was incorporated into PEEK to fabricate HA/PEEK biocomposite using a compounding and injection-molding technique. The tensile properties of the prepared HA/PEEK composites (HA content from 0 to 40 wt%) were tested to choose an optimal HA content. To evaluate the bioactivity of the composite, the cell attachment, proliferation, spreading and alkaline phosphatase (ALP) activity of MC3T3-E1 cells, and apatite formation after immersion in simulated body fluid (SBF), and osseointegration in a rabbit cranial defect model were investigated. The results were compared to those from ultra-high molecular weight polyethylene (UHMWPE) and pure PEEK. RESULTS: By evaluating the tensile properties and elastic moduli of PEEK composite samples/PEEK composites with different HA contents, the 30 wt% HA/PEEK composite was chosen for use in the subsequent tests. The results of the cell tests demonstrated that PEEK composite samples/PEEK composite exhibited better cell attachment, proliferation, spreading, and higher ALP activity than those of UHMWPE and pure PEEK. Apatite islands formed on the HA/PEEK composite after immersion in SBF for 7 days and grew continuously with longer time periods. Animal tests indicated that bone contact and new bone formation around the HA/PEEK composite were more obvious than those around UHMWPE and pure PEEK. CONCLUSIONS: The HA/PEEK biocomposite created by a compounding and injection-molding technique exhibited enhanced osteogenesis and could be used as a candidate of orthopedic implants.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N53c2f4621e8741619b0b8767249f71ae
47 N84d0494d3f394a2dbb9534a2ffe742cd
48 sg:journal.1036452
49 schema:name Evaluating the bioactivity of a hydroxyapatite-incorporated polyetheretherketone biocomposite
50 schema:pagination 32
51 schema:productId N11f6bafb45b0404a922d0e242060c379
52 N5488f88c1ed44bd398edc61150d6dd3d
53 N5ff28f75a1a84b569570eefccb771587
54 Na3a1b76cc3244b46bfbf81a9f0fb91d3
55 Ncb71c0ced3ed4ddd9da342350f4691f2
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111654826
57 https://doi.org/10.1186/s13018-019-1069-1
58 schema:sdDatePublished 2019-04-11T08:58
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N02b181cb66eb4b71b9769286c5ef4707
61 schema:url https://link.springer.com/10.1186%2Fs13018-019-1069-1
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N02b181cb66eb4b71b9769286c5ef4707 schema:name Springer Nature - SN SciGraph project
66 rdf:type schema:Organization
67 N11f6bafb45b0404a922d0e242060c379 schema:name doi
68 schema:value 10.1186/s13018-019-1069-1
69 rdf:type schema:PropertyValue
70 N513c7caa8e2f4b5083cd5e5fb84db2c4 rdf:first sg:person.0774712132.83
71 rdf:rest Ndf74921c0a2042219dc5fbc3e6f402b5
72 N53c2f4621e8741619b0b8767249f71ae schema:issueNumber 1
73 rdf:type schema:PublicationIssue
74 N5488f88c1ed44bd398edc61150d6dd3d schema:name dimensions_id
75 schema:value pub.1111654826
76 rdf:type schema:PropertyValue
77 N5ff28f75a1a84b569570eefccb771587 schema:name nlm_unique_id
78 schema:value 101265112
79 rdf:type schema:PropertyValue
80 N84d0494d3f394a2dbb9534a2ffe742cd schema:volumeNumber 14
81 rdf:type schema:PublicationVolume
82 Na3a1b76cc3244b46bfbf81a9f0fb91d3 schema:name readcube_id
83 schema:value 0fec84e0c59ae88cfa37b42eb8b9ae066321e517cc526f79f0b7fd5ae11a880d
84 rdf:type schema:PropertyValue
85 Ncb71c0ced3ed4ddd9da342350f4691f2 schema:name pubmed_id
86 schema:value 30683125
87 rdf:type schema:PropertyValue
88 Ndf74921c0a2042219dc5fbc3e6f402b5 rdf:first sg:person.0775556447.18
89 rdf:rest rdf:nil
90 anzsrc-for:09 schema:inDefinedTermSet anzsrc-for:
91 schema:name Engineering
92 rdf:type schema:DefinedTerm
93 anzsrc-for:0912 schema:inDefinedTermSet anzsrc-for:
94 schema:name Materials Engineering
95 rdf:type schema:DefinedTerm
96 sg:journal.1036452 schema:issn 1749-799X
97 schema:name Journal of Orthopaedic Surgery and Research
98 rdf:type schema:Periodical
99 sg:person.0774712132.83 schema:affiliation https://www.grid.ac/institutes/grid.452672.0
100 schema:familyName Ma
101 schema:givenName Rui
102 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774712132.83
103 rdf:type schema:Person
104 sg:person.0775556447.18 schema:affiliation https://www.grid.ac/institutes/grid.43169.39
105 schema:familyName Guo
106 schema:givenName Dagang
107 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775556447.18
108 rdf:type schema:Person
109 sg:pub.10.1007/s10856-005-2539-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1052986676
110 https://doi.org/10.1007/s10856-005-2539-z
111 rdf:type schema:CreativeWork
112 sg:pub.10.1007/s11771-001-0015-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037166669
113 https://doi.org/10.1007/s11771-001-0015-6
114 rdf:type schema:CreativeWork
115 sg:pub.10.1007/s11837-008-0030-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008358212
116 https://doi.org/10.1007/s11837-008-0030-2
117 rdf:type schema:CreativeWork
118 https://app.dimensions.ai/details/publication/pub.1077806924 schema:CreativeWork
119 https://app.dimensions.ai/details/publication/pub.1098862559 schema:CreativeWork
120 https://doi.org/10.1002/app.37926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019870068
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1002/jbm.820050611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021142525
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1002/jbm.820251105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050415898
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1002/jbm.a.32298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004527285
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1002/jor.20305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012661371
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1016/0142-9612(81)90050-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007615207
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1016/j.actbio.2009.02.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015813326
133 rdf:type schema:CreativeWork
134 https://doi.org/10.1016/j.actbio.2012.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016024005
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1016/j.actbio.2012.11.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034714006
137 rdf:type schema:CreativeWork
138 https://doi.org/10.1016/j.biomaterials.2004.07.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011401913
139 rdf:type schema:CreativeWork
140 https://doi.org/10.1016/j.biomaterials.2005.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012896436
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1016/j.biomaterials.2006.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043310296
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1016/j.biomaterials.2006.07.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031433414
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1016/j.biomaterials.2007.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034129798
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1016/j.biomaterials.2009.12.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028391893
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/j.biomaterials.2010.07.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016289676
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/j.biomaterials.2010.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037325586
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/j.cej.2007.07.076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022801860
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/j.matlet.2011.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007183272
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.matlet.2013.01.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025846336
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/s0142-9612(03)00044-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047382986
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/s0142-9612(99)00075-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006912506
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/s0266-3538(02)00230-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050032261
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/s0921-5093(02)00289-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008100597
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1034/j.1600-0501.1997.080306.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012747769
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1097/00003086-198606000-00046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060161676
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1111/j.1582-4934.2008.00606.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035572685
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1163/156856299x00865 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014186849
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1263/jbb.100.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019530490
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1586/17434440.2.3.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033755038
179 rdf:type schema:CreativeWork
180 https://doi.org/10.3390/ijms15045426 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007337156
181 rdf:type schema:CreativeWork
182 https://www.grid.ac/institutes/grid.43169.39 schema:alternateName Xi'an Jiaotong University
183 schema:name State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, 710049, Xi’an, China
184 rdf:type schema:Organization
185 https://www.grid.ac/institutes/grid.452672.0 schema:alternateName Second Affiliated Hospital of Xi'an Jiaotong University
186 schema:name Department of Orthopedics, The Second Affiliated Hospital of Xi’an Jiaotong University, 710004, Xi’an, Shaanxi, China
187 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...