Exploring the key genes and pathways of side population cells in human osteosarcoma using gene expression array analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Yi-Ming Ren, Yuan-Hui Duan, Yun-Bo Sun, Tao Yang, Wen-Jun Zhao, Dong-Liang Zhang, Zheng-Wei Tian, Meng-Qiang Tian

ABSTRACT

BACKGROUND: Human osteosarcoma (OS) is one of the most common primary bone sarcoma, because of early metastasis and few treatment strategies. It has been reported that the tumorigenicity and self-renewal capacity of side population (SP) cells play roles in human OS via regulating of target genes. This study aims to complement the differentially expressed genes (DEGs) that regulated between the SP cells and the non-SP cells from primary human OS and identify their functions and molecular pathways associated with OS. METHODS: The gene expression profile GSE63390 was downloaded, and bioinformatics analysis was made. RESULTS: One hundred forty-one DEGs totally were identified. Among them, 72 DEGs (51.06%) were overexpressed, and the remaining 69 DEGs (48.94%) were underexpressed. Gene ontology (GO) and pathway enrichment analysis of target genes were performed. We furthermore identified some relevant core genes using gene-gene interaction network analysis such as EIF4E, FAU, HSPD1, IL-6, and KISS1, which may have a relationship with the development process of OS. We also discovered that EIF4E/mTOR signaling pathway could be a potential research target for therapy and tumorigenesis of OS. CONCLUSION: This analysis provides a comprehensive understanding of the roles of DEGs coming from SP cells in the development of OS. However, these predictions need further experimental validation in future studies. More... »

PAGES

153

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13018-018-0860-8

DOI

http://dx.doi.org/10.1186/s13018-018-0860-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104991192

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29921292


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Joint and Sport Medicine, Tianjin Union Medical Center, Jieyuan Road 190, Hongqiao District, 300121, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ren", 
        "givenName": "Yi-Ming", 
        "id": "sg:person.01135216257.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135216257.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Joint and Sport Medicine, Tianjin Union Medical Center, Jieyuan Road 190, Hongqiao District, 300121, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duan", 
        "givenName": "Yuan-Hui", 
        "id": "sg:person.011467115026.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011467115026.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Joint and Sport Medicine, Tianjin Union Medical Center, Jieyuan Road 190, Hongqiao District, 300121, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Yun-Bo", 
        "id": "sg:person.016323641014.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016323641014.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Joint and Sport Medicine, Tianjin Union Medical Center, Jieyuan Road 190, Hongqiao District, 300121, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Tao", 
        "id": "sg:person.014730700014.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014730700014.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Joint and Sport Medicine, Tianjin Union Medical Center, Jieyuan Road 190, Hongqiao District, 300121, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Wen-Jun", 
        "id": "sg:person.07620567614.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07620567614.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Joint and Sport Medicine, Tianjin Union Medical Center, Jieyuan Road 190, Hongqiao District, 300121, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Dong-Liang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Joint and Sport Medicine, Tianjin Union Medical Center, Jieyuan Road 190, Hongqiao District, 300121, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tian", 
        "givenName": "Zheng-Wei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin People's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.417031.0", 
          "name": [
            "Department of Joint and Sport Medicine, Tianjin Union Medical Center, Jieyuan Road 190, Hongqiao District, 300121, Tianjin, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tian", 
        "givenName": "Meng-Qiang", 
        "id": "sg:person.016001644626.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016001644626.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3389/fonc.2013.00168", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000518261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12013-015-0579-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001906770", 
          "https://doi.org/10.1007/s12013-015-0579-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-0284-9_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007435377", 
          "https://doi.org/10.1007/978-1-4419-0284-9_1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4419-0284-9_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007435377", 
          "https://doi.org/10.1007/978-1-4419-0284-9_1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e318223d0c1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008516702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/mph.0b013e318223d0c1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008516702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13018-015-0275-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010197215", 
          "https://doi.org/10.1186/s13018-015-0275-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv1500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011860877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012674084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.9-4-422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012709267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-016-2294-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014386938", 
          "https://doi.org/10.1186/s12885-016-2294-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-016-2294-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014386938", 
          "https://doi.org/10.1186/s12885-016-2294-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015289087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015289087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2008.03.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018593232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep37690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018688706", 
          "https://doi.org/10.1038/srep37690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10253890701314863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019809216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021570459", 
          "https://doi.org/10.1038/sj.bjc.6605723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0400067101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024245226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gm83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025436905", 
          "https://doi.org/10.1186/gm83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026120882", 
          "https://doi.org/10.1038/sj.onc.1206283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026120882", 
          "https://doi.org/10.1038/sj.onc.1206283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2012.08.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029698860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40880-016-0109-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030076543", 
          "https://doi.org/10.1186/s40880-016-0109-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032453250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2012.11.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032946423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/blo.0b013e318059b8c9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033015365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/blo.0b013e318059b8c9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033015365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033137600", 
          "https://doi.org/10.1038/sj.onc.1207549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033137600", 
          "https://doi.org/10.1038/sj.onc.1207549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-2531", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034810586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-3557", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034972609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-009-9365-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037199093", 
          "https://doi.org/10.1007/s12032-009-9365-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12032-009-9365-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037199093", 
          "https://doi.org/10.1007/s12032-009-9365-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4081/ejh.2013.e30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037665127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039651292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/cancers7020784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040751015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0307618100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043818400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2014.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043844474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-0999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044850270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13018-016-0487-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045645724", 
          "https://doi.org/10.1186/s13018-016-0487-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13018-016-0487-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045645724", 
          "https://doi.org/10.1186/s13018-016-0487-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1098-2264(199909)26:1<62::aid-gcc9>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051800920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0030907", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053087113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053346580", 
          "https://doi.org/10.1038/nm.3418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2006-1553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064248428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2460/ajvr.73.9.1335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070765190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/or.2016.4922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071534629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/cbm-2012-0227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078511144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078934993", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079025524", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1878-0261.12043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083740401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1302/2046-3758.63.bjr-2016-0151.r2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084265281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2017.05.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085193523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13018-017-0599-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090382784", 
          "https://doi.org/10.1186/s13018-017-0599-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13018-017-0599-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090382784", 
          "https://doi.org/10.1186/s13018-017-0599-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13018-017-0664-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092593258", 
          "https://doi.org/10.1186/s13018-017-0664-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Human osteosarcoma (OS) is one of the most common primary bone sarcoma, because of early metastasis and few treatment strategies. It has been reported that the tumorigenicity and self-renewal capacity of side population (SP) cells play roles in human OS via regulating of target genes. This study aims to complement the differentially expressed genes (DEGs) that regulated between the SP cells and the non-SP cells from primary human OS and identify their functions and molecular pathways associated with OS.\nMETHODS: The gene expression profile GSE63390 was downloaded, and bioinformatics analysis was made.\nRESULTS: One hundred forty-one DEGs totally were identified. Among them, 72 DEGs (51.06%) were overexpressed, and the remaining 69 DEGs (48.94%) were underexpressed. Gene ontology (GO) and pathway enrichment analysis of target genes were performed. We furthermore identified some relevant core genes using gene-gene interaction network analysis such as EIF4E, FAU, HSPD1, IL-6, and KISS1, which may have a relationship with the development process of OS. We also discovered that EIF4E/mTOR signaling pathway could be a potential research target for therapy and tumorigenesis of OS.\nCONCLUSION: This analysis provides a comprehensive understanding of the roles of DEGs coming from SP cells in the development of OS. However, these predictions need further experimental validation in future studies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13018-018-0860-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036452", 
        "issn": [
          "1749-799X"
        ], 
        "name": "Journal of Orthopaedic Surgery and Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Exploring the key genes and pathways of side population cells in human osteosarcoma using gene expression array analysis", 
    "pagination": "153", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "884c83e96b8bd3b2e8dfa6a80915c501df9e61fdeec151fb274c9bdc8071209e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29921292"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101265112"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13018-018-0860-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104991192"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13018-018-0860-8", 
      "https://app.dimensions.ai/details/publication/pub.1104991192"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000572.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13018-018-0860-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13018-018-0860-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13018-018-0860-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13018-018-0860-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13018-018-0860-8'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      76 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13018-018-0860-8 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Ndaa9406af4a74d879a3b5e1d12fcfb0f
4 schema:citation sg:pub.10.1007/978-1-4419-0284-9_1
5 sg:pub.10.1007/s12013-015-0579-7
6 sg:pub.10.1007/s12032-009-9365-y
7 sg:pub.10.1038/nm.3418
8 sg:pub.10.1038/sj.bjc.6605723
9 sg:pub.10.1038/sj.onc.1206283
10 sg:pub.10.1038/sj.onc.1207549
11 sg:pub.10.1038/srep37690
12 sg:pub.10.1186/gm83
13 sg:pub.10.1186/s12885-016-2294-1
14 sg:pub.10.1186/s13018-015-0275-8
15 sg:pub.10.1186/s13018-016-0487-6
16 sg:pub.10.1186/s13018-017-0599-7
17 sg:pub.10.1186/s13018-017-0664-2
18 sg:pub.10.1186/s40880-016-0109-z
19 https://app.dimensions.ai/details/publication/pub.1078934993
20 https://app.dimensions.ai/details/publication/pub.1079025524
21 https://doi.org/10.1002/(sici)1098-2264(199909)26:1<62::aid-gcc9>3.0.co;2-f
22 https://doi.org/10.1002/1878-0261.12043
23 https://doi.org/10.1002/cncr.24121
24 https://doi.org/10.1002/hep.21227
25 https://doi.org/10.1016/j.bbrc.2017.05.032
26 https://doi.org/10.1016/j.bcp.2012.11.021
27 https://doi.org/10.1016/j.canlet.2008.03.048
28 https://doi.org/10.1016/j.canlet.2012.08.029
29 https://doi.org/10.1016/j.stem.2014.04.007
30 https://doi.org/10.1073/pnas.0307618100
31 https://doi.org/10.1073/pnas.0400067101
32 https://doi.org/10.1080/10253890701314863
33 https://doi.org/10.1093/nar/gkv1500
34 https://doi.org/10.1097/blo.0b013e318059b8c9
35 https://doi.org/10.1097/mph.0b013e318223d0c1
36 https://doi.org/10.1158/0008-5472.can-05-0592
37 https://doi.org/10.1158/0008-5472.can-06-3557
38 https://doi.org/10.1158/0008-5472.can-07-0999
39 https://doi.org/10.1158/0008-5472.can-11-2531
40 https://doi.org/10.1210/en.2006-1553
41 https://doi.org/10.1302/2046-3758.63.bjr-2016-0151.r2
42 https://doi.org/10.1371/journal.pone.0030907
43 https://doi.org/10.1634/stemcells.2005-0282
44 https://doi.org/10.1634/theoncologist.9-4-422
45 https://doi.org/10.2460/ajvr.73.9.1335
46 https://doi.org/10.3233/cbm-2012-0227
47 https://doi.org/10.3389/fonc.2013.00168
48 https://doi.org/10.3390/cancers7020784
49 https://doi.org/10.3892/or.2016.4922
50 https://doi.org/10.4081/ejh.2013.e30
51 schema:datePublished 2018-12
52 schema:datePublishedReg 2018-12-01
53 schema:description BACKGROUND: Human osteosarcoma (OS) is one of the most common primary bone sarcoma, because of early metastasis and few treatment strategies. It has been reported that the tumorigenicity and self-renewal capacity of side population (SP) cells play roles in human OS via regulating of target genes. This study aims to complement the differentially expressed genes (DEGs) that regulated between the SP cells and the non-SP cells from primary human OS and identify their functions and molecular pathways associated with OS. METHODS: The gene expression profile GSE63390 was downloaded, and bioinformatics analysis was made. RESULTS: One hundred forty-one DEGs totally were identified. Among them, 72 DEGs (51.06%) were overexpressed, and the remaining 69 DEGs (48.94%) were underexpressed. Gene ontology (GO) and pathway enrichment analysis of target genes were performed. We furthermore identified some relevant core genes using gene-gene interaction network analysis such as EIF4E, FAU, HSPD1, IL-6, and KISS1, which may have a relationship with the development process of OS. We also discovered that EIF4E/mTOR signaling pathway could be a potential research target for therapy and tumorigenesis of OS. CONCLUSION: This analysis provides a comprehensive understanding of the roles of DEGs coming from SP cells in the development of OS. However, these predictions need further experimental validation in future studies.
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf N1bfae37f375a42628aa457698bef9b99
58 N3fcdd308633d4fdc9c69ae4567b67657
59 sg:journal.1036452
60 schema:name Exploring the key genes and pathways of side population cells in human osteosarcoma using gene expression array analysis
61 schema:pagination 153
62 schema:productId N25ad006f391146369441c8ed0cae7d32
63 N585fa97bca014604a36e5923e8426eab
64 N98f3fc103ee647b2aebab83d1ded1066
65 Ncdf9efaecbf243fcbd03a85d54a2afa2
66 Ncfbbcf1d7d0c47bea2054fa297cebac0
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104991192
68 https://doi.org/10.1186/s13018-018-0860-8
69 schema:sdDatePublished 2019-04-11T01:17
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N6abc9cb05dee43e4a7857c74ccb5d8df
72 schema:url https://link.springer.com/10.1186%2Fs13018-018-0860-8
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N1bfae37f375a42628aa457698bef9b99 schema:volumeNumber 13
77 rdf:type schema:PublicationVolume
78 N25ad006f391146369441c8ed0cae7d32 schema:name doi
79 schema:value 10.1186/s13018-018-0860-8
80 rdf:type schema:PropertyValue
81 N3fcdd308633d4fdc9c69ae4567b67657 schema:issueNumber 1
82 rdf:type schema:PublicationIssue
83 N585fa97bca014604a36e5923e8426eab schema:name nlm_unique_id
84 schema:value 101265112
85 rdf:type schema:PropertyValue
86 N6abc9cb05dee43e4a7857c74ccb5d8df schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N6c501c20850a45afa44afb8ce542ede1 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
89 schema:familyName Tian
90 schema:givenName Zheng-Wei
91 rdf:type schema:Person
92 N6e50bcd1ff8e4b87bfcae3b6e6b2675e rdf:first Na25772fc845741afa1432061109b1a0e
93 rdf:rest Nfd22321642ea444f8029ce300f28af91
94 N98f3fc103ee647b2aebab83d1ded1066 schema:name dimensions_id
95 schema:value pub.1104991192
96 rdf:type schema:PropertyValue
97 Na25772fc845741afa1432061109b1a0e schema:affiliation https://www.grid.ac/institutes/grid.417031.0
98 schema:familyName Zhang
99 schema:givenName Dong-Liang
100 rdf:type schema:Person
101 Na90bf561b6914c78a4499768a1f635f2 rdf:first sg:person.014730700014.09
102 rdf:rest Nb31ac22f843e4002aabd48a8818cb4bc
103 Na94cbe524d81493f862528a600a040b1 rdf:first sg:person.011467115026.32
104 rdf:rest Nf83ebd935864412eb50997a0ab0dcc47
105 Nb31ac22f843e4002aabd48a8818cb4bc rdf:first sg:person.07620567614.50
106 rdf:rest N6e50bcd1ff8e4b87bfcae3b6e6b2675e
107 Ncdf9efaecbf243fcbd03a85d54a2afa2 schema:name readcube_id
108 schema:value 884c83e96b8bd3b2e8dfa6a80915c501df9e61fdeec151fb274c9bdc8071209e
109 rdf:type schema:PropertyValue
110 Ncfbbcf1d7d0c47bea2054fa297cebac0 schema:name pubmed_id
111 schema:value 29921292
112 rdf:type schema:PropertyValue
113 Nd11a02ff813248a68cc8216b4a0c455b rdf:first sg:person.016001644626.05
114 rdf:rest rdf:nil
115 Ndaa9406af4a74d879a3b5e1d12fcfb0f rdf:first sg:person.01135216257.34
116 rdf:rest Na94cbe524d81493f862528a600a040b1
117 Nf83ebd935864412eb50997a0ab0dcc47 rdf:first sg:person.016323641014.04
118 rdf:rest Na90bf561b6914c78a4499768a1f635f2
119 Nfd22321642ea444f8029ce300f28af91 rdf:first N6c501c20850a45afa44afb8ce542ede1
120 rdf:rest Nd11a02ff813248a68cc8216b4a0c455b
121 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
122 schema:name Biological Sciences
123 rdf:type schema:DefinedTerm
124 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
125 schema:name Genetics
126 rdf:type schema:DefinedTerm
127 sg:journal.1036452 schema:issn 1749-799X
128 schema:name Journal of Orthopaedic Surgery and Research
129 rdf:type schema:Periodical
130 sg:person.01135216257.34 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
131 schema:familyName Ren
132 schema:givenName Yi-Ming
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135216257.34
134 rdf:type schema:Person
135 sg:person.011467115026.32 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
136 schema:familyName Duan
137 schema:givenName Yuan-Hui
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011467115026.32
139 rdf:type schema:Person
140 sg:person.014730700014.09 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
141 schema:familyName Yang
142 schema:givenName Tao
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014730700014.09
144 rdf:type schema:Person
145 sg:person.016001644626.05 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
146 schema:familyName Tian
147 schema:givenName Meng-Qiang
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016001644626.05
149 rdf:type schema:Person
150 sg:person.016323641014.04 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
151 schema:familyName Sun
152 schema:givenName Yun-Bo
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016323641014.04
154 rdf:type schema:Person
155 sg:person.07620567614.50 schema:affiliation https://www.grid.ac/institutes/grid.417031.0
156 schema:familyName Zhao
157 schema:givenName Wen-Jun
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07620567614.50
159 rdf:type schema:Person
160 sg:pub.10.1007/978-1-4419-0284-9_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007435377
161 https://doi.org/10.1007/978-1-4419-0284-9_1
162 rdf:type schema:CreativeWork
163 sg:pub.10.1007/s12013-015-0579-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001906770
164 https://doi.org/10.1007/s12013-015-0579-7
165 rdf:type schema:CreativeWork
166 sg:pub.10.1007/s12032-009-9365-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1037199093
167 https://doi.org/10.1007/s12032-009-9365-y
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/nm.3418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053346580
170 https://doi.org/10.1038/nm.3418
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/sj.bjc.6605723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021570459
173 https://doi.org/10.1038/sj.bjc.6605723
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/sj.onc.1206283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026120882
176 https://doi.org/10.1038/sj.onc.1206283
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/sj.onc.1207549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033137600
179 https://doi.org/10.1038/sj.onc.1207549
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/srep37690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018688706
182 https://doi.org/10.1038/srep37690
183 rdf:type schema:CreativeWork
184 sg:pub.10.1186/gm83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025436905
185 https://doi.org/10.1186/gm83
186 rdf:type schema:CreativeWork
187 sg:pub.10.1186/s12885-016-2294-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014386938
188 https://doi.org/10.1186/s12885-016-2294-1
189 rdf:type schema:CreativeWork
190 sg:pub.10.1186/s13018-015-0275-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010197215
191 https://doi.org/10.1186/s13018-015-0275-8
192 rdf:type schema:CreativeWork
193 sg:pub.10.1186/s13018-016-0487-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045645724
194 https://doi.org/10.1186/s13018-016-0487-6
195 rdf:type schema:CreativeWork
196 sg:pub.10.1186/s13018-017-0599-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090382784
197 https://doi.org/10.1186/s13018-017-0599-7
198 rdf:type schema:CreativeWork
199 sg:pub.10.1186/s13018-017-0664-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092593258
200 https://doi.org/10.1186/s13018-017-0664-2
201 rdf:type schema:CreativeWork
202 sg:pub.10.1186/s40880-016-0109-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1030076543
203 https://doi.org/10.1186/s40880-016-0109-z
204 rdf:type schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1078934993 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1079025524 schema:CreativeWork
207 https://doi.org/10.1002/(sici)1098-2264(199909)26:1<62::aid-gcc9>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1051800920
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1002/1878-0261.12043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083740401
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1002/cncr.24121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032453250
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1002/hep.21227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039651292
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.bbrc.2017.05.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085193523
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.bcp.2012.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032946423
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.canlet.2008.03.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018593232
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.canlet.2012.08.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029698860
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.stem.2014.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043844474
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1073/pnas.0307618100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043818400
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1073/pnas.0400067101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024245226
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1080/10253890701314863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019809216
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/nar/gkv1500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011860877
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1097/blo.0b013e318059b8c9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033015365
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1097/mph.0b013e318223d0c1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008516702
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1158/0008-5472.can-05-0592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012674084
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1158/0008-5472.can-06-3557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034972609
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1158/0008-5472.can-07-0999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044850270
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1158/0008-5472.can-11-2531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034810586
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1210/en.2006-1553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064248428
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1302/2046-3758.63.bjr-2016-0151.r2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084265281
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1371/journal.pone.0030907 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053087113
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1634/stemcells.2005-0282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015289087
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1634/theoncologist.9-4-422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012709267
254 rdf:type schema:CreativeWork
255 https://doi.org/10.2460/ajvr.73.9.1335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070765190
256 rdf:type schema:CreativeWork
257 https://doi.org/10.3233/cbm-2012-0227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078511144
258 rdf:type schema:CreativeWork
259 https://doi.org/10.3389/fonc.2013.00168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000518261
260 rdf:type schema:CreativeWork
261 https://doi.org/10.3390/cancers7020784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040751015
262 rdf:type schema:CreativeWork
263 https://doi.org/10.3892/or.2016.4922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071534629
264 rdf:type schema:CreativeWork
265 https://doi.org/10.4081/ejh.2013.e30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037665127
266 rdf:type schema:CreativeWork
267 https://www.grid.ac/institutes/grid.417031.0 schema:alternateName Tianjin People's Hospital
268 schema:name Department of Joint and Sport Medicine, Tianjin Union Medical Center, Jieyuan Road 190, Hongqiao District, 300121, Tianjin, People’s Republic of China
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...