Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSSati Akbaba, Thomas Held, Kristin Lang, Juliane Hoerner-Rieber, Karim Zaoui, Tobias Forster, Stefan Rieken, Peter Plinkert, Juergen Debus, Sebastian Adeberg
ABSTRACTPURPOSE: Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has become a valuable, potentially curative therapeutic option. Thus, we aimed to determine prognostic factors for survival outcome in order to optimize patient selection for salvage radiotherapy after failure of first-line treatment with surgery alone in this special patient cohort. METHODS: Seventy-five patients (85% male, median age of 64 years) underwent salvage RT in a secondary setting for recurrent hypopharyngeal or laryngeal SCC after prior surgery alone between 2007 and 2017. On average, patients were treated with one prior surgery (range 1-4 surgeries). Median time between surgery and salvage RT was 7 months (range 1-47 months) for initially advanced tumors (T3/4, N+, extracapsular spread) and 18 months (range 5-333 months) for initially early stage tumors. The majority of patients received concomitant chemotherapy (n = 48; 64%) or other kind of systemic treatment concurrent to radiotherapy (n = 10; 13%). RESULTS: Median follow-up was 41 months (range 3-120 months). Overall, fifteen patients were diagnosed with local failure (all were in-field) at last follow-up (20%). Median time to recurrence was 35 months (range 3-120 months) and 3-year local progression-free survival (LPFS) was 75%, respectively. Dose-escalated RT with 70.4 Gy applied in 2.1 Gy or 2.2 Gy fractions corresponding an EQD2 > 70 Gy (p = 0.032) and the use of concomitant cisplatin weekly chemotherapy (p = 0.006) had a significant positive impact on LPFS. 3-year OS and DPFS were 76 and 85%, respectively. No toxicity-related deaths occurred. Reported grade > 3 side effects were rare (n = 4/70, 6%). CONCLUSION: Salvage radiotherapy resulted in excellent local control rates while radiation dose and the use of cisplatin weekly chemotherapy were identified as prognostic factors for LPFS. Nevertheless, patient selection for curative salvage treatment remains challenging. More... »
PAGES34
http://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8
DOIhttp://dx.doi.org/10.1186/s13014-019-1238-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112229213
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30782197
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Chemoradiotherapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cisplatin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hypopharyngeal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kaplan-Meier Estimate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Laryngeal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Recurrence, Local",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Salvage Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Squamous Cell Carcinoma of Head and Neck",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Akbaba",
"givenName": "Sati",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Held",
"givenName": "Thomas",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Lang",
"givenName": "Kristin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Hoerner-Rieber",
"givenName": "Juliane",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Heidelberg",
"id": "https://www.grid.ac/institutes/grid.5253.1",
"name": [
"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Zaoui",
"givenName": "Karim",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Forster",
"givenName": "Tobias",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Rieken",
"givenName": "Stefan",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Heidelberg",
"id": "https://www.grid.ac/institutes/grid.5253.1",
"name": [
"Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Plinkert",
"givenName": "Peter",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Debus",
"givenName": "Juergen",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Adeberg",
"givenName": "Sebastian",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/s0167-8140(97)00079-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001597212"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mlg.0000161354.28073.bc",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005609326"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mlg.0000161354.28073.bc",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005609326"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mlg.0000161354.28073.bc",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005609326"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10147-016-0964-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006889279",
"https://doi.org/10.1007/s10147-016-0964-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2007.04.088",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007164714"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.2820690526",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009180313"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.2820690526",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009180313"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199106133242402",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009370183"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2006.07.4559",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009457761"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.26066",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012092609"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa031317",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012809616"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejso.2016.05.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013596620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(01)01538-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013607972"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hed.21113",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013700090"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hed.21113",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013700090"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0002-9610(05)80734-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015825718"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/02841869409083923",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016445788"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0360-3016(88)90259-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017494811"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hed.24355",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018708949"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0094456",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019899057"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.6647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023484184"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archotol.132.1.59",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025697808"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2008.10.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026558254"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.oraloncology.2016.03.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026829988"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(00)90011-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028182366"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/lary.23387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029287664"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0360-3016(91)90274-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029995613"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(00)00663-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031121100"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/92.3.205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032301848"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archotol.129.1.44",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032648156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hed.23796",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035776084"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0360-3016(86)90058-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038120900"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jjco/hyt136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040781331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jjco/hyt136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040781331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2007.14.8841",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042333490"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00405-010-1274-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043098995",
"https://doi.org/10.1007/s00405-010-1274-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00405-010-1274-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043098995",
"https://doi.org/10.1007/s00405-010-1274-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.20181",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046323076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10147-008-0787-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050267138",
"https://doi.org/10.1007/s10147-008-0787-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10147-008-0787-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050267138",
"https://doi.org/10.1007/s10147-008-0787-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2012.43.6097",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053087344"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.radonc.2009.04.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053500952"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1259/bjr/85942136",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064570335"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/ol.2015.3640",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071526551"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/ol.2015.3640",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071526551"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.oraloncology.2017.01.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074236348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.oraloncology.2017.01.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074236348"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2001.19.20.4029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074893675"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1148/radiology.182.1.1727295",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077365160"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/hed.24757",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084012379"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-319-40618-3_11",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1087262088",
"https://doi.org/10.1007/978-3-319-40618-3_11"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13014-017-0900-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092346752",
"https://doi.org/10.1186/s13014-017-0900-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s13014-017-0900-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092346752",
"https://doi.org/10.1186/s13014-017-0900-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.anorl.2017.11.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1093120552"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.anorl.2017.11.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1093120552"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.anorl.2017.11.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1093120552"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3390/cancers10080267",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1106112545"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jso.25185",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1106293653"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "PURPOSE: Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has become a valuable, potentially curative therapeutic option. Thus, we aimed to determine prognostic factors for survival outcome in order to optimize patient selection for salvage radiotherapy after failure of first-line treatment with surgery alone in this special patient cohort.\nMETHODS: Seventy-five patients (85% male, median age of 64\u2009years) underwent salvage RT in a secondary setting for recurrent hypopharyngeal or laryngeal SCC after prior surgery alone between 2007 and 2017. On average, patients were treated with one prior surgery (range 1-4 surgeries). Median time between surgery and salvage RT was 7\u2009months (range 1-47\u2009months) for initially advanced tumors (T3/4, N+, extracapsular spread) and 18\u2009months (range 5-333\u2009months) for initially early stage tumors. The majority of patients received concomitant chemotherapy (n\u2009=\u200948; 64%) or other kind of systemic treatment concurrent to radiotherapy (n\u2009=\u200910; 13%).\nRESULTS: Median follow-up was 41\u2009months (range 3-120\u2009months). Overall, fifteen patients were diagnosed with local failure (all were in-field) at last follow-up (20%). Median time to recurrence was 35\u2009months (range 3-120\u2009months) and 3-year local progression-free survival (LPFS) was 75%, respectively. Dose-escalated RT with 70.4\u2009Gy applied in 2.1\u2009Gy or 2.2\u2009Gy fractions corresponding an EQD2\u2009>\u200970\u2009Gy (p\u2009=\u20090.032) and the use of concomitant cisplatin weekly chemotherapy (p\u2009=\u20090.006) had a significant positive impact on LPFS. 3-year OS and DPFS were 76 and 85%, respectively. No toxicity-related deaths occurred. Reported grade\u2009>\u20093 side effects were rare (n\u2009=\u20094/70, 6%).\nCONCLUSION: Salvage radiotherapy resulted in excellent local control rates while radiation dose and the use of cisplatin weekly chemotherapy were identified as prognostic factors for LPFS. Nevertheless, patient selection for curative salvage treatment remains challenging.",
"genre": "research_article",
"id": "sg:pub.10.1186/s13014-019-1238-8",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1036451",
"issn": [
"1748-717X"
],
"name": "Radiation Oncology",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "14"
}
],
"name": "Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre experience",
"pagination": "34",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"cd39a28ab39dc67fb9be55ae53cda643c3a6ef935a4cba1d4073182030096637"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30782197"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101265111"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13014-019-1238-8"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112229213"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13014-019-1238-8",
"https://app.dimensions.ai/details/publication/pub.1112229213"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T14:00",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130826_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs13014-019-1238-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8'
This table displays all metadata directly associated to this object as RDF triples.
336 TRIPLES
21 PREDICATES
92 URIs
37 LITERALS
25 BLANK NODES