Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Sati Akbaba, Thomas Held, Kristin Lang, Juliane Hoerner-Rieber, Karim Zaoui, Tobias Forster, Stefan Rieken, Peter Plinkert, Juergen Debus, Sebastian Adeberg

ABSTRACT

PURPOSE: Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has become a valuable, potentially curative therapeutic option. Thus, we aimed to determine prognostic factors for survival outcome in order to optimize patient selection for salvage radiotherapy after failure of first-line treatment with surgery alone in this special patient cohort. METHODS: Seventy-five patients (85% male, median age of 64 years) underwent salvage RT in a secondary setting for recurrent hypopharyngeal or laryngeal SCC after prior surgery alone between 2007 and 2017. On average, patients were treated with one prior surgery (range 1-4 surgeries). Median time between surgery and salvage RT was 7 months (range 1-47 months) for initially advanced tumors (T3/4, N+, extracapsular spread) and 18 months (range 5-333 months) for initially early stage tumors. The majority of patients received concomitant chemotherapy (n = 48; 64%) or other kind of systemic treatment concurrent to radiotherapy (n = 10; 13%). RESULTS: Median follow-up was 41 months (range 3-120 months). Overall, fifteen patients were diagnosed with local failure (all were in-field) at last follow-up (20%). Median time to recurrence was 35 months (range 3-120 months) and 3-year local progression-free survival (LPFS) was 75%, respectively. Dose-escalated RT with 70.4 Gy applied in 2.1 Gy or 2.2 Gy fractions corresponding an EQD2 > 70 Gy (p = 0.032) and the use of concomitant cisplatin weekly chemotherapy (p = 0.006) had a significant positive impact on LPFS. 3-year OS and DPFS were 76 and 85%, respectively. No toxicity-related deaths occurred. Reported grade > 3 side effects were rare (n = 4/70, 6%). CONCLUSION: Salvage radiotherapy resulted in excellent local control rates while radiation dose and the use of cisplatin weekly chemotherapy were identified as prognostic factors for LPFS. Nevertheless, patient selection for curative salvage treatment remains challenging. More... »

PAGES

34

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8

DOI

http://dx.doi.org/10.1186/s13014-019-1238-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112229213

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30782197


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoradiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypopharyngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kaplan-Meier Estimate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Laryngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Salvage Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Squamous Cell Carcinoma of Head and Neck", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akbaba", 
        "givenName": "Sati", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Held", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lang", 
        "givenName": "Kristin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoerner-Rieber", 
        "givenName": "Juliane", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zaoui", 
        "givenName": "Karim", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Forster", 
        "givenName": "Tobias", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rieken", 
        "givenName": "Stefan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Plinkert", 
        "givenName": "Peter", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Debus", 
        "givenName": "Juergen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adeberg", 
        "givenName": "Sebastian", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0167-8140(97)00079-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001597212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlg.0000161354.28073.bc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005609326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlg.0000161354.28073.bc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005609326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlg.0000161354.28073.bc", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005609326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-016-0964-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006889279", 
          "https://doi.org/10.1007/s10147-016-0964-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.04.088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007164714"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.2820690526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009180313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.2820690526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009180313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199106133242402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009370183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.07.4559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009457761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012092609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa031317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012809616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejso.2016.05.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013596620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(01)01538-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013607972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.21113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013700090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.21113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013700090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9610(05)80734-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015825718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02841869409083923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016445788"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(88)90259-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017494811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.24355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018708949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0094456", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019899057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.6647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023484184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.132.1.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025697808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2008.10.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026558254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.oraloncology.2016.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026829988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)90011-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028182366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lary.23387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029287664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(91)90274-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029995613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(00)00663-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031121100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.3.205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032301848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archotol.129.1.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032648156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.23796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035776084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(86)90058-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038120900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyt136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040781331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyt136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040781331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.14.8841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042333490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-010-1274-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043098995", 
          "https://doi.org/10.1007/s00405-010-1274-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00405-010-1274-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043098995", 
          "https://doi.org/10.1007/s00405-010-1274-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046323076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-008-0787-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050267138", 
          "https://doi.org/10.1007/s10147-008-0787-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10147-008-0787-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050267138", 
          "https://doi.org/10.1007/s10147-008-0787-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.43.6097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053087344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2009.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053500952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/bjr/85942136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064570335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2015.3640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071526551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ol.2015.3640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071526551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.oraloncology.2017.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074236348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.oraloncology.2017.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074236348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2001.19.20.4029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074893675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1148/radiology.182.1.1727295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077365160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.24757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084012379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-319-40618-3_11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1087262088", 
          "https://doi.org/10.1007/978-3-319-40618-3_11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-017-0900-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092346752", 
          "https://doi.org/10.1186/s13014-017-0900-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-017-0900-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092346752", 
          "https://doi.org/10.1186/s13014-017-0900-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.anorl.2017.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093120552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.anorl.2017.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093120552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.anorl.2017.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1093120552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/cancers10080267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106112545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jso.25185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106293653"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "PURPOSE: Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has become a valuable, potentially curative therapeutic option. Thus, we aimed to determine prognostic factors for survival outcome in order to optimize patient selection for salvage radiotherapy after failure of first-line treatment with surgery alone in this special patient cohort.\nMETHODS: Seventy-five patients (85% male, median age of 64\u2009years) underwent salvage RT in a secondary setting for recurrent hypopharyngeal or laryngeal SCC after prior surgery alone between 2007 and 2017. On average, patients were treated with one prior surgery (range 1-4 surgeries). Median time between surgery and salvage RT was 7\u2009months (range 1-47\u2009months) for initially advanced tumors (T3/4, N+, extracapsular spread) and 18\u2009months (range 5-333\u2009months) for initially early stage tumors. The majority of patients received concomitant chemotherapy (n\u2009=\u200948; 64%) or other kind of systemic treatment concurrent to radiotherapy (n\u2009=\u200910; 13%).\nRESULTS: Median follow-up was 41\u2009months (range 3-120\u2009months). Overall, fifteen patients were diagnosed with local failure (all were in-field) at last follow-up (20%). Median time to recurrence was 35\u2009months (range 3-120\u2009months) and 3-year local progression-free survival (LPFS) was 75%, respectively. Dose-escalated RT with 70.4\u2009Gy applied in 2.1\u2009Gy or 2.2\u2009Gy fractions corresponding an EQD2\u2009>\u200970\u2009Gy (p\u2009=\u20090.032) and the use of concomitant cisplatin weekly chemotherapy (p\u2009=\u20090.006) had a significant positive impact on LPFS. 3-year OS and DPFS were 76 and 85%, respectively. No toxicity-related deaths occurred. Reported grade\u2009>\u20093 side effects were rare (n\u2009=\u20094/70, 6%).\nCONCLUSION: Salvage radiotherapy resulted in excellent local control rates while radiation dose and the use of cisplatin weekly chemotherapy were identified as prognostic factors for LPFS. Nevertheless, patient selection for curative salvage treatment remains challenging.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13014-019-1238-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036451", 
        "issn": [
          "1748-717X"
        ], 
        "name": "Radiation Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre experience", 
    "pagination": "34", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cd39a28ab39dc67fb9be55ae53cda643c3a6ef935a4cba1d4073182030096637"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30782197"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101265111"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13014-019-1238-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112229213"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13014-019-1238-8", 
      "https://app.dimensions.ai/details/publication/pub.1112229213"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130826_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13014-019-1238-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-019-1238-8'


 

This table displays all metadata directly associated to this object as RDF triples.

336 TRIPLES      21 PREDICATES      92 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13014-019-1238-8 schema:about N1fd89f4b1d784759bdb5535d86c631bb
2 N284ec092d4e14c5bb8a6637a4e4d130c
3 N2a14a1a51184447c9ede240f0ee8e906
4 N3112a0162c8b41fbb069079c026fa6d2
5 N5551647e4f8047a997b015a52cea9861
6 N5958906428d647d99010cdd5df88118f
7 N6174675158ca42199abd1f08f4205159
8 N64304535159a494f976f79db75ba22b7
9 N6cd67413e97e454099f05f687bd646c7
10 N708eb7897ac74117bf8c340109b2d26d
11 N87bcef4d9a1e4abeaaed1829722e8967
12 Na88112c2b5e644fb81313eae1d55a338
13 Ndf12a73e0bc542e2bf015aea7ec65bb9
14 Nf4941c8e58ac40858990b440b45a4932
15 Nfbea8aaa696141c3a6d2768228810595
16 Nff53d1898aa34ebe871a4a86c33445fc
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N9127297296dd47099a93ff42ac06e5ce
20 schema:citation sg:pub.10.1007/978-3-319-40618-3_11
21 sg:pub.10.1007/s00405-010-1274-3
22 sg:pub.10.1007/s10147-008-0787-x
23 sg:pub.10.1007/s10147-016-0964-2
24 sg:pub.10.1186/s13014-017-0900-2
25 https://doi.org/10.1001/archotol.129.1.44
26 https://doi.org/10.1001/archotol.132.1.59
27 https://doi.org/10.1002/cncr.20181
28 https://doi.org/10.1002/cncr.26066
29 https://doi.org/10.1002/cncr.2820690526
30 https://doi.org/10.1002/hed.21113
31 https://doi.org/10.1002/hed.23796
32 https://doi.org/10.1002/hed.24355
33 https://doi.org/10.1002/hed.24757
34 https://doi.org/10.1002/jso.25185
35 https://doi.org/10.1002/lary.23387
36 https://doi.org/10.1016/0360-3016(86)90058-1
37 https://doi.org/10.1016/0360-3016(88)90259-3
38 https://doi.org/10.1016/0360-3016(91)90274-8
39 https://doi.org/10.1016/j.anorl.2017.11.001
40 https://doi.org/10.1016/j.ejca.2008.10.026
41 https://doi.org/10.1016/j.ejso.2016.05.017
42 https://doi.org/10.1016/j.ijrobp.2007.04.088
43 https://doi.org/10.1016/j.oraloncology.2016.03.014
44 https://doi.org/10.1016/j.oraloncology.2017.01.008
45 https://doi.org/10.1016/j.radonc.2009.04.014
46 https://doi.org/10.1016/s0002-9610(05)80734-2
47 https://doi.org/10.1016/s0140-6736(00)90011-4
48 https://doi.org/10.1016/s0167-8140(97)00079-0
49 https://doi.org/10.1016/s0360-3016(00)00663-5
50 https://doi.org/10.1016/s0360-3016(01)01538-3
51 https://doi.org/10.1056/nejm199106133242402
52 https://doi.org/10.1056/nejmoa031317
53 https://doi.org/10.1093/jjco/hyt136
54 https://doi.org/10.1093/jnci/92.3.205
55 https://doi.org/10.1097/01.mlg.0000161354.28073.bc
56 https://doi.org/10.1148/radiology.182.1.1727295
57 https://doi.org/10.1200/jco.2001.19.20.4029
58 https://doi.org/10.1200/jco.2006.07.4559
59 https://doi.org/10.1200/jco.2007.14.6647
60 https://doi.org/10.1200/jco.2007.14.8841
61 https://doi.org/10.1200/jco.2012.43.6097
62 https://doi.org/10.1259/bjr/85942136
63 https://doi.org/10.1371/journal.pone.0094456
64 https://doi.org/10.3109/02841869409083923
65 https://doi.org/10.3390/cancers10080267
66 https://doi.org/10.3892/ol.2015.3640
67 schema:datePublished 2019-12
68 schema:datePublishedReg 2019-12-01
69 schema:description PURPOSE: Salvage surgery of recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) results in limited local control and survival rates. As a result of recent technological progress, radiotherapy (RT) has become a valuable, potentially curative therapeutic option. Thus, we aimed to determine prognostic factors for survival outcome in order to optimize patient selection for salvage radiotherapy after failure of first-line treatment with surgery alone in this special patient cohort. METHODS: Seventy-five patients (85% male, median age of 64 years) underwent salvage RT in a secondary setting for recurrent hypopharyngeal or laryngeal SCC after prior surgery alone between 2007 and 2017. On average, patients were treated with one prior surgery (range 1-4 surgeries). Median time between surgery and salvage RT was 7 months (range 1-47 months) for initially advanced tumors (T3/4, N+, extracapsular spread) and 18 months (range 5-333 months) for initially early stage tumors. The majority of patients received concomitant chemotherapy (n = 48; 64%) or other kind of systemic treatment concurrent to radiotherapy (n = 10; 13%). RESULTS: Median follow-up was 41 months (range 3-120 months). Overall, fifteen patients were diagnosed with local failure (all were in-field) at last follow-up (20%). Median time to recurrence was 35 months (range 3-120 months) and 3-year local progression-free survival (LPFS) was 75%, respectively. Dose-escalated RT with 70.4 Gy applied in 2.1 Gy or 2.2 Gy fractions corresponding an EQD2 > 70 Gy (p = 0.032) and the use of concomitant cisplatin weekly chemotherapy (p = 0.006) had a significant positive impact on LPFS. 3-year OS and DPFS were 76 and 85%, respectively. No toxicity-related deaths occurred. Reported grade > 3 side effects were rare (n = 4/70, 6%). CONCLUSION: Salvage radiotherapy resulted in excellent local control rates while radiation dose and the use of cisplatin weekly chemotherapy were identified as prognostic factors for LPFS. Nevertheless, patient selection for curative salvage treatment remains challenging.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree true
73 schema:isPartOf N0cad33e4c6d543d9b194f715c11c6a91
74 Neab450e5a92a4eb6ba1a1a4d94f1c075
75 sg:journal.1036451
76 schema:name Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre experience
77 schema:pagination 34
78 schema:productId N46418ab4737c4b4c8c186ff01592bd77
79 N82a0bbadc408456fa298000ea5629ed9
80 N983f4c4d9b814788b8371ccead0472f8
81 Na639b4629ab542ef9dc80b192cfff30a
82 Nb427eb4c75ab43a2a01687367a067a41
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112229213
84 https://doi.org/10.1186/s13014-019-1238-8
85 schema:sdDatePublished 2019-04-11T14:00
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher Ne1a628fcd2f54159a32e3201a77ff5a8
88 schema:url https://link.springer.com/10.1186%2Fs13014-019-1238-8
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N0c14459543c74bf3bad415e65395a172 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
93 schema:familyName Debus
94 schema:givenName Juergen
95 rdf:type schema:Person
96 N0cad33e4c6d543d9b194f715c11c6a91 schema:issueNumber 1
97 rdf:type schema:PublicationIssue
98 N0ef53efff3874c02842886c78f8e5045 rdf:first Nb5539a7154d74cfd9b8ed9b15b1b6c45
99 rdf:rest N739fd6bbd03a4947bf14a6a16b8b37a2
100 N1fd89f4b1d784759bdb5535d86c631bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Salvage Therapy
102 rdf:type schema:DefinedTerm
103 N284ec092d4e14c5bb8a6637a4e4d130c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Hypopharyngeal Neoplasms
105 rdf:type schema:DefinedTerm
106 N2a14a1a51184447c9ede240f0ee8e906 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Adult
108 rdf:type schema:DefinedTerm
109 N3112a0162c8b41fbb069079c026fa6d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Chemoradiotherapy
111 rdf:type schema:DefinedTerm
112 N46418ab4737c4b4c8c186ff01592bd77 schema:name doi
113 schema:value 10.1186/s13014-019-1238-8
114 rdf:type schema:PropertyValue
115 N5551647e4f8047a997b015a52cea9861 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Kaplan-Meier Estimate
117 rdf:type schema:DefinedTerm
118 N5958906428d647d99010cdd5df88118f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Laryngeal Neoplasms
120 rdf:type schema:DefinedTerm
121 N6174675158ca42199abd1f08f4205159 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Female
123 rdf:type schema:DefinedTerm
124 N64304535159a494f976f79db75ba22b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Cisplatin
126 rdf:type schema:DefinedTerm
127 N69f633354bd34b34b2f5d6d3480cc31c schema:affiliation https://www.grid.ac/institutes/grid.5253.1
128 schema:familyName Plinkert
129 schema:givenName Peter
130 rdf:type schema:Person
131 N6cd67413e97e454099f05f687bd646c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Aged, 80 and over
133 rdf:type schema:DefinedTerm
134 N6d5895f665ac4cd4bdaa71ac18c14f61 rdf:first Nfb134f565ba54ad6b75e7aa25a2b61bf
135 rdf:rest Nefb4063620c3486b924f7ae1e0546dce
136 N708eb7897ac74117bf8c340109b2d26d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Squamous Cell Carcinoma of Head and Neck
138 rdf:type schema:DefinedTerm
139 N739fd6bbd03a4947bf14a6a16b8b37a2 rdf:first Ne44a835a84d1444c979912e79f69448f
140 rdf:rest N6d5895f665ac4cd4bdaa71ac18c14f61
141 N7699e04972b940ecb34b0d301b7dddaa schema:affiliation https://www.grid.ac/institutes/grid.488831.e
142 schema:familyName Akbaba
143 schema:givenName Sati
144 rdf:type schema:Person
145 N82a0bbadc408456fa298000ea5629ed9 schema:name pubmed_id
146 schema:value 30782197
147 rdf:type schema:PropertyValue
148 N87bcef4d9a1e4abeaaed1829722e8967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Antineoplastic Agents
150 rdf:type schema:DefinedTerm
151 N9127297296dd47099a93ff42ac06e5ce rdf:first N7699e04972b940ecb34b0d301b7dddaa
152 rdf:rest Naff1842390bb4345b1fec82c7862d03f
153 N983f4c4d9b814788b8371ccead0472f8 schema:name nlm_unique_id
154 schema:value 101265111
155 rdf:type schema:PropertyValue
156 N9c0576ddbab54ae5bf02f0422d6b3605 rdf:first Nc75db6bf21e84feb9679ffbd7d89703f
157 rdf:rest rdf:nil
158 Na5aecddcab0d4a3a82a9416ae54d0c95 rdf:first N0c14459543c74bf3bad415e65395a172
159 rdf:rest N9c0576ddbab54ae5bf02f0422d6b3605
160 Na639b4629ab542ef9dc80b192cfff30a schema:name readcube_id
161 schema:value cd39a28ab39dc67fb9be55ae53cda643c3a6ef935a4cba1d4073182030096637
162 rdf:type schema:PropertyValue
163 Na88112c2b5e644fb81313eae1d55a338 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Neoplasm Recurrence, Local
165 rdf:type schema:DefinedTerm
166 Nac1be286c4814679825958dafd54ecb8 rdf:first Ne979e1600c6d4dd38b3068d0cc812de8
167 rdf:rest Nb5c3694733d2450fb7ed251bdec09a43
168 Naff1842390bb4345b1fec82c7862d03f rdf:first Nc80e42c3d75a481b911b2d9f4816bf8f
169 rdf:rest N0ef53efff3874c02842886c78f8e5045
170 Nb427eb4c75ab43a2a01687367a067a41 schema:name dimensions_id
171 schema:value pub.1112229213
172 rdf:type schema:PropertyValue
173 Nb5539a7154d74cfd9b8ed9b15b1b6c45 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
174 schema:familyName Lang
175 schema:givenName Kristin
176 rdf:type schema:Person
177 Nb5c3694733d2450fb7ed251bdec09a43 rdf:first N69f633354bd34b34b2f5d6d3480cc31c
178 rdf:rest Na5aecddcab0d4a3a82a9416ae54d0c95
179 Nc75db6bf21e84feb9679ffbd7d89703f schema:affiliation https://www.grid.ac/institutes/grid.488831.e
180 schema:familyName Adeberg
181 schema:givenName Sebastian
182 rdf:type schema:Person
183 Nc80e42c3d75a481b911b2d9f4816bf8f schema:affiliation https://www.grid.ac/institutes/grid.488831.e
184 schema:familyName Held
185 schema:givenName Thomas
186 rdf:type schema:Person
187 Ndf12a73e0bc542e2bf015aea7ec65bb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Humans
189 rdf:type schema:DefinedTerm
190 Ne1a628fcd2f54159a32e3201a77ff5a8 schema:name Springer Nature - SN SciGraph project
191 rdf:type schema:Organization
192 Ne44a835a84d1444c979912e79f69448f schema:affiliation https://www.grid.ac/institutes/grid.488831.e
193 schema:familyName Hoerner-Rieber
194 schema:givenName Juliane
195 rdf:type schema:Person
196 Ne979e1600c6d4dd38b3068d0cc812de8 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
197 schema:familyName Rieken
198 schema:givenName Stefan
199 rdf:type schema:Person
200 Neab450e5a92a4eb6ba1a1a4d94f1c075 schema:volumeNumber 14
201 rdf:type schema:PublicationVolume
202 Neec0edb99a9a41b6a6b0e041d2b15600 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
203 schema:familyName Forster
204 schema:givenName Tobias
205 rdf:type schema:Person
206 Nefb4063620c3486b924f7ae1e0546dce rdf:first Neec0edb99a9a41b6a6b0e041d2b15600
207 rdf:rest Nac1be286c4814679825958dafd54ecb8
208 Nf4941c8e58ac40858990b440b45a4932 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Middle Aged
210 rdf:type schema:DefinedTerm
211 Nfb134f565ba54ad6b75e7aa25a2b61bf schema:affiliation https://www.grid.ac/institutes/grid.5253.1
212 schema:familyName Zaoui
213 schema:givenName Karim
214 rdf:type schema:Person
215 Nfbea8aaa696141c3a6d2768228810595 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Male
217 rdf:type schema:DefinedTerm
218 Nff53d1898aa34ebe871a4a86c33445fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Aged
220 rdf:type schema:DefinedTerm
221 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
222 schema:name Medical and Health Sciences
223 rdf:type schema:DefinedTerm
224 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
225 schema:name Oncology and Carcinogenesis
226 rdf:type schema:DefinedTerm
227 sg:journal.1036451 schema:issn 1748-717X
228 schema:name Radiation Oncology
229 rdf:type schema:Periodical
230 sg:pub.10.1007/978-3-319-40618-3_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1087262088
231 https://doi.org/10.1007/978-3-319-40618-3_11
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/s00405-010-1274-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043098995
234 https://doi.org/10.1007/s00405-010-1274-3
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/s10147-008-0787-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050267138
237 https://doi.org/10.1007/s10147-008-0787-x
238 rdf:type schema:CreativeWork
239 sg:pub.10.1007/s10147-016-0964-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006889279
240 https://doi.org/10.1007/s10147-016-0964-2
241 rdf:type schema:CreativeWork
242 sg:pub.10.1186/s13014-017-0900-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092346752
243 https://doi.org/10.1186/s13014-017-0900-2
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1001/archotol.129.1.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032648156
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1001/archotol.132.1.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025697808
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/cncr.20181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046323076
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/cncr.26066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012092609
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/cncr.2820690526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009180313
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/hed.21113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013700090
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/hed.23796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035776084
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/hed.24355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018708949
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/hed.24757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084012379
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/jso.25185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106293653
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/lary.23387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029287664
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/0360-3016(86)90058-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038120900
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/0360-3016(88)90259-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017494811
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/0360-3016(91)90274-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029995613
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.anorl.2017.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093120552
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.ejca.2008.10.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026558254
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.ejso.2016.05.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013596620
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.ijrobp.2007.04.088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007164714
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.oraloncology.2016.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026829988
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.oraloncology.2017.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074236348
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.radonc.2009.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053500952
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0002-9610(05)80734-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015825718
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0140-6736(00)90011-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028182366
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s0167-8140(97)00079-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001597212
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s0360-3016(00)00663-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031121100
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s0360-3016(01)01538-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013607972
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1056/nejm199106133242402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009370183
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1056/nejmoa031317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012809616
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/jjco/hyt136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040781331
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/jnci/92.3.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032301848
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1097/01.mlg.0000161354.28073.bc schema:sameAs https://app.dimensions.ai/details/publication/pub.1005609326
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1148/radiology.182.1.1727295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077365160
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1200/jco.2001.19.20.4029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074893675
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1200/jco.2006.07.4559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009457761
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1200/jco.2007.14.6647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023484184
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1200/jco.2007.14.8841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042333490
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1200/jco.2012.43.6097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053087344
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1259/bjr/85942136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064570335
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1371/journal.pone.0094456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019899057
322 rdf:type schema:CreativeWork
323 https://doi.org/10.3109/02841869409083923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016445788
324 rdf:type schema:CreativeWork
325 https://doi.org/10.3390/cancers10080267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106112545
326 rdf:type schema:CreativeWork
327 https://doi.org/10.3892/ol.2015.3640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071526551
328 rdf:type schema:CreativeWork
329 https://www.grid.ac/institutes/grid.488831.e schema:alternateName Heidelberger Institut für Radioonkologie
330 schema:name Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
331 Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
332 Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany
333 rdf:type schema:Organization
334 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
335 schema:name Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
336 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...