Ontology type: schema:ScholarlyArticle Open Access: True
2018-12
AUTHORSSati Akbaba, Robert Foerster, Nils Henrik Nicolay, Nathalie Arians, Tilman Bostel, Juergen Debus, Henrik Hauswald
ABSTRACTBACKGROUND: The purpose of this retrospective analysis is to analyze clinical outcome, visual acuity and enucleation rates after linear accelerator-based stereotactic fractionated photon radiotherapy for primary uveal melanoma. METHODS: Twenty-four patients with primary uveal melanoma treated at the Department of Radiation and Oncology of the University Hospital Heidelberg between 1991 and 2015 were analyzed regarding survival and treatment-related toxicity including eye- and sight-preservation. RESULTS: Photon radiotherapy (RT) offered good overall local control rates with a local progression-free survival (LPFS) of 82% after 5 years and a median LPFS of 5.5 years at a median follow-up time of 5.2 years. Gender had a significant impact on LPFS yielding a mean LPFS of 8.1 years for women and 8.7 years for men (p = 0.04). Of all local progressions, 80% occurred within the first 5 years after RT. In one case, enucleation as final therapy option was necessary. Enucleation-free survival (EFS) was related to the radiotherapy dose (p < 0.0001). Thus, higher prescribed doses led to a significantly higher enucleation rate. T-stage had no significant impact on EFS, but affected the enucleation rate (p = 0.01). The overall survival (OS) rate was 100% after 2 years and 70% after 5 years with a median OS of 5.75 years. Age (p = 0.046), T stage (p = 0.019), local control rate (p = 0.041) and the time between diagnosis and the first radiation session (p = 0.01) had a significant effect on OS. Applied biologically effective dose (BED) did not significantly influence OS or PFS. A 2-year sight preservation rate of 75% could be achieved. In all patients, irradiation could be applied safely without any interruptions due to side effects. Six significant late toxicities with consequential blindness could be observed, making a secondary enucleation necessary in four patients. An impairment of visual acuity due to chronic optic nerve atrophy was identified in five patients within 2 years after treatment. CONCLUSIONS: Linear accelerator-based stereotactic fractionated photon radiotherapy is an effective method in the treatment of uveal melanoma with excellent local control rates and a 2-year vision retention rate comparable to brachytherapy (BRT) or proton beam radiotherapy, even available in small centers and easy to implement. Interdisciplinary decision making is necessary to guarantee best treatment for every patient. More... »
PAGES140
http://scigraph.springernature.com/pub.10.1186/s13014-018-1088-9
DOIhttp://dx.doi.org/10.1186/s13014-018-1088-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1105971761
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30071857
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Akbaba",
"givenName": "Sati",
"id": "sg:person.010630245520.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010630245520.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital of Zurich",
"id": "https://www.grid.ac/institutes/grid.412004.3",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany",
"Department of Radiation Oncology, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland"
],
"type": "Organization"
},
"familyName": "Foerster",
"givenName": "Robert",
"id": "sg:person.01334401742.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334401742.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany",
"Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Nicolay",
"givenName": "Nils Henrik",
"id": "sg:person.01154104172.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154104172.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Arians",
"givenName": "Nathalie",
"id": "sg:person.0712176245.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712176245.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Bostel",
"givenName": "Tilman",
"id": "sg:person.01220066176.27",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220066176.27"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany",
"Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Debus",
"givenName": "Juergen",
"id": "sg:person.010621536472.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010621536472.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberger Institut f\u00fcr Radioonkologie",
"id": "https://www.grid.ac/institutes/grid.488831.e",
"name": [
"Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany",
"National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Hauswald",
"givenName": "Henrik",
"id": "sg:person.0712766653.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712766653.37"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.ijrobp.2015.01.029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002117848"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archopht.119.7.969",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008585211"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.radonc.2010.03.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010724325"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2010.04.035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015299982"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2005.01.058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017405441"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2005.01.058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017405441"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000098525",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018866944"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archopht.119.7.951",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023363043"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bjo.2008.142208",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023465468"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ajo.2016.02.027",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025719189"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0161-6420(02)01277-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026875338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0161-6420(02)01277-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026875338"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/02841860500468950",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031371823"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bjo.2010.195594",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031492233"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4103/0974-620x.116652",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033487136"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4103/0974-620x.116652",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033487136"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0039-6257(88)90173-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033825021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000328259",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035613883"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/aos.12731",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036227156"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/09286580600977281",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036470792"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2147/opth.s3555",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037001045"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(00)01430-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041087127"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clon.2016.01.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043164597"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2003.10.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043190070"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ophtha.2004.11.038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043744383"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ohc.2004.08.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043745358"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0167-8140(00)00164-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046739166"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2012.08.026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048191066"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0167-8140(02)00345-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050434746"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0167-8140(02)00345-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050434746"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archopht.120.7.933",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050611384"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074473111",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075223798",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/107327480401100504",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1076894579"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/107327480401100504",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1076894579"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2012.8.gks121002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078656011"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2012.8.gks121002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078656011"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2012.8.gks121002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078656011"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/2012.8.gks121002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078656011"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078879977",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2017.02.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083912219"
],
"type": "CreativeWork"
}
],
"datePublished": "2018-12",
"datePublishedReg": "2018-12-01",
"description": "BACKGROUND: The purpose of this retrospective analysis is to analyze clinical outcome, visual acuity and enucleation rates after linear accelerator-based stereotactic fractionated photon radiotherapy for primary uveal melanoma.\nMETHODS: Twenty-four patients with primary uveal melanoma treated at the Department of Radiation and Oncology of the University Hospital Heidelberg between 1991 and 2015 were analyzed regarding survival and treatment-related toxicity including eye- and sight-preservation.\nRESULTS: Photon radiotherapy (RT) offered good overall local control rates with a local progression-free survival (LPFS) of 82% after 5\u00a0years and a median LPFS of 5.5\u00a0years at a median follow-up time of 5.2\u00a0years. Gender had a significant impact on LPFS yielding a mean LPFS of 8.1\u00a0years for women and 8.7\u00a0years for men (p\u2009=\u20090.04). Of all local progressions, 80% occurred within the first 5\u00a0years after RT. In one case, enucleation as final therapy option was necessary. Enucleation-free survival (EFS) was related to the radiotherapy dose (p\u2009<\u20090.0001). Thus, higher prescribed doses led to a significantly higher enucleation rate. T-stage had no significant impact on EFS, but affected the enucleation rate (p\u2009=\u20090.01). The overall survival (OS) rate was 100% after 2\u00a0years and 70% after 5\u00a0years with a median OS of 5.75\u00a0years. Age (p\u2009=\u20090.046), T stage (p\u2009=\u20090.019), local control rate (p\u2009=\u20090.041) and the time between diagnosis and the first radiation session (p\u2009=\u20090.01) had a significant effect on OS. Applied biologically effective dose (BED) did not significantly influence OS or PFS. A 2-year sight preservation rate of 75% could be achieved. In all patients, irradiation could be applied safely without any interruptions due to side effects. Six significant late toxicities with consequential blindness could be observed, making a secondary enucleation necessary in four patients. An impairment of visual acuity due to chronic optic nerve atrophy was identified in five patients within 2\u00a0years after treatment.\nCONCLUSIONS: Linear accelerator-based stereotactic fractionated photon radiotherapy is an effective method in the treatment of uveal melanoma with excellent local control rates and a 2-year vision retention rate comparable to brachytherapy (BRT) or proton beam radiotherapy, even available in small centers and easy to implement. Interdisciplinary decision making is necessary to guarantee best treatment for every patient.",
"genre": "research_article",
"id": "sg:pub.10.1186/s13014-018-1088-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1036451",
"issn": [
"1748-717X"
],
"name": "Radiation Oncology",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "13"
}
],
"name": "Linear accelerator-based stereotactic fractionated photon radiotherapy as an eye-conserving treatment for uveal melanoma",
"pagination": "140",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"e82371ccd904284b37b020e3bf9f56d2eac0eeb03331eafe5ef60d95d1959bb8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30071857"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101265111"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13014-018-1088-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1105971761"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13014-018-1088-9",
"https://app.dimensions.ai/details/publication/pub.1105971761"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T22:42",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000571.jsonl",
"type": "ScholarlyArticle",
"url": "https://link.springer.com/10.1186%2Fs13014-018-1088-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1088-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1088-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1088-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1088-9'
This table displays all metadata directly associated to this object as RDF triples.
217 TRIPLES
21 PREDICATES
62 URIs
21 LITERALS
9 BLANK NODES