Postoperative (chemo) radiation in patients with squamous cell cancers of the head and neck – clinical results from the cohort ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Cornelius Maihoefer, Lars Schüttrumpf, Corinna Macht, Ulrike Pflugradt, Julia Hess, Ludmila Schneider, Christine Woischke, Axel Walch, Philipp Baumeister, Thomas Kirchner, Horst Zitzelsberger, Claus Belka, Ute Ganswindt

ABSTRACT

BACKGROUND: Postoperative (chemo) radiation improves tumor control and survival in high-risk patients with head and neck squamous cell carcinoma based on established risk factors. The clinical cooperation group "Personalized Radiotherapy in Head and Neck Cancer" focuses on the identification and validation of new biomarkers, which are aimed at eventually stratifying and personalizing the therapy concept. Hence, we reviewed all patients with head and neck squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx, treated with postoperative (chemo) radiation from 06/2008 until 06/2015 at the Department of Radiation Oncology in the University Hospital, LMU Munich. Here we report the clinical results of the cohort, laying the foundation for further research within the framework of a clinical cooperation group. METHODS: Patient data were retrospectively (until 2013) and prospectively (from 2013) collected and analyzed for outcome and treatment failures with regard to previously described and established risk factors. RESULTS: We identified 302 patients (median follow-up 45 months, average age 60.7 years), having received postoperative (chemo)radiation (median 64 Gy). Chemotherapy was added in 58% of cases, mostly Cisplatin/5- Fluorouracil in concordance with the ARO 96-3 study. The 3-year overall survival, local, locoregional and distant failure estimates were 70.5, 9.7, 12.2 and 13.5%, respectively. Human papillomavirus-associated oropharyngeal cancer was associated with a significant improved overall survival, locoregional, distant and overall tumor control rates in multivariate analysis. Additionally, in multivariate analysis, for local failure, resection status and perineural invasion, for locoregional and distant failure extracapsular extension and for overall survival the presence of nodal disease were significant adverse factors. Moreover, 138 patients have been treated in concordance with the ARO 96-3 protocol, corroborating the results of this study. CONCLUSIONS: Our cohort represents a large unselected cohort of patients with head and neck squamous cell carcinoma treated with postoperative (chemo)radiation. Tumor control rates and survival rates are consistent with the results of previously reported data. More... »

PAGES

123

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13014-018-1067-1

DOI

http://dx.doi.org/10.1186/s13014-018-1067-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105295833

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29970111


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemoradiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germany", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Head and Neck Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Laryngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mouth Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pharyngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postoperative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maihoefer", 
        "givenName": "Cornelius", 
        "id": "sg:person.01046472517.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046472517.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00fcttrumpf", 
        "givenName": "Lars", 
        "id": "sg:person.01325665732.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325665732.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Gemeinschaftspraxis f\u00fcr Strahlentherapie und Radioonkolgie am Klinikum Schwabing, K\u00f6lner Platz 1, 80804, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Macht", 
        "givenName": "Corinna", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pflugradt", 
        "givenName": "Ulrike", 
        "id": "sg:person.012742402630.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742402630.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Research Unit Radiation Cytogenetics, Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hess", 
        "givenName": "Julia", 
        "id": "sg:person.01272113525.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272113525.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Research Unit Radiation Cytogenetics, Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schneider", 
        "givenName": "Ludmila", 
        "id": "sg:person.016523142641.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016523142641.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Institute of Pathology, Faculty of Medicine, LMU Munich, Marchioninistr. 27, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woischke", 
        "givenName": "Christine", 
        "id": "sg:person.01030545525.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030545525.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Research Unit Analytical Pathology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walch", 
        "givenName": "Axel", 
        "id": "sg:person.01113032151.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113032151.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baumeister", 
        "givenName": "Philipp", 
        "id": "sg:person.0757120612.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757120612.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Institute of Pathology, Faculty of Medicine, LMU Munich, Marchioninistr. 27, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirchner", 
        "givenName": "Thomas", 
        "id": "sg:person.0650074000.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650074000.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Research Unit Radiation Cytogenetics, Helmholtz Zentrum Mu\u0308nchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zitzelsberger", 
        "givenName": "Horst", 
        "id": "sg:person.01063607465.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063607465.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belka", 
        "givenName": "Claus", 
        "id": "sg:person.0632042327.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632042327.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Clinical Cooperation Group \u2018Personalized Radiotherapy in Head and Neck Cancer\u2019, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health GmbH, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Neuherberg, Germany", 
            "Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany", 
            "Department of Radiation Oncology, University of Innsbruck, Anichstra\u00dfe 35, 6020, Innsbruck, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ganswindt", 
        "givenName": "Ute", 
        "id": "sg:person.01127253114.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127253114.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ejca.2016.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003115276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2016.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003115276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djn011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004334002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.24486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006507974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12885-015-1598-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007042446", 
          "https://doi.org/10.1186/s12885-015-1598-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-011-1139-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008883110", 
          "https://doi.org/10.1007/s00066-011-1139-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0912217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009375074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2007.09.058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012101445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-015-0490-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013409601", 
          "https://doi.org/10.1186/s13014-015-0490-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-015-0490-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013409601", 
          "https://doi.org/10.1186/s13014-015-0490-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2014.11.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015502287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2014.11.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015502287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015621155"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70237-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023133092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-011-2262-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026565367", 
          "https://doi.org/10.1007/s00066-011-2262-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-011-2262-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026565367", 
          "https://doi.org/10.1007/s00066-011-2262-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa032641", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026683382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027234612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-016-0999-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028332773", 
          "https://doi.org/10.1007/s00066-016-0999-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-016-0999-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028332773", 
          "https://doi.org/10.1007/s00066-016-0999-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.oraloncology.2016.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031308961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.oraloncology.2016.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031308961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(97)00817-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032979639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2012.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034399414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.53.9163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034427787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.53.9163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034427787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-014-0753-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036433500", 
          "https://doi.org/10.1007/s00066-014-0753-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1602252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036710957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.20279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040753073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.20279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040753073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-015-0561-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046091911", 
          "https://doi.org/10.1186/s13014-015-0561-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-015-0561-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046091911", 
          "https://doi.org/10.1186/s13014-015-0561-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2015.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047229832", 
          "https://doi.org/10.1038/bjc.2015.111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-2456(96)00075-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047730164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(15)00560-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050082725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jjco/hyw099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059803119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2017.02.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084071179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.30770", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085211462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2016-0318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085468069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2016-0318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085468069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fonc.2017.00129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090299416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hed.24974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092131390"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semradonc.2017.08.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092993958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.31213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099655593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2017.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100113169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2017.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100113169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-17-2345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100165621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-17-2345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100165621"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Postoperative (chemo) radiation improves tumor control and survival in high-risk patients with head and neck squamous cell carcinoma based on established risk factors. The clinical cooperation group \"Personalized Radiotherapy in Head and Neck Cancer\" focuses on the identification and validation of new biomarkers, which are aimed at eventually stratifying and personalizing the therapy concept. Hence, we reviewed all patients with head and neck squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx, treated with postoperative (chemo) radiation from 06/2008 until 06/2015 at the Department of Radiation Oncology in the University Hospital, LMU Munich. Here we report the clinical results of the cohort, laying the foundation for further research within the framework of a clinical cooperation group.\nMETHODS: Patient data were retrospectively (until 2013) and prospectively (from 2013) collected and analyzed for outcome and treatment failures with regard to previously described and established risk factors.\nRESULTS: We identified 302 patients (median follow-up 45\u00a0months, average age 60.7\u00a0years), having received postoperative (chemo)radiation (median 64\u00a0Gy). Chemotherapy was added in 58% of cases, mostly Cisplatin/5- Fluorouracil in concordance with the ARO 96-3 study. The 3-year overall survival, local, locoregional and distant failure estimates were 70.5, 9.7, 12.2 and 13.5%, respectively. Human papillomavirus-associated oropharyngeal cancer was associated with a significant improved overall survival, locoregional, distant and overall tumor control rates in multivariate analysis. Additionally, in multivariate analysis, for local failure, resection status and perineural invasion, for locoregional and distant failure extracapsular extension and for overall survival the presence of nodal disease were significant adverse factors. Moreover, 138 patients have been treated in concordance with the ARO 96-3 protocol, corroborating the results of this study.\nCONCLUSIONS: Our cohort represents a large unselected cohort of patients with head and neck squamous cell carcinoma treated with postoperative (chemo)radiation. Tumor control rates and survival rates are consistent with the results of previously reported data.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13014-018-1067-1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036451", 
        "issn": [
          "1748-717X"
        ], 
        "name": "Radiation Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Postoperative (chemo) radiation in patients with squamous cell cancers of the head and neck \u2013 clinical results from the cohort of the clinical cooperation group \u201cPersonalized Radiotherapy in Head and Neck Cancer\u201d", 
    "pagination": "123", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "869108a3761b9fc9d3b3f0c1e320c8388c749f19b9a0a68edd9b576f70742fb7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29970111"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101265111"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13014-018-1067-1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105295833"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13014-018-1067-1", 
      "https://app.dimensions.ai/details/publication/pub.1105295833"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000573.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13014-018-1067-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1067-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1067-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1067-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1067-1'


 

This table displays all metadata directly associated to this object as RDF triples.

370 TRIPLES      21 PREDICATES      88 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13014-018-1067-1 schema:about N0a911256978e46ab9154b0fde6d2f646
2 N1cee531a43504f808ca8e23781c4aa1a
3 N2411ba6a505241b79ea6ac85a84d59ee
4 N3050969873d74f019c593fc7a5c4e53c
5 N38cf973b49804f9e89c1b3e69db1cc7f
6 N4964349f8d7f4d2dacd4d47c489d0ab1
7 N49c19934039d484eb2721744ae8179c7
8 N66afc7c6426e4d1e935dc861603c9fc6
9 N69753d4f60cb49e899d7ae7fef67e50b
10 N69dca585693b4e66b203a4f87ed4354f
11 N86cfcd1a84954b22b6902b5a3ae8e920
12 N87ff8a5ef5364e28a34dba15583b77be
13 N8f81161da8bc4a70833481d41ae01569
14 Nb57c1a7fc12d4654870387cf89c0c852
15 Nb941ffc24328413ab5d41dd854570787
16 Nbc9c3027b1c948b2904f89809f180929
17 Nc4e58dfa24364cf2b828acc3471b83a1
18 Nd37f24d5a5cd4c47b1c219cdf63848b7
19 Nd3d00c4eef914041a898e6273a0db297
20 Ne9bb09d594674387b89d010c9062c2a1
21 Nea9087dfd9ca4bc4ae636e7ab9f40425
22 Nee3be3999ab24e54aeaf7129c5cafea2
23 Nfe126fac829d47a29e2ff73bdc05462e
24 anzsrc-for:11
25 anzsrc-for:1112
26 schema:author N3865212871f34a2c85f772e43504b30f
27 schema:citation sg:pub.10.1007/s00066-011-1139-8
28 sg:pub.10.1007/s00066-011-2262-2
29 sg:pub.10.1007/s00066-014-0753-7
30 sg:pub.10.1007/s00066-016-0999-3
31 sg:pub.10.1038/bjc.2015.111
32 sg:pub.10.1186/s12885-015-1598-x
33 sg:pub.10.1186/s13014-015-0490-9
34 sg:pub.10.1186/s13014-015-0561-y
35 https://doi.org/10.1002/cncr.23206
36 https://doi.org/10.1002/hed.20279
37 https://doi.org/10.1002/hed.24486
38 https://doi.org/10.1002/hed.24974
39 https://doi.org/10.1002/ijc.30770
40 https://doi.org/10.1002/ijc.31213
41 https://doi.org/10.1016/0197-2456(96)00075-x
42 https://doi.org/10.1016/j.ejca.2016.01.003
43 https://doi.org/10.1016/j.ejca.2017.02.018
44 https://doi.org/10.1016/j.ijrobp.2007.09.058
45 https://doi.org/10.1016/j.ijrobp.2012.05.008
46 https://doi.org/10.1016/j.oraloncology.2016.10.003
47 https://doi.org/10.1016/j.radonc.2014.11.011
48 https://doi.org/10.1016/j.radonc.2017.12.007
49 https://doi.org/10.1016/j.semradonc.2017.08.001
50 https://doi.org/10.1016/s0360-3016(97)00817-1
51 https://doi.org/10.1016/s1470-2045(12)70237-1
52 https://doi.org/10.1016/s1470-2045(15)00560-4
53 https://doi.org/10.1056/nejmoa032641
54 https://doi.org/10.1056/nejmoa032646
55 https://doi.org/10.1056/nejmoa0912217
56 https://doi.org/10.1056/nejmoa1602252
57 https://doi.org/10.1093/jjco/hyw099
58 https://doi.org/10.1093/jnci/djn011
59 https://doi.org/10.1158/1078-0432.ccr-17-2345
60 https://doi.org/10.1200/jco.2013.53.9163
61 https://doi.org/10.1634/theoncologist.2016-0318
62 https://doi.org/10.3389/fonc.2017.00129
63 schema:datePublished 2018-12
64 schema:datePublishedReg 2018-12-01
65 schema:description BACKGROUND: Postoperative (chemo) radiation improves tumor control and survival in high-risk patients with head and neck squamous cell carcinoma based on established risk factors. The clinical cooperation group "Personalized Radiotherapy in Head and Neck Cancer" focuses on the identification and validation of new biomarkers, which are aimed at eventually stratifying and personalizing the therapy concept. Hence, we reviewed all patients with head and neck squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx, treated with postoperative (chemo) radiation from 06/2008 until 06/2015 at the Department of Radiation Oncology in the University Hospital, LMU Munich. Here we report the clinical results of the cohort, laying the foundation for further research within the framework of a clinical cooperation group. METHODS: Patient data were retrospectively (until 2013) and prospectively (from 2013) collected and analyzed for outcome and treatment failures with regard to previously described and established risk factors. RESULTS: We identified 302 patients (median follow-up 45 months, average age 60.7 years), having received postoperative (chemo)radiation (median 64 Gy). Chemotherapy was added in 58% of cases, mostly Cisplatin/5- Fluorouracil in concordance with the ARO 96-3 study. The 3-year overall survival, local, locoregional and distant failure estimates were 70.5, 9.7, 12.2 and 13.5%, respectively. Human papillomavirus-associated oropharyngeal cancer was associated with a significant improved overall survival, locoregional, distant and overall tumor control rates in multivariate analysis. Additionally, in multivariate analysis, for local failure, resection status and perineural invasion, for locoregional and distant failure extracapsular extension and for overall survival the presence of nodal disease were significant adverse factors. Moreover, 138 patients have been treated in concordance with the ARO 96-3 protocol, corroborating the results of this study. CONCLUSIONS: Our cohort represents a large unselected cohort of patients with head and neck squamous cell carcinoma treated with postoperative (chemo)radiation. Tumor control rates and survival rates are consistent with the results of previously reported data.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf N2d3f5ca8e26549dbb57009fd278fcfb0
70 Ndd0b9d8f0020457bb5a655ff36cb1217
71 sg:journal.1036451
72 schema:name Postoperative (chemo) radiation in patients with squamous cell cancers of the head and neck – clinical results from the cohort of the clinical cooperation group “Personalized Radiotherapy in Head and Neck Cancer”
73 schema:pagination 123
74 schema:productId N139924aaaa5a438fba947c482bfea552
75 N1750b4f4d83d4082a2d3acff14152e54
76 N31fd65838c8448a5a5500b646eb2a7b6
77 Ne1f6b51531804185a55a10df59cbd05e
78 Nf126882aa6084de7aafb77435af46210
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105295833
80 https://doi.org/10.1186/s13014-018-1067-1
81 schema:sdDatePublished 2019-04-10T20:56
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N8735ed1e31264a6da232aa04bca90dc1
84 schema:url https://link.springer.com/10.1186%2Fs13014-018-1067-1
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N031fc2abdf3644f8a2b9a8568b0881ba rdf:first sg:person.01063607465.70
89 rdf:rest Nee983e83f19e431f8256507668034b01
90 N0a911256978e46ab9154b0fde6d2f646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Antineoplastic Agents
92 rdf:type schema:DefinedTerm
93 N139924aaaa5a438fba947c482bfea552 schema:name pubmed_id
94 schema:value 29970111
95 rdf:type schema:PropertyValue
96 N1750b4f4d83d4082a2d3acff14152e54 schema:name dimensions_id
97 schema:value pub.1105295833
98 rdf:type schema:PropertyValue
99 N1c7920aebb5b465c802a8322432512d0 rdf:first sg:person.012742402630.97
100 rdf:rest N58c8dbd7c8c8401b8c00bf3430d6a242
101 N1cee531a43504f808ca8e23781c4aa1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Epithelial Cells
103 rdf:type schema:DefinedTerm
104 N1dd2921a41a64f9180d4b059227a40e7 schema:affiliation Ne63fe1f768904f9786c2b76c5d74af4a
105 schema:familyName Macht
106 schema:givenName Corinna
107 rdf:type schema:Person
108 N2411ba6a505241b79ea6ac85a84d59ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Aged, 80 and over
110 rdf:type schema:DefinedTerm
111 N26b54ebccc284bbe8e0b93d05fe16d7f rdf:first sg:person.0757120612.25
112 rdf:rest N78166a4e42694a41b85e5c58f18c9e90
113 N2d3f5ca8e26549dbb57009fd278fcfb0 schema:volumeNumber 13
114 rdf:type schema:PublicationVolume
115 N3050969873d74f019c593fc7a5c4e53c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Laryngeal Neoplasms
117 rdf:type schema:DefinedTerm
118 N31fd65838c8448a5a5500b646eb2a7b6 schema:name readcube_id
119 schema:value 869108a3761b9fc9d3b3f0c1e320c8388c749f19b9a0a68edd9b576f70742fb7
120 rdf:type schema:PropertyValue
121 N3865212871f34a2c85f772e43504b30f rdf:first sg:person.01046472517.05
122 rdf:rest Ne2f5cc20be444a59abff29fa9a5e8aad
123 N38cf973b49804f9e89c1b3e69db1cc7f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Head and Neck Neoplasms
125 rdf:type schema:DefinedTerm
126 N4964349f8d7f4d2dacd4d47c489d0ab1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Mouth Neoplasms
128 rdf:type schema:DefinedTerm
129 N49c19934039d484eb2721744ae8179c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Germany
131 rdf:type schema:DefinedTerm
132 N58c8dbd7c8c8401b8c00bf3430d6a242 rdf:first sg:person.01272113525.24
133 rdf:rest N6903d385c1f340bd811284dd7e5b0088
134 N66afc7c6426e4d1e935dc861603c9fc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Chemoradiotherapy
136 rdf:type schema:DefinedTerm
137 N6903d385c1f340bd811284dd7e5b0088 rdf:first sg:person.016523142641.00
138 rdf:rest Nec1ca11938f0486e9658bf1feae423fe
139 N69753d4f60cb49e899d7ae7fef67e50b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Male
141 rdf:type schema:DefinedTerm
142 N69dca585693b4e66b203a4f87ed4354f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Adult
144 rdf:type schema:DefinedTerm
145 N78166a4e42694a41b85e5c58f18c9e90 rdf:first sg:person.0650074000.01
146 rdf:rest N031fc2abdf3644f8a2b9a8568b0881ba
147 N86cfcd1a84954b22b6902b5a3ae8e920 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cisplatin
149 rdf:type schema:DefinedTerm
150 N8735ed1e31264a6da232aa04bca90dc1 schema:name Springer Nature - SN SciGraph project
151 rdf:type schema:Organization
152 N87ff8a5ef5364e28a34dba15583b77be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Aged
154 rdf:type schema:DefinedTerm
155 N8f81161da8bc4a70833481d41ae01569 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Middle Aged
157 rdf:type schema:DefinedTerm
158 N9e986b937f4b4a39b468126b4646fdc2 rdf:first sg:person.01127253114.17
159 rdf:rest rdf:nil
160 Nb57c1a7fc12d4654870387cf89c0c852 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Fluorouracil
162 rdf:type schema:DefinedTerm
163 Nb941ffc24328413ab5d41dd854570787 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Prospective Studies
165 rdf:type schema:DefinedTerm
166 Nbc9c3027b1c948b2904f89809f180929 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Postoperative Care
168 rdf:type schema:DefinedTerm
169 Nc4e58dfa24364cf2b828acc3471b83a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Carcinoma, Squamous Cell
171 rdf:type schema:DefinedTerm
172 Nc9bcf516bc414928ba714937bc75034b rdf:first N1dd2921a41a64f9180d4b059227a40e7
173 rdf:rest N1c7920aebb5b465c802a8322432512d0
174 Nd37f24d5a5cd4c47b1c219cdf63848b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Pharyngeal Neoplasms
176 rdf:type schema:DefinedTerm
177 Nd3d00c4eef914041a898e6273a0db297 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Female
179 rdf:type schema:DefinedTerm
180 Ndd0b9d8f0020457bb5a655ff36cb1217 schema:issueNumber 1
181 rdf:type schema:PublicationIssue
182 Ne1f6b51531804185a55a10df59cbd05e schema:name doi
183 schema:value 10.1186/s13014-018-1067-1
184 rdf:type schema:PropertyValue
185 Ne2f5cc20be444a59abff29fa9a5e8aad rdf:first sg:person.01325665732.31
186 rdf:rest Nc9bcf516bc414928ba714937bc75034b
187 Ne63fe1f768904f9786c2b76c5d74af4a schema:name Gemeinschaftspraxis für Strahlentherapie und Radioonkolgie am Klinikum Schwabing, Kölner Platz 1, 80804, Munich, Germany
188 rdf:type schema:Organization
189 Ne9397cfb7ad643d4b69f5b6d92400cb1 rdf:first sg:person.01113032151.01
190 rdf:rest N26b54ebccc284bbe8e0b93d05fe16d7f
191 Ne9bb09d594674387b89d010c9062c2a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Retrospective Studies
193 rdf:type schema:DefinedTerm
194 Nea9087dfd9ca4bc4ae636e7ab9f40425 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Combined Modality Therapy
196 rdf:type schema:DefinedTerm
197 Nec1ca11938f0486e9658bf1feae423fe rdf:first sg:person.01030545525.52
198 rdf:rest Ne9397cfb7ad643d4b69f5b6d92400cb1
199 Nee3be3999ab24e54aeaf7129c5cafea2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Humans
201 rdf:type schema:DefinedTerm
202 Nee983e83f19e431f8256507668034b01 rdf:first sg:person.0632042327.96
203 rdf:rest N9e986b937f4b4a39b468126b4646fdc2
204 Nf126882aa6084de7aafb77435af46210 schema:name nlm_unique_id
205 schema:value 101265111
206 rdf:type schema:PropertyValue
207 Nfe126fac829d47a29e2ff73bdc05462e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Neoplasm Recurrence, Local
209 rdf:type schema:DefinedTerm
210 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
211 schema:name Medical and Health Sciences
212 rdf:type schema:DefinedTerm
213 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
214 schema:name Oncology and Carcinogenesis
215 rdf:type schema:DefinedTerm
216 sg:journal.1036451 schema:issn 1748-717X
217 schema:name Radiation Oncology
218 rdf:type schema:Periodical
219 sg:person.01030545525.52 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
220 schema:familyName Woischke
221 schema:givenName Christine
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030545525.52
223 rdf:type schema:Person
224 sg:person.01046472517.05 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
225 schema:familyName Maihoefer
226 schema:givenName Cornelius
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046472517.05
228 rdf:type schema:Person
229 sg:person.01063607465.70 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
230 schema:familyName Zitzelsberger
231 schema:givenName Horst
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063607465.70
233 rdf:type schema:Person
234 sg:person.01113032151.01 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
235 schema:familyName Walch
236 schema:givenName Axel
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113032151.01
238 rdf:type schema:Person
239 sg:person.01127253114.17 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
240 schema:familyName Ganswindt
241 schema:givenName Ute
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127253114.17
243 rdf:type schema:Person
244 sg:person.01272113525.24 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
245 schema:familyName Hess
246 schema:givenName Julia
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272113525.24
248 rdf:type schema:Person
249 sg:person.012742402630.97 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
250 schema:familyName Pflugradt
251 schema:givenName Ulrike
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742402630.97
253 rdf:type schema:Person
254 sg:person.01325665732.31 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
255 schema:familyName Schüttrumpf
256 schema:givenName Lars
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325665732.31
258 rdf:type schema:Person
259 sg:person.016523142641.00 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
260 schema:familyName Schneider
261 schema:givenName Ludmila
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016523142641.00
263 rdf:type schema:Person
264 sg:person.0632042327.96 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
265 schema:familyName Belka
266 schema:givenName Claus
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632042327.96
268 rdf:type schema:Person
269 sg:person.0650074000.01 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
270 schema:familyName Kirchner
271 schema:givenName Thomas
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650074000.01
273 rdf:type schema:Person
274 sg:person.0757120612.25 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
275 schema:familyName Baumeister
276 schema:givenName Philipp
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757120612.25
278 rdf:type schema:Person
279 sg:pub.10.1007/s00066-011-1139-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008883110
280 https://doi.org/10.1007/s00066-011-1139-8
281 rdf:type schema:CreativeWork
282 sg:pub.10.1007/s00066-011-2262-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026565367
283 https://doi.org/10.1007/s00066-011-2262-2
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/s00066-014-0753-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036433500
286 https://doi.org/10.1007/s00066-014-0753-7
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s00066-016-0999-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028332773
289 https://doi.org/10.1007/s00066-016-0999-3
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/bjc.2015.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047229832
292 https://doi.org/10.1038/bjc.2015.111
293 rdf:type schema:CreativeWork
294 sg:pub.10.1186/s12885-015-1598-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007042446
295 https://doi.org/10.1186/s12885-015-1598-x
296 rdf:type schema:CreativeWork
297 sg:pub.10.1186/s13014-015-0490-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013409601
298 https://doi.org/10.1186/s13014-015-0490-9
299 rdf:type schema:CreativeWork
300 sg:pub.10.1186/s13014-015-0561-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1046091911
301 https://doi.org/10.1186/s13014-015-0561-y
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/cncr.23206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027234612
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1002/hed.20279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040753073
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1002/hed.24486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006507974
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1002/hed.24974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092131390
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1002/ijc.30770 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085211462
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1002/ijc.31213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099655593
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/0197-2456(96)00075-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047730164
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.ejca.2016.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003115276
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.ejca.2017.02.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084071179
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.ijrobp.2007.09.058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012101445
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/j.ijrobp.2012.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034399414
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/j.oraloncology.2016.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031308961
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.radonc.2014.11.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015502287
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.radonc.2017.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100113169
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.semradonc.2017.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092993958
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/s0360-3016(97)00817-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032979639
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/s1470-2045(12)70237-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023133092
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/s1470-2045(15)00560-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050082725
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1056/nejmoa032641 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026683382
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1056/nejmoa032646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015621155
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1056/nejmoa0912217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009375074
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1056/nejmoa1602252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036710957
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1093/jjco/hyw099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059803119
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1093/jnci/djn011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004334002
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1158/1078-0432.ccr-17-2345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100165621
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1200/jco.2013.53.9163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034427787
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1634/theoncologist.2016-0318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085468069
356 rdf:type schema:CreativeWork
357 https://doi.org/10.3389/fonc.2017.00129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090299416
358 rdf:type schema:CreativeWork
359 https://www.grid.ac/institutes/grid.4567.0 schema:alternateName Helmholtz Zentrum München
360 schema:name Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany
361 Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany
362 Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany
363 Department of Radiation Oncology, University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria
364 Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany
365 Research Unit Radiation Cytogenetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany
366 rdf:type schema:Organization
367 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
368 schema:name Clinical Cooperation Group ‘Personalized Radiotherapy in Head and Neck Cancer’, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany
369 Institute of Pathology, Faculty of Medicine, LMU Munich, Marchioninistr. 27, 81377, Munich, Germany
370 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...