Influence of 68Ga-DOTATOC on sparing of normal tissue for radiation therapy of skull base meningioma: differential impact of photon and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Falk Stade, Jan-Oliver Dittmar, Oliver Jäkel, Clemens Kratochwil, Uwe Haberkorn, Jürgen Debus, Stephanie E. Combs

ABSTRACT

BACKGROUND: To evaluate the impact of 68Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons. METHODS: From the institutional database consisting of 507 skull base meningiomas 10 patients were chosen randomly for the present analysis. Target volume definition was performed based on CT and MRI only, as well as with additional 68Ga-DOTATOC-PET. Treatment plans were performed for Intensity Modulated Radiotherapy (IMRT) and proton therapy using active raster scanning on both target volumes. We calculated doses to relevant organs at risk (OAR), conformity indices as well as differences in normal tissue sparing between both radiation modalities based on CT/MRI planning as well as CT/MRI/PET planning. RESULTS: For photon treatment plans, PET-based treatment plans showed a reduction of brain stem Dmax and Dmedian for different levels of total dose. At the optic chiasm, use of 68Ga-DOTATOC significantly reduces Dmax; moreover, the Dmedian is reduced in most cases, too. For both right and left optic nerve, reduction of dose by addition of 68Ga-DOTATOC-PET is minimal and depends on the anatomical location of the meningioma. In protons, the impact of 68Ga-DOTATOC-PET is minimal compared to photons. CONCLUSION: Addition of 68Ga-DOTATOC-PET information into treatment planning for skull base meningiomas has a significant impact on target volumes. In most cases, PET-planning leads to significant reductions of the treatment volumes. Subsequently, reduced doses are applied to OAR. Using protons, the benefit of additional PET is smaller since target coverage is more conformal and dose to OAR is already reduced compared to photons. Therefore, PET-imaging has the greatest margin of benefit in advanced photon techniques, and combination of PET-planning and high-precision treatment leads to comparable treatment plans as with protons. More... »

PAGES

58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13014-018-1008-z

DOI

http://dx.doi.org/10.1186/s13014-018-1008-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101897750

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29606149


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meningeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Meningioma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroimaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Octreotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Organometallic Compounds", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Photons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proton Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiotherapy Planning, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skull Base Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Deutsches Konsortium f\u00fcr Translationale Krebsforschung (dktk), Partner Site Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stade", 
        "givenName": "Falk", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Deutsches Konsortium f\u00fcr Translationale Krebsforschung (dktk), Partner Site Heidelberg, Heidelberg, Germany", 
            "Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Stra\u00dfe 22, 81675, Munich, Germany", 
            "Deutsches Konsortium f\u00fcr Translationale Krebsforschung (dktk), Partner Site Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dittmar", 
        "givenName": "Jan-Oliver", 
        "id": "sg:person.0644502061.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644502061.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Deutsches Konsortium f\u00fcr Translationale Krebsforschung (dktk), Partner Site Heidelberg, Heidelberg, Germany", 
            "Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
            "Heidelberg Ion Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00e4kel", 
        "givenName": "Oliver", 
        "id": "sg:person.01137064231.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137064231.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Nuclear Medicine, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kratochwil", 
        "givenName": "Clemens", 
        "id": "sg:person.01151616225.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151616225.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Nuclear Medicine, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haberkorn", 
        "givenName": "Uwe", 
        "id": "sg:person.01142772466.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142772466.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany", 
            "Deutsches Konsortium f\u00fcr Translationale Krebsforschung (dktk), Partner Site Heidelberg, Heidelberg, Germany", 
            "Heidelberg Ion Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Debus", 
        "givenName": "J\u00fcrgen", 
        "id": "sg:person.013541325272.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013541325272.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz Zentrum M\u00fcnchen", 
          "id": "https://www.grid.ac/institutes/grid.4567.0", 
          "name": [
            "Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Stra\u00dfe 22, 81675, Munich, Germany", 
            "Deutsches Konsortium f\u00fcr Translationale Krebsforschung (dktk), Partner Site Munich, Munich, Germany", 
            "Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum M\u00fcnchen, Ingolst\u00e4dter Landstra\u00dfe 1, 85764, Oberschlei\u00dfheim, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Combs", 
        "givenName": "Stephanie E.", 
        "id": "sg:person.01307350271.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307350271.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.3109/0284186x.2014.973062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001450924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.07.1753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002927389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1746-160x-8-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003319401", 
          "https://doi.org/10.1186/1746-160x-8-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/nou131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006824206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-7-226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013571149", 
          "https://doi.org/10.1186/1748-717x-7-226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2012.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014742964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fonc.2015.00261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025079559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2005.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025890455"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00104-006-1268-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025916437", 
          "https://doi.org/10.1007/s00104-006-1268-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00104-006-1268-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025916437", 
          "https://doi.org/10.1007/s00104-006-1268-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/0284186x.2013.762996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026870664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1270-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027737316", 
          "https://doi.org/10.1007/s00259-009-1270-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1270-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027737316", 
          "https://doi.org/10.1007/s00259-009-1270-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-009-1270-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027737316", 
          "https://doi.org/10.1007/s00259-009-1270-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.08.078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028008977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00247-008-1098-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029572317", 
          "https://doi.org/10.1007/s00247-008-1098-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00247-008-1098-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029572317", 
          "https://doi.org/10.1007/s00247-008-1098-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-012-2155-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030346893", 
          "https://doi.org/10.1007/s00259-012-2155-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hp.0b013e318261113d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030449257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/hp.0b013e318261113d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030449257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-27994-2_23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030730641", 
          "https://doi.org/10.1007/978-3-642-27994-2_23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2012.03.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044332535"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2010.10.078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045515019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/0284186x.2013.818255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050615759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/54/20/003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059027855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/54/20/003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059027855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/57/2/499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059029419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/rr0527.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068194984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076595158", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-017-1156-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086044638", 
          "https://doi.org/10.1007/s00066-017-1156-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-017-1156-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086044638", 
          "https://doi.org/10.1007/s00066-017-1156-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13014-017-0913-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092562953", 
          "https://doi.org/10.1186/s13014-017-0913-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: To evaluate the impact of 68Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons.\nMETHODS: From the institutional database consisting of 507 skull base meningiomas 10 patients were chosen randomly for the present analysis. Target volume definition was performed based on CT and MRI only, as well as with additional 68Ga-DOTATOC-PET. Treatment plans were performed for Intensity Modulated Radiotherapy (IMRT) and proton therapy using active raster scanning on both target volumes. We calculated doses to relevant organs at risk (OAR), conformity indices as well as differences in normal tissue sparing between both radiation modalities based on CT/MRI planning as well as CT/MRI/PET planning.\nRESULTS: For photon treatment plans, PET-based treatment plans showed a reduction of brain stem Dmax and Dmedian for different levels of total dose. At the optic chiasm, use of 68Ga-DOTATOC significantly reduces Dmax; moreover, the Dmedian is reduced in most cases, too. For both right and left optic nerve, reduction of dose by addition of 68Ga-DOTATOC-PET is minimal and depends on the anatomical location of the meningioma. In protons, the impact of 68Ga-DOTATOC-PET is minimal compared to photons.\nCONCLUSION: Addition of 68Ga-DOTATOC-PET information into treatment planning for skull base meningiomas has a significant impact on target volumes. In most cases, PET-planning leads to significant reductions of the treatment volumes. Subsequently, reduced doses are applied to OAR. Using protons, the benefit of additional PET is smaller since target coverage\u00a0is more conformal and\u00a0dose to OAR is already reduced compared to photons. Therefore, PET-imaging has the greatest margin of benefit in advanced photon techniques, and combination of PET-planning and high-precision treatment leads to comparable treatment plans as with protons.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13014-018-1008-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036451", 
        "issn": [
          "1748-717X"
        ], 
        "name": "Radiation Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Influence of 68Ga-DOTATOC on sparing of normal tissue for radiation therapy of skull base meningioma: differential impact of photon and proton radiotherapy", 
    "pagination": "58", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b5db0693a63ff9afd181dcedbdccd085f557d9ae0d96c16aed44e5bc47666bac"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29606149"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101265111"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13014-018-1008-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1101897750"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13014-018-1008-z", 
      "https://app.dimensions.ai/details/publication/pub.1101897750"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130808_00000005.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2Fs13014-018-1008-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1008-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1008-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1008-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-018-1008-z'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      21 PREDICATES      71 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13014-018-1008-z schema:about N1971d874765045229ec0472513c52667
2 N1aa482d0c8b2434392657b76cd7d6fc9
3 N4316bb3a9562468c9cad64d381ab566a
4 N43360703feb548a3a834384d386e4b10
5 N452ab783699640319efa7abdca5a5163
6 N49917874e9e34301ae208fedd83f87fb
7 N5f2728183e364c74927eaab09bdb1253
8 N662a32520c2c48bc922661b7e7200759
9 N694d2351ec3745aaaf508a07af3ed435
10 N73f8805677f34e7d885ef91090d44d52
11 N8668729f00434218b315d6b6606d0eab
12 N89a8c2680b554b978a17828c5e68648c
13 N90da2c7626df447db0af79a220dd375a
14 N99b61c44cc3f404abb4913ffba86f8c8
15 N99c0fe95e26d4725bd0467a2b5981ce3
16 Na3b27abd10634a79aac5ba5a6791748e
17 Nc4272749cddf40e886bc57b51e30a51d
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Nc677f99641e844a6a49238e61428bdd5
21 schema:citation sg:pub.10.1007/978-3-642-27994-2_23
22 sg:pub.10.1007/s00066-017-1156-3
23 sg:pub.10.1007/s00104-006-1268-2
24 sg:pub.10.1007/s00247-008-1098-0
25 sg:pub.10.1007/s00259-009-1270-2
26 sg:pub.10.1007/s00259-012-2155-3
27 sg:pub.10.1186/1746-160x-8-1
28 sg:pub.10.1186/1748-717x-7-226
29 sg:pub.10.1186/s13014-017-0913-x
30 https://app.dimensions.ai/details/publication/pub.1076595158
31 https://doi.org/10.1016/j.ijrobp.2005.12.006
32 https://doi.org/10.1016/j.ijrobp.2009.07.1753
33 https://doi.org/10.1016/j.ijrobp.2009.08.078
34 https://doi.org/10.1016/j.ijrobp.2010.10.078
35 https://doi.org/10.1016/j.ijrobp.2012.03.021
36 https://doi.org/10.1016/j.radonc.2012.07.008
37 https://doi.org/10.1088/0031-9155/54/20/003
38 https://doi.org/10.1088/0031-9155/57/2/499
39 https://doi.org/10.1093/neuonc/nou131
40 https://doi.org/10.1097/hp.0b013e318261113d
41 https://doi.org/10.1667/rr0527.1
42 https://doi.org/10.3109/0284186x.2013.762996
43 https://doi.org/10.3109/0284186x.2013.818255
44 https://doi.org/10.3109/0284186x.2014.973062
45 https://doi.org/10.3389/fonc.2015.00261
46 schema:datePublished 2018-12
47 schema:datePublishedReg 2018-12-01
48 schema:description BACKGROUND: To evaluate the impact of 68Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons. METHODS: From the institutional database consisting of 507 skull base meningiomas 10 patients were chosen randomly for the present analysis. Target volume definition was performed based on CT and MRI only, as well as with additional 68Ga-DOTATOC-PET. Treatment plans were performed for Intensity Modulated Radiotherapy (IMRT) and proton therapy using active raster scanning on both target volumes. We calculated doses to relevant organs at risk (OAR), conformity indices as well as differences in normal tissue sparing between both radiation modalities based on CT/MRI planning as well as CT/MRI/PET planning. RESULTS: For photon treatment plans, PET-based treatment plans showed a reduction of brain stem Dmax and Dmedian for different levels of total dose. At the optic chiasm, use of 68Ga-DOTATOC significantly reduces Dmax; moreover, the Dmedian is reduced in most cases, too. For both right and left optic nerve, reduction of dose by addition of 68Ga-DOTATOC-PET is minimal and depends on the anatomical location of the meningioma. In protons, the impact of 68Ga-DOTATOC-PET is minimal compared to photons. CONCLUSION: Addition of 68Ga-DOTATOC-PET information into treatment planning for skull base meningiomas has a significant impact on target volumes. In most cases, PET-planning leads to significant reductions of the treatment volumes. Subsequently, reduced doses are applied to OAR. Using protons, the benefit of additional PET is smaller since target coverage is more conformal and dose to OAR is already reduced compared to photons. Therefore, PET-imaging has the greatest margin of benefit in advanced photon techniques, and combination of PET-planning and high-precision treatment leads to comparable treatment plans as with protons.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N1d1b1ac0daaf4d9ab275e86a35be9899
53 N40aa77829a5b428f9db455077ca60fda
54 sg:journal.1036451
55 schema:name Influence of 68Ga-DOTATOC on sparing of normal tissue for radiation therapy of skull base meningioma: differential impact of photon and proton radiotherapy
56 schema:pagination 58
57 schema:productId N4e896b1897384595a85adad639ccb61b
58 N52112bfa51d34b51ba1d14a9b374de67
59 Ned288e598593434cbf0e552b53271579
60 Ned503be6f3f5404cb862c12be830d83f
61 Nfe50ef64260a48128271db065a07ad64
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101897750
63 https://doi.org/10.1186/s13014-018-1008-z
64 schema:sdDatePublished 2019-04-11T13:54
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N5017a453730c48d8810686875f6c1adc
67 schema:url https://link.springer.com/10.1186%2Fs13014-018-1008-z
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N17ec9baa9f004f60b0df8fc061d28299 rdf:first sg:person.01142772466.17
72 rdf:rest N2410764ffe71487cb0ec7e934dd9a745
73 N1971d874765045229ec0472513c52667 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Radiotherapy Planning, Computer-Assisted
75 rdf:type schema:DefinedTerm
76 N1aa482d0c8b2434392657b76cd7d6fc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Male
78 rdf:type schema:DefinedTerm
79 N1d1b1ac0daaf4d9ab275e86a35be9899 schema:issueNumber 1
80 rdf:type schema:PublicationIssue
81 N2410764ffe71487cb0ec7e934dd9a745 rdf:first sg:person.013541325272.97
82 rdf:rest N89a78709a7864ed180f00d6a7428172a
83 N40aa77829a5b428f9db455077ca60fda schema:volumeNumber 13
84 rdf:type schema:PublicationVolume
85 N4316bb3a9562468c9cad64d381ab566a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Humans
87 rdf:type schema:DefinedTerm
88 N43360703feb548a3a834384d386e4b10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Middle Aged
90 rdf:type schema:DefinedTerm
91 N452ab783699640319efa7abdca5a5163 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Aged
93 rdf:type schema:DefinedTerm
94 N49917874e9e34301ae208fedd83f87fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Positron-Emission Tomography
96 rdf:type schema:DefinedTerm
97 N4e896b1897384595a85adad639ccb61b schema:name dimensions_id
98 schema:value pub.1101897750
99 rdf:type schema:PropertyValue
100 N5017a453730c48d8810686875f6c1adc schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N52112bfa51d34b51ba1d14a9b374de67 schema:name doi
103 schema:value 10.1186/s13014-018-1008-z
104 rdf:type schema:PropertyValue
105 N5f2728183e364c74927eaab09bdb1253 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Proton Therapy
107 rdf:type schema:DefinedTerm
108 N662a32520c2c48bc922661b7e7200759 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Female
110 rdf:type schema:DefinedTerm
111 N694d2351ec3745aaaf508a07af3ed435 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Octreotide
113 rdf:type schema:DefinedTerm
114 N732b6c987758403b9588e5b016bbaa24 rdf:first sg:person.01151616225.91
115 rdf:rest N17ec9baa9f004f60b0df8fc061d28299
116 N73f8805677f34e7d885ef91090d44d52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Magnetic Resonance Imaging
118 rdf:type schema:DefinedTerm
119 N80fc9be058124bb5ab38d521c6e1d07f schema:affiliation https://www.grid.ac/institutes/grid.5253.1
120 schema:familyName Stade
121 schema:givenName Falk
122 rdf:type schema:Person
123 N8668729f00434218b315d6b6606d0eab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Meningeal Neoplasms
125 rdf:type schema:DefinedTerm
126 N89a78709a7864ed180f00d6a7428172a rdf:first sg:person.01307350271.06
127 rdf:rest rdf:nil
128 N89a8c2680b554b978a17828c5e68648c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Skull Base Neoplasms
130 rdf:type schema:DefinedTerm
131 N8f2774b123944fb8afe990371238e2a4 rdf:first sg:person.01137064231.64
132 rdf:rest N732b6c987758403b9588e5b016bbaa24
133 N90da2c7626df447db0af79a220dd375a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Neuroimaging
135 rdf:type schema:DefinedTerm
136 N99b61c44cc3f404abb4913ffba86f8c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Photons
138 rdf:type schema:DefinedTerm
139 N99c0fe95e26d4725bd0467a2b5981ce3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Meningioma
141 rdf:type schema:DefinedTerm
142 Na3b27abd10634a79aac5ba5a6791748e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Adult
144 rdf:type schema:DefinedTerm
145 Nc4272749cddf40e886bc57b51e30a51d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Organometallic Compounds
147 rdf:type schema:DefinedTerm
148 Nc677f99641e844a6a49238e61428bdd5 rdf:first N80fc9be058124bb5ab38d521c6e1d07f
149 rdf:rest Nf73dc3832f344132943968dd47e384f9
150 Ned288e598593434cbf0e552b53271579 schema:name readcube_id
151 schema:value b5db0693a63ff9afd181dcedbdccd085f557d9ae0d96c16aed44e5bc47666bac
152 rdf:type schema:PropertyValue
153 Ned503be6f3f5404cb862c12be830d83f schema:name pubmed_id
154 schema:value 29606149
155 rdf:type schema:PropertyValue
156 Nf73dc3832f344132943968dd47e384f9 rdf:first sg:person.0644502061.45
157 rdf:rest N8f2774b123944fb8afe990371238e2a4
158 Nfe50ef64260a48128271db065a07ad64 schema:name nlm_unique_id
159 schema:value 101265111
160 rdf:type schema:PropertyValue
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
165 schema:name Clinical Sciences
166 rdf:type schema:DefinedTerm
167 sg:journal.1036451 schema:issn 1748-717X
168 schema:name Radiation Oncology
169 rdf:type schema:Periodical
170 sg:person.01137064231.64 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
171 schema:familyName Jäkel
172 schema:givenName Oliver
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137064231.64
174 rdf:type schema:Person
175 sg:person.01142772466.17 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
176 schema:familyName Haberkorn
177 schema:givenName Uwe
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142772466.17
179 rdf:type schema:Person
180 sg:person.01151616225.91 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
181 schema:familyName Kratochwil
182 schema:givenName Clemens
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151616225.91
184 rdf:type schema:Person
185 sg:person.01307350271.06 schema:affiliation https://www.grid.ac/institutes/grid.4567.0
186 schema:familyName Combs
187 schema:givenName Stephanie E.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307350271.06
189 rdf:type schema:Person
190 sg:person.013541325272.97 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
191 schema:familyName Debus
192 schema:givenName Jürgen
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013541325272.97
194 rdf:type schema:Person
195 sg:person.0644502061.45 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
196 schema:familyName Dittmar
197 schema:givenName Jan-Oliver
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644502061.45
199 rdf:type schema:Person
200 sg:pub.10.1007/978-3-642-27994-2_23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030730641
201 https://doi.org/10.1007/978-3-642-27994-2_23
202 rdf:type schema:CreativeWork
203 sg:pub.10.1007/s00066-017-1156-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086044638
204 https://doi.org/10.1007/s00066-017-1156-3
205 rdf:type schema:CreativeWork
206 sg:pub.10.1007/s00104-006-1268-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025916437
207 https://doi.org/10.1007/s00104-006-1268-2
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/s00247-008-1098-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029572317
210 https://doi.org/10.1007/s00247-008-1098-0
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/s00259-009-1270-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027737316
213 https://doi.org/10.1007/s00259-009-1270-2
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/s00259-012-2155-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030346893
216 https://doi.org/10.1007/s00259-012-2155-3
217 rdf:type schema:CreativeWork
218 sg:pub.10.1186/1746-160x-8-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003319401
219 https://doi.org/10.1186/1746-160x-8-1
220 rdf:type schema:CreativeWork
221 sg:pub.10.1186/1748-717x-7-226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013571149
222 https://doi.org/10.1186/1748-717x-7-226
223 rdf:type schema:CreativeWork
224 sg:pub.10.1186/s13014-017-0913-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1092562953
225 https://doi.org/10.1186/s13014-017-0913-x
226 rdf:type schema:CreativeWork
227 https://app.dimensions.ai/details/publication/pub.1076595158 schema:CreativeWork
228 https://doi.org/10.1016/j.ijrobp.2005.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025890455
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.ijrobp.2009.07.1753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002927389
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.ijrobp.2009.08.078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028008977
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.ijrobp.2010.10.078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045515019
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.ijrobp.2012.03.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044332535
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.radonc.2012.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014742964
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1088/0031-9155/54/20/003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059027855
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1088/0031-9155/57/2/499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059029419
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1093/neuonc/nou131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006824206
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1097/hp.0b013e318261113d schema:sameAs https://app.dimensions.ai/details/publication/pub.1030449257
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1667/rr0527.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068194984
249 rdf:type schema:CreativeWork
250 https://doi.org/10.3109/0284186x.2013.762996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026870664
251 rdf:type schema:CreativeWork
252 https://doi.org/10.3109/0284186x.2013.818255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050615759
253 rdf:type schema:CreativeWork
254 https://doi.org/10.3109/0284186x.2014.973062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001450924
255 rdf:type schema:CreativeWork
256 https://doi.org/10.3389/fonc.2015.00261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025079559
257 rdf:type schema:CreativeWork
258 https://www.grid.ac/institutes/grid.4567.0 schema:alternateName Helmholtz Zentrum München
259 schema:name Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, Munich, Germany
260 Deutsches Konsortium für Translationale Krebsforschung (dktk), Partner Site Munich, Munich, Germany
261 Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Oberschleißheim, Germany
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
264 schema:name Department of Nuclear Medicine, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
265 Department of Radiation Oncology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, Munich, Germany
266 Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
267 Deutsches Konsortium für Translationale Krebsforschung (dktk), Partner Site Heidelberg, Heidelberg, Germany
268 Deutsches Konsortium für Translationale Krebsforschung (dktk), Partner Site Munich, Munich, Germany
269 Heidelberg Ion Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
272 schema:name Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
273 Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany
274 Deutsches Konsortium für Translationale Krebsforschung (dktk), Partner Site Heidelberg, Heidelberg, Germany
275 Heidelberg Ion Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120, Heidelberg, Germany
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...