Late normal tissue response in the rat spinal cord after carbon ion irradiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-12

AUTHORS

Maria Saager, Peter Peschke, Thomas Welzel, Lifi Huang, Stephan Brons, Rebecca Grün, Michael Scholz, Jürgen Debus, Christian P. Karger

ABSTRACT

BACKGROUND: The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the "clinical research group ion beam therapy" funded by the German Research Foundation (DFG, KFO 214). METHODS AND MATERIALS: Dose-response curves for the endpoint radiation-induced myelopathy were determined at 6 different positions (LET 16-99 keV/μm) within a 6 cm spread-out Bragg peak using either 1, 2 or 6 fractions of carbon ions. Based on the tolerance dose TD50 of carbon ions and photons, the relative biological effectiveness (RBE) was determined and compared with predictions of the local effect model (LEM I and IV). Within a longitudinal magnetic resonance imaging (MRI)-based study the temporal development of radiation-induced changes in the spinal cord was characterized. To test the protective potential of the ACE (angiotensin converting enzyme)-inhibitor ramipril™, an additional dose-response experiment was performed. RESULTS: The RBE-values increased with LET and the increase was found to be larger for smaller fractional doses. Benchmarking the RBE-values as predicted by LEM I and LEM IV with the measured data revealed that LEM IV is more accurate in the high-LET, while LEM I is more accurate in the low-LET region. Characterization of the temporal development of radiation-induced changes with MRI demonstrated a shorter latency time for carbon ions, reflected on the histological level by an increased vessel perforation after carbon ion as compared to photon irradiations. For the ACE-inhibitor ramipril™, a mitigative rather than protective effect was found. CONCLUSIONS: This comprehensive study established a large and consistent RBE data base for late effects in the rat spinal cord after carbon ion irradiation which will be further extended in ongoing studies. Using MRI, an extensive characterization of the temporal development of radiation-induced alterations was obtained. The reduced latency time for carbon ions is expected to originate from a dynamic interaction of various complex pathological processes. A dominant observation after carbon ion irradiation was an increase in vessel perforation preferentially in the white matter. To enable a targeted pharmacological intervention more details of the molecular pathways, responsible for the development of radiation-induced myelopathy are required. More... »

PAGES

5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13014-017-0950-5

DOI

http://dx.doi.org/10.1186/s13014-017-0950-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100316901

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29325596


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0299", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Other Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Radiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heavy Ion Radiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Injuries", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation-Protective Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ramipril", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Relative Biological Effectiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spinal Cord", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany", 
            "Department of Medical Physics in Radiation Oncology (E040), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
            "National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saager", 
        "givenName": "Maria", 
        "id": "sg:person.01325636144.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325636144.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany", 
            "Clinical Cooperation Unit Molecular Radiooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peschke", 
        "givenName": "Peter", 
        "id": "sg:person.01153607022.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153607022.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany", 
            "National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Welzel", 
        "givenName": "Thomas", 
        "id": "sg:person.01010560071.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010560071.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Medical Physics in Radiation Oncology (E040), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
            "National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Lifi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany", 
            "Heidelberg Ion Beam Therapy Center (HIT), Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brons", 
        "givenName": "Stephan", 
        "id": "sg:person.01301500624.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301500624.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GSI Helmholtz Centre for Heavy Ion Research", 
          "id": "https://www.grid.ac/institutes/grid.159791.2", 
          "name": [
            "Department of Biophysics, Helmholtz Center for Heavy Ion Research (GSI), Darmstadt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gr\u00fcn", 
        "givenName": "Rebecca", 
        "id": "sg:person.01252060512.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252060512.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GSI Helmholtz Centre for Heavy Ion Research", 
          "id": "https://www.grid.ac/institutes/grid.159791.2", 
          "name": [
            "Department of Biophysics, Helmholtz Center for Heavy Ion Research (GSI), Darmstadt, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Scholz", 
        "givenName": "Michael", 
        "id": "sg:person.01061120134.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061120134.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany", 
            "National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Debus", 
        "givenName": "J\u00fcrgen", 
        "id": "sg:person.013541325272.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013541325272.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberger Institut f\u00fcr Radioonkologie", 
          "id": "https://www.grid.ac/institutes/grid.488831.e", 
          "name": [
            "Department of Medical Physics in Radiation Oncology (E040), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany", 
            "National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karger", 
        "givenName": "Christian P.", 
        "id": "sg:person.01010222256.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010222256.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jmri.1880070113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002356756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)00735-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005464935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(03)00735-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005464935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.28606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009125848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(82)90551-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010675418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jocn.2006.12.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011308512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-006-9256-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012327738", 
          "https://doi.org/10.1007/s11060-006-9256-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-010-0282-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013753599", 
          "https://doi.org/10.1007/s11060-010-0282-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197506)35:6<1692::aid-cncr2820350631>3.0.co;2-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014220585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2005.06.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016033337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1440-1789.2001.00408.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017319506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2006.08.045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017868982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0360-3016(01)02687-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017887737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2010.05.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020309507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2004.10.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021575702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-9002(93)91335-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021789937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0168-9002(93)91335-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021789937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023769932", 
          "https://doi.org/10.1038/sj.bjc.6601646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023769932", 
          "https://doi.org/10.1038/sj.bjc.6601646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004110050055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023774900", 
          "https://doi.org/10.1007/s004110050055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2005.01.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025623758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2005.01.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025623758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)90228-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027963031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.28877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030419918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1522-2586(199909)10:3<223::aid-jmri2>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030826627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0146-6410(00)00112-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031683863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2014.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034682322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1789.1998.tb00099.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035635508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0000000000000078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036138481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/ppo.0000000000000078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036138481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/0284186x.2015.1069890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037546990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rpor.2015.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039924660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.brainres.2014.06.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042166794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-5-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042431128", 
          "https://doi.org/10.1186/1748-717x-5-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.29443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044031397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2015.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049812314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-016-2128-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050705528", 
          "https://doi.org/10.1007/s11064-016-2128-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11064-016-2128-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050705528", 
          "https://doi.org/10.1007/s11064-016-2128-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/0284186x.2016.1250947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051561868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(92)91066-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051619036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(94)90484-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052401611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/45/11/313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059023864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/55/22/008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059028435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/55/22/008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059028435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1088/0031-9155/60/1/437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059030778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/0007-1285-47-559-393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064550268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/0007-1285-60-719-1099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064556816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/bjr/15169876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064568049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/3063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068194945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/rr3117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068196177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/rr3124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068196189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/rr3597.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068196678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3575694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070378579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3579462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070381857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3579980", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070382300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076575075", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082760626", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083019245", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the \"clinical research group ion beam therapy\" funded by the German Research Foundation (DFG, KFO 214).\nMETHODS AND MATERIALS: Dose-response curves for the endpoint radiation-induced myelopathy were determined at 6 different positions (LET 16-99\u00a0keV/\u03bcm) within a 6\u00a0cm spread-out Bragg peak using either 1, 2 or 6 fractions of carbon ions. Based on the tolerance dose TD50 of carbon ions and photons, the relative biological effectiveness (RBE) was determined and compared with predictions of the local effect model (LEM I and IV). Within a longitudinal magnetic resonance imaging (MRI)-based study the temporal development of radiation-induced changes in the spinal cord was characterized. To test the protective potential of the ACE (angiotensin converting enzyme)-inhibitor ramipril\u2122, an additional dose-response experiment was performed.\nRESULTS: The RBE-values increased with LET and the increase was found to be larger for smaller fractional doses. Benchmarking the RBE-values as predicted by LEM I and LEM IV with the measured data revealed that LEM IV is more accurate in the high-LET, while LEM I is more accurate in the low-LET region. Characterization of the temporal development of radiation-induced changes with MRI demonstrated a shorter latency time for carbon ions, reflected on the histological level by an increased vessel perforation after carbon ion as compared to photon irradiations. For the ACE-inhibitor ramipril\u2122, a mitigative rather than protective effect was found.\nCONCLUSIONS: This comprehensive study established a large and consistent RBE data base for late effects in the rat spinal cord after carbon ion irradiation which will be further extended in ongoing studies. Using MRI, an extensive characterization of the temporal development of radiation-induced alterations was obtained. The reduced latency time for carbon ions is expected to originate from a dynamic interaction of various complex pathological processes. A dominant observation after carbon ion irradiation was an increase in vessel perforation preferentially in the white matter. To enable a targeted pharmacological intervention more details of the molecular pathways, responsible for the development of radiation-induced myelopathy are required.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13014-017-0950-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036451", 
        "issn": [
          "1748-717X"
        ], 
        "name": "Radiation Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Late normal tissue response in the rat spinal cord after carbon ion irradiation", 
    "pagination": "5", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f3cc6af362956137459a3a730adca1310796fa782f5039f2d50ce236038d18bb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29325596"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101265111"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13014-017-0950-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100316901"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13014-017-0950-5", 
      "https://app.dimensions.ai/details/publication/pub.1100316901"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000493.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186/s13014-017-0950-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-017-0950-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-017-0950-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-017-0950-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-017-0950-5'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      91 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13014-017-0950-5 schema:about N1555340e6dce4d0fab406dc4fc1fe1d2
2 N1d0ec781cf394e37a79aa681a7199e80
3 N39bf058be0104f109a8892c250c4b0c0
4 N449846c9425542caaf8bff624a4ecf92
5 N4fc6a17b45ac4185a4e89f28c5d3e834
6 N6779788b37c946a78d8744fbfd46a23c
7 N6819d783ce7b4d5cb5f2c8da1b3a8a15
8 N84ce4285203746ecba859b9028c91417
9 N925136250c4f4590a0506888f2960c91
10 N96bf59daeabb4ff6a97473c2fdbc835c
11 Nbd0f8be9153a418d8aae8bdd096ac5aa
12 anzsrc-for:02
13 anzsrc-for:0299
14 schema:author Nf4afbf0264544eb99f45a9f4df6aab35
15 schema:citation sg:pub.10.1007/s004110050055
16 sg:pub.10.1007/s11060-006-9256-4
17 sg:pub.10.1007/s11060-010-0282-x
18 sg:pub.10.1007/s11064-016-2128-1
19 sg:pub.10.1038/sj.bjc.6601646
20 sg:pub.10.1186/1748-717x-5-6
21 https://app.dimensions.ai/details/publication/pub.1076575075
22 https://app.dimensions.ai/details/publication/pub.1082760626
23 https://app.dimensions.ai/details/publication/pub.1083019245
24 https://doi.org/10.1002/(sici)1522-2586(199909)10:3<223::aid-jmri2>3.0.co;2-s
25 https://doi.org/10.1002/1097-0142(197506)35:6<1692::aid-cncr2820350631>3.0.co;2-m
26 https://doi.org/10.1002/cncr.28606
27 https://doi.org/10.1002/cncr.28877
28 https://doi.org/10.1002/cncr.29443
29 https://doi.org/10.1002/jmri.1880070113
30 https://doi.org/10.1016/0168-9002(93)91335-k
31 https://doi.org/10.1016/0360-3016(82)90551-x
32 https://doi.org/10.1016/0360-3016(92)91066-v
33 https://doi.org/10.1016/0360-3016(94)90228-3
34 https://doi.org/10.1016/0360-3016(94)90484-7
35 https://doi.org/10.1016/j.brainres.2014.06.014
36 https://doi.org/10.1016/j.ijrobp.2004.10.018
37 https://doi.org/10.1016/j.ijrobp.2005.01.061
38 https://doi.org/10.1016/j.ijrobp.2005.06.046
39 https://doi.org/10.1016/j.ijrobp.2006.08.045
40 https://doi.org/10.1016/j.ijrobp.2010.05.014
41 https://doi.org/10.1016/j.ijrobp.2014.05.008
42 https://doi.org/10.1016/j.jocn.2006.12.003
43 https://doi.org/10.1016/j.radonc.2015.07.006
44 https://doi.org/10.1016/j.rpor.2015.01.008
45 https://doi.org/10.1016/s0146-6410(00)00112-5
46 https://doi.org/10.1016/s0360-3016(01)02687-6
47 https://doi.org/10.1016/s0360-3016(03)00735-1
48 https://doi.org/10.1046/j.1440-1789.2001.00408.x
49 https://doi.org/10.1080/0284186x.2016.1250947
50 https://doi.org/10.1088/0031-9155/45/11/313
51 https://doi.org/10.1088/0031-9155/55/22/008
52 https://doi.org/10.1088/0031-9155/60/1/437
53 https://doi.org/10.1097/ppo.0000000000000078
54 https://doi.org/10.1111/j.1440-1789.1998.tb00099.x
55 https://doi.org/10.1259/0007-1285-47-559-393
56 https://doi.org/10.1259/0007-1285-60-719-1099
57 https://doi.org/10.1259/bjr/15169876
58 https://doi.org/10.1667/3063
59 https://doi.org/10.1667/rr3117
60 https://doi.org/10.1667/rr3124
61 https://doi.org/10.1667/rr3597.1
62 https://doi.org/10.2307/3575694
63 https://doi.org/10.2307/3579462
64 https://doi.org/10.2307/3579980
65 https://doi.org/10.3109/0284186x.2015.1069890
66 schema:datePublished 2018-12
67 schema:datePublishedReg 2018-12-01
68 schema:description BACKGROUND: The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the "clinical research group ion beam therapy" funded by the German Research Foundation (DFG, KFO 214). METHODS AND MATERIALS: Dose-response curves for the endpoint radiation-induced myelopathy were determined at 6 different positions (LET 16-99 keV/μm) within a 6 cm spread-out Bragg peak using either 1, 2 or 6 fractions of carbon ions. Based on the tolerance dose TD50 of carbon ions and photons, the relative biological effectiveness (RBE) was determined and compared with predictions of the local effect model (LEM I and IV). Within a longitudinal magnetic resonance imaging (MRI)-based study the temporal development of radiation-induced changes in the spinal cord was characterized. To test the protective potential of the ACE (angiotensin converting enzyme)-inhibitor ramipril™, an additional dose-response experiment was performed. RESULTS: The RBE-values increased with LET and the increase was found to be larger for smaller fractional doses. Benchmarking the RBE-values as predicted by LEM I and LEM IV with the measured data revealed that LEM IV is more accurate in the high-LET, while LEM I is more accurate in the low-LET region. Characterization of the temporal development of radiation-induced changes with MRI demonstrated a shorter latency time for carbon ions, reflected on the histological level by an increased vessel perforation after carbon ion as compared to photon irradiations. For the ACE-inhibitor ramipril™, a mitigative rather than protective effect was found. CONCLUSIONS: This comprehensive study established a large and consistent RBE data base for late effects in the rat spinal cord after carbon ion irradiation which will be further extended in ongoing studies. Using MRI, an extensive characterization of the temporal development of radiation-induced alterations was obtained. The reduced latency time for carbon ions is expected to originate from a dynamic interaction of various complex pathological processes. A dominant observation after carbon ion irradiation was an increase in vessel perforation preferentially in the white matter. To enable a targeted pharmacological intervention more details of the molecular pathways, responsible for the development of radiation-induced myelopathy are required.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf N1485bab18878410597b1bea77b6762bb
73 N511014ba1de844d2884d6bb343f0390a
74 sg:journal.1036451
75 schema:name Late normal tissue response in the rat spinal cord after carbon ion irradiation
76 schema:pagination 5
77 schema:productId N2adfe424516c449499800f8c96952511
78 N89b3254a8a284795803c551ebea6282b
79 Nb2af1d8bb4224b33a3ea4f62b49d05c9
80 Nd342ae9a94a543fb9a08aea32e6e3401
81 Ne5915736f0e14c4a82a7332b65ce7f1f
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100316901
83 https://doi.org/10.1186/s13014-017-0950-5
84 schema:sdDatePublished 2019-04-10T21:33
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher N25aea3aed61b47d2b670df404721a54b
87 schema:url http://link.springer.com/10.1186/s13014-017-0950-5
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N1189d40d013a44ae8cb9d45c883dc9c9 rdf:first sg:person.01010222256.43
92 rdf:rest rdf:nil
93 N1485bab18878410597b1bea77b6762bb schema:volumeNumber 13
94 rdf:type schema:PublicationVolume
95 N1555340e6dce4d0fab406dc4fc1fe1d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Female
97 rdf:type schema:DefinedTerm
98 N1d0ec781cf394e37a79aa681a7199e80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Spinal Cord
100 rdf:type schema:DefinedTerm
101 N248cc8f26aea4e98ae3bc23ac2ab86e2 rdf:first N9e4015b21c9343f59305af1c19a394b4
102 rdf:rest N80fe38d6f01d440abbb56acddf7855da
103 N25aea3aed61b47d2b670df404721a54b schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N266dcad7a4e343adb2ea9103c5d0ebb0 rdf:first sg:person.01010560071.15
106 rdf:rest N248cc8f26aea4e98ae3bc23ac2ab86e2
107 N2adfe424516c449499800f8c96952511 schema:name pubmed_id
108 schema:value 29325596
109 rdf:type schema:PropertyValue
110 N39bf058be0104f109a8892c250c4b0c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Rats
112 rdf:type schema:DefinedTerm
113 N3f0089aabbc040568031601b163b64c7 rdf:first sg:person.01153607022.30
114 rdf:rest N266dcad7a4e343adb2ea9103c5d0ebb0
115 N449846c9425542caaf8bff624a4ecf92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Relative Biological Effectiveness
117 rdf:type schema:DefinedTerm
118 N4fc6a17b45ac4185a4e89f28c5d3e834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Ramipril
120 rdf:type schema:DefinedTerm
121 N511014ba1de844d2884d6bb343f0390a schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N55d92d97a9904409b821fde725000a42 rdf:first sg:person.013541325272.97
124 rdf:rest N1189d40d013a44ae8cb9d45c883dc9c9
125 N6779788b37c946a78d8744fbfd46a23c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Dose-Response Relationship, Radiation
127 rdf:type schema:DefinedTerm
128 N6819d783ce7b4d5cb5f2c8da1b3a8a15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Radiation Injuries
130 rdf:type schema:DefinedTerm
131 N80fe38d6f01d440abbb56acddf7855da rdf:first sg:person.01301500624.86
132 rdf:rest Nb7e217295cda4b528ddaa6a442633443
133 N84ce4285203746ecba859b9028c91417 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Radiation-Protective Agents
135 rdf:type schema:DefinedTerm
136 N89b3254a8a284795803c551ebea6282b schema:name readcube_id
137 schema:value f3cc6af362956137459a3a730adca1310796fa782f5039f2d50ce236038d18bb
138 rdf:type schema:PropertyValue
139 N925136250c4f4590a0506888f2960c91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Rats, Sprague-Dawley
141 rdf:type schema:DefinedTerm
142 N96bf59daeabb4ff6a97473c2fdbc835c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Heavy Ion Radiotherapy
144 rdf:type schema:DefinedTerm
145 N9e4015b21c9343f59305af1c19a394b4 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
146 schema:familyName Huang
147 schema:givenName Lifi
148 rdf:type schema:Person
149 Naf95ca8ef41a404c9e4bf7a887cfab86 rdf:first sg:person.01061120134.47
150 rdf:rest N55d92d97a9904409b821fde725000a42
151 Nb2af1d8bb4224b33a3ea4f62b49d05c9 schema:name nlm_unique_id
152 schema:value 101265111
153 rdf:type schema:PropertyValue
154 Nb7e217295cda4b528ddaa6a442633443 rdf:first sg:person.01252060512.60
155 rdf:rest Naf95ca8ef41a404c9e4bf7a887cfab86
156 Nbd0f8be9153a418d8aae8bdd096ac5aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Animals
158 rdf:type schema:DefinedTerm
159 Nd342ae9a94a543fb9a08aea32e6e3401 schema:name doi
160 schema:value 10.1186/s13014-017-0950-5
161 rdf:type schema:PropertyValue
162 Ne5915736f0e14c4a82a7332b65ce7f1f schema:name dimensions_id
163 schema:value pub.1100316901
164 rdf:type schema:PropertyValue
165 Nf4afbf0264544eb99f45a9f4df6aab35 rdf:first sg:person.01325636144.61
166 rdf:rest N3f0089aabbc040568031601b163b64c7
167 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
168 schema:name Physical Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:0299 schema:inDefinedTermSet anzsrc-for:
171 schema:name Other Physical Sciences
172 rdf:type schema:DefinedTerm
173 sg:journal.1036451 schema:issn 1748-717X
174 schema:name Radiation Oncology
175 rdf:type schema:Periodical
176 sg:person.01010222256.43 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
177 schema:familyName Karger
178 schema:givenName Christian P.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010222256.43
180 rdf:type schema:Person
181 sg:person.01010560071.15 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
182 schema:familyName Welzel
183 schema:givenName Thomas
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010560071.15
185 rdf:type schema:Person
186 sg:person.01061120134.47 schema:affiliation https://www.grid.ac/institutes/grid.159791.2
187 schema:familyName Scholz
188 schema:givenName Michael
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061120134.47
190 rdf:type schema:Person
191 sg:person.01153607022.30 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
192 schema:familyName Peschke
193 schema:givenName Peter
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153607022.30
195 rdf:type schema:Person
196 sg:person.01252060512.60 schema:affiliation https://www.grid.ac/institutes/grid.159791.2
197 schema:familyName Grün
198 schema:givenName Rebecca
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252060512.60
200 rdf:type schema:Person
201 sg:person.01301500624.86 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
202 schema:familyName Brons
203 schema:givenName Stephan
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301500624.86
205 rdf:type schema:Person
206 sg:person.01325636144.61 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
207 schema:familyName Saager
208 schema:givenName Maria
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325636144.61
210 rdf:type schema:Person
211 sg:person.013541325272.97 schema:affiliation https://www.grid.ac/institutes/grid.488831.e
212 schema:familyName Debus
213 schema:givenName Jürgen
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013541325272.97
215 rdf:type schema:Person
216 sg:pub.10.1007/s004110050055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023774900
217 https://doi.org/10.1007/s004110050055
218 rdf:type schema:CreativeWork
219 sg:pub.10.1007/s11060-006-9256-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012327738
220 https://doi.org/10.1007/s11060-006-9256-4
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/s11060-010-0282-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013753599
223 https://doi.org/10.1007/s11060-010-0282-x
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s11064-016-2128-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050705528
226 https://doi.org/10.1007/s11064-016-2128-1
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/sj.bjc.6601646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023769932
229 https://doi.org/10.1038/sj.bjc.6601646
230 rdf:type schema:CreativeWork
231 sg:pub.10.1186/1748-717x-5-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042431128
232 https://doi.org/10.1186/1748-717x-5-6
233 rdf:type schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1076575075 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1082760626 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1083019245 schema:CreativeWork
237 https://doi.org/10.1002/(sici)1522-2586(199909)10:3<223::aid-jmri2>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1030826627
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/1097-0142(197506)35:6<1692::aid-cncr2820350631>3.0.co;2-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1014220585
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/cncr.28606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009125848
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1002/cncr.28877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030419918
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/cncr.29443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044031397
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/jmri.1880070113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002356756
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0168-9002(93)91335-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1021789937
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0360-3016(82)90551-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010675418
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0360-3016(92)91066-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1051619036
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0360-3016(94)90228-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027963031
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/0360-3016(94)90484-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052401611
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.brainres.2014.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042166794
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.ijrobp.2004.10.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021575702
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.ijrobp.2005.01.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025623758
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.ijrobp.2005.06.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016033337
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.ijrobp.2006.08.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017868982
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.ijrobp.2010.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020309507
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.ijrobp.2014.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034682322
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.jocn.2006.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011308512
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.radonc.2015.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049812314
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.rpor.2015.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039924660
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0146-6410(00)00112-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031683863
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0360-3016(01)02687-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017887737
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0360-3016(03)00735-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005464935
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1046/j.1440-1789.2001.00408.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017319506
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1080/0284186x.2016.1250947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051561868
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1088/0031-9155/45/11/313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059023864
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1088/0031-9155/55/22/008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059028435
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1088/0031-9155/60/1/437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059030778
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1097/ppo.0000000000000078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036138481
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1440-1789.1998.tb00099.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035635508
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1259/0007-1285-47-559-393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064550268
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1259/0007-1285-60-719-1099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064556816
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1259/bjr/15169876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064568049
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1667/3063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068194945
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1667/rr3117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068196177
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1667/rr3124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068196189
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1667/rr3597.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068196678
312 rdf:type schema:CreativeWork
313 https://doi.org/10.2307/3575694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070378579
314 rdf:type schema:CreativeWork
315 https://doi.org/10.2307/3579462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070381857
316 rdf:type schema:CreativeWork
317 https://doi.org/10.2307/3579980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070382300
318 rdf:type schema:CreativeWork
319 https://doi.org/10.3109/0284186x.2015.1069890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037546990
320 rdf:type schema:CreativeWork
321 https://www.grid.ac/institutes/grid.159791.2 schema:alternateName GSI Helmholtz Centre for Heavy Ion Research
322 schema:name Department of Biophysics, Helmholtz Center for Heavy Ion Research (GSI), Darmstadt, Germany
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.488831.e schema:alternateName Heidelberger Institut für Radioonkologie
325 schema:name Department of Medical Physics in Radiation Oncology (E040), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
326 Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany
327 Heidelberg Ion Beam Therapy Center (HIT), Heidelberg, Germany
328 National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
331 schema:name Clinical Cooperation Unit Molecular Radiooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany
332 National Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, Germany
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...