Next-generation sequencing: hype and hope for development of personalized radiation therapy? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Ingeborg Tinhofer, Franziska Niehr, Robert Konschak, Sandra Liebs, Matthias Munz, Albrecht Stenzinger, Wilko Weichert, Ulrich Keilholz, Volker Budach

ABSTRACT

The introduction of next-generation sequencing (NGS) in the field of cancer research has boosted worldwide efforts of genome-wide personalized oncology aiming at identifying predictive biomarkers and novel actionable targets. Despite considerable progress in understanding the molecular biology of distinct cancer entities by the use of this revolutionary technology and despite contemporaneous innovations in drug development, translation of NGS findings into improved concepts for cancer treatment remains a challenge. The aim of this article is to describe shortly the NGS platforms for DNA sequencing and in more detail key achievements and unresolved hurdles. A special focus will be given on potential clinical applications of this innovative technique in the field of radiation oncology. More... »

PAGES

183

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/s13014-015-0481-x

    DOI

    http://dx.doi.org/10.1186/s13014-015-0481-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001668693

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26316159


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