Ontology type: schema:ScholarlyArticle Open Access: True
2015-12
AUTHORSClaudia Blattmann, Susanne Oertel, Markus Thiemann, Anne Dittmar, Eva Roth, Andreas E. Kulozik, Volker Ehemann, Wilko Weichert, Peter E. Huber, Albrecht Stenzinger, Jürgen Debus
ABSTRACTBACKGROUND: Minimal improvements in treatment or survival of patients with osteosarcoma have been achieved during the last three decades. Especially in the case of incomplete tumor resection, prognosis remains poor. Heavy ion radiotherapy (HIT) and modern anticancer drugs like histone deacetylase inhibitors (HDACi) have shown promising effects in osteosarcoma in vitro. In this study, we tested the effect of HIT and the combination of HIT and the HDACi suberoylanilide hydroxamic acid (SAHA) in a xenograft mouse model. METHODS: Osteosarcoma xenografts were established by subcutaneous injection of KHOS-24OS cells and treated with either vehicle (DMSO), SAHA, HIT or HIT and SAHA. Tumor growth was determined and tumor necrosis, proliferation rate, apoptotic rate as well as vessel density were evaluated. RESULTS: Here, we show that the combination of HIT and SAHA induced a significant delay of tumor growth through increased rate of apoptosis, increased expression of p53 and p21(Waf1/Cip1), inhibition of proliferation and angiogenesis compared to tumors treated with HIT only. CONCLUSION: HIT and in particular the combination of HIT and histone deacetylase inhibition is a promising treatment strategy in OS and may be tested in clinical trials. More... »
PAGES146
http://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z
DOIhttp://dx.doi.org/10.1186/s13014-015-0455-z
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1004087566
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/26178881
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Apoptosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Division",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclin-Dependent Kinase Inhibitor p21",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation, Neoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes, p53",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Heavy Ion Radiotherapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Histone Deacetylase Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hydroxamic Acids",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice, SCID",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neovascularization, Pathologic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Osteosarcoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiation Tolerance",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Subcutaneous Tissue",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Suppressor Protein p53",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Vorinostat",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Xenograft Model Antitumor Assays",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Olgahospital",
"id": "https://www.grid.ac/institutes/grid.459687.1",
"name": [
"Department of Pediatric Oncology, Hematology and Immunology, University Children\u2019s, Hospital of Heidelberg, Heidelberg, Germany",
"Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany",
"German Cancer Consortium (DKTK), Heidelberg, Germany",
"P\u00e4diatrie 5, Olgahospital, Kriegsbergstr. 62, 70174, Stuttgart, Germany"
],
"type": "Organization"
},
"familyName": "Blattmann",
"givenName": "Claudia",
"id": "sg:person.01144774645.48",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144774645.48"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany",
"Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Oertel",
"givenName": "Susanne",
"id": "sg:person.01311707757.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311707757.41"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Department of Pediatric Oncology, Hematology and Immunology, University Children\u2019s, Hospital of Heidelberg, Heidelberg, Germany",
"Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Thiemann",
"givenName": "Markus",
"id": "sg:person.0714642437.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714642437.68"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany",
"Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Dittmar",
"givenName": "Anne",
"id": "sg:person.0603413261.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603413261.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Department of Pediatric Oncology, Hematology and Immunology, University Children\u2019s, Hospital of Heidelberg, Heidelberg, Germany",
"Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Roth",
"givenName": "Eva",
"id": "sg:person.01220134511.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220134511.97"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Department of Pediatric Oncology, Hematology and Immunology, University Children\u2019s, Hospital of Heidelberg, Heidelberg, Germany",
"German Cancer Consortium (DKTK), Heidelberg, Germany",
"National Center for Tumor Diseases (NCT), University of Heidelberg, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Kulozik",
"givenName": "Andreas E.",
"id": "sg:person.01022515007.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022515007.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Institute of Pathology, University of Heidelberg, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Ehemann",
"givenName": "Volker",
"id": "sg:person.01236510615.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236510615.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Institute of Pathology, University of Heidelberg, Heidelberg, Germany",
"German Cancer Consortium (DKTK), Heidelberg, Germany",
"National Center for Tumor Diseases (NCT), University of Heidelberg, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Weichert",
"givenName": "Wilko",
"id": "sg:person.0657434205.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Huber",
"givenName": "Peter E.",
"id": "sg:person.0660061332.00",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660061332.00"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Institute of Pathology, University of Heidelberg, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Stenzinger",
"givenName": "Albrecht",
"id": "sg:person.0642700650.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642700650.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Cancer Research Center",
"id": "https://www.grid.ac/institutes/grid.7497.d",
"name": [
"Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany",
"Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Debus",
"givenName": "J\u00fcrgen",
"id": "sg:person.013541325272.97",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013541325272.97"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1158/1078-0432.ccr-11-0650",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000929501"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.27451",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003695448"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1535-6108(03)00165-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006377613"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m213093200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008327079"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-04-2088",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008714989"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2009.01.068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010082995"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1748-717x-7-170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010391090",
"https://doi.org/10.1186/1748-717x-7-170"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10637-010-9596-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011776454",
"https://doi.org/10.1007/s10637-010-9596-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10637-010-9596-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011776454",
"https://doi.org/10.1007/s10637-010-9596-y"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10637-010-9596-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011776454",
"https://doi.org/10.1007/s10637-010-9596-y"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-08-2786",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016232380"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1582-4934.2011.01296.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016610403"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00066-013-0372-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018706577",
"https://doi.org/10.1007/s00066-013-0372-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc864",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018869258",
"https://doi.org/10.1038/nrc864"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc864",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018869258",
"https://doi.org/10.1038/nrc864"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1748-717x-6-119",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019903857",
"https://doi.org/10.1186/1748-717x-6-119"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2010.03.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020179459"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd2133",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023003326",
"https://doi.org/10.1038/nrd2133"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrd2133",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023003326",
"https://doi.org/10.1038/nrd2133"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1215/15228517-2006-032",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023996205"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.26.7.2782-2790.2006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024056818"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.canlet.2010.04.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025148160"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cad.0000000000000040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025472299"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cad.0000000000000040",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025472299"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bcp.2011.11.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028350381"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.canlet.2010.02.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030039467"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2407-10-96",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031949910",
"https://doi.org/10.1186/1471-2407-10-96"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1748-717x-7-52",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037412499",
"https://doi.org/10.1186/1748-717x-7-52"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0505585102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038645703"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0505585102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038645703"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.radonc.2012.09.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043816673"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11864-008-0057-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046867626",
"https://doi.org/10.1007/s11864-008-0057-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.canlet.2009.02.042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053415993"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejca.2009.06.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053532512"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1103/revmodphys.82.383",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060839709"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1103/revmodphys.82.383",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060839709"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.20.3.776",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064202797"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1259/bjr/71511359",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064570044"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/156800910793358014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1069191074"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3892/ijo_00000728",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071518708"
],
"type": "CreativeWork"
}
],
"datePublished": "2015-12",
"datePublishedReg": "2015-12-01",
"description": "BACKGROUND: Minimal improvements in treatment or survival of patients with osteosarcoma have been achieved during the last three decades. Especially in the case of incomplete tumor resection, prognosis remains poor. Heavy ion radiotherapy (HIT) and modern anticancer drugs like histone deacetylase inhibitors (HDACi) have shown promising effects in osteosarcoma in vitro. In this study, we tested the effect of HIT and the combination of HIT and the HDACi suberoylanilide hydroxamic acid (SAHA) in a xenograft mouse model.\nMETHODS: Osteosarcoma xenografts were established by subcutaneous injection of KHOS-24OS cells and treated with either vehicle (DMSO), SAHA, HIT or HIT and SAHA. Tumor growth was determined and tumor necrosis, proliferation rate, apoptotic rate as well as vessel density were evaluated.\nRESULTS: Here, we show that the combination of HIT and SAHA induced a significant delay of tumor growth through increased rate of apoptosis, increased expression of p53 and p21(Waf1/Cip1), inhibition of proliferation and angiogenesis compared to tumors treated with HIT only.\nCONCLUSION: HIT and in particular the combination of HIT and histone deacetylase inhibition is a promising treatment strategy in OS and may be tested in clinical trials.",
"genre": "research_article",
"id": "sg:pub.10.1186/s13014-015-0455-z",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1036451",
"issn": [
"1748-717X"
],
"name": "Radiation Oncology",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "10"
}
],
"name": "Histone deacetylase inhibition sensitizes osteosarcoma to heavy ion radiotherapy",
"pagination": "146",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"137a0659718e35f7ca71bb1f7a0593fbfd0d8c53e500c8bb6a5e7d290926474f"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"26178881"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101265111"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/s13014-015-0455-z"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1004087566"
]
}
],
"sameAs": [
"https://doi.org/10.1186/s13014-015-0455-z",
"https://app.dimensions.ai/details/publication/pub.1004087566"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:08",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88233_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2Fs13014-015-0455-z"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z'
This table displays all metadata directly associated to this object as RDF triples.
348 TRIPLES
21 PREDICATES
84 URIs
43 LITERALS
31 BLANK NODES