Histone deacetylase inhibition sensitizes osteosarcoma to heavy ion radiotherapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Claudia Blattmann, Susanne Oertel, Markus Thiemann, Anne Dittmar, Eva Roth, Andreas E. Kulozik, Volker Ehemann, Wilko Weichert, Peter E. Huber, Albrecht Stenzinger, Jürgen Debus

ABSTRACT

BACKGROUND: Minimal improvements in treatment or survival of patients with osteosarcoma have been achieved during the last three decades. Especially in the case of incomplete tumor resection, prognosis remains poor. Heavy ion radiotherapy (HIT) and modern anticancer drugs like histone deacetylase inhibitors (HDACi) have shown promising effects in osteosarcoma in vitro. In this study, we tested the effect of HIT and the combination of HIT and the HDACi suberoylanilide hydroxamic acid (SAHA) in a xenograft mouse model. METHODS: Osteosarcoma xenografts were established by subcutaneous injection of KHOS-24OS cells and treated with either vehicle (DMSO), SAHA, HIT or HIT and SAHA. Tumor growth was determined and tumor necrosis, proliferation rate, apoptotic rate as well as vessel density were evaluated. RESULTS: Here, we show that the combination of HIT and SAHA induced a significant delay of tumor growth through increased rate of apoptosis, increased expression of p53 and p21(Waf1/Cip1), inhibition of proliferation and angiogenesis compared to tumors treated with HIT only. CONCLUSION: HIT and in particular the combination of HIT and histone deacetylase inhibition is a promising treatment strategy in OS and may be tested in clinical trials. More... »

PAGES

146

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z

DOI

http://dx.doi.org/10.1186/s13014-015-0455-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004087566

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26178881


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p21", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heavy Ion Radiotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histone Deacetylase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxamic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, SCID", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Pathologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteosarcoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiation Tolerance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Subcutaneous Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vorinostat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Olgahospital", 
          "id": "https://www.grid.ac/institutes/grid.459687.1", 
          "name": [
            "Department of Pediatric Oncology, Hematology and Immunology, University Children\u2019s, Hospital of Heidelberg, Heidelberg, Germany", 
            "Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany", 
            "German Cancer Consortium (DKTK), Heidelberg, Germany", 
            "P\u00e4diatrie 5, Olgahospital, Kriegsbergstr. 62, 70174, Stuttgart, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blattmann", 
        "givenName": "Claudia", 
        "id": "sg:person.01144774645.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144774645.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany", 
            "Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oertel", 
        "givenName": "Susanne", 
        "id": "sg:person.01311707757.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311707757.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Pediatric Oncology, Hematology and Immunology, University Children\u2019s, Hospital of Heidelberg, Heidelberg, Germany", 
            "Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thiemann", 
        "givenName": "Markus", 
        "id": "sg:person.0714642437.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714642437.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany", 
            "Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dittmar", 
        "givenName": "Anne", 
        "id": "sg:person.0603413261.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603413261.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Pediatric Oncology, Hematology and Immunology, University Children\u2019s, Hospital of Heidelberg, Heidelberg, Germany", 
            "Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roth", 
        "givenName": "Eva", 
        "id": "sg:person.01220134511.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220134511.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Pediatric Oncology, Hematology and Immunology, University Children\u2019s, Hospital of Heidelberg, Heidelberg, Germany", 
            "German Cancer Consortium (DKTK), Heidelberg, Germany", 
            "National Center for Tumor Diseases (NCT), University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kulozik", 
        "givenName": "Andreas E.", 
        "id": "sg:person.01022515007.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022515007.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Institute of Pathology, University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ehemann", 
        "givenName": "Volker", 
        "id": "sg:person.01236510615.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236510615.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Institute of Pathology, University of Heidelberg, Heidelberg, Germany", 
            "German Cancer Consortium (DKTK), Heidelberg, Germany", 
            "National Center for Tumor Diseases (NCT), University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weichert", 
        "givenName": "Wilko", 
        "id": "sg:person.0657434205.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huber", 
        "givenName": "Peter E.", 
        "id": "sg:person.0660061332.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660061332.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "Institute of Pathology, University of Heidelberg, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stenzinger", 
        "givenName": "Albrecht", 
        "id": "sg:person.0642700650.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642700650.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Cancer Research Center", 
          "id": "https://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany", 
            "Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Debus", 
        "givenName": "J\u00fcrgen", 
        "id": "sg:person.013541325272.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013541325272.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-0650", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000929501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.27451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003695448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1535-6108(03)00165-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006377613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m213093200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008327079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-04-2088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008714989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2009.01.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010082995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-7-170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010391090", 
          "https://doi.org/10.1186/1748-717x-7-170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-010-9596-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011776454", 
          "https://doi.org/10.1007/s10637-010-9596-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-010-9596-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011776454", 
          "https://doi.org/10.1007/s10637-010-9596-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-010-9596-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011776454", 
          "https://doi.org/10.1007/s10637-010-9596-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-2786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016232380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1582-4934.2011.01296.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016610403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00066-013-0372-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018706577", 
          "https://doi.org/10.1007/s00066-013-0372-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018869258", 
          "https://doi.org/10.1038/nrc864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018869258", 
          "https://doi.org/10.1038/nrc864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-6-119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019903857", 
          "https://doi.org/10.1186/1748-717x-6-119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijrobp.2010.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020179459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023003326", 
          "https://doi.org/10.1038/nrd2133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023003326", 
          "https://doi.org/10.1038/nrd2133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1215/15228517-2006-032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023996205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.26.7.2782-2790.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024056818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2010.04.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025148160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0000000000000040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025472299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cad.0000000000000040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025472299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bcp.2011.11.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028350381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2010.02.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030039467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-10-96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031949910", 
          "https://doi.org/10.1186/1471-2407-10-96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1748-717x-7-52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037412499", 
          "https://doi.org/10.1186/1748-717x-7-52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0505585102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038645703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0505585102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038645703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2012.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043816673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11864-008-0057-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046867626", 
          "https://doi.org/10.1007/s11864-008-0057-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2009.02.042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053415993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2009.06.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053532512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/revmodphys.82.383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060839709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1103/revmodphys.82.383", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060839709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.3.776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1259/bjr/71511359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064570044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156800910793358014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069191074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijo_00000728", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071518708"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-12", 
    "datePublishedReg": "2015-12-01", 
    "description": "BACKGROUND: Minimal improvements in treatment or survival of patients with osteosarcoma have been achieved during the last three decades. Especially in the case of incomplete tumor resection, prognosis remains poor. Heavy ion radiotherapy (HIT) and modern anticancer drugs like histone deacetylase inhibitors (HDACi) have shown promising effects in osteosarcoma in vitro. In this study, we tested the effect of HIT and the combination of HIT and the HDACi suberoylanilide hydroxamic acid (SAHA) in a xenograft mouse model.\nMETHODS: Osteosarcoma xenografts were established by subcutaneous injection of KHOS-24OS cells and treated with either vehicle (DMSO), SAHA, HIT or HIT and SAHA. Tumor growth was determined and tumor necrosis, proliferation rate, apoptotic rate as well as vessel density were evaluated.\nRESULTS: Here, we show that the combination of HIT and SAHA induced a significant delay of tumor growth through increased rate of apoptosis, increased expression of p53 and p21(Waf1/Cip1), inhibition of proliferation and angiogenesis compared to tumors treated with HIT only.\nCONCLUSION: HIT and in particular the combination of HIT and histone deacetylase inhibition is a promising treatment strategy in OS and may be tested in clinical trials.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/s13014-015-0455-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1036451", 
        "issn": [
          "1748-717X"
        ], 
        "name": "Radiation Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Histone deacetylase inhibition sensitizes osteosarcoma to heavy ion radiotherapy", 
    "pagination": "146", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "137a0659718e35f7ca71bb1f7a0593fbfd0d8c53e500c8bb6a5e7d290926474f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26178881"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101265111"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/s13014-015-0455-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004087566"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/s13014-015-0455-z", 
      "https://app.dimensions.ai/details/publication/pub.1004087566"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:08", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000367_0000000367/records_88233_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fs13014-015-0455-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/s13014-015-0455-z'


 

This table displays all metadata directly associated to this object as RDF triples.

348 TRIPLES      21 PREDICATES      84 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/s13014-015-0455-z schema:about N03abf3e2738547f8bd690b21e32959e3
2 N0bbaf8a193c54fa0abfbf2e4b2fdc896
3 N29d95dfb5d254696a4a8a73a2a312b0b
4 N3f2a31e664964a19983773190503beb0
5 N46b6b17f466d4d59989dc2bc938c7c3b
6 N475716e17fa646e3ae5b73dbd28301d8
7 N5c65bff66ebb4ce1add30615f888b702
8 N6324cc8a3b864445a441a03ab61523ac
9 N6a8c992faaec4f029c308928a3aaf2dd
10 N942db2938f7e472ca4b717ee0a0c3503
11 Na7fac8283e494cff96d1a9610ad18a70
12 Nb13df75357384dabbd4c13eb0fbb438c
13 Nb4a78253193f403d8b52fc611e81c3b8
14 Nc67ef876ac2c4e56aa066a1778b6d392
15 Nc7c38f98ee474791bd710fc4fbce5541
16 Ncc5a9c27ae574cca959b9b308a91b82e
17 Nd705fd31143641289d941545875a236f
18 Nd815370146ae4c2b8afc7d5465da97aa
19 Ndf96f7a1df114373891e1071ad8d82ae
20 Ne1051372935044328b9e57bb06f602c5
21 Ned4b4c1f67f543c8bd98f60f1d409164
22 Nf10f2af6f2bc44bc891e080f1d370367
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author N917dc1714a1c4b86a135b9b00ba95fcf
26 schema:citation sg:pub.10.1007/s00066-013-0372-8
27 sg:pub.10.1007/s10637-010-9596-y
28 sg:pub.10.1007/s11864-008-0057-1
29 sg:pub.10.1038/nrc864
30 sg:pub.10.1038/nrd2133
31 sg:pub.10.1186/1471-2407-10-96
32 sg:pub.10.1186/1748-717x-6-119
33 sg:pub.10.1186/1748-717x-7-170
34 sg:pub.10.1186/1748-717x-7-52
35 https://doi.org/10.1002/cncr.27451
36 https://doi.org/10.1016/j.bcp.2011.11.010
37 https://doi.org/10.1016/j.canlet.2009.02.042
38 https://doi.org/10.1016/j.canlet.2010.02.016
39 https://doi.org/10.1016/j.canlet.2010.04.014
40 https://doi.org/10.1016/j.ejca.2009.06.006
41 https://doi.org/10.1016/j.ijrobp.2009.01.068
42 https://doi.org/10.1016/j.ijrobp.2010.03.010
43 https://doi.org/10.1016/j.radonc.2012.09.010
44 https://doi.org/10.1016/s1535-6108(03)00165-x
45 https://doi.org/10.1073/pnas.0505585102
46 https://doi.org/10.1074/jbc.m213093200
47 https://doi.org/10.1097/cad.0000000000000040
48 https://doi.org/10.1103/revmodphys.82.383
49 https://doi.org/10.1111/j.1582-4934.2011.01296.x
50 https://doi.org/10.1128/mcb.26.7.2782-2790.2006
51 https://doi.org/10.1158/1078-0432.ccr-04-2088
52 https://doi.org/10.1158/1078-0432.ccr-08-2786
53 https://doi.org/10.1158/1078-0432.ccr-11-0650
54 https://doi.org/10.1200/jco.20.3.776
55 https://doi.org/10.1215/15228517-2006-032
56 https://doi.org/10.1259/bjr/71511359
57 https://doi.org/10.2174/156800910793358014
58 https://doi.org/10.3892/ijo_00000728
59 schema:datePublished 2015-12
60 schema:datePublishedReg 2015-12-01
61 schema:description BACKGROUND: Minimal improvements in treatment or survival of patients with osteosarcoma have been achieved during the last three decades. Especially in the case of incomplete tumor resection, prognosis remains poor. Heavy ion radiotherapy (HIT) and modern anticancer drugs like histone deacetylase inhibitors (HDACi) have shown promising effects in osteosarcoma in vitro. In this study, we tested the effect of HIT and the combination of HIT and the HDACi suberoylanilide hydroxamic acid (SAHA) in a xenograft mouse model. METHODS: Osteosarcoma xenografts were established by subcutaneous injection of KHOS-24OS cells and treated with either vehicle (DMSO), SAHA, HIT or HIT and SAHA. Tumor growth was determined and tumor necrosis, proliferation rate, apoptotic rate as well as vessel density were evaluated. RESULTS: Here, we show that the combination of HIT and SAHA induced a significant delay of tumor growth through increased rate of apoptosis, increased expression of p53 and p21(Waf1/Cip1), inhibition of proliferation and angiogenesis compared to tumors treated with HIT only. CONCLUSION: HIT and in particular the combination of HIT and histone deacetylase inhibition is a promising treatment strategy in OS and may be tested in clinical trials.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N76d2966ebd384c98b8ba0cf0f9850de8
66 Nfcd7a71c17b34408aaec6d5d80881730
67 sg:journal.1036451
68 schema:name Histone deacetylase inhibition sensitizes osteosarcoma to heavy ion radiotherapy
69 schema:pagination 146
70 schema:productId N57f32276a66a42c98cd08ab2c54b1728
71 N5c81b79c43bb46bd998f4459966433c0
72 N9aff2546043647f1a6ff112d308db979
73 Nbe6a602fd0f04b009029d29662fc61a6
74 Nec9cb62047814a4ca503c0b96c47972f
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004087566
76 https://doi.org/10.1186/s13014-015-0455-z
77 schema:sdDatePublished 2019-04-11T13:08
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher Naef9d25d77614760bbcef12c9407874c
80 schema:url http://link.springer.com/10.1186%2Fs13014-015-0455-z
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N03abf3e2738547f8bd690b21e32959e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Mice, SCID
86 rdf:type schema:DefinedTerm
87 N0bbaf8a193c54fa0abfbf2e4b2fdc896 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Apoptosis
89 rdf:type schema:DefinedTerm
90 N29d95dfb5d254696a4a8a73a2a312b0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Humans
92 rdf:type schema:DefinedTerm
93 N2aa5198d491b407b9b9ef514bbc926d6 rdf:first sg:person.0660061332.00
94 rdf:rest N9e2a183ff885465c9e906a53614fb1da
95 N2ece11250ef841b596efbe04327f2401 rdf:first sg:person.0714642437.68
96 rdf:rest N383e8cf69be9468c9a671dd5e5280156
97 N383e8cf69be9468c9a671dd5e5280156 rdf:first sg:person.0603413261.63
98 rdf:rest N38c946bbb1f242fd803c5cd5f9414127
99 N38c946bbb1f242fd803c5cd5f9414127 rdf:first sg:person.01220134511.97
100 rdf:rest Nab9e014499064b87a9ea1418f999ac5f
101 N3f2a31e664964a19983773190503beb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Neoplasm Proteins
103 rdf:type schema:DefinedTerm
104 N46b6b17f466d4d59989dc2bc938c7c3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Cyclin-Dependent Kinase Inhibitor p21
106 rdf:type schema:DefinedTerm
107 N475716e17fa646e3ae5b73dbd28301d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Animals
109 rdf:type schema:DefinedTerm
110 N57f32276a66a42c98cd08ab2c54b1728 schema:name readcube_id
111 schema:value 137a0659718e35f7ca71bb1f7a0593fbfd0d8c53e500c8bb6a5e7d290926474f
112 rdf:type schema:PropertyValue
113 N5a42c5d7fef842bd84eca0277197c44d rdf:first sg:person.01311707757.41
114 rdf:rest N2ece11250ef841b596efbe04327f2401
115 N5c65bff66ebb4ce1add30615f888b702 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Gene Expression Regulation, Neoplastic
117 rdf:type schema:DefinedTerm
118 N5c81b79c43bb46bd998f4459966433c0 schema:name dimensions_id
119 schema:value pub.1004087566
120 rdf:type schema:PropertyValue
121 N6324cc8a3b864445a441a03ab61523ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Tumor Suppressor Protein p53
123 rdf:type schema:DefinedTerm
124 N6a8c992faaec4f029c308928a3aaf2dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Histone Deacetylase Inhibitors
126 rdf:type schema:DefinedTerm
127 N765a65ca002b466395a10141131b5220 rdf:first sg:person.01236510615.66
128 rdf:rest Nc0916a7866d14c08909d93a4fb85b082
129 N76d2966ebd384c98b8ba0cf0f9850de8 schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 N871156d728dd43599f3bbf13fbb09bad rdf:first sg:person.013541325272.97
132 rdf:rest rdf:nil
133 N917dc1714a1c4b86a135b9b00ba95fcf rdf:first sg:person.01144774645.48
134 rdf:rest N5a42c5d7fef842bd84eca0277197c44d
135 N942db2938f7e472ca4b717ee0a0c3503 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Radiation Tolerance
137 rdf:type schema:DefinedTerm
138 N9aff2546043647f1a6ff112d308db979 schema:name nlm_unique_id
139 schema:value 101265111
140 rdf:type schema:PropertyValue
141 N9e2a183ff885465c9e906a53614fb1da rdf:first sg:person.0642700650.98
142 rdf:rest N871156d728dd43599f3bbf13fbb09bad
143 Na7fac8283e494cff96d1a9610ad18a70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Bone Neoplasms
145 rdf:type schema:DefinedTerm
146 Nab9e014499064b87a9ea1418f999ac5f rdf:first sg:person.01022515007.00
147 rdf:rest N765a65ca002b466395a10141131b5220
148 Naef9d25d77614760bbcef12c9407874c schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 Nb13df75357384dabbd4c13eb0fbb438c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Genes, p53
152 rdf:type schema:DefinedTerm
153 Nb4a78253193f403d8b52fc611e81c3b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Osteosarcoma
155 rdf:type schema:DefinedTerm
156 Nbe6a602fd0f04b009029d29662fc61a6 schema:name doi
157 schema:value 10.1186/s13014-015-0455-z
158 rdf:type schema:PropertyValue
159 Nc0916a7866d14c08909d93a4fb85b082 rdf:first sg:person.0657434205.21
160 rdf:rest N2aa5198d491b407b9b9ef514bbc926d6
161 Nc67ef876ac2c4e56aa066a1778b6d392 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Subcutaneous Tissue
163 rdf:type schema:DefinedTerm
164 Nc7c38f98ee474791bd710fc4fbce5541 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Mice
166 rdf:type schema:DefinedTerm
167 Ncc5a9c27ae574cca959b9b308a91b82e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Neovascularization, Pathologic
169 rdf:type schema:DefinedTerm
170 Nd705fd31143641289d941545875a236f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Hydroxamic Acids
172 rdf:type schema:DefinedTerm
173 Nd815370146ae4c2b8afc7d5465da97aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Vorinostat
175 rdf:type schema:DefinedTerm
176 Ndf96f7a1df114373891e1071ad8d82ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Cell Line, Tumor
178 rdf:type schema:DefinedTerm
179 Ne1051372935044328b9e57bb06f602c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Xenograft Model Antitumor Assays
181 rdf:type schema:DefinedTerm
182 Nec9cb62047814a4ca503c0b96c47972f schema:name pubmed_id
183 schema:value 26178881
184 rdf:type schema:PropertyValue
185 Ned4b4c1f67f543c8bd98f60f1d409164 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Heavy Ion Radiotherapy
187 rdf:type schema:DefinedTerm
188 Nf10f2af6f2bc44bc891e080f1d370367 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Cell Division
190 rdf:type schema:DefinedTerm
191 Nfcd7a71c17b34408aaec6d5d80881730 schema:volumeNumber 10
192 rdf:type schema:PublicationVolume
193 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
194 schema:name Medical and Health Sciences
195 rdf:type schema:DefinedTerm
196 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
197 schema:name Oncology and Carcinogenesis
198 rdf:type schema:DefinedTerm
199 sg:journal.1036451 schema:issn 1748-717X
200 schema:name Radiation Oncology
201 rdf:type schema:Periodical
202 sg:person.01022515007.00 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
203 schema:familyName Kulozik
204 schema:givenName Andreas E.
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022515007.00
206 rdf:type schema:Person
207 sg:person.01144774645.48 schema:affiliation https://www.grid.ac/institutes/grid.459687.1
208 schema:familyName Blattmann
209 schema:givenName Claudia
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144774645.48
211 rdf:type schema:Person
212 sg:person.01220134511.97 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
213 schema:familyName Roth
214 schema:givenName Eva
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220134511.97
216 rdf:type schema:Person
217 sg:person.01236510615.66 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
218 schema:familyName Ehemann
219 schema:givenName Volker
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236510615.66
221 rdf:type schema:Person
222 sg:person.01311707757.41 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
223 schema:familyName Oertel
224 schema:givenName Susanne
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311707757.41
226 rdf:type schema:Person
227 sg:person.013541325272.97 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
228 schema:familyName Debus
229 schema:givenName Jürgen
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013541325272.97
231 rdf:type schema:Person
232 sg:person.0603413261.63 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
233 schema:familyName Dittmar
234 schema:givenName Anne
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603413261.63
236 rdf:type schema:Person
237 sg:person.0642700650.98 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
238 schema:familyName Stenzinger
239 schema:givenName Albrecht
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642700650.98
241 rdf:type schema:Person
242 sg:person.0657434205.21 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
243 schema:familyName Weichert
244 schema:givenName Wilko
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21
246 rdf:type schema:Person
247 sg:person.0660061332.00 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
248 schema:familyName Huber
249 schema:givenName Peter E.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660061332.00
251 rdf:type schema:Person
252 sg:person.0714642437.68 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
253 schema:familyName Thiemann
254 schema:givenName Markus
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714642437.68
256 rdf:type schema:Person
257 sg:pub.10.1007/s00066-013-0372-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018706577
258 https://doi.org/10.1007/s00066-013-0372-8
259 rdf:type schema:CreativeWork
260 sg:pub.10.1007/s10637-010-9596-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1011776454
261 https://doi.org/10.1007/s10637-010-9596-y
262 rdf:type schema:CreativeWork
263 sg:pub.10.1007/s11864-008-0057-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046867626
264 https://doi.org/10.1007/s11864-008-0057-1
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nrc864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018869258
267 https://doi.org/10.1038/nrc864
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nrd2133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023003326
270 https://doi.org/10.1038/nrd2133
271 rdf:type schema:CreativeWork
272 sg:pub.10.1186/1471-2407-10-96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031949910
273 https://doi.org/10.1186/1471-2407-10-96
274 rdf:type schema:CreativeWork
275 sg:pub.10.1186/1748-717x-6-119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019903857
276 https://doi.org/10.1186/1748-717x-6-119
277 rdf:type schema:CreativeWork
278 sg:pub.10.1186/1748-717x-7-170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010391090
279 https://doi.org/10.1186/1748-717x-7-170
280 rdf:type schema:CreativeWork
281 sg:pub.10.1186/1748-717x-7-52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037412499
282 https://doi.org/10.1186/1748-717x-7-52
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/cncr.27451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003695448
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.bcp.2011.11.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028350381
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.canlet.2009.02.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053415993
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.canlet.2010.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030039467
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.canlet.2010.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025148160
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1016/j.ejca.2009.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053532512
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1016/j.ijrobp.2009.01.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010082995
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.ijrobp.2010.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020179459
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.radonc.2012.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043816673
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/s1535-6108(03)00165-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006377613
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1073/pnas.0505585102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038645703
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1074/jbc.m213093200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008327079
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1097/cad.0000000000000040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025472299
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1103/revmodphys.82.383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060839709
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1111/j.1582-4934.2011.01296.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016610403
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1128/mcb.26.7.2782-2790.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024056818
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1158/1078-0432.ccr-04-2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008714989
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1158/1078-0432.ccr-08-2786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016232380
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1158/1078-0432.ccr-11-0650 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000929501
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1200/jco.20.3.776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202797
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1215/15228517-2006-032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023996205
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1259/bjr/71511359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064570044
327 rdf:type schema:CreativeWork
328 https://doi.org/10.2174/156800910793358014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069191074
329 rdf:type schema:CreativeWork
330 https://doi.org/10.3892/ijo_00000728 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071518708
331 rdf:type schema:CreativeWork
332 https://www.grid.ac/institutes/grid.459687.1 schema:alternateName Olgahospital
333 schema:name Department of Pediatric Oncology, Hematology and Immunology, University Children’s, Hospital of Heidelberg, Heidelberg, Germany
334 Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
335 German Cancer Consortium (DKTK), Heidelberg, Germany
336 Pädiatrie 5, Olgahospital, Kriegsbergstr. 62, 70174, Stuttgart, Germany
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
339 schema:name Department of Pediatric Oncology, Hematology and Immunology, University Children’s, Hospital of Heidelberg, Heidelberg, Germany
340 Department of Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
341 Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
342 German Cancer Consortium (DKTK), Heidelberg, Germany
343 Institute of Pathology, University of Heidelberg, Heidelberg, Germany
344 National Center for Tumor Diseases (NCT), University of Heidelberg, Heidelberg, Germany
345 rdf:type schema:Organization
346 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
347 schema:name Institute of Pathology, University of Heidelberg, Heidelberg, Germany
348 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...